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The map label for this gene is 21243283

Identifier: 21243283

GI number: 21243283

Start: 3008451

End: 3009389

Strand: Reverse

Name: 21243283

Synonym: XAC2550

Alternate gene names: NA

Gene position: 3009389-3008451 (Counterclockwise)

Preceding gene: 21243288

Following gene: 77748662

Centisome position: 58.15

GC content: 69.12

Gene sequence:

>939_bases
ATGCACACCATCGACGTCATCGACTCCCACACGGCAGGCGAGCCTACCCGCGTGGTCCTTTCCGGTTTTCCAGATCTGGG
CGATGGCGATCTGGCGCAGTGCCGCGAACGCTTCCGCAGCGAGTTCGACCACTGGCGCAGCGCCATCGCCTGCGAGCCGC
GTGGGTCGGACACCATGGTGGGCGCCTTGTTGCTGCCGCCGCGCGACCCGAGCGCCTGCACCGGGGTGATCTTCTTCAAT
AACGTCGGCTACCTGGGCATGTGCGGGCACGGCACGATTGGCGTGGTGCGCACGCTGGCCGAACTGGGGCGCATCGCGCC
GGGCCAGCACCGGATCGAGACACCGGTCGGCACGGTGGGCGTGGAGCTGGCCGACGACGGCACGGTGTCGGTAGACAATG
TCGAGAGCTATCGTTTTGCCAGCGGGGTCGAGGTGGAGGTGCCGGGGCATGGCCGGGTGTGCGGCGACGTGGCCTGGGGC
GGCAACTGGTTTTTCATCACCGAGCATGCGCCGTGCGCGCTGGACCTGGCGCACCAGCGCGAGCTGACCGCGTATACCGA
GGCGATTCGGCTGGCCCTGGAAGCGGCCGGGATCACTGGCGAGGCCGGTGGCGAGATCGACCATATCGAAGTCAACGGCG
CTGCGCCCGACGGTAGCGGCGTGGCGCGCAATTTCGTGCTGTGCCCGGGGCTGGCCTATGACCGCTCGCCGTGCGGCACC
GGCACCAGCGCCAAGCTGGCCTGCCTGGCGGCGGACGGCAAGTTGGCCGAAGGCGAGCGCTGGGTGCAGCAAGGCATTCT
GGGCAGCGCCTTCGAAGGCAATTATCGGCTGAGCGGGCGCGGCATCGCACCGCGCATCAGTGGGCGGGCGTACATCACCG
CGCGCGCGCAACTGGTGATCGACCCGGCGGACCCGTTCGCCTGGGGCATCGTGGCCTGA

Upstream 100 bases:

>100_bases
ACGCGCGGTTGTGATTCGGGTGGGTGATTGTGCGGATTTCCGCATTTTCACTTGGCATTGAACGCTAGTCGTCCGCGGGT
CGGCAGTGGGAGCATGAGCC

Downstream 100 bases:

>100_bases
TGGAACCCCAGCGGCCCGCGCCGGTGCTTGCGTCGGTCACGCCGTCTGGCGCAGCAGTGTCTGCTGCGATGACAGGGACT
GCCCCTGCAACGCCTGCGTC

Product: hypothetical protein

Products: NA

Alternate protein names: Hydroxyproline-2-epimerase; HyPRE [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MHTIDVIDSHTAGEPTRVVLSGFPDLGDGDLAQCRERFRSEFDHWRSAIACEPRGSDTMVGALLLPPRDPSACTGVIFFN
NVGYLGMCGHGTIGVVRTLAELGRIAPGQHRIETPVGTVGVELADDGTVSVDNVESYRFASGVEVEVPGHGRVCGDVAWG
GNWFFITEHAPCALDLAHQRELTAYTEAIRLALEAAGITGEAGGEIDHIEVNGAAPDGSGVARNFVLCPGLAYDRSPCGT
GTSAKLACLAADGKLAEGERWVQQGILGSAFEGNYRLSGRGIAPRISGRAYITARAQLVIDPADPFAWGIVA

Sequences:

