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The map label for this gene is xylR [H]

Identifier: 21243753

GI number: 21243753

Start: 3533270

End: 3534874

Strand: Reverse

Name: xylR [H]

Synonym: XAC3026

Alternate gene names: 21243753

Gene position: 3534874-3533270 (Counterclockwise)

Preceding gene: 77748688

Following gene: 21243736

Centisome position: 68.3

GC content: 64.11

Gene sequence:

>1605_bases
TTGCCGACGGTCTGGTCAGGGATGGCGCGACTTGGGTCTGGCCGCCTTCCGAGCGCGCCAGTAGATCAGGTCGAAAGCAT
CATGGAAAAGCAAGTCTTTGATGTAGTGCAGCGCGCCTATTTCTCAGGCGATCCCTTGGAGAAAATGCTGGGAAAGATCG
CTGCACAACTGTCGCAGAGCGCGATCACGAACGGCGCGGTATGTGAGTTTGTCGCGGTGGAGCATCACGGTCCACCGGGT
CCGGTTCTGGCAGAAATCCAGCCCCCGCCCACGCAGTGTTTTCCCGTCCAGCACGGCCGGCAAGTGCTCGGCACACTGAA
TGTCACGCCGGCTCAAGAACGAATGACCCCGGAGGCGATGACGCTGTGCCAGCAGATCGCAAAGTATTGTGCGTACCTGA
TCAAGCGCGATGCCGCGCGGGCGTTCGCGCAAGACCGGTTTGGTCGCGCGCTGTCGATCGTGGGCGTGAGCGAAGAGGTC
TTGACGATCGACGAATTTGTCGAGCACGGCGCATACAGTCGCTTGCCGGTCATCGTGCGCGGCGAGTTCGGAACCGAGAA
GGAAACGGTGGCCGTTTTGCTGCATGCAGCTGCACACTGGCGGGAGGGGCCGTTCGTTGCGATCGACTGCGCCGCTCCCG
GCGACGCACCGGCGGCATGGTTCAAGCGCGGGGCCGGGGGAACGCTGTTCCTGCAGAGCGTGGACGAGCTCGACGACGCG
CTACAGCGCCAGTTGGCCGGGCAGCTTTGTGGCCTCGGCGGGCCATGGTCCGCCGTGGACGGCGAGGACTCGCCACGCGT
GGTCGCCTCCACGACCGCTGATCTGTCGCGCCGCGTACGTGCCGGACGCTTCTCGCGGGCGCTGCTGTCGCAACTGGATG
TCCTATCGATCGAACTTACCCCGTTGCGCAAGCGACGGACAGATATCGGCTTTCACGTCGAGCATGTGCTGGATCGGCAT
GGCTTGGATCACGGTCAGGTGGTCACCGAGGTGTTGATGGACGCCCTGACCCACTACTCATGGCCGGAAAACCTCCAGGA
GCTGGAGCGGGTGGTGCTGCGCTTGGCGGTCATGACAGCCGGCAGGCCGATCGGCAGCGCCGACATCCAGCGCCACGCAC
CGCGTCTGTTGGAAGGCCGGGTGAAGGGAGCGCAGCACGATGCATGCGCGACGATGTCGCAACCGGCCGATCTTCCGGCT
GAGCCCACGCCGCCGGGAACGCCTGTCGACTGGATCGACGGCCTTCCGCATCGCCCCGGGCAACGTCTCGCCACGCTGCA
CGACGCACTGCGGCGCGCATTGGTGCATCTGGGCGAGCACTATGCCGAGCCGCTGACCCTGGGCGATCTGGCCCGGCAGG
CGCACGTTAGCCAGTCGCATCTGGGCTTTCTGTTCCGCGACGAACTCGGCACCCCGTTCAAACCGATGTTGCAGCAGCTA
CGGATCGAAAAGGCCAAGGAGCTTTTGCATCAGCAGCGCAAGCTGCGCATCACCGAAGTGGCGCTGAAGGTCGGTTTCGG
CGACCTGAGCCATTTCGAAAAGAGCTTCCGACGGCTGGCTGGGGTGAGCCCGCGTGAGTTCCGTAGGGTCTATGGCCAGG
ATTGA

Upstream 100 bases:

>100_bases
TCCAGTCACCGCAAGCGAGCGTTGTCTCACATCAGGGTGGATCGACCGAGGGCGGGCGAGGGGAGCGTTCGTAGAAAAAG
CGGAATGCACGCTTGGAGCT

Downstream 100 bases:

>100_bases
CCGTCAGATATGAGGCCCCAACTTCGTGCTGGGTTCATCGGCTGGGCCCAGCATGCGGTTGCTTACAAATGCGCCGCCTC
TCAGAAAAAATTCTATTCAA

Product: transcriptional regulator

Products: NA

Alternate protein names: 67 kDa protein [H]

Number of amino acids: Translated: 534; Mature: 533

Protein sequence:

>534_residues
MPTVWSGMARLGSGRLPSAPVDQVESIMEKQVFDVVQRAYFSGDPLEKMLGKIAAQLSQSAITNGAVCEFVAVEHHGPPG
PVLAEIQPPPTQCFPVQHGRQVLGTLNVTPAQERMTPEAMTLCQQIAKYCAYLIKRDAARAFAQDRFGRALSIVGVSEEV
LTIDEFVEHGAYSRLPVIVRGEFGTEKETVAVLLHAAAHWREGPFVAIDCAAPGDAPAAWFKRGAGGTLFLQSVDELDDA
LQRQLAGQLCGLGGPWSAVDGEDSPRVVASTTADLSRRVRAGRFSRALLSQLDVLSIELTPLRKRRTDIGFHVEHVLDRH
GLDHGQVVTEVLMDALTHYSWPENLQELERVVLRLAVMTAGRPIGSADIQRHAPRLLEGRVKGAQHDACATMSQPADLPA
EPTPPGTPVDWIDGLPHRPGQRLATLHDALRRALVHLGEHYAEPLTLGDLARQAHVSQSHLGFLFRDELGTPFKPMLQQL
RIEKAKELLHQQRKLRITEVALKVGFGDLSHFEKSFRRLAGVSPREFRRVYGQD

Sequences:

>Translated_534_residues
MPTVWSGMARLGSGRLPSAPVDQVESIMEKQVFDVVQRAYFSGDPLEKMLGKIAAQLSQSAITNGAVCEFVAVEHHGPPG
PVLAEIQPPPTQCFPVQHGRQVLGTLNVTPAQERMTPEAMTLCQQIAKYCAYLIKRDAARAFAQDRFGRALSIVGVSEEV
LTIDEFVEHGAYSRLPVIVRGEFGTEKETVAVLLHAAAHWREGPFVAIDCAAPGDAPAAWFKRGAGGTLFLQSVDELDDA
LQRQLAGQLCGLGGPWSAVDGEDSPRVVASTTADLSRRVRAGRFSRALLSQLDVLSIELTPLRKRRTDIGFHVEHVLDRH
GLDHGQVVTEVLMDALTHYSWPENLQELERVVLRLAVMTAGRPIGSADIQRHAPRLLEGRVKGAQHDACATMSQPADLPA
EPTPPGTPVDWIDGLPHRPGQRLATLHDALRRALVHLGEHYAEPLTLGDLARQAHVSQSHLGFLFRDELGTPFKPMLQQL
RIEKAKELLHQQRKLRITEVALKVGFGDLSHFEKSFRRLAGVSPREFRRVYGQD
>Mature_533_residues
PTVWSGMARLGSGRLPSAPVDQVESIMEKQVFDVVQRAYFSGDPLEKMLGKIAAQLSQSAITNGAVCEFVAVEHHGPPGP
VLAEIQPPPTQCFPVQHGRQVLGTLNVTPAQERMTPEAMTLCQQIAKYCAYLIKRDAARAFAQDRFGRALSIVGVSEEVL
TIDEFVEHGAYSRLPVIVRGEFGTEKETVAVLLHAAAHWREGPFVAIDCAAPGDAPAAWFKRGAGGTLFLQSVDELDDAL
QRQLAGQLCGLGGPWSAVDGEDSPRVVASTTADLSRRVRAGRFSRALLSQLDVLSIELTPLRKRRTDIGFHVEHVLDRHG
LDHGQVVTEVLMDALTHYSWPENLQELERVVLRLAVMTAGRPIGSADIQRHAPRLLEGRVKGAQHDACATMSQPADLPAE
PTPPGTPVDWIDGLPHRPGQRLATLHDALRRALVHLGEHYAEPLTLGDLARQAHVSQSHLGFLFRDELGTPFKPMLQQLR
IEKAKELLHQQRKLRITEVALKVGFGDLSHFEKSFRRLAGVSPREFRRVYGQD

Specific function: Regulatory protein of the TOL plasmid xyl operons. In the presence of m-xylene or m-methylbenzyl alcohol xylR activates both the xylCMABN operon and the regulatory gene xylS; xylS itself activates the xylXYZLTEGFJQKIH operon. XylR interacts with sigma- 54

