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The map label for this gene is Ada [H]

Identifier: 21243549

GI number: 21243549

Start: 3306901

End: 3308364

Strand: Direct

Name: Ada [H]

Synonym: XAC2822

Alternate gene names: 21243549

Gene position: 3306901-3308364 (Clockwise)

Preceding gene: 21243544

Following gene: 21243550

Centisome position: 63.89

GC content: 71.86

Gene sequence:

>1464_bases
ATGCAGACCGCAACGCCCGACCGAACCCAATGCGACCGCGCCCGCCTGGCACGCGATGCGCGCTTCGACGGGCTGTTTTT
CACCGCCGTGCGCAGCACCGGCATCTATTGCCGCCCGGTGTGTCCGGCGCCGCCGCCGAATCCGTCCAATATCAGTTACT
ACCCCACTGCCGCGGCGGCCAGCGCCGCCGGCTACCGGCCATGCCTGCGCTGCCGGCCGGAGCTGTCGCCGCAGGCGCAG
CAGCATCTGGGCGAAGAAAGCGTGCAGCGTGCGCTGGCGATGATTGCCGACGGCGCGCTGCAGGAGCAGCCGGTGCAGAC
GCTGGCCGACGCGGTGGGCTTGAGCGCGCGCCAACTGCAGCGGCAATTCGTGCAGCAGCTGGGCGCCACGCCGATCCAGG
TGCACGGCACGCATCGGCTGCTGCTGGCCAAGCAATTGCTGACCGAAACCGCCCTGCCGGTCACCGAGGTCGCGCTCGCG
GCCGGCTTCAACAGCCTGCGCCGCTTCAATGCGGCCTTCCTGCAGGGCTGCGGCATGCCGCCTTCTGCACTGCGCAAGCA
GCGTGCCGAGGTGCCGGGCGGCGAACTGACATTGCGCCTGGGCTATCGCCCGCCGCTGGACCTGCCGGCGATGCTGGCCT
TCTTGCAGCGCCGCGCGATCCCGGGCATCGAGCAGGTCGATGCGAACGGCTACCGGCGCGTGATCGGCGCGCCGGGCAAC
GCCAGCGTGATCGAGGTCAGCGCGGCACCGCAGCGCGCGGAGCTGCTGCTGCGCATCGGCGCCACCGACCCGCGCCAGAT
TCCGCAGATCGTGCGACGCGTGCGCCGGCTGTTCGATCTGGATGCAGACCTGCAGGCCGTGCACGCCACGCTCGCGCCGG
AACCGCTGCTGGCCGAGGCAATCGCGCGCCGACCCGGCCTACGCGTGCCCGGTGGCTGGGACGGCTTCGAAGTGGCGGTG
CGTGCGGTCCTGGGGCAACAGATCAGCGTGGCCGGCGCGGCCACGCTGGCAGCGCGGCTGGTCGACCGCCACGGCGGCCA
TCATGCCGACATGCCCCCCGGACTGGATCGCAGTTTCCCCATGCCCGAACAGCTGGCCGACGCGCCGCTGGAACAGCTCG
GGCTGCCGCGTGCGCGCGCCGCCACGCTGCGTGCGCTGGCCTCGGCCTGCGCGCAAGGCCAGCTGCACTTCGGCGCCGGA
CAGCGCCTGCCTGATTTCATCGCCGCCTGCACCGCGCTGCCCGGAATCGGACCGTGGACCGCGCATTACGTGGCCATGCG
CGCGTTGTCGCATCCGGACGCGTTTCCGGCCGGCGACCTGATCCTGCAGCAAGTGCTCGGCGCCCCCGGGCGCCTGAGCG
AACGCGCCACCGATGCCCGTTCGCAAGCGTGGCGACCGTGGCGCGCCTACGCCGTGCTGCACCTGTGGCATCTGGCCAAC
GACCGCAAGGACACCCGCGCATGA

Upstream 100 bases:

>100_bases
AATGGATCGATGGGTTGACCCGGCCATGAACGCGCAGGTCCGCCGCAACCGCGTCCGAAAACGGCCAGCCGGCGCGGGGG
CGAGCGCATAGACTGGCGAC

Downstream 100 bases:

>100_bases
GCACACTGCACTACGACACCTTCCCCTCGCCGATCGGCGCGCTCAGCGTGGCCGCCGACGACAAAGGCGTGCACCACATC
CTGTTTGCGCAGAACCGCTA

Product: DNA methylation and regulatory protein

Products: NA

Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MQTATPDRTQCDRARLARDARFDGLFFTAVRSTGIYCRPVCPAPPPNPSNISYYPTAAAASAAGYRPCLRCRPELSPQAQ
QHLGEESVQRALAMIADGALQEQPVQTLADAVGLSARQLQRQFVQQLGATPIQVHGTHRLLLAKQLLTETALPVTEVALA
AGFNSLRRFNAAFLQGCGMPPSALRKQRAEVPGGELTLRLGYRPPLDLPAMLAFLQRRAIPGIEQVDANGYRRVIGAPGN
ASVIEVSAAPQRAELLLRIGATDPRQIPQIVRRVRRLFDLDADLQAVHATLAPEPLLAEAIARRPGLRVPGGWDGFEVAV
RAVLGQQISVAGAATLAARLVDRHGGHHADMPPGLDRSFPMPEQLADAPLEQLGLPRARAATLRALASACAQGQLHFGAG
QRLPDFIAACTALPGIGPWTAHYVAMRALSHPDAFPAGDLILQQVLGAPGRLSERATDARSQAWRPWRAYAVLHLWHLAN
DRKDTRA

Sequences:

>Translated_487_residues
MQTATPDRTQCDRARLARDARFDGLFFTAVRSTGIYCRPVCPAPPPNPSNISYYPTAAAASAAGYRPCLRCRPELSPQAQ
QHLGEESVQRALAMIADGALQEQPVQTLADAVGLSARQLQRQFVQQLGATPIQVHGTHRLLLAKQLLTETALPVTEVALA
AGFNSLRRFNAAFLQGCGMPPSALRKQRAEVPGGELTLRLGYRPPLDLPAMLAFLQRRAIPGIEQVDANGYRRVIGAPGN
ASVIEVSAAPQRAELLLRIGATDPRQIPQIVRRVRRLFDLDADLQAVHATLAPEPLLAEAIARRPGLRVPGGWDGFEVAV
RAVLGQQISVAGAATLAARLVDRHGGHHADMPPGLDRSFPMPEQLADAPLEQLGLPRARAATLRALASACAQGQLHFGAG
QRLPDFIAACTALPGIGPWTAHYVAMRALSHPDAFPAGDLILQQVLGAPGRLSERATDARSQAWRPWRAYAVLHLWHLAN
DRKDTRA
>Mature_487_residues
MQTATPDRTQCDRARLARDARFDGLFFTAVRSTGIYCRPVCPAPPPNPSNISYYPTAAAASAAGYRPCLRCRPELSPQAQ
QHLGEESVQRALAMIADGALQEQPVQTLADAVGLSARQLQRQFVQQLGATPIQVHGTHRLLLAKQLLTETALPVTEVALA
AGFNSLRRFNAAFLQGCGMPPSALRKQRAEVPGGELTLRLGYRPPLDLPAMLAFLQRRAIPGIEQVDANGYRRVIGAPGN
ASVIEVSAAPQRAELLLRIGATDPRQIPQIVRRVRRLFDLDADLQAVHATLAPEPLLAEAIARRPGLRVPGGWDGFEVAV
RAVLGQQISVAGAATLAARLVDRHGGHHADMPPGLDRSFPMPEQLADAPLEQLGLPRARAATLRALASACAQGQLHFGAG
QRLPDFIAACTALPGIGPWTAHYVAMRALSHPDAFPAGDLILQQVLGAPGRLSERATDARSQAWRPWRAYAVLHLWHLAN
DRKDTRA

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=288, Percent_Identity=34.0277777777778, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1788542, Length=150, Percent_Identity=40.6666666666667, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR010316
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR023170
- InterPro:   IPR012294 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 52511; Mature: 52511

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTATPDRTQCDRARLARDARFDGLFFTAVRSTGIYCRPVCPAPPPNPSNISYYPTAAAA
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCCEECCCHHHH
SAAGYRPCLRCRPELSPQAQQHLGEESVQRALAMIADGALQEQPVQTLADAVGLSARQLQ
HHCCCCHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHH
RQFVQQLGATPIQVHGTHRLLLAKQLLTETALPVTEVALAAGFNSLRRFNAAFLQGCGMP
HHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
PSALRKQRAEVPGGELTLRLGYRPPLDLPAMLAFLQRRAIPGIEQVDANGYRRVIGAPGN
HHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCEEEEECCCC
ASVIEVSAAPQRAELLLRIGATDPRQIPQIVRRVRRLFDLDADLQAVHATLAPEPLLAEA
CCEEEECCCCHHHHHHHEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHH
IARRPGLRVPGGWDGFEVAVRAVLGQQISVAGAATLAARLVDRHGGHHADMPPGLDRSFP
HHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
MPEQLADAPLEQLGLPRARAATLRALASACAQGQLHFGAGQRLPDFIAACTALPGIGPWT
CCHHHHCCCHHHHCCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHCCCCCHHH
AHYVAMRALSHPDAFPAGDLILQQVLGAPGRLSERATDARSQAWRPWRAYAVLHLWHLAN
HHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
DRKDTRA
CCCCCCC
>Mature Secondary Structure
MQTATPDRTQCDRARLARDARFDGLFFTAVRSTGIYCRPVCPAPPPNPSNISYYPTAAAA
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCCEECCCHHHH
SAAGYRPCLRCRPELSPQAQQHLGEESVQRALAMIADGALQEQPVQTLADAVGLSARQLQ
HHCCCCHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHH
RQFVQQLGATPIQVHGTHRLLLAKQLLTETALPVTEVALAAGFNSLRRFNAAFLQGCGMP
HHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
PSALRKQRAEVPGGELTLRLGYRPPLDLPAMLAFLQRRAIPGIEQVDANGYRRVIGAPGN
HHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCEEEEECCCC
ASVIEVSAAPQRAELLLRIGATDPRQIPQIVRRVRRLFDLDADLQAVHATLAPEPLLAEA
CCEEEECCCCHHHHHHHEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHH
IARRPGLRVPGGWDGFEVAVRAVLGQQISVAGAATLAARLVDRHGGHHADMPPGLDRSFP
HHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
MPEQLADAPLEQLGLPRARAATLRALASACAQGQLHFGAGQRLPDFIAACTALPGIGPWT
CCHHHHCCCHHHHCCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHCCCCCHHH
AHYVAMRALSHPDAFPAGDLILQQVLGAPGRLSERATDARSQAWRPWRAYAVLHLWHLAN
HHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
DRKDTRA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]