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The map label for this gene is uvrC

Identifier: 21242831

GI number: 21242831

Start: 2440833

End: 2442692

Strand: Direct

Name: uvrC

Synonym: XAC2092

Alternate gene names: 21242831

Gene position: 2440833-2442692 (Clockwise)

Preceding gene: 21242830

Following gene: 21242832

Centisome position: 47.16

GC content: 64.73

Gene sequence:

>1860_bases
ATGAGCGTCAGACCCCAAAACGATTTCGATGGAAAAGCGTTTGCTGCGCAACTGAGCACCGCGCCTGGCGTCTATCGCAT
GTATGCGGGCGACGACACCTTGTTGTACGTCGGCAAGGCGGGCGCGCTGCGCAAGCGCGTGGGAAGCTATTTCAACGGGA
CGCCGAAGAACGCCCGGTTGACCTCGATGCTGTCGCAGGTCGCGCGCATGGACGTCACCGTCACCCGCAGCGAAGCCGAA
GCGCTACTGCTGGAAAACCAGCTGATCAAATCGTTGTCGCCGCGCTACAACGTTTCGTTGCGCGACGACAAAAGCTACCC
ATACGTGTTGCTGACGCGCGAACAATGGCCCCGTATTGCCTTGCATCGCGGTCCGCGTGCGGTGCAAGGGCGTTATTTCG
GCCCTTACACGGGCGTCACCGGTGTACGCGAAACGCTGAGCCTGATGCATAAGCTCTTCAAGCTGCGCAGTTGCGAGGAC
AGCGTGTTCCGCAACCGTTCGCGGCCATGCCTGCAGTATCAGATCGGGCGTTGCAGCGGCCCGTGCGTGGATTTGGTGGC
GGCTCCGGATTACGCCGAATCGGTACGCCGCGCTACCATGTTTCTCGAAGGCAAGAGCGATCAGCTCGGCGAAGAGATCA
TGCACTCGATGCAGCAGGCCAGCGAGGCGCTGGAATTCGAGCGCGCCGCGCGTTTGCGCGATTTGCTCTCGTCGCTGCGC
AGCATGCAGAACCGTCAATACGTCGACGGCCGTGCAGCGGATCTGGACGTGCTGGCCTGCGCCACGCAATCCAGCCAGGC
GTGCGTCCTGTTGCTGAGTTTTCGCGATGGCCGCAATCTCGGCACGCGCTCGTTCTTTCCCAAGACCAACGGGGAAGATA
GCGCCGACGAAATTCTTGGCGCGTTCGTATCGCAGTACTACGCCGAGCACTCTCCCCCGCGCGAAATCCTGCTCGACCGC
GAGATTCCGGAAGCCGAGCTGATCGAAGCCGCGCTCAGTACGGCCGCCGAGCACAAGGTGGCGCTGAAGTGGAACGTGCG
CGGCGAGCGTGCCGGCTATCTGCTGCTGGCCACGCGCAATGCGCAGCTGACCCTTGTCACCGAGCTCACCAGCCAGAGCG
CGCAGCATGCACGCAGCGAAGCCTTGCGCGAGCTGCTTGGACTTGCCGAGCCGGTCAAGCGCGTGGAGTGTTTCGACATC
AGTCACACCATGGGCGAAGCGACCGTCGCCTCGTGCGTGGTATTCGACGCCAGCGGCCCGGTGCGTGGCCAGTACCGGCG
CTTCAATATTTCCGGCATCACGCCGGGCGACGACTACGCAGCCATGCGGCAGGCGATCGAGCGCCGCTTCCGTCGCGCCG
TGGAAGAGAACGGCGTGATCCCCGACGTGCTGCTGATCGACGGTGGCGCCGGCCAGCTGGCACAGGCCCAGGCCGCGTTG
GCCGATCTCGGGGTCGAGAACGTGTTGCTGGTCGGCGTGGCCAAGGGCGAAGAGCGCCGGGCAGGGCACGAAGCGTTGAT
CATGGCCGACGGGCGCGAGCTACGGCCGGGCGCGGCGTCGCCTGCGCTGCAATTCATCCAGCAAGTGCGTGACGAAGCGC
ACCGCTTTGCGATCACCGGCCACCGCGGGCGCCGCCAGAAGGCGCGCATGACCAGCAAGCTCGAGGATATCCCCGGCATC
GGCCCTCGGCGCCGCGCGAGCCTGCTCAAGCATTTCGGAGGACTGGTCGGGCTCAAGGCCGCTGGCGAGGCCGAGATTGC
ACGGGTGGAGGGGGTCAATGCCGCACTTGCCGCGCGAATCTACGCTAACCTGCACGGGCTGGCGCTTCCCGATGCGGCAG
GCGAGGCAAGTCCGCAATGA

Upstream 100 bases:

>100_bases
CGGTCGCCGCCGGTGCGGTCTGGATCGCAGAAACCGATGCACATGCCATCTTGCGGTACGACCTTGCAAGCGGCGCACTG
AGTGATGTTTCGATAGACGA

Downstream 100 bases:

>100_bases
AGTTGACCATCCCCACGTGGCTGACACTGCTGAGGATCGTGATGATCCCGGTGTTGGTCGTGGTGTTCTACCTGCCCTAC
ACGTGGACGAACTTCGCGTC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MSVRPQNDFDGKAFAAQLSTAPGVYRMYAGDDTLLYVGKAGALRKRVGSYFNGTPKNARLTSMLSQVARMDVTVTRSEAE
ALLLENQLIKSLSPRYNVSLRDDKSYPYVLLTREQWPRIALHRGPRAVQGRYFGPYTGVTGVRETLSLMHKLFKLRSCED
SVFRNRSRPCLQYQIGRCSGPCVDLVAAPDYAESVRRATMFLEGKSDQLGEEIMHSMQQASEALEFERAARLRDLLSSLR
SMQNRQYVDGRAADLDVLACATQSSQACVLLLSFRDGRNLGTRSFFPKTNGEDSADEILGAFVSQYYAEHSPPREILLDR
EIPEAELIEAALSTAAEHKVALKWNVRGERAGYLLLATRNAQLTLVTELTSQSAQHARSEALRELLGLAEPVKRVECFDI
SHTMGEATVASCVVFDASGPVRGQYRRFNISGITPGDDYAAMRQAIERRFRRAVEENGVIPDVLLIDGGAGQLAQAQAAL
ADLGVENVLLVGVAKGEERRAGHEALIMADGRELRPGAASPALQFIQQVRDEAHRFAITGHRGRRQKARMTSKLEDIPGI
GPRRRASLLKHFGGLVGLKAAGEAEIARVEGVNAALAARIYANLHGLALPDAAGEASPQ

Sequences:

>Translated_619_residues
MSVRPQNDFDGKAFAAQLSTAPGVYRMYAGDDTLLYVGKAGALRKRVGSYFNGTPKNARLTSMLSQVARMDVTVTRSEAE
ALLLENQLIKSLSPRYNVSLRDDKSYPYVLLTREQWPRIALHRGPRAVQGRYFGPYTGVTGVRETLSLMHKLFKLRSCED
SVFRNRSRPCLQYQIGRCSGPCVDLVAAPDYAESVRRATMFLEGKSDQLGEEIMHSMQQASEALEFERAARLRDLLSSLR
SMQNRQYVDGRAADLDVLACATQSSQACVLLLSFRDGRNLGTRSFFPKTNGEDSADEILGAFVSQYYAEHSPPREILLDR
EIPEAELIEAALSTAAEHKVALKWNVRGERAGYLLLATRNAQLTLVTELTSQSAQHARSEALRELLGLAEPVKRVECFDI
SHTMGEATVASCVVFDASGPVRGQYRRFNISGITPGDDYAAMRQAIERRFRRAVEENGVIPDVLLIDGGAGQLAQAQAAL
ADLGVENVLLVGVAKGEERRAGHEALIMADGRELRPGAASPALQFIQQVRDEAHRFAITGHRGRRQKARMTSKLEDIPGI
GPRRRASLLKHFGGLVGLKAAGEAEIARVEGVNAALAARIYANLHGLALPDAAGEASPQ
>Mature_618_residues
SVRPQNDFDGKAFAAQLSTAPGVYRMYAGDDTLLYVGKAGALRKRVGSYFNGTPKNARLTSMLSQVARMDVTVTRSEAEA
LLLENQLIKSLSPRYNVSLRDDKSYPYVLLTREQWPRIALHRGPRAVQGRYFGPYTGVTGVRETLSLMHKLFKLRSCEDS
VFRNRSRPCLQYQIGRCSGPCVDLVAAPDYAESVRRATMFLEGKSDQLGEEIMHSMQQASEALEFERAARLRDLLSSLRS
MQNRQYVDGRAADLDVLACATQSSQACVLLLSFRDGRNLGTRSFFPKTNGEDSADEILGAFVSQYYAEHSPPREILLDRE
IPEAELIEAALSTAAEHKVALKWNVRGERAGYLLLATRNAQLTLVTELTSQSAQHARSEALRELLGLAEPVKRVECFDIS
HTMGEATVASCVVFDASGPVRGQYRRFNISGITPGDDYAAMRQAIERRFRRAVEENGVIPDVLLIDGGAGQLAQAQAALA
DLGVENVLLVGVAKGEERRAGHEALIMADGRELRPGAASPALQFIQQVRDEAHRFAITGHRGRRQKARMTSKLEDIPGIG
PRRRASLLKHFGGLVGLKAAGEAEIARVEGVNAALAARIYANLHGLALPDAAGEASPQ

