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The map label for this gene is 21243182

Identifier: 21243182

GI number: 21243182

Start: 2850917

End: 2851537

Strand: Direct

Name: 21243182

Synonym: XAC2449

Alternate gene names: NA

Gene position: 2850917-2851537 (Clockwise)

Preceding gene: 21243179

Following gene: 21243184

Centisome position: 55.08

GC content: 67.79

Gene sequence:

>621_bases
ATGCCTGCAAAGCCCTTGCCCCGCACGTTCTATGCCCACGACGCCCGCCAGGTCGCGCCGCGATTGCTCAACAAGGTGCT
GGTCAGTGCTGACGGACGCTGCGGGCGCATCACCGAAGTGGAAGCCTACTGCGGTAGCGACGACCCGGCCGCGCACTCGT
TCCGCGGCATGACCCCGCGCACGCGGGTGATGTTCGGTGCGCCCGGGCACCTGTATGTGTATTTCATCTATGGCATGCAT
TGGGCAATCAACGTGGTCTGCGGCGGTGCGCCCGGGCATGCGGTGCTGATCCGTGCATTGGAACCGCTGGACGGTATCGA
CCGCATGCAGGCCGCGCGCGGCGCCGCCCCGTTCACTGCGTTGACCACCGGCCCAGGCCGCCTGGCGCAGGCGTTCGGCG
TGACCGCTGCGGACAATGGGCTGGATCTCAGCACCGCGGCCGCGCGGCTCTGGATCGAAGACGACGGCGCGCCGCCTCCG
TCCAATCCAGTGGCCACGCCGCGCATCGGCATCCGCAAGGCCGTGGATGCGCCATGGCGCTGGGTGGTTGCAGATAGCCG
CTATTTATCGCGTCCGCTTCCGCGCGTGACCGGAAAAGGCACGGTGCTTGCCGGCGATTGA

Upstream 100 bases:

>100_bases
GCGCTCGTCACAGCCCATATTCGGAAAAACCCTACCCCCGCCCGTGCGCTGTCCAGGCCAATCCGCTGGGACATCACGTC
CACGCAGCTATGCTTTGGCC

Downstream 100 bases:

>100_bases
GCCAACAAGCGCTCCATCGGCGATTGTTCTGCCGCGCCCGGTCCGCGCTGCAGCAGACGCAGCGCCTGCTCGGCTTGCTC
GGGCGTAAGCTCCTGCAAGG

Product: 3-methyladenine DNA glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MPAKPLPRTFYAHDARQVAPRLLNKVLVSADGRCGRITEVEAYCGSDDPAAHSFRGMTPRTRVMFGAPGHLYVYFIYGMH
WAINVVCGGAPGHAVLIRALEPLDGIDRMQAARGAAPFTALTTGPGRLAQAFGVTAADNGLDLSTAAARLWIEDDGAPPP
SNPVATPRIGIRKAVDAPWRWVVADSRYLSRPLPRVTGKGTVLAGD

Sequences:

>Translated_206_residues
MPAKPLPRTFYAHDARQVAPRLLNKVLVSADGRCGRITEVEAYCGSDDPAAHSFRGMTPRTRVMFGAPGHLYVYFIYGMH
WAINVVCGGAPGHAVLIRALEPLDGIDRMQAARGAAPFTALTTGPGRLAQAFGVTAADNGLDLSTAAARLWIEDDGAPPP
SNPVATPRIGIRKAVDAPWRWVVADSRYLSRPLPRVTGKGTVLAGD
>Mature_205_residues
PAKPLPRTFYAHDARQVAPRLLNKVLVSADGRCGRITEVEAYCGSDDPAAHSFRGMTPRTRVMFGAPGHLYVYFIYGMHW
AINVVCGGAPGHAVLIRALEPLDGIDRMQAARGAAPFTALTTGPGRLAQAFGVTAADNGLDLSTAAARLWIEDDGAPPPS
NPVATPRIGIRKAVDAPWRWVVADSRYLSRPLPRVTGKGTVLAGD

Specific function: Unknown

COG id: COG2094

COG function: function code L; 3-methyladenine DNA glycosylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA glycosylase MPG family

Homologues:

Organism=Homo sapiens, GI62632769, Length=173, Percent_Identity=39.8843930635838, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI62632771, Length=173, Percent_Identity=39.8843930635838, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI62632765, Length=173, Percent_Identity=39.8843930635838, Blast_Score=98, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 3MGH_XANAC (Q8PJT1)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642764.1
- ProteinModelPortal:   Q8PJT1
- SMR:   Q8PJT1
- GeneID:   1156520
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2449
- NMPDR:   fig|190486.1.peg.2408
- HOGENOM:   HBG664239
- OMA:   LCSGPGK
- ProtClustDB:   PRK00802
- BioCyc:   XAXO190486:XAC2449-MONOMER
- HAMAP:   MF_00527
- InterPro:   IPR011034
- InterPro:   IPR003180
- Gene3D:   G3DSA:3.10.300.10
- PANTHER:   PTHR10429
- TIGRFAMs:   TIGR00567

Pfam domain/function: PF02245 Pur_DNA_glyco; SSF50486 FMT_C_like

EC number: 3.2.2.-

Molecular weight: Translated: 21981; Mature: 21850

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAKPLPRTFYAHDARQVAPRLLNKVLVSADGRCGRITEVEAYCGSDDPAAHSFRGMTPR
CCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHCCCCCCC
TRVMFGAPGHLYVYFIYGMHWAINVVCGGAPGHAVLIRALEPLDGIDRMQAARGAAPFTA
CEEEECCCCCEEEEEEEHHCEEEEEEECCCCCCEEEEEHHCCCCHHHHHHHHCCCCCEEE
LTTGPGRLAQAFGVTAADNGLDLSTAAARLWIEDDGAPPPSNPVATPRIGIRKAVDAPWR
EECCCHHHHHHHCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCEE
WVVADSRYLSRPLPRVTGKGTVLAGD
EEEECCHHHHCCCCCCCCCCEEEECC
>Mature Secondary Structure 
PAKPLPRTFYAHDARQVAPRLLNKVLVSADGRCGRITEVEAYCGSDDPAAHSFRGMTPR
CCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHCCCCCCC
TRVMFGAPGHLYVYFIYGMHWAINVVCGGAPGHAVLIRALEPLDGIDRMQAARGAAPFTA
CEEEECCCCCEEEEEEEHHCEEEEEEECCCCCCEEEEEHHCCCCHHHHHHHHCCCCCEEE
LTTGPGRLAQAFGVTAADNGLDLSTAAARLWIEDDGAPPPSNPVATPRIGIRKAVDAPWR
EECCCHHHHHHHCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCEE
WVVADSRYLSRPLPRVTGKGTVLAGD
EEEECCHHHHCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217