COG id: COG3604

COG function: function code KT; Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=245, Percent_Identity=31.4285714285714, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790437, Length=227, Percent_Identity=32.15859030837, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082152, Length=235, Percent_Identity=32.3404255319149, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790299, Length=250, Percent_Identity=28.8, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI87081872, Length=232, Percent_Identity=31.0344827586207, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789233, Length=221, Percent_Identity=28.9592760180996, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI87082117, Length=241, Percent_Identity=28.6307053941909, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787583, Length=239, Percent_Identity=27.6150627615063, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1786524, Length=276, Percent_Identity=28.2608695652174, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788905, Length=248, Percent_Identity=27.8225806451613, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789087, Length=325, Percent_Identity=27.6923076923077, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87081858, Length=231, Percent_Identity=29.4372294372294, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR004096
- InterPro:   IPR010523
- ProDom:   PD485437 [H]

Pfam domain/function: PF02954 HTH_8; PF00158 Sigma54_activat; PF02830 V4R; PF06505 XylR_N [H]

EC number: NA

Molecular weight: Translated: 58729; Mature: 58598

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTVWSGMARLGSGRLPSAPVDQVESIMEKQVFDVVQRAYFSGDPLEKMLGKIAAQLSQS
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AITNGAVCEFVAVEHHGPPGPVLAEIQPPPTQCFPVQHGRQVLGTLNVTPAQERMTPEAM
HCCCCCCEEEEEEECCCCCCCEEECCCCCCCCCCCHHHHHHHHHCCCCCCHHHHCCHHHH
TLCQQIAKYCAYLIKRDAARAFAQDRFGRALSIVGVSEEVLTIDEFVEHGAYSRLPVIVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHCCCCCCCCEEEE
GEFGTEKETVAVLLHAAAHWREGPFVAIDCAAPGDAPAAWFKRGAGGTLFLQSVDELDDA
CCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHCCCCCEEHHHHHHHHHHH
LQRQLAGQLCGLGGPWSAVDGEDSPRVVASTTADLSRRVRAGRFSRALLSQLDVLSIELT
HHHHHHHHHCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEC
PLRKRRTDIGFHVEHVLDRHGLDHGQVVTEVLMDALTHYSWPENLQELERVVLRLAVMTA
CHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
GRPIGSADIQRHAPRLLEGRVKGAQHDACATMSQPADLPAEPTPPGTPVDWIDGLPHRPG
CCCCCCHHHHHHCHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCH
QRLATLHDALRRALVHLGEHYAEPLTLGDLARQAHVSQSHLGFLFRDELGTPFKPMLQQL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHCHHHHHHCCCCHHHHHHHH
RIEKAKELLHQQRKLRITEVALKVGFGDLSHFEKSFRRLAGVSPREFRRVYGQD
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure 
PTVWSGMARLGSGRLPSAPVDQVESIMEKQVFDVVQRAYFSGDPLEKMLGKIAAQLSQS
CCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AITNGAVCEFVAVEHHGPPGPVLAEIQPPPTQCFPVQHGRQVLGTLNVTPAQERMTPEAM
HCCCCCCEEEEEEECCCCCCCEEECCCCCCCCCCCHHHHHHHHHCCCCCCHHHHCCHHHH
TLCQQIAKYCAYLIKRDAARAFAQDRFGRALSIVGVSEEVLTIDEFVEHGAYSRLPVIVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHCCCCCCCCEEEE
GEFGTEKETVAVLLHAAAHWREGPFVAIDCAAPGDAPAAWFKRGAGGTLFLQSVDELDDA
CCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHCCCCCEEHHHHHHHHHHH
LQRQLAGQLCGLGGPWSAVDGEDSPRVVASTTADLSRRVRAGRFSRALLSQLDVLSIELT
HHHHHHHHHCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEC
PLRKRRTDIGFHVEHVLDRHGLDHGQVVTEVLMDALTHYSWPENLQELERVVLRLAVMTA
CHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
GRPIGSADIQRHAPRLLEGRVKGAQHDACATMSQPADLPAEPTPPGTPVDWIDGLPHRPG
CCCCCCHHHHHHCHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCH
QRLATLHDALRRALVHLGEHYAEPLTLGDLARQAHVSQSHLGFLFRDELGTPFKPMLQQL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHCHHHHHHCCCCHHHHHHHH
RIEKAKELLHQQRKLRITEVALKVGFGDLSHFEKSFRRLAGVSPREFRRVYGQD
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3169574; 2993247; 2430049 [H]