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The map label for this gene is ampR [H]

Identifier: 21243889

GI number: 21243889

Start: 3715677

End: 3716552

Strand: Direct

Name: ampR [H]

Synonym: XAC3163

Alternate gene names: 21243889

Gene position: 3715677-3716552 (Clockwise)

Preceding gene: 21243887

Following gene: 21243892

Centisome position: 71.79

GC content: 70.32

Gene sequence:

>876_bases
ATGCCCCGCCCCCGCCTGCCGCTCAATGCCCTGCGCGCGTTCGAAGCCGCCGCGCGCCATCAGAATCTGACCCGTGCGGC
CAACGAGCTGTGCGTCAGCCAGGCCGCGCTGAGTCACCAGATCAAGGCGCTGGAGCAGCAGTTGGGCGCCAGCCTGTTCC
ACCGCCTGCCGCGCGGGGTGGCACTGACCGACGAAGGCGCCGCACTGGCTCCGGTGCTCGGCGAGGCCTTCGACCGCATC
GCCGCCACCCTGGAACGCTTTGCCGAGGGCCGTTACCGCGAGGTGCTCAGCGTGGGCGTGGTGGGCACCTTCGCCACTGG
CTGGCTATTGCCGCGGCTGGCGGCGTTCCATGCGGCGCATGCGGATATCGAGCTGCGCCTGTCCACCCACAACAACCGCG
TCGACCTGGCCGGAGAAGGCCTGGATCTGGCCATCCGCTTCGGCGATGGCGATTGGCAGGGCCAGGTTGCCGAAGCCGTG
ATGGAAGCGCCCTTTGCGCCGGCGTGTGCGCCGGCAATGGCGCGCGGCTTGCGCGTGCCGGAGGATCTGGCGCGCGTGCC
GTTACTGCGCTCGTATCGTCTGGATGAGTGGCCGCAGTGGTTCCGCGCGGCGCGTGTGACGGAGGTGCCCGCGCGCGGCA
CCATGTTCGATTCGTCGCTCACCCTGGCCAGCGCAGCGGCAGCCGGCGGCGGCGTGGCGTTGTTGCCGCTGCCGATGTTT
CGCCAGGACCTGGATGCCGGACGCCTGGTCTGCCCGTTCCCGATCGCCATCGATGCCGGGCGCTACTGGCTGACGCGGCT
ACGGTCGCGGCCGCAAAGCGACGCCGGGCGCCGGTTGCGCGATTGGCTACTGGCAGAACAGCACATCAGCAGCTGA

Upstream 100 bases:

>100_bases
GCGGTTGCCTCCTTGAGAGAGCCCGCAGTATCGATGCGCACGAGGCAGCCGACCATCGCGATGTTTCGATCTCAGGCATG
AATTGAACTAATCTCTGCCC

Downstream 100 bases:

>100_bases
GCAGCACTGCCGCGCTTAGGGCGCTTTGGACGTCTTTCCCACCTGCACGGCCAACTGACGAAACGCCTCGTACTGCGCCC
TGTCGGCGAACCAATGCGGG

Product: transcriptional activator ampR family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MPRPRLPLNALRAFEAAARHQNLTRAANELCVSQAALSHQIKALEQQLGASLFHRLPRGVALTDEGAALAPVLGEAFDRI
AATLERFAEGRYREVLSVGVVGTFATGWLLPRLAAFHAAHADIELRLSTHNNRVDLAGEGLDLAIRFGDGDWQGQVAEAV
MEAPFAPACAPAMARGLRVPEDLARVPLLRSYRLDEWPQWFRAARVTEVPARGTMFDSSLTLASAAAAGGGVALLPLPMF
RQDLDAGRLVCPFPIAIDAGRYWLTRLRSRPQSDAGRRLRDWLLAEQHISS

Sequences:

>Translated_291_residues
MPRPRLPLNALRAFEAAARHQNLTRAANELCVSQAALSHQIKALEQQLGASLFHRLPRGVALTDEGAALAPVLGEAFDRI
AATLERFAEGRYREVLSVGVVGTFATGWLLPRLAAFHAAHADIELRLSTHNNRVDLAGEGLDLAIRFGDGDWQGQVAEAV
MEAPFAPACAPAMARGLRVPEDLARVPLLRSYRLDEWPQWFRAARVTEVPARGTMFDSSLTLASAAAAGGGVALLPLPMF
RQDLDAGRLVCPFPIAIDAGRYWLTRLRSRPQSDAGRRLRDWLLAEQHISS
>Mature_290_residues
PRPRLPLNALRAFEAAARHQNLTRAANELCVSQAALSHQIKALEQQLGASLFHRLPRGVALTDEGAALAPVLGEAFDRIA
ATLERFAEGRYREVLSVGVVGTFATGWLLPRLAAFHAAHADIELRLSTHNNRVDLAGEGLDLAIRFGDGDWQGQVAEAVM
EAPFAPACAPAMARGLRVPEDLARVPLLRSYRLDEWPQWFRAARVTEVPARGTMFDSSLTLASAAAAGGGVALLPLPMFR
QDLDAGRLVCPFPIAIDAGRYWLTRLRSRPQSDAGRRLRDWLLAEQHISS

Specific function: This protein is a positive regulator of gene expression of beta-lactamase (AmpC) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789173, Length=285, Percent_Identity=35.7894736842105, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1786448, Length=289, Percent_Identity=32.8719723183391, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788706, Length=275, Percent_Identity=30.5454545454545, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1787128, Length=256, Percent_Identity=28.125, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI145693193, Length=264, Percent_Identity=29.5454545454545, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787589, Length=252, Percent_Identity=25, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081978, Length=144, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI157672245, Length=143, Percent_Identity=33.5664335664336, Blast_Score=61, Evalue=8e-11,
Organism=Escherichia coli, GI1786401, Length=278, Percent_Identity=24.1007194244604, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31763; Mature: 31632

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPRLPLNALRAFEAAARHQNLTRAANELCVSQAALSHQIKALEQQLGASLFHRLPRGV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ALTDEGAALAPVLGEAFDRIAATLERFAEGRYREVLSVGVVGTFATGWLLPRLAAFHAAH
EECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ADIELRLSTHNNRVDLAGEGLDLAIRFGDGDWQGQVAEAVMEAPFAPACAPAMARGLRVP
CCEEEEEECCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCC
EDLARVPLLRSYRLDEWPQWFRAARVTEVPARGTMFDSSLTLASAAAAGGGVALLPLPMF
HHHHHCCHHHHCCCCHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHCCCCCEEEEECHHH
RQDLDAGRLVCPFPIAIDAGRYWLTRLRSRPQSDAGRRLRDWLLAEQHISS
HHCCCCCCEEECCCEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PRPRLPLNALRAFEAAARHQNLTRAANELCVSQAALSHQIKALEQQLGASLFHRLPRGV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ALTDEGAALAPVLGEAFDRIAATLERFAEGRYREVLSVGVVGTFATGWLLPRLAAFHAAH
EECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ADIELRLSTHNNRVDLAGEGLDLAIRFGDGDWQGQVAEAVMEAPFAPACAPAMARGLRVP
CCEEEEEECCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCC
EDLARVPLLRSYRLDEWPQWFRAARVTEVPARGTMFDSSLTLASAAAAGGGVALLPLPMF
HHHHHCCHHHHCCCCHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHCCCCCEEEEECHHH
RQDLDAGRLVCPFPIAIDAGRYWLTRLRSRPQSDAGRRLRDWLLAEQHISS
HHCCCCCCEEECCCEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8405939; 10984043; 2125210 [H]