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The map label for this gene is aroB

Identifier: 21243738

GI number: 21243738

Start: 3521075

End: 3522187

Strand: Direct

Name: aroB

Synonym: XAC3011

Alternate gene names: 21243738

Gene position: 3521075-3522187 (Clockwise)

Preceding gene: 21243737

Following gene: 21243739

Centisome position: 68.03

GC content: 69.9

Gene sequence:

>1113_bases
ATGACACTTTCCCGTTCTTCGCGCAGCGTCGATGTCGACGGTGCGCAGCCTTACACCATCACCATCGCCCCGGGCCTGCT
GGCCGACGGTGCGCGCCTGGCCAGCCATGTGCGCGGCCGCCACGCGCTGCTGCTCAGCGACTCGCAGGTGGCTCCGCATT
ACGCGGCCGGCGTACGCGCCGCCTTGTCGCGCGCGCGGCCGGATCTGCAGGTCGGCGAATTGGTGATTGCCGCCGGCGAA
GCCTCCAAAACCTTGGAGACCTTTGGTTCTGCGATCACCGCACTGGCCGAACTCGGTGCCACCCGCGACGCCTGCGTGTT
CGCGCTGGGCGGCGGCGTGGTCGGCGACCTGGCCGGCTTTGCGGCGGCGTGCTGGATGCGCGGCGTGGATTGCGTGCAAC
TGCCCACCAGCCTGCTGGCAATGGTGGATTCGTCGGTCGGCGGCAAGACCGCGGTGGACATCCCGCAGGGCAAGAACCTG
GTCGGCGCCTTCCATCCGCCGCGCGCGGTGATCGCCGACACCGACACCTTGCGCACCCTGCCCGCACGCGAACTGCGCGC
CGGCCTGGCCGAGGTGATCAAGTACGGCGCCATCCGCGACCCGCTGTTCTTCCAGTGGCTGCATGCCGAACGCCGCGCCC
TGCTCGATGGCGATGCAGCGGCGCTGGCGCAGGCCATCGCCCGCAGCTGCGAGCACAAGGCCGAGATCGTGGCGCGCGAC
CCGCTGGAAAAAGGCGAGCGCGCCCTGCTCAACCTGGGCCACACCTTCGGCCACGCCATCGAAACCGAGCAAGGCTACGG
CGCACCCGGCAACGACAACCTCAACCATGGCGAGGCCGTCGCGGTGGGCATGGTGCTGGCGGCGCGCCTGTCGGCCGCGC
TGGGTATGAGCGACGTGCAGGACACCGAGACGCTACGCGCCTTGCTGCACGACTTCGACCTGCCCACCGAGATCCCGCCC
GGCCTGACCCCTCAGGCCCTGCTCGCGCGCATGCGCCTGGACAAGAAGAACATCGCCGGCCGCCTGCGCCTGGTGTTGTG
GCGCGGCATCGGCAAGGCCGAGGTGGTGCCGGATGTGGAAGAGGCAGCGGTGCTGGAGATCCTGGCCGGATAA

Upstream 100 bases:

>100_bases
CAGATCTCAGCCTGGAAACCGATCATCTTTCCCCCGCCGAAGCCACAGCGCAGCTGGTGCTGCGCCTGGCCGCGCAATGG
CGCATGTCGAGTAACCCCGC

Downstream 100 bases:

>100_bases
GGCCAGCCGACCGATAAGGCACGGCACGCTGGACGCTCGCACCCAGCTGCCGTCGATCGCCACGACGCTCGCTATTTGTA
GGAGCGCCCCCCGGGCGCGA

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MTLSRSSRSVDVDGAQPYTITIAPGLLADGARLASHVRGRHALLLSDSQVAPHYAAGVRAALSRARPDLQVGELVIAAGE
ASKTLETFGSAITALAELGATRDACVFALGGGVVGDLAGFAAACWMRGVDCVQLPTSLLAMVDSSVGGKTAVDIPQGKNL
VGAFHPPRAVIADTDTLRTLPARELRAGLAEVIKYGAIRDPLFFQWLHAERRALLDGDAAALAQAIARSCEHKAEIVARD
PLEKGERALLNLGHTFGHAIETEQGYGAPGNDNLNHGEAVAVGMVLAARLSAALGMSDVQDTETLRALLHDFDLPTEIPP
GLTPQALLARMRLDKKNIAGRLRLVLWRGIGKAEVVPDVEEAAVLEILAG

Sequences:

>Translated_370_residues
MTLSRSSRSVDVDGAQPYTITIAPGLLADGARLASHVRGRHALLLSDSQVAPHYAAGVRAALSRARPDLQVGELVIAAGE
ASKTLETFGSAITALAELGATRDACVFALGGGVVGDLAGFAAACWMRGVDCVQLPTSLLAMVDSSVGGKTAVDIPQGKNL
VGAFHPPRAVIADTDTLRTLPARELRAGLAEVIKYGAIRDPLFFQWLHAERRALLDGDAAALAQAIARSCEHKAEIVARD
PLEKGERALLNLGHTFGHAIETEQGYGAPGNDNLNHGEAVAVGMVLAARLSAALGMSDVQDTETLRALLHDFDLPTEIPP
GLTPQALLARMRLDKKNIAGRLRLVLWRGIGKAEVVPDVEEAAVLEILAG
>Mature_369_residues
TLSRSSRSVDVDGAQPYTITIAPGLLADGARLASHVRGRHALLLSDSQVAPHYAAGVRAALSRARPDLQVGELVIAAGEA
SKTLETFGSAITALAELGATRDACVFALGGGVVGDLAGFAAACWMRGVDCVQLPTSLLAMVDSSVGGKTAVDIPQGKNLV
GAFHPPRAVIADTDTLRTLPARELRAGLAEVIKYGAIRDPLFFQWLHAERRALLDGDAAALAQAIARSCEHKAEIVARDP
LEKGERALLNLGHTFGHAIETEQGYGAPGNDNLNHGEAVAVGMVLAARLSAALGMSDVQDTETLRALLHDFDLPTEIPPG
LTPQALLARMRLDKKNIAGRLRLVLWRGIGKAEVVPDVEEAAVLEILAG

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=362, Percent_Identity=48.8950276243094, Blast_Score=287, Evalue=7e-79,
Organism=Saccharomyces cerevisiae, GI6320332, Length=320, Percent_Identity=37.5, Blast_Score=173, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_XANAC (Q8PI87)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643320.1
- ProteinModelPortal:   Q8PI87
- SMR:   Q8PI87
- GeneID:   1157082
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3011
- NMPDR:   fig|190486.1.peg.2964
- HOGENOM:   HBG632303
- OMA:   CEIKAEV
- ProtClustDB:   PRK00002
- BioCyc:   XAXO190486:XAC3011-MONOMER
- BRENDA:   4.2.3.4
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 38816; Mature: 38685

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSRSSRSVDVDGAQPYTITIAPGLLADGARLASHVRGRHALLLSDSQVAPHYAAGVRA
CCCCCCCCCEECCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHH
ALSRARPDLQVGELVIAAGEASKTLETFGSAITALAELGATRDACVFALGGGVVGDLAGF
HHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHH
AAACWMRGVDCVQLPTSLLAMVDSSVGGKTAVDIPQGKNLVGAFHPPRAVIADTDTLRTL
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEECCCCCCEEEECCHHHHHC
PARELRAGLAEVIKYGAIRDPLFFQWLHAERRALLDGDAAALAQAIARSCEHKAEIVARD
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
PLEKGERALLNLGHTFGHAIETEQGYGAPGNDNLNHGEAVAVGMVLAARLSAALGMSDVQ
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCH
DTETLRALLHDFDLPTEIPPGLTPQALLARMRLDKKNIAGRLRLVLWRGIGKAEVVPDVE
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHECCCCCCCCCCCHH
EAAVLEILAG
HHHHHHHHCC
>Mature Secondary Structure 
TLSRSSRSVDVDGAQPYTITIAPGLLADGARLASHVRGRHALLLSDSQVAPHYAAGVRA
CCCCCCCCEECCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHH
ALSRARPDLQVGELVIAAGEASKTLETFGSAITALAELGATRDACVFALGGGVVGDLAGF
HHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHH
AAACWMRGVDCVQLPTSLLAMVDSSVGGKTAVDIPQGKNLVGAFHPPRAVIADTDTLRTL
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEECCCCCCEEEECCHHHHHC
PARELRAGLAEVIKYGAIRDPLFFQWLHAERRALLDGDAAALAQAIARSCEHKAEIVARD
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
PLEKGERALLNLGHTFGHAIETEQGYGAPGNDNLNHGEAVAVGMVLAARLSAALGMSDVQ
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCH
DTETLRALLHDFDLPTEIPPGLTPQALLARMRLDKKNIAGRLRLVLWRGIGKAEVVPDVE
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHECCCCCCCCCCCHH
EAAVLEILAG
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217