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The map label for this gene is aroK

Identifier: 21243737

GI number: 21243737

Start: 3520536

End: 3521078

Strand: Direct

Name: aroK

Synonym: XAC3010

Alternate gene names: 21243737

Gene position: 3520536-3521078 (Clockwise)

Preceding gene: 21243728

Following gene: 21243738

Centisome position: 68.02

GC content: 65.93

Gene sequence:

>543_bases
ATGAACCCCGCACCCAATCTCGTGATGGTCGGCCCGATGGGCGCCGGAAAAAGCTGCATCGGCCGTCGCCTGGCCGAGCG
CTTCGGGCTGGAATTCGTCGATGTGGACCAGGCCATCGTCGAACAGGTGGGCAGCAGCATCCCGGCCATCTTCGAGCAGC
ATGGCGAAGCCAGGTTTCGGCAGCACGAGGCGGAAACCCTGCAGGCGCTGCTGGAACAGGACAACAAACTGATTTCCACC
GGTGGCGGCGCAGTGCTGGATCCGCGCAACCGCGAGCGCATCTGCGCGCGTGGGTTCGTGGTGTACCTGCATGTCAGTGT
GCCGGCGCAATTGACACGCCTGGCGCGCGACCGCAATCGCCCGCTGCTGCAACGCGCCGACCGCGAGCAGGTGCTGCATG
CGATGGCCGCGCACCGCACGCCGCTGTACCACCAGGTCGCAGATCTCAGCCTGGAAACCGATCATCTTTCCCCCGCCGAA
GCCACAGCGCAGCTGGTGCTGCGCCTGGCCGCGCAATGGCGCATGTCGAGTAACCCCGCATGA

Upstream 100 bases:

>100_bases
ATCGAATCGCCGGATCGGCACGCGGTTGGCGTGGTTGAGGACAGCCATTGCGCCGTGCCATCGGCCCGGCCCGATGGCGT
GAATGCTACGATCCCTGCGC

Downstream 100 bases:

>100_bases
CACTTTCCCGTTCTTCGCGCAGCGTCGATGTCGACGGTGCGCAGCCTTACACCATCACCATCGCCCCGGGCCTGCTGGCC
GACGGTGCGCGCCTGGCCAG

Product: shikimate kinase

Products: NA

Alternate protein names: SK

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MNPAPNLVMVGPMGAGKSCIGRRLAERFGLEFVDVDQAIVEQVGSSIPAIFEQHGEARFRQHEAETLQALLEQDNKLIST
GGGAVLDPRNRERICARGFVVYLHVSVPAQLTRLARDRNRPLLQRADREQVLHAMAAHRTPLYHQVADLSLETDHLSPAE
ATAQLVLRLAAQWRMSSNPA

Sequences:

>Translated_180_residues
MNPAPNLVMVGPMGAGKSCIGRRLAERFGLEFVDVDQAIVEQVGSSIPAIFEQHGEARFRQHEAETLQALLEQDNKLIST
GGGAVLDPRNRERICARGFVVYLHVSVPAQLTRLARDRNRPLLQRADREQVLHAMAAHRTPLYHQVADLSLETDHLSPAE
ATAQLVLRLAAQWRMSSNPA
>Mature_180_residues
MNPAPNLVMVGPMGAGKSCIGRRLAERFGLEFVDVDQAIVEQVGSSIPAIFEQHGEARFRQHEAETLQALLEQDNKLIST
GGGAVLDPRNRERICARGFVVYLHVSVPAQLTRLARDRNRPLLQRADREQVLHAMAAHRTPLYHQVADLSLETDHLSPAE
ATAQLVLRLAAQWRMSSNPA

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family

Homologues:

Organism=Escherichia coli, GI87082255, Length=167, Percent_Identity=40.7185628742515, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1786587, Length=162, Percent_Identity=29.6296296296296, Blast_Score=74, Evalue=5e-15,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): AROK_XANAC (Q8PI88)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643319.1
- ProteinModelPortal:   Q8PI88
- SMR:   Q8PI88
- GeneID:   1157081
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3010
- NMPDR:   fig|190486.1.peg.2963
- HOGENOM:   HBG335815
- OMA:   VIYLRAN
- ProtClustDB:   PRK00131
- BioCyc:   XAXO190486:XAC3010-MONOMER
- BRENDA:   2.7.1.71
- GO:   GO:0005737
- HAMAP:   MF_00109
- InterPro:   IPR000623
- InterPro:   IPR023000
- PRINTS:   PR01100

Pfam domain/function: PF01202 SKI

EC number: =2.7.1.71

Molecular weight: Translated: 19916; Mature: 19916

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: BINDING 36-36 BINDING 60-60 BINDING 82-82 BINDING 120-120 BINDING 139-139

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPAPNLVMVGPMGAGKSCIGRRLAERFGLEFVDVDQAIVEQVGSSIPAIFEQHGEARFR
CCCCCCEEEECCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHCCCCHHHHHHHHHHHHH
QHEAETLQALLEQDNKLISTGGGAVLDPRNRERICARGFVVYLHVSVPAQLTRLARDRNR
HHHHHHHHHHHHCCCCEEECCCCCEECCCCHHHHHHCCEEEEEEECCHHHHHHHHHHCCC
PLLQRADREQVLHAMAAHRTPLYHQVADLSLETDHLSPAEATAQLVLRLAAQWRMSSNPA
HHHHHCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNPAPNLVMVGPMGAGKSCIGRRLAERFGLEFVDVDQAIVEQVGSSIPAIFEQHGEARFR
CCCCCCEEEECCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHCCCCHHHHHHHHHHHHH
QHEAETLQALLEQDNKLISTGGGAVLDPRNRERICARGFVVYLHVSVPAQLTRLARDRNR
HHHHHHHHHHHHCCCCEEECCCCCEECCCCHHHHHHCCEEEEEEECCHHHHHHHHHHCCC
PLLQRADREQVLHAMAAHRTPLYHQVADLSLETDHLSPAEATAQLVLRLAAQWRMSSNPA
HHHHHCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217