Click here to switch to the map view.

The map label for this gene is cls [H]

Identifier: 21244870

GI number: 21244870

Start: 4882485

End: 4883900

Strand: Reverse

Name: cls [H]

Synonym: XAC4153

Alternate gene names: 21244870

Gene position: 4883900-4882485 (Counterclockwise)

Preceding gene: 21244871

Following gene: 21244869

Centisome position: 94.36

GC content: 65.47

Gene sequence:

>1416_bases
TTGCCCGATTGGGTCACAGGCACTTGGCTGCTGGCACTGGACTGGGCGATCCGCCTGGCCGCACTGCTCTGGATTCCCGC
CCGCACCACGCCGGGTGCGGCGCGCAGCTGGCTGCTGCTGATCGGCTTCGTACCGGTGGTCGGCCTGCCGCTGTATCTGT
TGTTCGGCCACCCGTGGTTGTCGCGGCTGCGGGTGGAGCGCCAAGCCACTGCCTCGCAGGTGATTCGCGAACAACAACTG
CCCTTGCATGCGTTGCGCTGGATGCCCCAGGCAGACACCAGCAGTGCCGAAGTGGTGCCGCTGATCGAACGCGAAGGCGA
TTTCATGCCCACGCTGGGCAACGCGGTGGAATTGCTCGACGACTATGCGCAGTCGTTGCAGGCCCTGATCGCGGCGATCG
ACGCGGCCGACAAACGTGTGCACTTGCTGTACTACCTGATGTTCGACGATGCGGTGGGCGAGGCGGTGGTCGTGGCGCTG
GAACGCGCCAGCGCGCGCGGCGTGCGTTGTCGCGTGCTGCTGGATGCGGTGGGCGCCAAGCGCGGCCTGCGTCGCTACCG
CAAGCGCCTGCAGGACGGTGGCGTGCAGGTGTTGGCGGTATTGCCGGGCGGCCTGCGCTGGCGTCGCAGCGGCCGCATGG
ATCTGCGCAACCATCGCAAGATTGCGGTGCTCGACAACCGGGTGGCGTTTGTCGGTTCGCAGAATCTGGCCGAGGCCGGC
TTCATTGATGGCGTGCCCAATCGCGAACTGGTGGCACGCGTGCGCGGGCCGGTGGTCAATCATCTGGAAGCGGTCTTCGC
CAGCGACTGGTTCACCGAAACCGGAGAGCGGCTGGACGTGTGGCCCGATGCACCGGTGTGCGAGGCCAATATCGCCACGC
AATTGCTGCCCAGCGGGCCGGCGTATCCGTTCGAAAATGCGCGCGATGCGATCAATGCGGTGATCCATCTGGCGCGGCGC
AAGGTGGTGCTGGTCACGCCGTACTTCGTGCCCGACGAAGCCTTGCTGAGCGCATTGCGCATCGCCCCAGTCTCGGGAGT
GGATGTGCAGTTGATCCTGTCCGAGCACAACAACCAACGCTTGGCCGCGTGGGCGCAGGAGGCCTATTTCGAAGAGCTGC
TGCGTTGCGGGGTGAAGATTGCGCTGTATCGCCCGCACTTTCTGCATGCCAAGCACCTGAGCATGGATGAAGACATCGCG
CTGGTGGGCTCGATCAATCTGGACATCCGCTCGTTCGCGCTCAACGCCGAGATCGGCATGCTCTGCTACGACACTGGCGT
GGTGCAGCGGTTGCGCGAGATCGAGCAGGACTATCTGGCCAACGCGCGGCAACTGACGTTGGAACAGTGGCGCCGCCGCC
CGGCCTGGCGCCGCAGTCGCGAGGGCATTGCGCGGCTGGCCGATGCGTTGATGTAG

Upstream 100 bases:

>100_bases
GGGCCGTTTCGCTATTGCCCCGCTGCCTGTGCGCAGCCGCCGTTGCGTTTACGCGCGGCCAAGTCAGAATCGGGTTCCTG
ATGAAGACGGACCACTGATG

Downstream 100 bases:

>100_bases
GGCGTGCGCGGTCCATGCGCGCGCAGTGCCCGTTGTGGCGCAGCGCGATGCCTGCGGTGGCAGGTGAAGTGGGGCGCGTC
TGGGGCGGCAAGATCGCGCT

Product: cardiolipin synthase

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MPDWVTGTWLLALDWAIRLAALLWIPARTTPGAARSWLLLIGFVPVVGLPLYLLFGHPWLSRLRVERQATASQVIREQQL
PLHALRWMPQADTSSAEVVPLIEREGDFMPTLGNAVELLDDYAQSLQALIAAIDAADKRVHLLYYLMFDDAVGEAVVVAL
ERASARGVRCRVLLDAVGAKRGLRRYRKRLQDGGVQVLAVLPGGLRWRRSGRMDLRNHRKIAVLDNRVAFVGSQNLAEAG
FIDGVPNRELVARVRGPVVNHLEAVFASDWFTETGERLDVWPDAPVCEANIATQLLPSGPAYPFENARDAINAVIHLARR
KVVLVTPYFVPDEALLSALRIAPVSGVDVQLILSEHNNQRLAAWAQEAYFEELLRCGVKIALYRPHFLHAKHLSMDEDIA
LVGSINLDIRSFALNAEIGMLCYDTGVVQRLREIEQDYLANARQLTLEQWRRRPAWRRSREGIARLADALM

Sequences:

>Translated_471_residues
MPDWVTGTWLLALDWAIRLAALLWIPARTTPGAARSWLLLIGFVPVVGLPLYLLFGHPWLSRLRVERQATASQVIREQQL
PLHALRWMPQADTSSAEVVPLIEREGDFMPTLGNAVELLDDYAQSLQALIAAIDAADKRVHLLYYLMFDDAVGEAVVVAL
ERASARGVRCRVLLDAVGAKRGLRRYRKRLQDGGVQVLAVLPGGLRWRRSGRMDLRNHRKIAVLDNRVAFVGSQNLAEAG
FIDGVPNRELVARVRGPVVNHLEAVFASDWFTETGERLDVWPDAPVCEANIATQLLPSGPAYPFENARDAINAVIHLARR
KVVLVTPYFVPDEALLSALRIAPVSGVDVQLILSEHNNQRLAAWAQEAYFEELLRCGVKIALYRPHFLHAKHLSMDEDIA
LVGSINLDIRSFALNAEIGMLCYDTGVVQRLREIEQDYLANARQLTLEQWRRRPAWRRSREGIARLADALM
>Mature_470_residues
PDWVTGTWLLALDWAIRLAALLWIPARTTPGAARSWLLLIGFVPVVGLPLYLLFGHPWLSRLRVERQATASQVIREQQLP
LHALRWMPQADTSSAEVVPLIEREGDFMPTLGNAVELLDDYAQSLQALIAAIDAADKRVHLLYYLMFDDAVGEAVVVALE
RASARGVRCRVLLDAVGAKRGLRRYRKRLQDGGVQVLAVLPGGLRWRRSGRMDLRNHRKIAVLDNRVAFVGSQNLAEAGF
IDGVPNRELVARVRGPVVNHLEAVFASDWFTETGERLDVWPDAPVCEANIATQLLPSGPAYPFENARDAINAVIHLARRK
VVLVTPYFVPDEALLSALRIAPVSGVDVQLILSEHNNQRLAAWAQEAYFEELLRCGVKIALYRPHFLHAKHLSMDEDIAL
VGSINLDIRSFALNAEIGMLCYDTGVVQRLREIEQDYLANARQLTLEQWRRRPAWRRSREGIARLADALM

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=469, Percent_Identity=32.6226012793177, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1787007, Length=333, Percent_Identity=29.4294294294294, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 52829; Mature: 52698

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDWVTGTWLLALDWAIRLAALLWIPARTTPGAARSWLLLIGFVPVVGLPLYLLFGHPWL
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
SRLRVERQATASQVIREQQLPLHALRWMPQADTSSAEVVPLIEREGDFMPTLGNAVELLD
HHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHH
DYAQSLQALIAAIDAADKRVHLLYYLMFDDAVGEAVVVALERASARGVRCRVLLDAVGAK
HHHHHHHHHHHHHHCCCCEEEEEEEEEEHHHCCHHHHHHHHHHCCCCCEEEHHHHHHHHH
RGLRRYRKRLQDGGVQVLAVLPGGLRWRRSGRMDLRNHRKIAVLDNRVAFVGSQNLAEAG
HHHHHHHHHHHCCCEEEEEECCCCCEECCCCCCCCCCCCEEEEECCEEEEECCCCCCCCC
FIDGVPNRELVARVRGPVVNHLEAVFASDWFTETGERLDVWPDAPVCEANIATQLLPSGP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHCCCCC
AYPFENARDAINAVIHLARRKVVLVTPYFVPDEALLSALRIAPVSGVDVQLILSEHNNQR
CCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCH
LAAWAQEAYFEELLRCGVKIALYRPHFLHAKHLSMDEDIALVGSINLDIRSFALNAEIGM
HHHHHHHHHHHHHHHCCCEEEEECCCEECHHHCCCCCCEEEEEEECCEEEEEEECCCCCE
LCYDTGVVQRLREIEQDYLANARQLTLEQWRRRPAWRRSREGIARLADALM
EEECHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PDWVTGTWLLALDWAIRLAALLWIPARTTPGAARSWLLLIGFVPVVGLPLYLLFGHPWL
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
SRLRVERQATASQVIREQQLPLHALRWMPQADTSSAEVVPLIEREGDFMPTLGNAVELLD
HHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHH
DYAQSLQALIAAIDAADKRVHLLYYLMFDDAVGEAVVVALERASARGVRCRVLLDAVGAK
HHHHHHHHHHHHHHCCCCEEEEEEEEEEHHHCCHHHHHHHHHHCCCCCEEEHHHHHHHHH
RGLRRYRKRLQDGGVQVLAVLPGGLRWRRSGRMDLRNHRKIAVLDNRVAFVGSQNLAEAG
HHHHHHHHHHHCCCEEEEEECCCCCEECCCCCCCCCCCCEEEEECCEEEEECCCCCCCCC
FIDGVPNRELVARVRGPVVNHLEAVFASDWFTETGERLDVWPDAPVCEANIATQLLPSGP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHCCCCC
AYPFENARDAINAVIHLARRKVVLVTPYFVPDEALLSALRIAPVSGVDVQLILSEHNNQR
CCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCH
LAAWAQEAYFEELLRCGVKIALYRPHFLHAKHLSMDEDIALVGSINLDIRSFALNAEIGM
HHHHHHHHHHHHHHHCCCEEEEECCCEECHHHCCCCCCEEEEEEECCEEEEEEECCCCCE
LCYDTGVVQRLREIEQDYLANARQLTLEQWRRRPAWRRSREGIARLADALM
EEECHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA