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The map label for this gene is gabP [H]

Identifier: 21243712

GI number: 21243712

Start: 3488829

End: 3490217

Strand: Reverse

Name: gabP [H]

Synonym: XAC2985

Alternate gene names: 21243712

Gene position: 3490217-3488829 (Counterclockwise)

Preceding gene: 21243713

Following gene: 21243711

Centisome position: 67.44

GC content: 67.03

Gene sequence:

>1389_bases
ATGCCGCTTCCGACCGATTCCGTTGCTGAGACCGCTGCGCCCGCCGCGCCTGCATTGCGCCATGCGCTGAAGCCGCGGCA
ATTGATGATGATGGGCCTGGGCACGGCGATCGGCGCCGGGCTGTTCCTGGGTTCCGGCGTGGGCATTCACGCGGCCGGGC
CGGCGGTGCTGATCTCGTATCTGATCGCCGGGGCGTTGGTCATCATTGTGATGAACGCGCTGGGCGAAATGGCCGCCGCC
AAGCCGGCCAGCGGGGCATTCTCGGTGTATGCCGCCGATGCGATGGGCCCGACGGCCGGCGCTACCGTGGGCTGGCTGTG
GTGGTTTCAGATAGTGGTGGTGATTGCGGCAGAAGCGGTAGGCGCAGCCGGGCTGCTGGCCACGGTCTGGCCGGCGTTGC
CGGTGCCGTTGCTCTCGTTGCTGTTCATGGCCACGTTCACTGCGATCAATCTGCTCGGCGTGCGCAACTTTGGCGAGTTC
GAGTTCTGGTTCGCCATCCTGAAAGTGCTGGCGATCGTGGTGTTCCTGCTGATCGGCGTGGCGTTGCTGGCGGGCTGGTT
GCCTGGGGTGGCGTCGCCCGGGCTGTCCAATTTCACCCAGAACGGCGGCTTTGCGCCGAAGGGCCTGGCCGGTATCGGCT
CGGCGTTGCTGGTGGTGGTGTTCGCCTTCGGCGGCACCGAAATCGTCGCGGTGGCCGCAGCGGAAACCGCCGACCCGGGA
CGCAGCCTGGCGCGCACCATCCGCACCGTGGCCTGGCGCATCCTGGTGTTCTACATCGGGTCGATCAGCGTGATCGTGGC
GGTGGTGCCATGGACCAGCGCCGCGCTCAGCTCGCCGTTTGCGGCCGTGCTGGAGGTGGCTCGCATTCCCGGTGCCGCCA
CGGCGATCACCCTGGTGGCGGTGGTCGCACTGCTGTCGGCGCTCAACGCCAATCTGTACGGCGCTTCGCGGATGATCTTC
TCGCTGGCCCAGCGCGGCGAAGCGCCGCGGTTGCTGGCCAGGACCAGCGGCGAGCAGGTGCCGCTGGTGGCGGTGATCGC
TAGCGTGTTGTTCGGCTTCGCCGCCGCAGCGTTGGAGTTGTTGTATCCGAACAAGGTGTTGCCAATGCTGCTCAACATCG
TCGGCGCCACCTGCCTGCTGGTGTGGACGATCTCGCTGGTGTCACAACTGATCTTGCGCGCCCGCGCGGACCGTGCCGGC
CTTGCGCTGCCGTTCCGCATGCGCGGCTATCCGTTTCTGACCGTGCTGGCGCTGGTCATCCTGGCCGTGATCTTCGTGTT
GTTGGCCTCTTCGGCCGATACGCGCGCGCAATTCCTCTCGATGGTCGCGCTGACCGCAGTCATCGCAGCGGTCAGCGAAA
TCGCGCGACGCGTGCGCGCGCGGATGTGA

Upstream 100 bases:

>100_bases
TCGGGCGACATCGCCACTCCTTCCCCGGGCTGGCGTCAAGAGGCGCGGCAGGCGCTGCGACGCGGTATCGTGTCGCGATT
CCATCCATGCAAGCCCGTCC

Downstream 100 bases:

