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The map label for this gene is alkB [C]

Identifier: 21244299

GI number: 21244299

Start: 4238187

End: 4238798

Strand: Reverse

Name: alkB [C]

Synonym: XAC3574

Alternate gene names: 21244299

Gene position: 4238798-4238187 (Counterclockwise)

Preceding gene: 21244302

Following gene: 21244294

Centisome position: 81.9

GC content: 65.69

Gene sequence:

>612_bases
GTGTCCGGCATGAGGATTCGGGTGGCATTGCCGGGAGCGGAGATCAACTGGTGGCGGGGTTGGCTGCAGCCTGCGCAGGC
CGATGCGCTGATGCAGGCGCTGCTGGCGCAGGCGCAGTGGGAGGTGCACCGCATCCGGATGTTCGGGCGCATGGTGGATT
CGCCACGCCTGAGCAGCTGGATCGGCGATCCGGAGGCGAGCTATCGCTACTCGGGCACGCGGTTCTCGCCACAGCCTTGG
CTGGACGTGCTGCAGCCAGTGCGCATACGGCTGGAGGACGAGACCGGTCACCGGTTCAACAGCGTGCTGGTCAATCGCTA
CCGAAGTGGCAGTGATGCGATGGGCTGGCACAGCGACGACGAGCCTGAGCTGGGCGCGCAGCCGTTGATTGCCTCTGTGA
GCCTGGGTGCCACGCGGCGCTTTGCGTTCAAGCACCGCGACGATGCGGCGGTGAAGCAAACGCTGGAGCTAGGCCACGGC
GACCTGTTGTTGATGGGCGGTGATACCCAGCGCCACTACAAACACGCGTTGCCGCGCACGGCGCGGCCGATGGGGGAACG
GATCAATCTGACCTTTCGGCAGATTGCGCCGGCTGAAGCAGGTTCAGGCTAG

Upstream 100 bases:

>100_bases
GCTCCCGTTGGCTCGATGGCTGTCGCGCATTTTCCGGGATTGCATGTGACGGCGGCAAATCGTGCCGATTCATCCGCAGT
GCGCAGGCCTGCGTGCTAGC

Downstream 100 bases:

>100_bases
CGCCTGCGGGACGCTTGCCGAGGGATGGTGTATGCGACTCATCCGGCGCTGCGCGTCACCTTCTCCCGCGTGCGGGAGAA
GGCAGGGCGACGTATCTGGG

Product: DNA repair system specific for alkylated DNA

Products: NA

Alternate protein names: Alkylated DNA Repair Protein; DNA Repair System Specific For Alkylated DNA; DNA-N1-Methyladenine Dioxygenase; 2OG-Fe(II) Oxygenase Superfamily Protein; Oxidoreductase 2OG-Fe(II) Oxygenase Family; 2OG-Fe(II) Oxygenase Family Oxidoreductase; Alkylated DNA Repair Protein-Like Protein; Oxidoreductase 2OG-Fe(II) Oxygenase Family Protein; Alkylated DNA Repair Protein AlkB; CRISPR-Associated Family Protein; DNA Repair System Specific For Alkylated DNA Protein; 2OG-Fe(II) Oxygenase Family Protein; DNA Repair System Protein

Number of amino acids: Translated: 203; Mature: 202

Protein sequence:

>203_residues
MSGMRIRVALPGAEINWWRGWLQPAQADALMQALLAQAQWEVHRIRMFGRMVDSPRLSSWIGDPEASYRYSGTRFSPQPW
LDVLQPVRIRLEDETGHRFNSVLVNRYRSGSDAMGWHSDDEPELGAQPLIASVSLGATRRFAFKHRDDAAVKQTLELGHG
DLLLMGGDTQRHYKHALPRTARPMGERINLTFRQIAPAEAGSG

Sequences:

>Translated_203_residues
MSGMRIRVALPGAEINWWRGWLQPAQADALMQALLAQAQWEVHRIRMFGRMVDSPRLSSWIGDPEASYRYSGTRFSPQPW
LDVLQPVRIRLEDETGHRFNSVLVNRYRSGSDAMGWHSDDEPELGAQPLIASVSLGATRRFAFKHRDDAAVKQTLELGHG
DLLLMGGDTQRHYKHALPRTARPMGERINLTFRQIAPAEAGSG
>Mature_202_residues
SGMRIRVALPGAEINWWRGWLQPAQADALMQALLAQAQWEVHRIRMFGRMVDSPRLSSWIGDPEASYRYSGTRFSPQPWL
DVLQPVRIRLEDETGHRFNSVLVNRYRSGSDAMGWHSDDEPELGAQPLIASVSLGATRRFAFKHRDDAAVKQTLELGHGD
LLLMGGDTQRHYKHALPRTARPMGERINLTFRQIAPAEAGSG

Specific function: Probably Involved In The Repair Of Alkylated DNA. Provides Extensive Resistance To Alkylating Agents Such As Mms And Dms (Sn2 Agents), But Not To Mmng And Mnu (Sn1 Agents). [C]

COG id: COG3145

COG function: function code L; Alkylated DNA repair protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI224451107, Length=181, Percent_Identity=39.2265193370166, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI48717226, Length=181, Percent_Identity=39.2265193370166, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI224451103, Length=181, Percent_Identity=39.2265193370166, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI21040275, Length=192, Percent_Identity=37.5, Blast_Score=127, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 22898; Mature: 22767

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGMRIRVALPGAEINWWRGWLQPAQADALMQALLAQAQWEVHRIRMFGRMVDSPRLSSW
CCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
IGDPEASYRYSGTRFSPQPWLDVLQPVRIRLEDETGHRFNSVLVNRYRSGSDAMGWHSDD
CCCCCCCEEECCCCCCCCHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCC
EPELGAQPLIASVSLGATRRFAFKHRDDAAVKQTLELGHGDLLLMGGDTQRHYKHALPRT
CCCCCCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHCCCC
ARPMGERINLTFRQIAPAEAGSG
CCCCCCCCCEEHHHCCCCCCCCC
>Mature Secondary Structure 
SGMRIRVALPGAEINWWRGWLQPAQADALMQALLAQAQWEVHRIRMFGRMVDSPRLSSW
CCCEEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
IGDPEASYRYSGTRFSPQPWLDVLQPVRIRLEDETGHRFNSVLVNRYRSGSDAMGWHSDD
CCCCCCCEEECCCCCCCCHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCC
EPELGAQPLIASVSLGATRRFAFKHRDDAAVKQTLELGHGDLLLMGGDTQRHYKHALPRT
CCCCCCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHCCCC
ARPMGERINLTFRQIAPAEAGSG
CCCCCCCCCEEHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA