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The map label for this gene is lolC [H]

Identifier: 21242820

GI number: 21242820

Start: 2427951

End: 2429192

Strand: Direct

Name: lolC [H]

Synonym: XAC2081

Alternate gene names: 21242820

Gene position: 2427951-2429192 (Clockwise)

Preceding gene: 21242819

Following gene: 21242821

Centisome position: 46.91

GC content: 62.0

Gene sequence:

>1242_bases
ATGTTCAAACCTATTCCGGTTGCCATCGGCTTGCGCTATCTGCGTGCCAAGCGGCGCAATGGCTTCATCTCGTTTATTTC
GATGGCGTCGATCCTGGGCATCGCCCTGGGCGTGACCGTGCTGATCACCACGCTTGCAGTGATGAGCGGTTTCCAGAAGG
AGATCCGCGACCGCCTGCTGCAGATGGCTGCCCACGCGACCGTCAGTGCAGAAGGCGCGCCGATGCGCGATTGGCAGCAT
GCGGTCGAGGTCGCCATGTCTGATTCGCGCGTGGCCGGTGCCGCGCCCTACATCGAAACCGAATCCTTATTGCAGGGCCC
GCGCAAGCAGCCGGCCATCGTGCGCGGCGTGATTCCTGCCGAAGAAGGCAAGGTGTCGGTGCTGGCCAAGAAGATGCAGC
AGGGTTCGGTCGACAGCCTGACGCCTGGGTCGTACAACATCGTCATCGGCAAGGAGCTGGCGTTGTGGCTTGGCGTGGAT
GTTGGCGACAGCATCGTCGTGTTGCTCAGCGACACCCAGGCGACGCCGCTGGGCGCGATGCCGCGGCTCAAGCGCTTTAC
CGTGAGCGGTATTTTCGAGGCCGGATACAACGAAATCGACCGCGGCCTCGCCGTGGTGAACATGCAGGACCTGGCGCGCG
TGCTGCGCATGGATGGCGTCACCGGCGTGCGCCTGCGCCTGCATGACATGGATCAGGCCTGGCCGGTGGCGCGCGATCTG
GCGGTGAGGTTGCACGGCCCGTATCGGGTCAGCGACTGGACCCAGGAAAACGCCAACCTGTACCACTCGTTGAAGATGGA
AAAGACGGTGATGGGCATCCTGCTGTCGCTGATCGTGGCGATGGGCGCGTTCAACCTGGTGTCCTCGCAGGTGATGCTGG
TGACCGATAAACAGGCCGATATCGCCATCTTGCGCACCCTCGGGCTGTCGCCGGCCGGGGTGATGCAGGTATTCATGGTG
CAGGGCTCGTTGATCGGCTTCATGGGTACCTTCATGGGCGTGATCGGCGGCATCGTGCTAACGCTCAATCTTGAACGCAT
CCTCGGCGTGATCGAAACGATTTTCAGCGTCAAGTTGCTACCCGAAGACGTGTACTACATCACCGGCCTGCCGACCGATA
TGCAAACCCAGGACGTGGTGGTGATCACCGTGGTGGCATTGGTGATGAGTTTCCTTGCGACCTTGTACCCGGCGTGGCGC
GCTTCGCGCACCCAGCCGGCGGAGGCGCTGCGTTATGAATGA

Upstream 100 bases:

>100_bases
CGCCGCAACGACGTGAACTGCGTCTGGCCGCTCAGGCCCACGCCATTTCGTCCGGGCGGCCGCTAGTGGCACCATAGCGT
CCCTTTCCCGGTTGAACCGC

Downstream 100 bases:

>100_bases
GATCCGGGAAACGCTCGTGCAAACACCAAAAAAGGCAACTGCGGTGATCCGCGCCGAAGCGCTGGCCAAGACCTACGCCG
AAGGCAAGATGCGCACGCCG

Product: lipoprotein releasing system transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MFKPIPVAIGLRYLRAKRRNGFISFISMASILGIALGVTVLITTLAVMSGFQKEIRDRLLQMAAHATVSAEGAPMRDWQH
AVEVAMSDSRVAGAAPYIETESLLQGPRKQPAIVRGVIPAEEGKVSVLAKKMQQGSVDSLTPGSYNIVIGKELALWLGVD
VGDSIVVLLSDTQATPLGAMPRLKRFTVSGIFEAGYNEIDRGLAVVNMQDLARVLRMDGVTGVRLRLHDMDQAWPVARDL
AVRLHGPYRVSDWTQENANLYHSLKMEKTVMGILLSLIVAMGAFNLVSSQVMLVTDKQADIAILRTLGLSPAGVMQVFMV
QGSLIGFMGTFMGVIGGIVLTLNLERILGVIETIFSVKLLPEDVYYITGLPTDMQTQDVVVITVVALVMSFLATLYPAWR
ASRTQPAEALRYE