>Translated_312_residues
MHTIDVIDSHTAGEPTRVVLSGFPDLGDGDLAQCRERFRSEFDHWRSAIACEPRGSDTMVGALLLPPRDPSACTGVIFFN
NVGYLGMCGHGTIGVVRTLAELGRIAPGQHRIETPVGTVGVELADDGTVSVDNVESYRFASGVEVEVPGHGRVCGDVAWG
GNWFFITEHAPCALDLAHQRELTAYTEAIRLALEAAGITGEAGGEIDHIEVNGAAPDGSGVARNFVLCPGLAYDRSPCGT
GTSAKLACLAADGKLAEGERWVQQGILGSAFEGNYRLSGRGIAPRISGRAYITARAQLVIDPADPFAWGIVA
>Mature_312_residues
MHTIDVIDSHTAGEPTRVVLSGFPDLGDGDLAQCRERFRSEFDHWRSAIACEPRGSDTMVGALLLPPRDPSACTGVIFFN
NVGYLGMCGHGTIGVVRTLAELGRIAPGQHRIETPVGTVGVELADDGTVSVDNVESYRFASGVEVEVPGHGRVCGDVAWG
GNWFFITEHAPCALDLAHQRELTAYTEAIRLALEAAGITGEAGGEIDHIEVNGAAPDGSGVARNFVLCPGLAYDRSPCGT
GTSAKLACLAADGKLAEGERWVQQGILGSAFEGNYRLSGRGIAPRISGRAYITARAQLVIDPADPFAWGIVA

Specific function: Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4- hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases [H]

COG id: COG3938

COG function: function code E; Proline racemase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the proline racemase family. 4- hydroxyproline epimerase subfamily [H]

Homologues:

Organism=Homo sapiens, GI21389361, Length=334, Percent_Identity=29.6407185628743, Blast_Score=134, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008794 [H]

Pfam domain/function: PF05544 Pro_racemase [H]

EC number: =5.1.1.8 [H]

Molecular weight: Translated: 32855; Mature: 32855

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTIDVIDSHTAGEPTRVVLSGFPDLGDGDLAQCRERFRSEFDHWRSAIACEPRGSDTMV
CCEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCEEE
GALLLPPRDPSACTGVIFFNNVGYLGMCGHGTIGVVRTLAELGRIAPGQHRIETPVGTVG
EEEEECCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEECCCCCEEE
VELADDGTVSVDNVESYRFASGVEVEVPGHGRVCGDVAWGGNWFFITEHAPCALDLAHQR
EEECCCCEEEECCCCCEEECCCCEEEECCCCCEEEEEEECCEEEEEECCCCEEEEHHHHH
ELTAYTEAIRLALEAAGITGEAGGEIDHIEVNGAAPDGSGVARNFVLCPGLAYDRSPCGT
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCC
GTSAKLACLAADGKLAEGERWVQQGILGSAFEGNYRLSGRGIAPRISGRAYITARAQLVI
CCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCCEEECCCCCCCEECCEEEEEEEEEEEE
DPADPFAWGIVA
ECCCCCEEECCC
>Mature Secondary Structure
MHTIDVIDSHTAGEPTRVVLSGFPDLGDGDLAQCRERFRSEFDHWRSAIACEPRGSDTMV
CCEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCEEE
GALLLPPRDPSACTGVIFFNNVGYLGMCGHGTIGVVRTLAELGRIAPGQHRIETPVGTVG
EEEEECCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEECCCCCEEE
VELADDGTVSVDNVESYRFASGVEVEVPGHGRVCGDVAWGGNWFFITEHAPCALDLAHQR
EEECCCCEEEECCCCCEEECCCCEEEECCCCCEEEEEEECCEEEEEECCCCEEEEHHHHH
ELTAYTEAIRLALEAAGITGEAGGEIDHIEVNGAAPDGSGVARNFVLCPGLAYDRSPCGT
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCC
GTSAKLACLAADGKLAEGERWVQQGILGSAFEGNYRLSGRGIAPRISGRAYITARAQLVI
CCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCCEEECCCCCCCEECCEEEEEEEEEEEE
DPADPFAWGIVA
ECCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA