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The map label for this gene is coxD

Identifier: 21244603

GI number: 21244603

Start: 4563625

End: 4564521

Strand: Reverse

Name: coxD

Synonym: XAC3879

Alternate gene names: 21244603

Gene position: 4564521-4563625 (Counterclockwise)

Preceding gene: 21244604

Following gene: 21244595

Centisome position: 88.19

GC content: 63.32

Gene sequence:

>897_bases
ATGGCTGTCAGCGCACGCGATTATTGGGATCTGACCAAACCCAAGGTGGTGGCACTGATCGTGTTCACCGCCTTGGTGGG
GATGTTCCTGGCTATTCCCGACATGCCGACCTGGCTGCAGGTGCGCACCGGCGCGCTGGGCTTCCTGGGCATCTGGCTGG
CCGCCTCGGCGGCGGCGGCGATCAACCAATTGCTTGATGCCAAGATCGACGCACAGATGGCGCGCACCTCATGGCGCCCA
TTGGTGGTGGGCAAGGTGCGGCCCTGGCAGGTGCTGGTGTTCGCCGGCGTGCTGATCGTGATCTCCATGACCATTCTGGT
GGTGTGGGTGAATGTCATCACCGCCGTGCTGACCTTCGCCTCGCTGATCGGGTATGCGGTGATCTACACCGTCTACCTGA
AGCGCGCGACCTCCCAGAACATCGTGATCGGCGGCCTGGCCGGCGCCACGCCGCCGATGCTGGGCTGGGCCGCGGTGACC
GGGCTGCCGACCAGCGCCGACTGGATCAATGCCTCGTTGCTGGTGCTGATCATCTTCATCTGGACGCCGCCGCATTTCTG
GGCGCTGGCAATCTTTCGTCGCGCCGATTACGCCAAGGCGGCCATCCCGATGTTGCCGGTAACCCATGGTGTGCCGCATA
CGCGCAAGCAGATCCTGGTCTACACCGTATTGCTGGCGATCGTGACCTTGGCGCCGGTGGCGGTGGGCATGAGCGGGATG
TTCTACCTGGGCGGCGCAGCCGTGCTCAATGCGGTGTTCCTCTGGTACGCGTGGCGCATGCTGAACCCGCCGGACGAACT
GTTTTCGATGAAGATGTTCGGGTACTCCATCGTGTACCTGATGGCGTTGTTCGCCTTCCTGATGGTCGACCATCTGCTGC
TGCCGTGGGTGCGCTAG

Upstream 100 bases:

>100_bases
CGCTGCCGCTGGAGGTCTCGCTCATGCATAACGGCGGGGCGGTGGCGTTGTTGTTCGTGCTGGTCTCGCTGCTGGCGCGG
CTGCGCGCGCCGGAGTGAGC

Downstream 100 bases:

>100_bases
TCGCTGCGCTGATACGAGCGGCAACGCGGTGTGGTCTGCCGCCACTGACTGCGTCGCACCAGCGTATGGATGGATCACGT
CTATAGCGCGCCTGCAGCGC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MAVSARDYWDLTKPKVVALIVFTALVGMFLAIPDMPTWLQVRTGALGFLGIWLAASAAAAINQLLDAKIDAQMARTSWRP
LVVGKVRPWQVLVFAGVLIVISMTILVVWVNVITAVLTFASLIGYAVIYTVYLKRATSQNIVIGGLAGATPPMLGWAAVT
GLPTSADWINASLLVLIIFIWTPPHFWALAIFRRADYAKAAIPMLPVTHGVPHTRKQILVYTVLLAIVTLAPVAVGMSGM
FYLGGAAVLNAVFLWYAWRMLNPPDELFSMKMFGYSIVYLMALFAFLMVDHLLLPWVR

Sequences:

>Translated_298_residues
MAVSARDYWDLTKPKVVALIVFTALVGMFLAIPDMPTWLQVRTGALGFLGIWLAASAAAAINQLLDAKIDAQMARTSWRP
LVVGKVRPWQVLVFAGVLIVISMTILVVWVNVITAVLTFASLIGYAVIYTVYLKRATSQNIVIGGLAGATPPMLGWAAVT
GLPTSADWINASLLVLIIFIWTPPHFWALAIFRRADYAKAAIPMLPVTHGVPHTRKQILVYTVLLAIVTLAPVAVGMSGM
FYLGGAAVLNAVFLWYAWRMLNPPDELFSMKMFGYSIVYLMALFAFLMVDHLLLPWVR
>Mature_297_residues
AVSARDYWDLTKPKVVALIVFTALVGMFLAIPDMPTWLQVRTGALGFLGIWLAASAAAAINQLLDAKIDAQMARTSWRPL
VVGKVRPWQVLVFAGVLIVISMTILVVWVNVITAVLTFASLIGYAVIYTVYLKRATSQNIVIGGLAGATPPMLGWAAVTG
LPTSADWINASLLVLIIFIWTPPHFWALAIFRRADYAKAAIPMLPVTHGVPHTRKQILVYTVLLAIVTLAPVAVGMSGMF
YLGGAAVLNAVFLWYAWRMLNPPDELFSMKMFGYSIVYLMALFAFLMVDHLLLPWVR

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=201, Percent_Identity=38.3084577114428, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1786631, Length=292, Percent_Identity=31.5068493150685, Blast_Score=132, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71998235, Length=272, Percent_Identity=31.6176470588235, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6325085, Length=197, Percent_Identity=33.502538071066, Blast_Score=93, Evalue=6e-20,
Organism=Drosophila melanogaster, GI19921064, Length=286, Percent_Identity=32.5174825174825, Blast_Score=124, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYOE_XANAC (Q8PFU4)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_644185.1
- GeneID:   1157950
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3879
- NMPDR:   fig|190486.1.peg.3829
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- ProtClustDB:   PRK04375
- BioCyc:   XAXO190486:XAC3879-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32734; Mature: 32603

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12ee74bc)-; HASH(0x13243f18)-; HASH(0x135ccb08)-; HASH(0x1326a76c)-; HASH(0xf43ad9c)-; HASH(0x131eb0d8)-; HASH(0x130a3fe4)-; HASH(0x13318e10)-; HASH(0x12cb4d60)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSARDYWDLTKPKVVALIVFTALVGMFLAIPDMPTWLQVRTGALGFLGIWLAASAAAA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHH
INQLLDAKIDAQMARTSWRPLVVGKVRPWQVLVFAGVLIVISMTILVVWVNVITAVLTFA
HHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLIGYAVIYTVYLKRATSQNIVIGGLAGATPPMLGWAAVTGLPTSADWINASLLVLIIFI
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHH
WTPPHFWALAIFRRADYAKAAIPMLPVTHGVPHTRKQILVYTVLLAIVTLAPVAVGMSGM
HCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCH
FYLGGAAVLNAVFLWYAWRMLNPPDELFSMKMFGYSIVYLMALFAFLMVDHLLLPWVR
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure 
AVSARDYWDLTKPKVVALIVFTALVGMFLAIPDMPTWLQVRTGALGFLGIWLAASAAAA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHH
INQLLDAKIDAQMARTSWRPLVVGKVRPWQVLVFAGVLIVISMTILVVWVNVITAVLTFA
HHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLIGYAVIYTVYLKRATSQNIVIGGLAGATPPMLGWAAVTGLPTSADWINASLLVLIIFI
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHH
WTPPHFWALAIFRRADYAKAAIPMLPVTHGVPHTRKQILVYTVLLAIVTLAPVAVGMSGM
HCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCH
FYLGGAAVLNAVFLWYAWRMLNPPDELFSMKMFGYSIVYLMALFAFLMVDHLLLPWVR
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12024217