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The map label for this gene is apt

Identifier: 21243125

GI number: 21243125

Start: 2786231

End: 2786791

Strand: Reverse

Name: apt

Synonym: XAC2391

Alternate gene names: 21243125

Gene position: 2786791-2786231 (Counterclockwise)

Preceding gene: 21243126

Following gene: 21243123

Centisome position: 53.85

GC content: 64.53

Gene sequence:

>561_bases
ATGACTGACTGCAGCCGCTGCGCCGGCACCAATACTTCCGGACCCAACCATTGGCCGGAGCGCATTCGCGACATCGTCGA
TTTCCCCAAGCCGGGCATCGTCTTCAAGGACATTACTCCGTTGCTGTCCGATGGTCCGGATTTCGCCTCTGCGCTGGACG
AAATGGCGCAGCCGTGGCGGACCACGCCGCTGGATGCGGTGCTGGGGATCGAGGCGCGCGGTTTCATTCTGGGGGCGGCG
CTGGCGCGCGAACTGCGGACCGGCTTCGTACCGGTGCGCAAGCCGGGCAAGCTGCCGGGGCGCACGCTGATCCAGGAATA
TGCGCTGGAATACGGCACCGATCGCATTGAAATGCATGAGGATGCGCTGCCGCGGGGGGCGCGCGTGCTGATTGTCGACG
ACGTGCTGGCCACCGGCGGCACGCTGCGTGCGGCCTTGGGACTTGCTGCCCAACTCGAACTTGAAGTCGTTGGCGCAGCC
GTGCTGGTGGAGTTGCAGGGACTGCAGGGTCGCCAGAAATGGGCGAACGATGTACCGCTGTTGGCGACGCTTTCTTACTG
A

Upstream 100 bases:

>100_bases
TCCTGACGCGCTCAGATGCAGGTATGCCGTAAATCCGGCGTGGATGGCGTACGCAGCCTAGAATAGGCGCAACCCCACCG
GCCACCACGCCACCGCCCTC

Downstream 100 bases:

>100_bases
GTCCAAGCTCTGGAAGCGACCCTGGGTGCGTGGCAGCGCCTGCCTCCAGGATTGCTCCTGCTGAACATCGGCGGCCGGCA
CGACGCCGGCCGCGCTGCGT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MTDCSRCAGTNTSGPNHWPERIRDIVDFPKPGIVFKDITPLLSDGPDFASALDEMAQPWRTTPLDAVLGIEARGFILGAA
LARELRTGFVPVRKPGKLPGRTLIQEYALEYGTDRIEMHEDALPRGARVLIVDDVLATGGTLRAALGLAAQLELEVVGAA
VLVELQGLQGRQKWANDVPLLATLSY

Sequences:

>Translated_186_residues
MTDCSRCAGTNTSGPNHWPERIRDIVDFPKPGIVFKDITPLLSDGPDFASALDEMAQPWRTTPLDAVLGIEARGFILGAA
LARELRTGFVPVRKPGKLPGRTLIQEYALEYGTDRIEMHEDALPRGARVLIVDDVLATGGTLRAALGLAAQLELEVVGAA
VLVELQGLQGRQKWANDVPLLATLSY
>Mature_185_residues
TDCSRCAGTNTSGPNHWPERIRDIVDFPKPGIVFKDITPLLSDGPDFASALDEMAQPWRTTPLDAVLGIEARGFILGAAL
ARELRTGFVPVRKPGKLPGRTLIQEYALEYGTDRIEMHEDALPRGARVLIVDDVLATGGTLRAALGLAAQLELEVVGAAV
LVELQGLQGRQKWANDVPLLATLSY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=170, Percent_Identity=47.0588235294118, Blast_Score=147, Evalue=4e-36,
Organism=Homo sapiens, GI71773201, Length=123, Percent_Identity=47.9674796747967, Blast_Score=115, Evalue=2e-26,
Organism=Escherichia coli, GI1786675, Length=158, Percent_Identity=46.8354430379747, Blast_Score=147, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=46.4705882352941, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=163, Percent_Identity=38.6503067484663, Blast_Score=108, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320649, Length=167, Percent_Identity=32.9341317365269, Blast_Score=75, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17136334, Length=165, Percent_Identity=37.5757575757576, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_XANAC (Q8PJY6)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642707.1
- ProteinModelPortal:   Q8PJY6
- SMR:   Q8PJY6
- GeneID:   1156462
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2391
- NMPDR:   fig|190486.1.peg.2351
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   XAXO190486:XAC2391-MONOMER
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 20098; Mature: 19967

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDCSRCAGTNTSGPNHWPERIRDIVDFPKPGIVFKDITPLLSDGPDFASALDEMAQPWR
CCCCCHHCCCCCCCCCHHHHHHHHHHCCCCCCEEHHHCCHHHCCCCHHHHHHHHHHCCCC
TTPLDAVLGIEARGFILGAALARELRTGFVPVRKPGKLPGRTLIQEYALEYGTDRIEMHE
CCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECC
DALPRGARVLIVDDVLATGGTLRAALGLAAQLELEVVGAAVLVELQGLQGRQKWANDVPL
CCCCCCCEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCE
LATLSY
EEEECC
>Mature Secondary Structure 
TDCSRCAGTNTSGPNHWPERIRDIVDFPKPGIVFKDITPLLSDGPDFASALDEMAQPWR
CCCCHHCCCCCCCCCHHHHHHHHHHCCCCCCEEHHHCCHHHCCCCHHHHHHHHHHCCCC
TTPLDAVLGIEARGFILGAALARELRTGFVPVRKPGKLPGRTLIQEYALEYGTDRIEMHE
CCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECC
DALPRGARVLIVDDVLATGGTLRAALGLAAQLELEVVGAAVLVELQGLQGRQKWANDVPL
CCCCCCCEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCE
LATLSY
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217