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The map label for this gene is tdcB [H]

Identifier: 21244179

GI number: 21244179

Start: 4075265

End: 4076383

Strand: Direct

Name: tdcB [H]

Synonym: XAC3454

Alternate gene names: 21244179

Gene position: 4075265-4076383 (Clockwise)

Preceding gene: 21244178

Following gene: 21244180

Centisome position: 78.74

GC content: 67.74

Gene sequence:

>1119_bases
ATGCCTGATTCCGGCCGCCCTTCCGCACAGGAGCCAGAGGTAGGCGACGTGGCCGTGAGCGTGGCCGACGTGCTGGCCGC
ACAGGCACGCCTGCGCAAGTACCTGTCGCCCACGCCGCTGCACTACGCCGAACGCTTCGGTGTGTGGTTGAAGCTGGAGA
ATTTGCAGCGCACCGGCTCCTACAAGGTGCGCGGCGCATTGAATGCGTTGCTGGCCGGGCTGGAACGCGGCGATGAGCGC
CCGGTGATCTGCGCCTCGGCCGGCAACCACGCGCAAGGTGTGGCGTGGTCGGCGTACCGGCTGGGTGTGCAGGCCATCAC
GGTAATGCCCTATGGCGCGCCGCAGACCAAGATTGCCGGTGTCGCGCATTGGGGTGCCACGGTGCGCCAACATGGCAACA
GCTACGACGAAGCGTTCGCGTTTGCGCGCGAGCTGGCCGACCAGAACGGCTATCGCTTCCTGTCCGCCTTCGACGACCCG
GACGTGATCGCCGGCCAGGGCACGGTGGGCATCGAGCTGGCGGCGCATGCGCCGGACGTGGTGATCGTGCCGATCGGCGG
CGGTGGCCTGGCCTCCGGCGTGGCGCTGGCATTGAAGTCGCAAGGCGTGCGCGTGGTCGGGGCGCAGGTGGAAGGCGTGG
ATTCGATGGCGCGCGCCGTCCGCGGCGATCTGCGCGAAATCGCTCCGGTCCCAACGCTGGCCGATGGCGTGAAGGTCAAG
ATTCCAGGCCTGCTCACGCGCCGCCTGTGCTCGAGCCTGCTCGATGATGTCGTGATCGTGCGCGAGGCCGAATTGCGCGA
AACATTGGTGCGCCTGGCACTGGACGAACACGTCATTGCCGAGGGCGCTGGCGCCCTCGCCCTGGCCGCCGGTCGCCGCG
TTTCCGGCAAACGCAAATGTGCGGTGGTCTCTGGCGGTAATATCGACGCAACCGTGCTGGCCACACTCTTGTCCGAGGTG
CGGCCGCGTCCGCCACGCAAGCCGCGCCGCCGCAATACCGAGCGACTCCGCAACGAACGCAGCGCCAATCCGCCACCCGC
CACACACGTTCTTTCCCGCCCATCCGCAGTCGCTTCAACGCCTGTCACCGCCATCGCCGTAGAGGAGTCTTCCTGGTGA

Upstream 100 bases:

>100_bases
GGAATCGGTCGAGGCTGCGGCATGAGCATGCAGACCTCGCGCGACCATCAGACTGCTGTCCGGAGGTGTCTTCTTCCGGA
TCGCCCGCGCGCGTGCCGCA

Downstream 100 bases:

>100_bases
ACACGACCGTATCCAACCAGACCCCGCGTATCCGAATTTTCGACACCACCCTGCGCGACGGCGAGCAATCCCCCGGCTGC
AGCATGACGCCCCAGCAGAA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MPDSGRPSAQEPEVGDVAVSVADVLAAQARLRKYLSPTPLHYAERFGVWLKLENLQRTGSYKVRGALNALLAGLERGDER
PVICASAGNHAQGVAWSAYRLGVQAITVMPYGAPQTKIAGVAHWGATVRQHGNSYDEAFAFARELADQNGYRFLSAFDDP
DVIAGQGTVGIELAAHAPDVVIVPIGGGGLASGVALALKSQGVRVVGAQVEGVDSMARAVRGDLREIAPVPTLADGVKVK
IPGLLTRRLCSSLLDDVVIVREAELRETLVRLALDEHVIAEGAGALALAAGRRVSGKRKCAVVSGGNIDATVLATLLSEV
RPRPPRKPRRRNTERLRNERSANPPPATHVLSRPSAVASTPVTAIAVEESSW

Sequences:

