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The map label for this gene is pdxH

Identifier: 21243736

GI number: 21243736

Start: 3519768

End: 3520367

Strand: Reverse

Name: pdxH

Synonym: XAC3009

Alternate gene names: 21243736

Gene position: 3520367-3519768 (Counterclockwise)

Preceding gene: 21243753

Following gene: 21243735

Centisome position: 68.02

GC content: 68.83

Gene sequence:

>600_bases
ATGACCGATCTGTACGCAGAAGCCCTTGCCACCTTCGCCGCGCTGTATGCCGAGGCGCAGAACAGCGCCGAACTGGAAGC
CAGCGCGATGACCGTGGCCACCGCCAACGTGGATGGCCGGCCGAGCGCGCGCACCGTGTTGCTCAAGGCCTTCGACGCGC
GCGGGTTCGTGTTCTACACCCATCTGGACAGCGCAAAGGGCCGCGACCTGCAGACCCACCCGCAGGCGGCGCTGCTGTTC
CTGTGGCGCAGCCTACGCGAAGCCGGCATCCAGGTGCGCATCGAAGGCGGCGTGCAGCTGGTGAGCGCGGACGAATCCGA
TGCGTACTTCGCCTCGCGCCCGCGCATGAGCCAGATCGGCGCGTGGGCCTCGCGGCAGTCGCAGGCGCTGGGCTCGCGCG
AAGAGTTCGATGCGGCCATTGCCAAGGTCGAAGCCACGTTCGCAGGGCGCGAGGTGCCGCGCCCGGATGGCTGGGGCGGG
TTCCGGGTGGTGCCGCAGGCGTTCGAGTTCTGGTACGGCGCCAAGTTCCGTCTGCACGAGCGCTGGCGCTACGAGGCCGA
CGCGGCCAGCCATTGGAGCAAGCGGATGCTGTATCCGTGA

Upstream 100 bases:

>100_bases
ACGCCAACCGCGTGCCGATCCGGCGATTCGATCGCGCTGCATAGGCGAAGCGCGGGCGATGCGCCCACAATAGGCGTCCA
TCTGGCTGCCACGCACCGTC

Downstream 100 bases:

>100_bases
GGCAGCCGCCCGGCATGGGGCGACACGCCAGCTGAACGGGCGGTTTGCTCGCCTGCCGCGCGCCTGACCAGCTGACTTTC
GGCCCTTTCTGCCGGTCACG

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MTDLYAEALATFAALYAEAQNSAELEASAMTVATANVDGRPSARTVLLKAFDARGFVFYTHLDSAKGRDLQTHPQAALLF
LWRSLREAGIQVRIEGGVQLVSADESDAYFASRPRMSQIGAWASRQSQALGSREEFDAAIAKVEATFAGREVPRPDGWGG
FRVVPQAFEFWYGAKFRLHERWRYEADAASHWSKRMLYP

Sequences:

>Translated_199_residues
MTDLYAEALATFAALYAEAQNSAELEASAMTVATANVDGRPSARTVLLKAFDARGFVFYTHLDSAKGRDLQTHPQAALLF
LWRSLREAGIQVRIEGGVQLVSADESDAYFASRPRMSQIGAWASRQSQALGSREEFDAAIAKVEATFAGREVPRPDGWGG
FRVVPQAFEFWYGAKFRLHERWRYEADAASHWSKRMLYP
>Mature_198_residues
TDLYAEALATFAALYAEAQNSAELEASAMTVATANVDGRPSARTVLLKAFDARGFVFYTHLDSAKGRDLQTHPQAALLFL
WRSLREAGIQVRIEGGVQLVSADESDAYFASRPRMSQIGAWASRQSQALGSREEFDAAIAKVEATFAGREVPRPDGWGGF
RVVPQAFEFWYGAKFRLHERWRYEADAASHWSKRMLYP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=176, Percent_Identity=42.6136363636364, Blast_Score=150, Evalue=5e-37,
Organism=Escherichia coli, GI1787926, Length=185, Percent_Identity=40, Blast_Score=142, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17553712, Length=174, Percent_Identity=37.3563218390805, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319509, Length=185, Percent_Identity=41.0810810810811, Blast_Score=137, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45551845, Length=161, Percent_Identity=44.0993788819876, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24644901, Length=161, Percent_Identity=44.0993788819876, Blast_Score=124, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_XANAC (Q8PI89)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643318.1
- ProteinModelPortal:   Q8PI89
- SMR:   Q8PI89
- GeneID:   1157080
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3009
- NMPDR:   fig|190486.1.peg.2962
- HOGENOM:   HBG327559
- OMA:   HWSGFRI
- ProtClustDB:   PRK05679
- BioCyc:   XAXO190486:XAC3009-MONOMER
- BRENDA:   1.4.3.5
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 22200; Mature: 22069

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 44-44 BINDING 47-47 BINDING 49-49 BINDING 66-66 BINDING 109-109 BINDING 113-113 BINDING 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLYAEALATFAALYAEAQNSAELEASAMTVATANVDGRPSARTVLLKAFDARGFVFYT
CCHHHHHHHHHHHHHHHHCCCCCCEEHHEEEEEEECCCCCCCHHEEEEEEECCCCEEEEE
HLDSAKGRDLQTHPQAALLFLWRSLREAGIQVRIEGGVQLVSADESDAYFASRPRMSQIG
ECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCEECCCCCHHHHH
AWASRQSQALGSREEFDAAIAKVEATFAGREVPRPDGWGGFRVVPQAFEFWYGAKFRLHE
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEHH
RWRYEADAASHWSKRMLYP
HHCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TDLYAEALATFAALYAEAQNSAELEASAMTVATANVDGRPSARTVLLKAFDARGFVFYT
CHHHHHHHHHHHHHHHHCCCCCCEEHHEEEEEEECCCCCCCHHEEEEEEECCCCEEEEE
HLDSAKGRDLQTHPQAALLFLWRSLREAGIQVRIEGGVQLVSADESDAYFASRPRMSQIG
ECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCEECCCCCHHHHH
AWASRQSQALGSREEFDAAIAKVEATFAGREVPRPDGWGGFRVVPQAFEFWYGAKFRLHE
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEHH
RWRYEADAASHWSKRMLYP
HHCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217