Click here to switch to the map view.

The map label for this gene is fabR [H]

Identifier: 21244680

GI number: 21244680

Start: 4657475

End: 4658122

Strand: Direct

Name: fabR [H]

Synonym: XAC3961

Alternate gene names: 21244680

Gene position: 4657475-4658122 (Clockwise)

Preceding gene: 21244677

Following gene: 21244681

Centisome position: 89.99

GC content: 66.67

Gene sequence:

>648_bases
ATGACCTCTATCGCCCTGCCTTCCCACGACGCGCCGCCGTCCCGCAAGCCGGCGATTTCACGGGAAGATCTCATCGCTGC
AGCGCTGTCCTTGATTGGCCCGCACCGCAGCCTGTCCACGCTGAGCCTGCGCGAGGTGGCACGCGAGGCGGGTATCGCGC
CGAACAGCTTCTATCGCCAGTTCCGCGACATGGACGAGCTCGCCGTGGCCTTGATCGACCTGGCCGGGCGTTCGCTGCGC
ACCATCATCGGCCAGGCGCGCCAGCGCGCCACCTCCACCGACCGCAGCGTCATCCGCGTCTCGGTCGAAGCCTTCATGGA
ACAGCTGCGCGCCGACGACAAGCTGCTGCACGTGCTGCTGCGCGAAGGCGCGGTGGGCTCGGACGCTTTCAAGCAAGCAG
TGGAGCGCGAACTCACCTATTTCGAAGACGAGCTGCGCGTAGACCTGATTCGCCTGGCCGCGGCCGACAACGCCAAGCTG
CACGCTCCTGCCCTGGTGTCCAAGGCGATCACCCGGTTGGTGTTTGCGATGGGCGCGGTGGCAATGGATTCCCCGCCGGA
AAAAGACCCCGAGCTGATCGAGCAGATCTCGCAGATGCTGCGCATGATCCTCACCGGCGCGCGCGCCCTGGGCACGCACG
CTGGCTGA

Upstream 100 bases:

>100_bases
AGGTTCATGGGTCGCACTATACGCATGCATGCACAGCCGTGTATACACTTGTATATTGCTGGAGGGGCTATGATTCAGAC
CCACGCCCGGCTGCAGCCTC

Downstream 100 bases:

>100_bases
TCGTCTGCACTGACGTTGGCGTGCGGGTGAAAGGGACATCGCAGGCGGTCGGCGTCGTGCCAGACGACGGATCTTCAGCG
ACGTGGCGGGCACGGCATCG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MTSIALPSHDAPPSRKPAISREDLIAAALSLIGPHRSLSTLSLREVAREAGIAPNSFYRQFRDMDELAVALIDLAGRSLR
TIIGQARQRATSTDRSVIRVSVEAFMEQLRADDKLLHVLLREGAVGSDAFKQAVERELTYFEDELRVDLIRLAAADNAKL
HAPALVSKAITRLVFAMGAVAMDSPPEKDPELIEQISQMLRMILTGARALGTHAG

Sequences:

>Translated_215_residues
MTSIALPSHDAPPSRKPAISREDLIAAALSLIGPHRSLSTLSLREVAREAGIAPNSFYRQFRDMDELAVALIDLAGRSLR
TIIGQARQRATSTDRSVIRVSVEAFMEQLRADDKLLHVLLREGAVGSDAFKQAVERELTYFEDELRVDLIRLAAADNAKL
HAPALVSKAITRLVFAMGAVAMDSPPEKDPELIEQISQMLRMILTGARALGTHAG
>Mature_214_residues
TSIALPSHDAPPSRKPAISREDLIAAALSLIGPHRSLSTLSLREVAREAGIAPNSFYRQFRDMDELAVALIDLAGRSLRT
IIGQARQRATSTDRSVIRVSVEAFMEQLRADDKLLHVLLREGAVGSDAFKQAVERELTYFEDELRVDLIRLAAADNAKLH
APALVSKAITRLVFAMGAVAMDSPPEKDPELIEQISQMLRMILTGARALGTHAG

Specific function: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, fabR directly influences the physical properties of the membrane bilayer [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693209, Length=192, Percent_Identity=43.75, Blast_Score=128, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23460; Mature: 23329

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSIALPSHDAPPSRKPAISREDLIAAALSLIGPHRSLSTLSLREVAREAGIAPNSFYRQ
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHH
FRDMDELAVALIDLAGRSLRTIIGQARQRATSTDRSVIRVSVEAFMEQLRADDKLLHVLL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
REGAVGSDAFKQAVERELTYFEDELRVDLIRLAAADNAKLHAPALVSKAITRLVFAMGAV
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
AMDSPPEKDPELIEQISQMLRMILTGARALGTHAG
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TSIALPSHDAPPSRKPAISREDLIAAALSLIGPHRSLSTLSLREVAREAGIAPNSFYRQ
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHH
FRDMDELAVALIDLAGRSLRTIIGQARQRATSTDRSVIRVSVEAFMEQLRADDKLLHVLL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
REGAVGSDAFKQAVERELTYFEDELRVDLIRLAAADNAKLHAPALVSKAITRLVFAMGAV
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
AMDSPPEKDPELIEQISQMLRMILTGARALGTHAG
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA