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The map label for this gene is oprM [H]

Identifier: 21243569

GI number: 21243569

Start: 3331350

End: 3332861

Strand: Reverse

Name: oprM [H]

Synonym: XAC2842

Alternate gene names: 21243569

Gene position: 3332861-3331350 (Counterclockwise)

Preceding gene: 21243570

Following gene: 21243568

Centisome position: 64.4

GC content: 65.61

Gene sequence:

>1512_bases
ATGACCACGATTCGCACGACACTCTGCGCGCTTGGCGTGGCCAGCGTGCTTTCCGGTTGCACGCTGATGCCGCGCTACAC
GCGGCCCGACGCACCGGTGCCAGCGCAATTTGCCGGCACCGACGTGTCGGTAGCCCCTCCGGCTGCCGCTGCCACTGCCG
ATACCGGCAACAACGCCGACACGGCCTATATTGCCGATATCGGCTGGCGCCAGGTCTTCACCGACCCGACGCTGCAGCAG
GTGATTGCGCTGGCACTGGACAATAACCGCGACCTGCGCGTGGCCGCGCTCAATATCGAGGTGGCACGCGCGCAATATCG
GGTGGACCGCGCCGCGTTGCTGCCCGCGATCGATGGCACCGGTACCGCCAACAATGCGCGCACGCCGTCGGAGCTGGCCA
TTCCCGGCCAGCCGCAGGTGTTCCGCACCTACAGCGCCAACATCGGCATCAGTGCCTATGAGCTGGACCTGTTCGGGCGC
GTGCGCAGCCTGAAGGAACAGGCATTGCAGCAATTCCTGTCCACCGCCGAGGCGCGCCGCAGTACGCATATCAGTCTGGT
GGCAGAAGTGGCCACCGCCTATCTGACCTTGGCGGCCGACCAGCAGTTGCTGCAGCTGGCGCAATCCACCCTGACTAGTC
AGAGCGACAGTTATCGCCTGCAGCAGCGCAGCTTCGAACTGGGCGTGGCCTCGCAACTGACCTTGCGTCAGGCGCAGACC
ACGGTGGAAACCGCACGCGTGGACGTGGAGCGCTACACCGCCCAAGTGGCGCAGGATCGCAACGCCCTGGTGCTGCTGGT
CGGCACGCAAGTGCCGGTGGAATTGCTGCCGCATGCATTGCCGGACAACGCCAGCGTGGAAGGCAATGTGTTGGCCAGCG
TGCCGGCCGGCTTGCCGTCGCAGTTGCTGCAACGTCGCCCCGACATTCTGGAAGCCGAGCGCAACTTGCGTGCGGCCAAC
GCCAATATCGGGGCGGCGCGGGCGGCGTTCTTCCCCAGCATCAGCCTGACCGCATCGACCGGTTCGTCCAGCAGTAGCCT
CTCGAGGTTGTTCGATGCCGGCACGCGTGCCTGGAGCTTCGTGCCCACGCTGACCTTGCCGATCTTCAATGCCGGGCGCA
ATCGCGCCAATCTGGACATGGCCAAGGCCAACCGCGATATCGAAGTGGCGCGCTACGAAAAGTCGATCCAAAGCGCGTTC
CGCGAGGTCTCCGACGCGTTGGCGCAGCGCGACACGCTGGGCAGGCAACTACAGGCCCAGCAAGCGCTGGTGGATGCCAC
TGCCGATAGCTACCGGCTGTCGCAGGCGCGTTTCGAACGGGGCATCGACAGCTATCTGCAGGCGCTGGATGCGCAGCGTT
CGCTGTACAGCGCGCAGCAGACCTTGATCAACACCCAGCTGTCGCGCTTCACCAACCTGGTGACGTTCTACAAGGCCATG
GGCGGTGGCTGGCTGCAAACCGCCGCGCCCACTGCCGTCGCGAGCCCAGCAGCGGAGCCGCCGCGTGGATGA

Upstream 100 bases:

>100_bases
GCGATCTTCTTCGTGCCGCTGTTCTTCGTGCTGGTGTGTGGCCTGTTCCAGCGCCGTCCACAGCCTGCTTCGCCCGCACC
GCAACCGACAGGACACTGAC

Downstream 100 bases:

>100_bases
TGACGCGCCGCCCATTGCACGTGCGCCACACGACAAGCGTGGCGCCATCCTGGCGGCGGCACGCGTGCTGTTTCAACAGC
ACGGCTTCGACAGGACCAGC

Product: outer membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MTTIRTTLCALGVASVLSGCTLMPRYTRPDAPVPAQFAGTDVSVAPPAAAATADTGNNADTAYIADIGWRQVFTDPTLQQ
VIALALDNNRDLRVAALNIEVARAQYRVDRAALLPAIDGTGTANNARTPSELAIPGQPQVFRTYSANIGISAYELDLFGR
VRSLKEQALQQFLSTAEARRSTHISLVAEVATAYLTLAADQQLLQLAQSTLTSQSDSYRLQQRSFELGVASQLTLRQAQT
TVETARVDVERYTAQVAQDRNALVLLVGTQVPVELLPHALPDNASVEGNVLASVPAGLPSQLLQRRPDILEAERNLRAAN
ANIGAARAAFFPSISLTASTGSSSSSLSRLFDAGTRAWSFVPTLTLPIFNAGRNRANLDMAKANRDIEVARYEKSIQSAF
REVSDALAQRDTLGRQLQAQQALVDATADSYRLSQARFERGIDSYLQALDAQRSLYSAQQTLINTQLSRFTNLVTFYKAM
GGGWLQTAAPTAVASPAAEPPRG

Sequences:

>Translated_503_residues
MTTIRTTLCALGVASVLSGCTLMPRYTRPDAPVPAQFAGTDVSVAPPAAAATADTGNNADTAYIADIGWRQVFTDPTLQQ
VIALALDNNRDLRVAALNIEVARAQYRVDRAALLPAIDGTGTANNARTPSELAIPGQPQVFRTYSANIGISAYELDLFGR
VRSLKEQALQQFLSTAEARRSTHISLVAEVATAYLTLAADQQLLQLAQSTLTSQSDSYRLQQRSFELGVASQLTLRQAQT
TVETARVDVERYTAQVAQDRNALVLLVGTQVPVELLPHALPDNASVEGNVLASVPAGLPSQLLQRRPDILEAERNLRAAN
ANIGAARAAFFPSISLTASTGSSSSSLSRLFDAGTRAWSFVPTLTLPIFNAGRNRANLDMAKANRDIEVARYEKSIQSAF
REVSDALAQRDTLGRQLQAQQALVDATADSYRLSQARFERGIDSYLQALDAQRSLYSAQQTLINTQLSRFTNLVTFYKAM
GGGWLQTAAPTAVASPAAEPPRG
>Mature_502_residues
TTIRTTLCALGVASVLSGCTLMPRYTRPDAPVPAQFAGTDVSVAPPAAAATADTGNNADTAYIADIGWRQVFTDPTLQQV
IALALDNNRDLRVAALNIEVARAQYRVDRAALLPAIDGTGTANNARTPSELAIPGQPQVFRTYSANIGISAYELDLFGRV
RSLKEQALQQFLSTAEARRSTHISLVAEVATAYLTLAADQQLLQLAQSTLTSQSDSYRLQQRSFELGVASQLTLRQAQTT
VETARVDVERYTAQVAQDRNALVLLVGTQVPVELLPHALPDNASVEGNVLASVPAGLPSQLLQRRPDILEAERNLRAANA
NIGAARAAFFPSISLTASTGSSSSSLSRLFDAGTRAWSFVPTLTLPIFNAGRNRANLDMAKANRDIEVARYEKSIQSAFR
EVSDALAQRDTLGRQLQAQQALVDATADSYRLSQARFERGIDSYLQALDAQRSLYSAQQTLINTQLSRFTNLVTFYKAMG
GGWLQTAAPTAVASPAAEPPRG

Specific function: The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor. Note=Attached to the outer membrane by a lipid anchor and via the transmembrane beta-barrel. The membrane anchor is not necessary for antibiotic efflux. In one report (PubMed:10889211) the Cys-18- Gly mutant is reported

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=484, Percent_Identity=41.3223140495868, Blast_Score=343, Evalue=1e-95,
Organism=Escherichia coli, GI2367348, Length=494, Percent_Identity=26.9230769230769, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 54066; Mature: 53935

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIRTTLCALGVASVLSGCTLMPRYTRPDAPVPAQFAGTDVSVAPPAAAATADTGNNAD
CCHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TAYIADIGWRQVFTDPTLQQVIALALDNNRDLRVAALNIEVARAQYRVDRAALLPAIDGT
EEEEECCCCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEEEEHHHHHHHHHHHHCCCCCCC
GTANNARTPSELAIPGQPQVFRTYSANIGISAYELDLFGRVRSLKEQALQQFLSTAEARR
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
STHISLVAEVATAYLTLAADQQLLQLAQSTLTSQSDSYRLQQRSFELGVASQLTLRQAQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHH
TVETARVDVERYTAQVAQDRNALVLLVGTQVPVELLPHALPDNASVEGNVLASVPAGLPS
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCCCCCCCCCCEEEECCCCCHH
QLLQRRPDILEAERNLRAANANIGAARAAFFPSISLTASTGSSSSSLSRLFDAGTRAWSF
HHHHCCCCHHHHHHCCCCCCCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEE
VPTLTLPIFNAGRNRANLDMAKANRDIEVARYEKSIQSAFREVSDALAQRDTLGRQLQAQ
HHHEEEEHCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QALVDATADSYRLSQARFERGIDSYLQALDAQRSLYSAQQTLINTQLSRFTNLVTFYKAM
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGGWLQTAAPTAVASPAAEPPRG
CCCEECCCCCHHHCCCCCCCCCC
>Mature Secondary Structure 
TTIRTTLCALGVASVLSGCTLMPRYTRPDAPVPAQFAGTDVSVAPPAAAATADTGNNAD
CHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TAYIADIGWRQVFTDPTLQQVIALALDNNRDLRVAALNIEVARAQYRVDRAALLPAIDGT
EEEEECCCCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEEEEHHHHHHHHHHHHCCCCCCC
GTANNARTPSELAIPGQPQVFRTYSANIGISAYELDLFGRVRSLKEQALQQFLSTAEARR
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
STHISLVAEVATAYLTLAADQQLLQLAQSTLTSQSDSYRLQQRSFELGVASQLTLRQAQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHH
TVETARVDVERYTAQVAQDRNALVLLVGTQVPVELLPHALPDNASVEGNVLASVPAGLPS
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCCCCCCCCCCEEEECCCCCHH
QLLQRRPDILEAERNLRAANANIGAARAAFFPSISLTASTGSSSSSLSRLFDAGTRAWSF
HHHHCCCCHHHHHHCCCCCCCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEE
VPTLTLPIFNAGRNRANLDMAKANRDIEVARYEKSIQSAFREVSDALAQRDTLGRQLQAQ
HHHEEEEHCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QALVDATADSYRLSQARFERGIDSYLQALDAQRSLYSAQQTLINTQLSRFTNLVTFYKAM
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGGWLQTAAPTAVASPAAEPPRG
CCCEECCCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8226684; 10889211; 10984043; 7968531; 8540696; 9401051; 9603892; 10952562 [H]