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The map label for this gene is hemL [H]

Identifier: 21244958

GI number: 21244958

Start: 5006527

End: 5007399

Strand: Reverse

Name: hemL [H]

Synonym: XAC4241

Alternate gene names: 21244958

Gene position: 5007399-5006527 (Counterclockwise)

Preceding gene: 21244959

Following gene: 21244957

Centisome position: 96.75

GC content: 68.73

Gene sequence:

>873_bases
TTGGTGTACGGCCTGCGCCTGCCCGGCACCGGCCGCATGGAAGCGATCGGCATTCCGCGTGGGGCGACCGCGCAGACCCA
GGAATGCCTGCCCAACGATCTGGACGCGCTGCGCCGCAAGCTGCAATTCAATCGCCTGCGTGGCGGGACCGCCGCGGTGC
TGCTCGAACCGCTGGGGCCGGAGAGCGGAACCCGCCCGGTGCATGCGGACTACAACCGCCAGGTGCGCGCGCTGTGCGAC
GAGTTCGGTGCGCTGCTGATCTTCGACGAAGTGGTCACCGGTTTCCGGCTGGGCCCCGGCGGTGCGCAAGGCTACTTCGG
CGTTGCACCGGACATCACCGTGCTGGGCAAGTGCCTGGCCGGCGGCTACCCGATGGCCGGGGCGATCGGTGGCCGCCGCG
AGGTGATGATGAGCCTGGTGGGCGGCATCGGCACGACCGCGCGGCGCGCGTTTGTCGGCGGCACGCTGTCGGCCAACCCG
CTGTCCTGCGTGGCCGGCTATTACGCGTTGCTGGAAGCGCAGCAGAACGATGCCGCCGGCCGCGCCGGCCGCGCGGGCGA
TCGCCTGCGCGCCGGACTGGAGGCGATCATCCAGCGCCGCGGATTGCCGTACGTGGTCTACAACATGGGTTCGATCGTGC
ACTTGCAGACCTCCGGCGTGCTGCTGCTGGACACCGGCAACCTCTACAAACTCTGGCGCGTGCGCAACGACGCCAAGGCG
CGCAAGCACATGATGGAAGAGATGGGCGCGGCGTATTCGGCGCACGGCCTGATCACCCTGGCCGGCAGCCGCATCTACAC
CAGCATGGCCGACACCGATGCGGTGATCGACGAGGCCTTGAACCGTTTCGACGATGTCTTCGCACTGGTCTGA

Upstream 100 bases:

>100_bases
AACCGAGGCGGTGATGGGCGCGGTGCGCCTGGCACGCGCGTATACCCGCTAGTGCTGGATCATCAAGATCGGCGGTGCGT
ATCACGGCTGGAGCGACCAG

Downstream 100 bases:

>100_bases
GCCGATGAACGCCACCGATGCCCTGCGCGACACCTGGCTGCAGACCCGCGAACGGCTGCAGGCGACCCACTTGCTCGGCG
ACGATGACGCGGCCCTGTCG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MVYGLRLPGTGRMEAIGIPRGATAQTQECLPNDLDALRRKLQFNRLRGGTAAVLLEPLGPESGTRPVHADYNRQVRALCD
EFGALLIFDEVVTGFRLGPGGAQGYFGVAPDITVLGKCLAGGYPMAGAIGGRREVMMSLVGGIGTTARRAFVGGTLSANP
LSCVAGYYALLEAQQNDAAGRAGRAGDRLRAGLEAIIQRRGLPYVVYNMGSIVHLQTSGVLLLDTGNLYKLWRVRNDAKA
RKHMMEEMGAAYSAHGLITLAGSRIYTSMADTDAVIDEALNRFDDVFALV

Sequences:

>Translated_290_residues
MVYGLRLPGTGRMEAIGIPRGATAQTQECLPNDLDALRRKLQFNRLRGGTAAVLLEPLGPESGTRPVHADYNRQVRALCD
EFGALLIFDEVVTGFRLGPGGAQGYFGVAPDITVLGKCLAGGYPMAGAIGGRREVMMSLVGGIGTTARRAFVGGTLSANP
LSCVAGYYALLEAQQNDAAGRAGRAGDRLRAGLEAIIQRRGLPYVVYNMGSIVHLQTSGVLLLDTGNLYKLWRVRNDAKA
RKHMMEEMGAAYSAHGLITLAGSRIYTSMADTDAVIDEALNRFDDVFALV
>Mature_290_residues
MVYGLRLPGTGRMEAIGIPRGATAQTQECLPNDLDALRRKLQFNRLRGGTAAVLLEPLGPESGTRPVHADYNRQVRALCD
EFGALLIFDEVVTGFRLGPGGAQGYFGVAPDITVLGKCLAGGYPMAGAIGGRREVMMSLVGGIGTTARRAFVGGTLSANP
LSCVAGYYALLEAQQNDAAGRAGRAGDRLRAGLEAIIQRRGLPYVVYNMGSIVHLQTSGVLLLDTGNLYKLWRVRNDAKA
RKHMMEEMGAAYSAHGLITLAGSRIYTSMADTDAVIDEALNRFDDVFALV

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=164, Percent_Identity=35.3658536585366, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI284507298, Length=163, Percent_Identity=34.3558282208589, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786349, Length=277, Percent_Identity=34.2960288808664, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1789016, Length=244, Percent_Identity=32.3770491803279, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI145693181, Length=165, Percent_Identity=35.7575757575758, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787560, Length=188, Percent_Identity=29.7872340425532, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789759, Length=137, Percent_Identity=34.3065693430657, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788044, Length=155, Percent_Identity=35.4838709677419, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786991, Length=130, Percent_Identity=37.6923076923077, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21357415, Length=167, Percent_Identity=33.5329341317365, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 30948; Mature: 30948

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYGLRLPGTGRMEAIGIPRGATAQTQECLPNDLDALRRKLQFNRLRGGTAAVLLEPLGP
CEEEEECCCCCCEEEEECCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEECCCC
ESGTRPVHADYNRQVRALCDEFGALLIFDEVVTGFRLGPGGAQGYFGVAPDITVLGKCLA
CCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHCEECCCCCCCCCCCCCCCHHHHHHHHH
GGYPMAGAIGGRREVMMSLVGGIGTTARRAFVGGTLSANPLSCVAGYYALLEAQQNDAAG
CCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
RAGRAGDRLRAGLEAIIQRRGLPYVVYNMGSIVHLQTSGVLLLDTGNLYKLWRVRNDAKA
CCCCCHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCEEEEECCCEEEEEEECCHHHH
RKHMMEEMGAAYSAHGLITLAGSRIYTSMADTDAVIDEALNRFDDVFALV
HHHHHHHHCCHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVYGLRLPGTGRMEAIGIPRGATAQTQECLPNDLDALRRKLQFNRLRGGTAAVLLEPLGP
CEEEEECCCCCCEEEEECCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEECCCC
ESGTRPVHADYNRQVRALCDEFGALLIFDEVVTGFRLGPGGAQGYFGVAPDITVLGKCLA
CCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHCEECCCCCCCCCCCCCCCHHHHHHHHH
GGYPMAGAIGGRREVMMSLVGGIGTTARRAFVGGTLSANPLSCVAGYYALLEAQQNDAAG
CCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
RAGRAGDRLRAGLEAIIQRRGLPYVVYNMGSIVHLQTSGVLLLDTGNLYKLWRVRNDAKA
CCCCCHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCEEEEECCCEEEEEEECCHHHH
RKHMMEEMGAAYSAHGLITLAGSRIYTSMADTDAVIDEALNRFDDVFALV
HHHHHHHHCCHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA