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The map label for this gene is plsC [H]

Identifier: 21244816

GI number: 21244816

Start: 4802080

End: 4802829

Strand: Reverse

Name: plsC [H]

Synonym: XAC4099

Alternate gene names: 21244816

Gene position: 4802829-4802080 (Counterclockwise)

Preceding gene: 21244817

Following gene: 21244815

Centisome position: 92.8

GC content: 63.87

Gene sequence:

>750_bases
ATGCCGTTGGCAAGGATGCCGCCGCGCCTGGCGTGGGCTGGGTTCAACCTGTTGCAATTGGCGTTTACGCTGGCCTTTAC
CGCTGGCGGGATCGTCTACGCGTTGGTATTGCTGGCGATCACGCGCGATGCCGACCGAATGCTGCGCATGGGCAGCTGGA
TGTGGTCGCCGGTGCTGTTCCGTGGTGCGGGCGCCACCGTCATCGTGGAAGGGCGCGAGCGGGTGGATTGGTCCAAGAAC
TATCTGTTCGTGAGCAACCACCAGTCGATCATCGACATCTGTGCGCTGTTCCATGCCTTGCCGGTGCCGCTGCGCTTCTT
GCTCAAGCAGGAAATGCGCAAGGTGCCGTTCGTGAACTGGTATGCGCATGCCGCCGGCATGCTGTTTCTGGACCGCGACA
GCCGCAGGGCAGGGGCGCTGGTGCGGCGCCAGGCTGCTGCACTGCTGCGCGAGGGCAAACAGTTGTGTCTGTTTCCCGAA
GGCACGCGCAGCCGCACCGGCGCATTATTGCCATTCAAGGCCGGACTACTGCAGGCCGCTATCGATGCTGGCGTGCAGGT
GGTTCCAGTGGCGCTGGATGGCTGCGGCAAGGTCTTGCCGGTCGATGGCCTGTTCAGGGTGAGGCCGGGCATCATTCGCG
TGCGGATCGGTGCGCCGATCGCGGTGACCGGGCCGGATGCGCCGGATCGCCAACAATTGACCGAGCAGGCACACAAGGCC
GTGGCTGCAATGCTTCAACCCAGGATCTGA

Upstream 100 bases:

>100_bases
AGATGGCGCGGCTCGGGCCGGATTTCTGGCGCGATCTGCTGCGCTGAGTGCGTGGCCTGGGGCAGCGACGGACGTGCATA
TTTTCGGGGGCAAGACAAAA

Downstream 100 bases:

>100_bases
GTTCCACGCTTATGGATTTCGTTGTGCCGCATGATCATCCCTGCCTGCCCGGACATTTCCCGGGCCGTCCCGTGGTGCCT
GGCGTGGTCGTGCTCGACCA

Product: acyltransferase

Products: NA

Alternate protein names: 1-AGP acyltransferase; 1-AGPAT; Lysophosphatidic acid acyltransferase; LPAAT [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MPLARMPPRLAWAGFNLLQLAFTLAFTAGGIVYALVLLAITRDADRMLRMGSWMWSPVLFRGAGATVIVEGRERVDWSKN
YLFVSNHQSIIDICALFHALPVPLRFLLKQEMRKVPFVNWYAHAAGMLFLDRDSRRAGALVRRQAAALLREGKQLCLFPE
GTRSRTGALLPFKAGLLQAAIDAGVQVVPVALDGCGKVLPVDGLFRVRPGIIRVRIGAPIAVTGPDAPDRQQLTEQAHKA
VAAMLQPRI

Sequences:

>Translated_249_residues
MPLARMPPRLAWAGFNLLQLAFTLAFTAGGIVYALVLLAITRDADRMLRMGSWMWSPVLFRGAGATVIVEGRERVDWSKN
YLFVSNHQSIIDICALFHALPVPLRFLLKQEMRKVPFVNWYAHAAGMLFLDRDSRRAGALVRRQAAALLREGKQLCLFPE
GTRSRTGALLPFKAGLLQAAIDAGVQVVPVALDGCGKVLPVDGLFRVRPGIIRVRIGAPIAVTGPDAPDRQQLTEQAHKA
VAAMLQPRI
>Mature_248_residues
PLARMPPRLAWAGFNLLQLAFTLAFTAGGIVYALVLLAITRDADRMLRMGSWMWSPVLFRGAGATVIVEGRERVDWSKNY
LFVSNHQSIIDICALFHALPVPLRFLLKQEMRKVPFVNWYAHAAGMLFLDRDSRRAGALVRRQAAALLREGKQLCLFPEG
TRSRTGALLPFKAGLLQAAIDAGVQVVPVALDGCGKVLPVDGLFRVRPGIIRVRIGAPIAVTGPDAPDRQQLTEQAHKAV
AAMLQPRI

Specific function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position [H]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI6041665, Length=220, Percent_Identity=28.1818181818182, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI5453718, Length=191, Percent_Identity=28.2722513089005, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI15100175, Length=191, Percent_Identity=28.2722513089005, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1789395, Length=158, Percent_Identity=30.379746835443, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17564032, Length=196, Percent_Identity=28.0612244897959, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17568319, Length=185, Percent_Identity=24.8648648648649, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320151, Length=163, Percent_Identity=34.3558282208589, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI281364648, Length=222, Percent_Identity=31.5315315315315, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24582856, Length=222, Percent_Identity=31.5315315315315, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24582854, Length=222, Percent_Identity=31.5315315315315, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR004552 [H]

Pfam domain/function: PF01553 Acyltransferase [H]

EC number: =2.3.1.51 [H]

Molecular weight: Translated: 27369; Mature: 27238

Theoretical pI: Translated: 11.37; Mature: 11.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLARMPPRLAWAGFNLLQLAFTLAFTAGGIVYALVLLAITRDADRMLRMGSWMWSPVLF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHE
RGAGATVIVEGRERVDWSKNYLFVSNHQSIIDICALFHALPVPLRFLLKQEMRKVPFVNW
ECCCCEEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
YAHAAGMLFLDRDSRRAGALVRRQAAALLREGKQLCLFPEGTRSRTGALLPFKAGLLQAA
HHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
IDAGVQVVPVALDGCGKVLPVDGLFRVRPGIIRVRIGAPIAVTGPDAPDRQQLTEQAHKA
HHCCCEEEEEEECCCCCEECCCCEEEECCCEEEEEECCEEEEECCCCCCHHHHHHHHHHH
VAAMLQPRI
HHHHHCCCC
>Mature Secondary Structure 
PLARMPPRLAWAGFNLLQLAFTLAFTAGGIVYALVLLAITRDADRMLRMGSWMWSPVLF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHE
RGAGATVIVEGRERVDWSKNYLFVSNHQSIIDICALFHALPVPLRFLLKQEMRKVPFVNW
ECCCCEEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
YAHAAGMLFLDRDSRRAGALVRRQAAALLREGKQLCLFPEGTRSRTGALLPFKAGLLQAA
HHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
IDAGVQVVPVALDGCGKVLPVDGLFRVRPGIIRVRIGAPIAVTGPDAPDRQQLTEQAHKA
HHCCCEEEEEEECCCCCEECCCCEEEECCCEEEEEECCEEEEECCCCCCHHHHHHHHHHH
VAAMLQPRI
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9403685; 7812434 [H]