>100_bases
GCGATGGTGGGCGTGGCTGGGTGCTGATGCGTTGTGTGCGATGACGGATTTGTAAGCTATAAGCAGCGGGCAGCCGCTCA
TGTGCGTGGGCAACGGGGAA

Product: amino acid transporter

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MPLPTDSVAETAAPAAPALRHALKPRQLMMMGLGTAIGAGLFLGSGVGIHAAGPAVLISYLIAGALVIIVMNALGEMAAA
KPASGAFSVYAADAMGPTAGATVGWLWWFQIVVVIAAEAVGAAGLLATVWPALPVPLLSLLFMATFTAINLLGVRNFGEF
EFWFAILKVLAIVVFLLIGVALLAGWLPGVASPGLSNFTQNGGFAPKGLAGIGSALLVVVFAFGGTEIVAVAAAETADPG
RSLARTIRTVAWRILVFYIGSISVIVAVVPWTSAALSSPFAAVLEVARIPGAATAITLVAVVALLSALNANLYGASRMIF
SLAQRGEAPRLLARTSGEQVPLVAVIASVLFGFAAAALELLYPNKVLPMLLNIVGATCLLVWTISLVSQLILRARADRAG
LALPFRMRGYPFLTVLALVILAVIFVLLASSADTRAQFLSMVALTAVIAAVSEIARRVRARM

Sequences:

>Translated_462_residues
MPLPTDSVAETAAPAAPALRHALKPRQLMMMGLGTAIGAGLFLGSGVGIHAAGPAVLISYLIAGALVIIVMNALGEMAAA
KPASGAFSVYAADAMGPTAGATVGWLWWFQIVVVIAAEAVGAAGLLATVWPALPVPLLSLLFMATFTAINLLGVRNFGEF
EFWFAILKVLAIVVFLLIGVALLAGWLPGVASPGLSNFTQNGGFAPKGLAGIGSALLVVVFAFGGTEIVAVAAAETADPG
RSLARTIRTVAWRILVFYIGSISVIVAVVPWTSAALSSPFAAVLEVARIPGAATAITLVAVVALLSALNANLYGASRMIF
SLAQRGEAPRLLARTSGEQVPLVAVIASVLFGFAAAALELLYPNKVLPMLLNIVGATCLLVWTISLVSQLILRARADRAG
LALPFRMRGYPFLTVLALVILAVIFVLLASSADTRAQFLSMVALTAVIAAVSEIARRVRARM
>Mature_461_residues
PLPTDSVAETAAPAAPALRHALKPRQLMMMGLGTAIGAGLFLGSGVGIHAAGPAVLISYLIAGALVIIVMNALGEMAAAK
PASGAFSVYAADAMGPTAGATVGWLWWFQIVVVIAAEAVGAAGLLATVWPALPVPLLSLLFMATFTAINLLGVRNFGEFE
FWFAILKVLAIVVFLLIGVALLAGWLPGVASPGLSNFTQNGGFAPKGLAGIGSALLVVVFAFGGTEIVAVAAAETADPGR
SLARTIRTVAWRILVFYIGSISVIVAVVPWTSAALSSPFAAVLEVARIPGAATAITLVAVVALLSALNANLYGASRMIFS
LAQRGEAPRLLARTSGEQVPLVAVIASVLFGFAAAALELLYPNKVLPMLLNIVGATCLLVWTISLVSQLILRARADRAGL
ALPFRMRGYPFLTVLALVILAVIFVLLASSADTRAQFLSMVALTAVIAAVSEIARRVRARM

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=430, Percent_Identity=23.7209302325581, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI258645169, Length=435, Percent_Identity=23.448275862069, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI114326544, Length=426, Percent_Identity=23.7089201877934, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI114326550, Length=426, Percent_Identity=23.7089201877934, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI181337167, Length=406, Percent_Identity=26.6009852216749, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI110347453, Length=367, Percent_Identity=24.2506811989101, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI258614005, Length=436, Percent_Identity=23.1651376146789, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI258614003, Length=436, Percent_Identity=23.1651376146789, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1789017, Length=408, Percent_Identity=40.9313725490196, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1786789, Length=429, Percent_Identity=37.5291375291375, Blast_Score=267, Evalue=9e-73,
Organism=Escherichia coli, GI1786302, Length=415, Percent_Identity=34.4578313253012, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI87081708, Length=435, Percent_Identity=37.2413793103448, Blast_Score=244, Evalue=8e-66,
Organism=Escherichia coli, GI1790653, Length=437, Percent_Identity=33.4096109839817, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1788480, Length=435, Percent_Identity=34.9425287356322, Blast_Score=242, Evalue=5e-65,
Organism=Escherichia coli, GI1786602, Length=425, Percent_Identity=35.7647058823529, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI48994972, Length=444, Percent_Identity=33.7837837837838, Blast_Score=228, Evalue=6e-61,
Organism=Escherichia coli, GI87081915, Length=423, Percent_Identity=33.5697399527187, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI87081869, Length=323, Percent_Identity=24.1486068111455, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=419, Percent_Identity=24.8210023866348, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320772, Length=441, Percent_Identity=32.8798185941043, Blast_Score=206, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6324061, Length=447, Percent_Identity=30.6487695749441, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6324553, Length=411, Percent_Identity=31.1435523114355, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6324924, Length=446, Percent_Identity=29.1479820627803, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6324059, Length=442, Percent_Identity=31.2217194570136, Blast_Score=173, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6322892, Length=370, Percent_Identity=31.6216216216216, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321053, Length=411, Percent_Identity=28.7104622871046, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319824, Length=410, Percent_Identity=26.8292682926829, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319542, Length=438, Percent_Identity=29.4520547945205, Blast_Score=153, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6324990, Length=411, Percent_Identity=28.7104622871046, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320717, Length=402, Percent_Identity=26.865671641791, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6319543, Length=416, Percent_Identity=26.9230769230769, Blast_Score=143, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6321629, Length=408, Percent_Identity=26.9607843137255, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320251, Length=426, Percent_Identity=26.7605633802817, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6322967, Length=354, Percent_Identity=29.0960451977401, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324981, Length=397, Percent_Identity=27.7078085642317, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6319608, Length=452, Percent_Identity=24.7787610619469, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320364, Length=504, Percent_Identity=22.8174603174603, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24668806, Length=423, Percent_Identity=24.113475177305, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21356285, Length=423, Percent_Identity=24.113475177305, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24668802, Length=423, Percent_Identity=24.113475177305, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI221512776, Length=402, Percent_Identity=24.6268656716418, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24666159, Length=411, Percent_Identity=24.5742092457421, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 47670; Mature: 47538

Theoretical pI: Translated: 10.81; Mature: 10.81

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLPTDSVAETAAPAAPALRHALKPRQLMMMGLGTAIGAGLFLGSGVGIHAAGPAVLISY
CCCCCCHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LIAGALVIIVMNALGEMAAAKPASGAFSVYAADAMGPTAGATVGWLWWFQIVVVIAAEAV
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
GAAGLLATVWPALPVPLLSLLFMATFTAINLLGVRNFGEFEFWFAILKVLAIVVFLLIGV
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALLAGWLPGVASPGLSNFTQNGGFAPKGLAGIGSALLVVVFAFGGTEIVAVAAAETADPG
HHHHHHCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCH
RSLARTIRTVAWRILVFYIGSISVIVAVVPWTSAALSSPFAAVLEVARIPGAATAITLVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHCCCHHHHHHHHH
VVALLSALNANLYGASRMIFSLAQRGEAPRLLARTSGEQVPLVAVIASVLFGFAAAALEL
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LYPNKVLPMLLNIVGATCLLVWTISLVSQLILRARADRAGLALPFRMRGYPFLTVLALVI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCHHHHHHHHH
LAVIFVLLASSADTRAQFLSMVALTAVIAAVSEIARRVRARM
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLPTDSVAETAAPAAPALRHALKPRQLMMMGLGTAIGAGLFLGSGVGIHAAGPAVLISY
CCCCCHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LIAGALVIIVMNALGEMAAAKPASGAFSVYAADAMGPTAGATVGWLWWFQIVVVIAAEAV
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
GAAGLLATVWPALPVPLLSLLFMATFTAINLLGVRNFGEFEFWFAILKVLAIVVFLLIGV
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALLAGWLPGVASPGLSNFTQNGGFAPKGLAGIGSALLVVVFAFGGTEIVAVAAAETADPG
HHHHHHCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCH
RSLARTIRTVAWRILVFYIGSISVIVAVVPWTSAALSSPFAAVLEVARIPGAATAITLVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHCCCHHHHHHHHH
VVALLSALNANLYGASRMIFSLAQRGEAPRLLARTSGEQVPLVAVIASVLFGFAAAALEL
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LYPNKVLPMLLNIVGATCLLVWTISLVSQLILRARADRAGLALPFRMRGYPFLTVLALVI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCHHHHHHHHH
LAVIFVLLASSADTRAQFLSMVALTAVIAAVSEIARRVRARM
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8951816; 8969499; 9384377 [H]