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The map label for this gene is pepA [H]

Identifier: 21244281

GI number: 21244281

Start: 4215145

End: 4216617

Strand: Direct

Name: pepA [H]

Synonym: XAC3556

Alternate gene names: 21244281

Gene position: 4215145-4216617 (Clockwise)

Preceding gene: 21244277

Following gene: 21244282

Centisome position: 81.44

GC content: 68.77

Gene sequence:

>1473_bases
ATGGCCCTGCAATTCACCCTGAACCAAGACGCGCCGGCAAGCGCTGCCGTCGACTGCATCGTGGTTGGCGTGTTCGCCGA
CAAGACCCTTTCGCCCGCTGCCCAGGCGCTGGACAGCGCCAGCCAGGGCCGTTTGACGGCCTTGGTCGCGCGCGGCGACG
TGGCCAGCAAGACCGGCAGCACCACACTGCTGCACGACCTGCCCGGCGTCACCGCGCCGCGCGTGCTGGTGGTCGGCCTG
GGCGAAGCCGGCAAGTTCGGCGTGGCGCCTTACCTCAAGGCCGTCGGCGATGCGACCCGGGCGCTGAAGACCGGCGCGGT
CGGCACCGCCCTGCTCACCCTGACCGAACTCACCGTCAAGGCCCGCGATGCAGCCTGGAACATCCGCCAGGCGGTGACCG
TCAGCGACCACGCGGCCTATCGCTACACCGCCACGCTGGGCAAGAAGAAGGTGGATGAAACCGGCTTGACCACCCTGGCG
ATTGCCGGCGACGACGCCCGCGCGCTCGCCGTGGGCGTGGCCACCGCCGAAGGCGTGGAATTCGCCCGCGAGCTGGGCAA
CCTGCCGCCGAACTACTGCACCCCGGCCTACCTGGCCGACACCGCGGCCGCGTTTGCCGGCAAGTTCCGCGGCGCCGAGG
CCGAGATCCTGGACGAGGCGCAGATGGAAGCGCTCGGCATGGGTTCGCTGTTGTCGGTGGCACGTGGCTCGGCCAACCGC
CCGCGCCTGATCGTGCTGAAGTGGAATGGCGGCGGCGACGCGCGCCCCTACGTGCTGGTCGGCAAGGGCATCACCTTCGA
CACCGGTGGCGTCAACCTCAAGACGCAGGGCGGCATCGAGGAAATGAAGTACGACATGTGCGGTGGCGCCAACGTCATCG
GCACCTTCGTGGCCACGGTCAAGGCCGAGCTGCCGATCAATCTGGTGGTGGTGGTGCCGGCGGTCGAGAACGCCATCGAC
GGCAACGCCTACCGCCCCTCCGACGTGATCACCAGCATGTCCGGCAAGACCATCGAAGTCGGCAATACCGACGCCGAAGG
CCGCCTGATCCTGTGCGATGCGCTGACCTACGCCGAACGCTTCAACCCCGAGGCACTGGTGGACGTGGCCACGCTGACCG
GCGCCTGCATGGTGGCGCTGGGCCACCAGACCGCCGGCCTGATGAGCAAGCACGACGACCTGGCTAACGAATTGCTGGCC
GCCGGCGAGCACGTGTTCGACCGCGCCTGGCGCCTGCCGCTGTGGGACGAATATCAGGGGCTGCTGGATTCCACCTTCGC
CGATGTCTACAACATCGGCGGCCGCTGGGGTGGTGCCATCACCGCCGGTTGCTTCCTGTCGCGCTTCACCGAAAACCAGC
GCTGGGCGCATCTGGACATCGCTGGCGTCGCCAGCGACGAAGGCAAGCGCGGCATGGCCACCGGCCGCCCGGTGGGCCTG
CTGACGCAGTGGTTGCTGGACCGCGCCGCCTGA

Upstream 100 bases:

>100_bases
GCTTGTTTTAAACTCTCGGATTCGTTCGCGGCGCCGCCAGCCTAGTCCGGTTGGCGTAAACAGCCCGCGATTGTACGGAT
TTGCCTACGGAATCTGATCA

Downstream 100 bases:

