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The map label for this gene is nuoL [H]

Identifier: 21243421

GI number: 21243421

Start: 3153603

End: 3155747

Strand: Reverse

Name: nuoL [H]

Synonym: XAC2693

Alternate gene names: 21243421

Gene position: 3155747-3153603 (Counterclockwise)

Preceding gene: 21243422

Following gene: 21243420

Centisome position: 60.97

GC content: 59.58

Gene sequence:

>2145_bases
ATGGAAATCACTCTCTCCAAGAGTCTGTTGATCGCGGTGGTGCTTGCACCGCTGCTCGGCAGCATCATCGCCGGCCTGTT
CGGGCGCCAGGTCGGGCGCAAGGGCGCGCAGTACGTCACCATCCTCGGTGTTGCGGTGAGCTGCGTGCTGTCGTGCGTGA
CGCTGTATCAGCTGGTCGAGCAGGGCGCCAGCCCGTTCAACCAGAACCTCTACACGTTCTTTGATGTCGGCAATTACTCT
GCGCATGTCGGCTTCATGGTCGATCGCCTGACCGCAATGATGATGGTGGTGGTGACCTTCGTGTCGCTGCTGGTGCACAT
CTACACCATCGGCTACATGGAAGAAGATCCGGGCTACCAGCGCTTCTTCAGCTACATCTCGTTGTTCACCTTCTCCATGC
TCACGCTGGTGATGAGCAACAACTTCCTGCAGCTGTTCTTCGGCTGGGAAGCGGTGGGTCTGGTGTCGTACCTGTTGATC
GGTTTCTGGTTCAAGCGTCCGACGGCCGTGTTCGCCAACATGAAGGCGTTCCTGGTCAATCGCGTCGGCGACTTCGGCTT
CATCCTCGGTATCGCCGGTGTGCTGTTGTGGTTCGGCTCGCTGGATTACTCCACCGTGTTCGCCAATGCGACCACCATGG
CCGGTGCCAAGGTGCAGCTGTTCGCGGGCCACGAATGGAGCGTGATGACGCTGATCTGCATCTGCCTGTTCATCGGTGCG
ATGGGCAAGTCGGCCCAGGTGCCGTTGCATGTGTGGCTGCCGGACTCGATGGAAGGCCCCACGCCGATCTCGGCGCTGAT
CCACGCAGCAACGATGGTGACCGCCGGCATCTTCATGGTGGCGCGCATGTCGCCGCTGTTCGAACTGTCGGAAACGGCGT
TGAACTTCATCCTGTTCATCGGTGCGACCACGGCGTTTTTCACCGGCCTGATCGGTATCGTGCAGAACGACATCAAGCGC
GTGGTCGCTTACTCCACGCTGTCGCAGCTGGGTTACATGACGGTGGCATTGGGCGTGTCGGCGTATTCGGCAGCCGTGTT
CCACCTGATGACCCACGCCTTTTTCAAGGCACTGCTGTTCCTGGCTGCCGGCTCTGTGATCATCGGCATGCACCACGAGC
AGGACATGCGCAAGATGGGTGGCCTGCGCAAGTACATGAAGGTGACCTACTGGACCAGCGTGATCGGTACGCTGGCACTG
GTCGGTACGCCGTTCTTCTCTGGCTTCTACTCGAAGGACACCATCATCGAAGCGGCCGCGCATCATGCGCATGAGTCGCA
TAACTGGGTCGCAACCTATGGCTACTGGGCCGTGCTCGGCGGCGTACTGGTGACCAGTTTCTACAGCTTCCGTCTGCTGT
TCCTGACCTTCCATGGAAAGGAGCGTTTCCGCGACGCCCATGCGCACGACGTGCATTCGCATCACGACAGTGCGCATACC
GATGCCGAAGCGCAGGTTCACTCGCACGATGCGCATGCCCACGACGATCACGGACATGGTCACCATGGCGCCCACGAGCC
GCATGAGTCCAAGTGGGTGGTAACGCTGCCGCTGGTCTTGTTAGCAATCCCCTCGATCGCGATCGGCTTCTTCACGATCG
GTCCGATGTTGTTCGGGACGGACTGGCAGGGCCACCATGCAGTGCACGCCATGAAGGGCCAGGCAGTTTCGTTCTTCACT
GGCATCGTCGATTTCTACGATCCGGCACGCGATACCGTTGGTGCGTTGGCCGAAGAGTTCCATGGTCCGGTCGCATTCGC
ACTGCATGGCATGCTGGCCGCTCCGTTCTTCCTGACGGTAGCCGGGCTGTTGCTGGCAGCGCTGTTCTACCTGTGGAAGC
CGGAACTGGCCACCAAGTCGCGCAAGACATTCGCGCCGATCGTGTGGTTGCTGGAAAACAAGTACGGCTTCGACAAGCTC
TGGATCAATGGCTTCGCCGGTGGTGGCGTTGTGCTTGGCAAGGCGTCACGTGCAGTCGATACCCATGTGGTCGACGGCGC
TGTCGTCAACGGTTCTGCCCGACTGATCGACCTGGCTGCAAATCTGCTGCGTCGCACGCAATCCGGTTTCCTCTATCACT
ACGCCTTCGCAATGATCATCGGTTTGATCGCCTTGTTGGCGGTACTGATGCATTTCTGGCGTTGA

Upstream 100 bases:

>100_bases
GCGGAGGCTGCGATCGGCCTTGCGATCCTGGTGACTCTGTTCCGCACGCGCCGCACGATCAATGTGGCCGAAGTCGATAC
GTTGAAGGGCTGACCTGTAG

Downstream 100 bases:

>100_bases
CCTGTACGGAATAAGAAAACGTGTCGAACTGGCCTTTACTGTCTATCTTGATCTGGCTGCCGATTATCGGTGGCGCCCTG
ATCCTTGCGTTGCGCAACGC

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 714; Mature: 714

Protein sequence:

>714_residues
MEITLSKSLLIAVVLAPLLGSIIAGLFGRQVGRKGAQYVTILGVAVSCVLSCVTLYQLVEQGASPFNQNLYTFFDVGNYS
AHVGFMVDRLTAMMMVVVTFVSLLVHIYTIGYMEEDPGYQRFFSYISLFTFSMLTLVMSNNFLQLFFGWEAVGLVSYLLI
GFWFKRPTAVFANMKAFLVNRVGDFGFILGIAGVLLWFGSLDYSTVFANATTMAGAKVQLFAGHEWSVMTLICICLFIGA
MGKSAQVPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSETALNFILFIGATTAFFTGLIGIVQNDIKR
VVAYSTLSQLGYMTVALGVSAYSAAVFHLMTHAFFKALLFLAAGSVIIGMHHEQDMRKMGGLRKYMKVTYWTSVIGTLAL
VGTPFFSGFYSKDTIIEAAAHHAHESHNWVATYGYWAVLGGVLVTSFYSFRLLFLTFHGKERFRDAHAHDVHSHHDSAHT
DAEAQVHSHDAHAHDDHGHGHHGAHEPHESKWVVTLPLVLLAIPSIAIGFFTIGPMLFGTDWQGHHAVHAMKGQAVSFFT
GIVDFYDPARDTVGALAEEFHGPVAFALHGMLAAPFFLTVAGLLLAALFYLWKPELATKSRKTFAPIVWLLENKYGFDKL
WINGFAGGGVVLGKASRAVDTHVVDGAVVNGSARLIDLAANLLRRTQSGFLYHYAFAMIIGLIALLAVLMHFWR

Sequences:

>Translated_714_residues
MEITLSKSLLIAVVLAPLLGSIIAGLFGRQVGRKGAQYVTILGVAVSCVLSCVTLYQLVEQGASPFNQNLYTFFDVGNYS
AHVGFMVDRLTAMMMVVVTFVSLLVHIYTIGYMEEDPGYQRFFSYISLFTFSMLTLVMSNNFLQLFFGWEAVGLVSYLLI
GFWFKRPTAVFANMKAFLVNRVGDFGFILGIAGVLLWFGSLDYSTVFANATTMAGAKVQLFAGHEWSVMTLICICLFIGA
MGKSAQVPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSETALNFILFIGATTAFFTGLIGIVQNDIKR
VVAYSTLSQLGYMTVALGVSAYSAAVFHLMTHAFFKALLFLAAGSVIIGMHHEQDMRKMGGLRKYMKVTYWTSVIGTLAL
VGTPFFSGFYSKDTIIEAAAHHAHESHNWVATYGYWAVLGGVLVTSFYSFRLLFLTFHGKERFRDAHAHDVHSHHDSAHT
DAEAQVHSHDAHAHDDHGHGHHGAHEPHESKWVVTLPLVLLAIPSIAIGFFTIGPMLFGTDWQGHHAVHAMKGQAVSFFT
GIVDFYDPARDTVGALAEEFHGPVAFALHGMLAAPFFLTVAGLLLAALFYLWKPELATKSRKTFAPIVWLLENKYGFDKL
WINGFAGGGVVLGKASRAVDTHVVDGAVVNGSARLIDLAANLLRRTQSGFLYHYAFAMIIGLIALLAVLMHFWR
>Mature_714_residues
MEITLSKSLLIAVVLAPLLGSIIAGLFGRQVGRKGAQYVTILGVAVSCVLSCVTLYQLVEQGASPFNQNLYTFFDVGNYS
AHVGFMVDRLTAMMMVVVTFVSLLVHIYTIGYMEEDPGYQRFFSYISLFTFSMLTLVMSNNFLQLFFGWEAVGLVSYLLI
GFWFKRPTAVFANMKAFLVNRVGDFGFILGIAGVLLWFGSLDYSTVFANATTMAGAKVQLFAGHEWSVMTLICICLFIGA
MGKSAQVPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSETALNFILFIGATTAFFTGLIGIVQNDIKR
VVAYSTLSQLGYMTVALGVSAYSAAVFHLMTHAFFKALLFLAAGSVIIGMHHEQDMRKMGGLRKYMKVTYWTSVIGTLAL
VGTPFFSGFYSKDTIIEAAAHHAHESHNWVATYGYWAVLGGVLVTSFYSFRLLFLTFHGKERFRDAHAHDVHSHHDSAHT
DAEAQVHSHDAHAHDDHGHGHHGAHEPHESKWVVTLPLVLLAIPSIAIGFFTIGPMLFGTDWQGHHAVHAMKGQAVSFFT
GIVDFYDPARDTVGALAEEFHGPVAFALHGMLAAPFFLTVAGLLLAALFYLWKPELATKSRKTFAPIVWLLENKYGFDKL
WINGFAGGGVVLGKASRAVDTHVVDGAVVNGSARLIDLAANLLRRTQSGFLYHYAFAMIIGLIALLAVLMHFWR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=381, Percent_Identity=42.5196850393701, Blast_Score=289, Evalue=6e-78,
Organism=Escherichia coli, GI1788614, Length=478, Percent_Identity=42.6778242677824, Blast_Score=340, Evalue=2e-94,
Organism=Escherichia coli, GI1788829, Length=444, Percent_Identity=29.7297297297297, Blast_Score=157, Evalue=3e-39,
Organism=Escherichia coli, GI1788831, Length=374, Percent_Identity=27.807486631016, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1788827, Length=354, Percent_Identity=29.0960451977401, Blast_Score=113, Evalue=5e-26,
Organism=Escherichia coli, GI1788613, Length=472, Percent_Identity=24.5762711864407, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI2367154, Length=136, Percent_Identity=32.3529411764706, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI145693160, Length=229, Percent_Identity=24.8908296943231, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 78376; Mature: 78376

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEITLSKSLLIAVVLAPLLGSIIAGLFGRQVGRKGAQYVTILGVAVSCVLSCVTLYQLVE
CCEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QGASPFNQNLYTFFDVGNYSAHVGFMVDRLTAMMMVVVTFVSLLVHIYTIGYMEEDPGYQ
HCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
RFFSYISLFTFSMLTLVMSNNFLQLFFGWEAVGLVSYLLIGFWFKRPTAVFANMKAFLVN
HHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RVGDFGFILGIAGVLLWFGSLDYSTVFANATTMAGAKVQLFAGHEWSVMTLICICLFIGA
HCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCEECCCEEEEEECCCHHHHHHHHHHHHHHC
MGKSAQVPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSETALNFILFI
CCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
GATTAFFTGLIGIVQNDIKRVVAYSTLSQLGYMTVALGVSAYSAAVFHLMTHAFFKALLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAGSVIIGMHHEQDMRKMGGLRKYMKVTYWTSVIGTLALVGTPFFSGFYSKDTIIEAAA
HHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCHHHHHHHH
HHAHESHNWVATYGYWAVLGGVLVTSFYSFRLLFLTFHGKERFRDAHAHDVHSHHDSAHT
HHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHCCCHHHHHHHCCCCCCC
DAEAQVHSHDAHAHDDHGHGHHGAHEPHESKWVVTLPLVLLAIPSIAIGFFTIGPMLFGT
CCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCC
DWQGHHAVHAMKGQAVSFFTGIVDFYDPARDTVGALAEEFHGPVAFALHGMLAAPFFLTV
CCCCCCHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AGLLLAALFYLWKPELATKSRKTFAPIVWLLENKYGFDKLWINGFAGGGVVLGKASRAVD
HHHHHHHHHHHHCCCHHHCCCCHHHHHHHEECCCCCCCHHEEECCCCCCEEEECCCHHHH
THVVDGAVVNGSARLIDLAANLLRRTQSGFLYHYAFAMIIGLIALLAVLMHFWR
HHHCCCEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEITLSKSLLIAVVLAPLLGSIIAGLFGRQVGRKGAQYVTILGVAVSCVLSCVTLYQLVE
CCEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QGASPFNQNLYTFFDVGNYSAHVGFMVDRLTAMMMVVVTFVSLLVHIYTIGYMEEDPGYQ
HCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
RFFSYISLFTFSMLTLVMSNNFLQLFFGWEAVGLVSYLLIGFWFKRPTAVFANMKAFLVN
HHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RVGDFGFILGIAGVLLWFGSLDYSTVFANATTMAGAKVQLFAGHEWSVMTLICICLFIGA
HCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCEECCCEEEEEECCCHHHHHHHHHHHHHHC
MGKSAQVPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSETALNFILFI
CCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
GATTAFFTGLIGIVQNDIKRVVAYSTLSQLGYMTVALGVSAYSAAVFHLMTHAFFKALLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAGSVIIGMHHEQDMRKMGGLRKYMKVTYWTSVIGTLALVGTPFFSGFYSKDTIIEAAA
HHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCHHHHHHHH
HHAHESHNWVATYGYWAVLGGVLVTSFYSFRLLFLTFHGKERFRDAHAHDVHSHHDSAHT
HHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHCCCHHHHHHHCCCCCCC
DAEAQVHSHDAHAHDDHGHGHHGAHEPHESKWVVTLPLVLLAIPSIAIGFFTIGPMLFGT
CCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCC
DWQGHHAVHAMKGQAVSFFTGIVDFYDPARDTVGALAEEFHGPVAFALHGMLAAPFFLTV
CCCCCCHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AGLLLAALFYLWKPELATKSRKTFAPIVWLLENKYGFDKLWINGFAGGGVVLGKASRAVD
HHHHHHHHHHHHCCCHHHCCCCHHHHHHHEECCCCCCCHHEEECCCCCCEEEECCCHHHH
THVVDGAVVNGSARLIDLAANLLRRTQSGFLYHYAFAMIIGLIALLAVLMHFWR
HHHCCCEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]