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=610, Percent_Identity=49.8360655737705, Blast_Score=597, Evalue=1e-172,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_XANAC (Q8PKS0)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642413.1
- HSSP:   P0A8G0
- ProteinModelPortal:   Q8PKS0
- GeneID:   1156163
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2092
- NMPDR:   fig|190486.1.peg.2057
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   XAXO190486:XAC2092-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 67880; Mature: 67749

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRPQNDFDGKAFAAQLSTAPGVYRMYAGDDTLLYVGKAGALRKRVGSYFNGTPKNARL
CCCCCCCCCCCHHHHHHHCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHCCCCCCCHHH
TSMLSQVARMDVTVTRSEAEALLLENQLIKSLSPRYNVSLRDDKSYPYVLLTREQWPRIA
HHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCH
LHRGPRAVQGRYFGPYTGVTGVRETLSLMHKLFKLRSCEDSVFRNRSRPCLQYQIGRCSG
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEECCCCCC
PCVDLVAAPDYAESVRRATMFLEGKSDQLGEEIMHSMQQASEALEFERAARLRDLLSSLR
CCEEEEECCCHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMQNRQYVDGRAADLDVLACATQSSQACVLLLSFRDGRNLGTRSFFPKTNGEDSADEILG
HHHCCCCCCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
AFVSQYYAEHSPPREILLDREIPEAELIEAALSTAAEHKVALKWNVRGERAGYLLLATRN
HHHHHHHHCCCCCHHHEECCCCCHHHHHHHHHHHHHHCEEEEEEECCCCCCCEEEEEECC
AQLTLVTELTSQSAQHARSEALRELLGLAEPVKRVECFDISHTMGEATVASCVVFDASGP
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHCHHHHEEEEEECCCCC
VRGQYRRFNISGITPGDDYAAMRQAIERRFRRAVEENGVIPDVLLIDGGAGQLAQAQAAL
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHH
ADLGVENVLLVGVAKGEERRAGHEALIMADGRELRPGAASPALQFIQQVRDEAHRFAITG
HHCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHEEEEEC
HRGRRQKARMTSKLEDIPGIGPRRRASLLKHFGGLVGLKAAGEAEIARVEGVNAALAARI
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHCCCHHHHHHHH
YANLHGLALPDAAGEASPQ
HHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SVRPQNDFDGKAFAAQLSTAPGVYRMYAGDDTLLYVGKAGALRKRVGSYFNGTPKNARL
CCCCCCCCCCHHHHHHHCCCCCEEEEEECCCEEEEEECCHHHHHHHHHHCCCCCCCHHH
TSMLSQVARMDVTVTRSEAEALLLENQLIKSLSPRYNVSLRDDKSYPYVLLTREQWPRIA
HHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCH
LHRGPRAVQGRYFGPYTGVTGVRETLSLMHKLFKLRSCEDSVFRNRSRPCLQYQIGRCSG
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEECCCCCC
PCVDLVAAPDYAESVRRATMFLEGKSDQLGEEIMHSMQQASEALEFERAARLRDLLSSLR
CCEEEEECCCHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMQNRQYVDGRAADLDVLACATQSSQACVLLLSFRDGRNLGTRSFFPKTNGEDSADEILG
HHHCCCCCCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
AFVSQYYAEHSPPREILLDREIPEAELIEAALSTAAEHKVALKWNVRGERAGYLLLATRN
HHHHHHHHCCCCCHHHEECCCCCHHHHHHHHHHHHHHCEEEEEEECCCCCCCEEEEEECC
AQLTLVTELTSQSAQHARSEALRELLGLAEPVKRVECFDISHTMGEATVASCVVFDASGP
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHCHHHHEEEEEECCCCC
VRGQYRRFNISGITPGDDYAAMRQAIERRFRRAVEENGVIPDVLLIDGGAGQLAQAQAAL
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHH
ADLGVENVLLVGVAKGEERRAGHEALIMADGRELRPGAASPALQFIQQVRDEAHRFAITG
HHCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHEEEEEC
HRGRRQKARMTSKLEDIPGIGPRRRASLLKHFGGLVGLKAAGEAEIARVEGVNAALAARI
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHCCCHHHHHHHH
YANLHGLALPDAAGEASPQ
HHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217