>100_bases
TGTCGCCGCGCGCTGCACTGGCCCTGATCGCCGGATTCGTGCTGGCGGACGGGGTCACCAGCACGCTGCCCAACTGGAAC
GGGCTTGCCAGCGACCTGGT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MALQFTLNQDAPASAAVDCIVVGVFADKTLSPAAQALDSASQGRLTALVARGDVASKTGSTTLLHDLPGVTAPRVLVVGL
GEAGKFGVAPYLKAVGDATRALKTGAVGTALLTLTELTVKARDAAWNIRQAVTVSDHAAYRYTATLGKKKVDETGLTTLA
IAGDDARALAVGVATAEGVEFARELGNLPPNYCTPAYLADTAAAFAGKFRGAEAEILDEAQMEALGMGSLLSVARGSANR
PRLIVLKWNGGGDARPYVLVGKGITFDTGGVNLKTQGGIEEMKYDMCGGANVIGTFVATVKAELPINLVVVVPAVENAID
GNAYRPSDVITSMSGKTIEVGNTDAEGRLILCDALTYAERFNPEALVDVATLTGACMVALGHQTAGLMSKHDDLANELLA
AGEHVFDRAWRLPLWDEYQGLLDSTFADVYNIGGRWGGAITAGCFLSRFTENQRWAHLDIAGVASDEGKRGMATGRPVGL
LTQWLLDRAA

Sequences:

>Translated_490_residues
MALQFTLNQDAPASAAVDCIVVGVFADKTLSPAAQALDSASQGRLTALVARGDVASKTGSTTLLHDLPGVTAPRVLVVGL
GEAGKFGVAPYLKAVGDATRALKTGAVGTALLTLTELTVKARDAAWNIRQAVTVSDHAAYRYTATLGKKKVDETGLTTLA
IAGDDARALAVGVATAEGVEFARELGNLPPNYCTPAYLADTAAAFAGKFRGAEAEILDEAQMEALGMGSLLSVARGSANR
PRLIVLKWNGGGDARPYVLVGKGITFDTGGVNLKTQGGIEEMKYDMCGGANVIGTFVATVKAELPINLVVVVPAVENAID
GNAYRPSDVITSMSGKTIEVGNTDAEGRLILCDALTYAERFNPEALVDVATLTGACMVALGHQTAGLMSKHDDLANELLA
AGEHVFDRAWRLPLWDEYQGLLDSTFADVYNIGGRWGGAITAGCFLSRFTENQRWAHLDIAGVASDEGKRGMATGRPVGL
LTQWLLDRAA
>Mature_489_residues
ALQFTLNQDAPASAAVDCIVVGVFADKTLSPAAQALDSASQGRLTALVARGDVASKTGSTTLLHDLPGVTAPRVLVVGLG
EAGKFGVAPYLKAVGDATRALKTGAVGTALLTLTELTVKARDAAWNIRQAVTVSDHAAYRYTATLGKKKVDETGLTTLAI
AGDDARALAVGVATAEGVEFARELGNLPPNYCTPAYLADTAAAFAGKFRGAEAEILDEAQMEALGMGSLLSVARGSANRP
RLIVLKWNGGGDARPYVLVGKGITFDTGGVNLKTQGGIEEMKYDMCGGANVIGTFVATVKAELPINLVVVVPAVENAIDG
NAYRPSDVITSMSGKTIEVGNTDAEGRLILCDALTYAERFNPEALVDVATLTGACMVALGHQTAGLMSKHDDLANELLAA
GEHVFDRAWRLPLWDEYQGLLDSTFADVYNIGGRWGGAITAGCFLSRFTENQRWAHLDIAGVASDEGKRGMATGRPVGLL
TQWLLDRAA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=485, Percent_Identity=34.8453608247423, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI47155554, Length=313, Percent_Identity=33.2268370607029, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1790710, Length=497, Percent_Identity=47.887323943662, Blast_Score=455, Evalue=1e-129,
Organism=Escherichia coli, GI87082123, Length=292, Percent_Identity=38.3561643835616, Blast_Score=171, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17556903, Length=308, Percent_Identity=35.3896103896104, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=254, Percent_Identity=35.4330708661417, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21355725, Length=508, Percent_Identity=31.2992125984252, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24661038, Length=508, Percent_Identity=30.9055118110236, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI20129969, Length=489, Percent_Identity=29.8568507157464, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21355645, Length=489, Percent_Identity=28.4253578732106, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24662223, Length=489, Percent_Identity=28.4253578732106, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24662227, Length=488, Percent_Identity=28.4836065573771, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI19922386, Length=488, Percent_Identity=28.6885245901639, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI20129963, Length=491, Percent_Identity=28.1059063136456, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI161077148, Length=490, Percent_Identity=28.5714285714286, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI20130057, Length=490, Percent_Identity=28.5714285714286, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI21357381, Length=263, Percent_Identity=35.7414448669202, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI221379063, Length=263, Percent_Identity=35.7414448669202, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI221379062, Length=263, Percent_Identity=35.7414448669202, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646701, Length=268, Percent_Identity=30.9701492537313, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24646703, Length=268, Percent_Identity=30.9701492537313, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21358201, Length=268, Percent_Identity=30.9701492537313, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 51182; Mature: 51051