Sequences:

>Translated_413_residues
MFKPIPVAIGLRYLRAKRRNGFISFISMASILGIALGVTVLITTLAVMSGFQKEIRDRLLQMAAHATVSAEGAPMRDWQH
AVEVAMSDSRVAGAAPYIETESLLQGPRKQPAIVRGVIPAEEGKVSVLAKKMQQGSVDSLTPGSYNIVIGKELALWLGVD
VGDSIVVLLSDTQATPLGAMPRLKRFTVSGIFEAGYNEIDRGLAVVNMQDLARVLRMDGVTGVRLRLHDMDQAWPVARDL
AVRLHGPYRVSDWTQENANLYHSLKMEKTVMGILLSLIVAMGAFNLVSSQVMLVTDKQADIAILRTLGLSPAGVMQVFMV
QGSLIGFMGTFMGVIGGIVLTLNLERILGVIETIFSVKLLPEDVYYITGLPTDMQTQDVVVITVVALVMSFLATLYPAWR
ASRTQPAEALRYE
>Mature_413_residues
MFKPIPVAIGLRYLRAKRRNGFISFISMASILGIALGVTVLITTLAVMSGFQKEIRDRLLQMAAHATVSAEGAPMRDWQH
AVEVAMSDSRVAGAAPYIETESLLQGPRKQPAIVRGVIPAEEGKVSVLAKKMQQGSVDSLTPGSYNIVIGKELALWLGVD
VGDSIVVLLSDTQATPLGAMPRLKRFTVSGIFEAGYNEIDRGLAVVNMQDLARVLRMDGVTGVRLRLHDMDQAWPVARDL
AVRLHGPYRVSDWTQENANLYHSLKMEKTVMGILLSLIVAMGAFNLVSSQVMLVTDKQADIAILRTLGLSPAGVMQVFMV
QGSLIGFMGTFMGVIGGIVLTLNLERILGVIETIFSVKLLPEDVYYITGLPTDMQTQDVVVITVVALVMSFLATLYPAWR
ASRTQPAEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787360, Length=417, Percent_Identity=36.21103117506, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1787362, Length=412, Percent_Identity=33.9805825242718, Blast_Score=211, Evalue=5e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 44986; Mature: 44986

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKPIPVAIGLRYLRAKRRNGFISFISMASILGIALGVTVLITTLAVMSGFQKEIRDRLL
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QMAAHATVSAEGAPMRDWQHAVEVAMSDSRVAGAAPYIETESLLQGPRKQPAIVRGVIPA
HHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCEEEECCCC
EEGKVSVLAKKMQQGSVDSLTPGSYNIVIGKELALWLGVDVGDSIVVLLSDTQATPLGAM
CCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCEEEEEECCCCCCEEEEEECCCCCCCCCC
PRLKRFTVSGIFEAGYNEIDRGLAVVNMQDLARVLRMDGVTGVRLRLHDMDQAWPVARDL
CHHHHHHHHHHHHHCHHHHHCCEEEECHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHH
AVRLHGPYRVSDWTQENANLYHSLKMEKTVMGILLSLIVAMGAFNLVSSQVMLVTDKQAD
EEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
IAILRTLGLSPAGVMQVFMVQGSLIGFMGTFMGVIGGIVLTLNLERILGVIETIFSVKLL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHCC
PEDVYYITGLPTDMQTQDVVVITVVALVMSFLATLYPAWRASRTQPAEALRYE
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCC
>Mature Secondary Structure
MFKPIPVAIGLRYLRAKRRNGFISFISMASILGIALGVTVLITTLAVMSGFQKEIRDRLL
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QMAAHATVSAEGAPMRDWQHAVEVAMSDSRVAGAAPYIETESLLQGPRKQPAIVRGVIPA
HHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCEEEECCCC
EEGKVSVLAKKMQQGSVDSLTPGSYNIVIGKELALWLGVDVGDSIVVLLSDTQATPLGAM
CCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCEEEEEECCCCCCEEEEEECCCCCCCCCC
PRLKRFTVSGIFEAGYNEIDRGLAVVNMQDLARVLRMDGVTGVRLRLHDMDQAWPVARDL
CHHHHHHHHHHHHHCHHHHHCCEEEECHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHH
AVRLHGPYRVSDWTQENANLYHSLKMEKTVMGILLSLIVAMGAFNLVSSQVMLVTDKQAD
EEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
IAILRTLGLSPAGVMQVFMVQGSLIGFMGTFMGVIGGIVLTLNLERILGVIETIFSVKLL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHCC
PEDVYYITGLPTDMQTQDVVVITVVALVMSFLATLYPAWRASRTQPAEALRYE
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]