>Translated_372_residues
MPDSGRPSAQEPEVGDVAVSVADVLAAQARLRKYLSPTPLHYAERFGVWLKLENLQRTGSYKVRGALNALLAGLERGDER
PVICASAGNHAQGVAWSAYRLGVQAITVMPYGAPQTKIAGVAHWGATVRQHGNSYDEAFAFARELADQNGYRFLSAFDDP
DVIAGQGTVGIELAAHAPDVVIVPIGGGGLASGVALALKSQGVRVVGAQVEGVDSMARAVRGDLREIAPVPTLADGVKVK
IPGLLTRRLCSSLLDDVVIVREAELRETLVRLALDEHVIAEGAGALALAAGRRVSGKRKCAVVSGGNIDATVLATLLSEV
RPRPPRKPRRRNTERLRNERSANPPPATHVLSRPSAVASTPVTAIAVEESSW
>Mature_371_residues
PDSGRPSAQEPEVGDVAVSVADVLAAQARLRKYLSPTPLHYAERFGVWLKLENLQRTGSYKVRGALNALLAGLERGDERP
VICASAGNHAQGVAWSAYRLGVQAITVMPYGAPQTKIAGVAHWGATVRQHGNSYDEAFAFARELADQNGYRFLSAFDDPD
VIAGQGTVGIELAAHAPDVVIVPIGGGGLASGVALALKSQGVRVVGAQVEGVDSMARAVRGDLREIAPVPTLADGVKVKI
PGLLTRRLCSSLLDDVVIVREAELRETLVRLALDEHVIAEGAGALALAAGRRVSGKRKCAVVSGGNIDATVLATLLSEVR
PRPPRKPRRRNTERLRNERSANPPPATHVLSRPSAVASTPVTAIAVEESSW

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=317, Percent_Identity=32.4921135646688, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI33469958, Length=251, Percent_Identity=30.6772908366534, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=41.1575562700965, Blast_Score=191, Evalue=7e-50,
Organism=Escherichia coli, GI1790207, Length=291, Percent_Identity=39.8625429553265, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI2367138, Length=292, Percent_Identity=26.027397260274, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71991565, Length=311, Percent_Identity=35.048231511254, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17508781, Length=319, Percent_Identity=28.5266457680251, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17537387, Length=278, Percent_Identity=35.2517985611511, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322631, Length=314, Percent_Identity=35.3503184713376, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320930, Length=255, Percent_Identity=35.6862745098039, Blast_Score=126, Evalue=7e-30,
Organism=Drosophila melanogaster, GI21355833, Length=314, Percent_Identity=35.3503184713376, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24645328, Length=220, Percent_Identity=35, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 39297; Mature: 39166

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDSGRPSAQEPEVGDVAVSVADVLAAQARLRKYLSPTPLHYAERFGVWLKLENLQRTGS
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEEEECHHCCCC
YKVRGALNALLAGLERGDERPVICASAGNHAQGVAWSAYRLGVQAITVMPYGAPQTKIAG
EEHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHCEEEEEEEECCCCCHHHHE
VAHWGATVRQHGNSYDEAFAFARELADQNGYRFLSAFDDPDVIAGQGTVGIELAAHAPDV
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCEEEEEEECCCCE
VIVPIGGGGLASGVALALKSQGVRVVGAQVEGVDSMARAVRGDLREIAPVPTLADGVKVK
EEEECCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCEEE
IPGLLTRRLCSSLLDDVVIVREAELRETLVRLALDEHVIAEGAGALALAAGRRVSGKRKC
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEE
AVVSGGNIDATVLATLLSEVRPRPPRKPRRRNTERLRNERSANPPPATHVLSRPSAVAST
EEEECCCCHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHCCCCCCCHHHHHCCCCHHHCC
PVTAIAVEESSW
CEEEEEEECCCC
>Mature Secondary Structure 
PDSGRPSAQEPEVGDVAVSVADVLAAQARLRKYLSPTPLHYAERFGVWLKLENLQRTGS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEEEECHHCCCC
YKVRGALNALLAGLERGDERPVICASAGNHAQGVAWSAYRLGVQAITVMPYGAPQTKIAG
EEHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHCEEEEEEEECCCCCHHHHE
VAHWGATVRQHGNSYDEAFAFARELADQNGYRFLSAFDDPDVIAGQGTVGIELAAHAPDV
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCEEEEEEECCCCE
VIVPIGGGGLASGVALALKSQGVRVVGAQVEGVDSMARAVRGDLREIAPVPTLADGVKVK
EEEECCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCEEE
IPGLLTRRLCSSLLDDVVIVREAELRETLVRLALDEHVIAEGAGALALAAGRRVSGKRKC
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEE
AVVSGGNIDATVLATLLSEVRPRPPRKPRRRNTERLRNERSANPPPATHVLSRPSAVAST
EEEECCCCHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHCCCCCCCHHHHHCCCCHHHCC
PVTAIAVEESSW
CEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]