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The map label for this gene is pnuC [H]

Identifier: 21244256

GI number: 21244256

Start: 4175515

End: 4176090

Strand: Direct

Name: pnuC [H]

Synonym: XAC3531

Alternate gene names: 21244256

Gene position: 4175515-4176090 (Clockwise)

Preceding gene: 21244255

Following gene: 21244257

Centisome position: 80.68

GC content: 63.89

Gene sequence:

>576_bases
ATGTCGCTGCTCGAATCCATCGCCGTTGTGATCAACCTGCTGGGCGTGTGGCTCACCGCGCGGCGCATCCGCTGGTGCTG
GCCGGTGGGCATCGTGGCGGTGGCGTTGTATGCGTGGCTGTTCTACCAGTGGAAGCTGTACTCGGACATGCTGCTGCAAG
GAGTCTATGTACTGACCCAGCTCTACGGATGGTGGCACTGGCAACCCGGAACCGCAGCAGACACACGAATACGCCCGCTG
CCGATGCCGTCCGCCGAACGCTGGCTCTCGCTGGGCATCGGCGCGGCGTTCGCTGCGACACTCGGCGCCTACATGCATTA
CCGCACCGATGCGGTGCTGCCGTGGCTGGACGCGGCGCTGGCCAGTTTCAGCCTGGTGGCCAGCGTGTGGGCAGCACGCA
AGCGCATCGCCAACTGGGTGTTGTGGATCGTGCTCGACTGCGTCTATGTCGGCGTCTTCATCAGCAAGGGGCTGTACCCC
ACTGCCGTGCTCTACGCAGGCTTCGTGGCGCTTGCGGTGTACGGCTGGCACAGCTGGAAAACCCAACAGAACCAGAACCT
GGCTGTCGCACGCTAA

Upstream 100 bases:

>100_bases
GGACGACGATGCGTCGTGTCCTACGTCTGAACTGTATGTCCTTCCCCCCCTCACGCGTCTTACCCCGCACCACGTTGATC
CGCACCGCACCAGGTACCGC

Downstream 100 bases:

>100_bases
GCCGGTCGCGGTTTGCGAGCGCGTTCTTCTTTACCATCGCAACATGCATGCCTTCCACCTCATTGCCTTGCTCACGCCCT
GCGTCTTCCGTCTGCGGTTC

Product: PnuC protein

Products: nicotinamide nucleotide [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 191; Mature: 190

Protein sequence:

>191_residues
MSLLESIAVVINLLGVWLTARRIRWCWPVGIVAVALYAWLFYQWKLYSDMLLQGVYVLTQLYGWWHWQPGTAADTRIRPL
PMPSAERWLSLGIGAAFAATLGAYMHYRTDAVLPWLDAALASFSLVASVWAARKRIANWVLWIVLDCVYVGVFISKGLYP
TAVLYAGFVALAVYGWHSWKTQQNQNLAVAR

Sequences:

>Translated_191_residues
MSLLESIAVVINLLGVWLTARRIRWCWPVGIVAVALYAWLFYQWKLYSDMLLQGVYVLTQLYGWWHWQPGTAADTRIRPL
PMPSAERWLSLGIGAAFAATLGAYMHYRTDAVLPWLDAALASFSLVASVWAARKRIANWVLWIVLDCVYVGVFISKGLYP
TAVLYAGFVALAVYGWHSWKTQQNQNLAVAR
>Mature_190_residues
SLLESIAVVINLLGVWLTARRIRWCWPVGIVAVALYAWLFYQWKLYSDMLLQGVYVLTQLYGWWHWQPGTAADTRIRPLP
MPSAERWLSLGIGAAFAATLGAYMHYRTDAVLPWLDAALASFSLVASVWAARKRIANWVLWIVLDCVYVGVFISKGLYPT
AVLYAGFVALAVYGWHSWKTQQNQNLAVAR

Specific function: Required for nicotinamide riboside transport across the inner membrane [H]

COG id: COG3201

COG function: function code H; Nicotinamide mononucleotide transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family [H]

Homologues:

Organism=Escherichia coli, GI1786965, Length=208, Percent_Identity=25.4807692307692, Blast_Score=73, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006419 [H]

Pfam domain/function: PF04973 NMN_transporter [H]

EC number: NA

Molecular weight: Translated: 21653; Mature: 21521

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLESIAVVINLLGVWLTARRIRWCWPVGIVAVALYAWLFYQWKLYSDMLLQGVYVLTQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYGWWHWQPGTAADTRIRPLPMPSAERWLSLGIGAAFAATLGAYMHYRTDAVLPWLDAAL
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASFSLVASVWAARKRIANWVLWIVLDCVYVGVFISKGLYPTAVLYAGFVALAVYGWHSWK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
TQQNQNLAVAR
CCCCCCCCCCC
>Mature Secondary Structure 
SLLESIAVVINLLGVWLTARRIRWCWPVGIVAVALYAWLFYQWKLYSDMLLQGVYVLTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYGWWHWQPGTAADTRIRPLPMPSAERWLSLGIGAAFAATLGAYMHYRTDAVLPWLDAAL
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASFSLVASVWAARKRIANWVLWIVLDCVYVGVFISKGLYPTAVLYAGFVALAVYGWHSWK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
TQQNQNLAVAR
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: nicotinamide nucleotide [Periplasm] [C]

Specific reaction: nicotinamide nucleotide [Periplasm] = nicotinamide nucleotide [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2198247; 11677609 [H]