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALQFTLNQDAPASAAVDCIVVGVFADKTLSPAAQALDSASQGRLTALVARGDVASKTGS
CEEEEEECCCCCCCCCEEEEEEEEECCCCCCHHHHHHCCCCCCCEEEEEECCCCCCCCCC
TTLLHDLPGVTAPRVLVVGLGEAGKFGVAPYLKAVGDATRALKTGAVGTALLTLTELTVK
EEEEECCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEE
ARDAAWNIRQAVTVSDHAAYRYTATLGKKKVDETGLTTLAIAGDDARALAVGVATAEGVE
ECCCCCCHHEEEEECCCCEEEEEEHHCCCCCCCCCCEEEEEECCCCCEEEEEEHHHHHHH
FARELGNLPPNYCTPAYLADTAAAFAGKFRGAEAEILDEAQMEALGMGSLLSVARGSANR
HHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCC
PRLIVLKWNGGGDARPYVLVGKGITFDTGGVNLKTQGGIEEMKYDMCGGANVIGTFVATV
CEEEEEEECCCCCCCCEEEEECCEEECCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHH
KAELPINLVVVVPAVENAIDGNAYRPSDVITSMSGKTIEVGNTDAEGRLILCDALTYAER
EECCCEEEEEEEECHHCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCCEEEEEHHHHHHH
FNPEALVDVATLTGACMVALGHQTAGLMSKHDDLANELLAAGEHVFDRAWRLPLWDEYQG
CCCHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHH
LLDSTFADVYNIGGRWGGAITAGCFLSRFTENQRWAHLDIAGVASDEGKRGMATGRPVGL
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCHHH
LTQWLLDRAA
HHHHHHHHCC
>Mature Secondary Structure 
ALQFTLNQDAPASAAVDCIVVGVFADKTLSPAAQALDSASQGRLTALVARGDVASKTGS
EEEEEECCCCCCCCCEEEEEEEEECCCCCCHHHHHHCCCCCCCEEEEEECCCCCCCCCC
TTLLHDLPGVTAPRVLVVGLGEAGKFGVAPYLKAVGDATRALKTGAVGTALLTLTELTVK
EEEEECCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEE
ARDAAWNIRQAVTVSDHAAYRYTATLGKKKVDETGLTTLAIAGDDARALAVGVATAEGVE
ECCCCCCHHEEEEECCCCEEEEEEHHCCCCCCCCCCEEEEEECCCCCEEEEEEHHHHHHH
FARELGNLPPNYCTPAYLADTAAAFAGKFRGAEAEILDEAQMEALGMGSLLSVARGSANR
HHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCC
PRLIVLKWNGGGDARPYVLVGKGITFDTGGVNLKTQGGIEEMKYDMCGGANVIGTFVATV
CEEEEEEECCCCCCCCEEEEECCEEECCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHH
KAELPINLVVVVPAVENAIDGNAYRPSDVITSMSGKTIEVGNTDAEGRLILCDALTYAER
EECCCEEEEEEEECHHCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCCEEEEEHHHHHHH
FNPEALVDVATLTGACMVALGHQTAGLMSKHDDLANELLAAGEHVFDRAWRLPLWDEYQG
CCCHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHH
LLDSTFADVYNIGGRWGGAITAGCFLSRFTENQRWAHLDIAGVASDEGKRGMATGRPVGL
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCHHH
LTQWLLDRAA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA