Click here to switch to the map view.

The map label for this gene is moeA [H]

Identifier: 21242766

GI number: 21242766

Start: 2365418

End: 2366638

Strand: Direct

Name: moeA [H]

Synonym: XAC2022

Alternate gene names: 21242766

Gene position: 2365418-2366638 (Clockwise)

Preceding gene: 21242765

Following gene: 21242768

Centisome position: 45.7

GC content: 66.42

Gene sequence:

>1221_bases
ATGACCGATTATCCTTCCCGCATTCCGTACGCGCAGGCGCTGCAGATTCTGCACAGTGTGGCGACCAGCAACCGTTCGCC
CGATGAAAACATCGCCATCTCGCGTGCCGATGGGCGGATCTCTGCAGGCGACCTGATCGCACCGCTGGCGCTGCCGCCAT
TCGCCAACAGCGCGATGGATGGCTTTGCGCTGCGGCACGCCGATATTGCGGCCGGCGACGCGTCGTTGCAGCTGGTTGGC
GAACAGTTTGCCGGCGAGCGCTGGGCTGGCACACTGGCTGCCGGGCAATGCCTGCGTATCACTACCGGCGCGCCACTGCC
CGATGGCGCCGATACCGTGATTCCCAAGGAAGATGCCGACGAACGCGACGGCATGGTGCGGTTTCAGACCGCGCCTGCAC
CGGGCGCAGCTGTGCGCCTGGCCGGCAGCGACGTACGCGCCGGCGATCTGGTGATCCAGGCCGGGCAGGTGCTGACGCCT
GCACGCATCGGTCTGGCTGCTGCGCTGGGGGTGTCGCGGCTTGCGGTCGCGCCGCGCCCGACCATTGCGGTGCTGGCCAC
GGGCGATGAGCTGATCGAACCAGGCATGCCGCTCGGCCCGGGACAGATCTACAACAGCAACCGCGACATGCTGATGGCGC
AACTGCGTGCATTGGGTTACGCGCCGACCGCCTGGCCGACATTGCCGGACGACCCGCAACGTATCGGCACCATGCTGGAA
GATGCGGCCGCGGCGTTCGATGTGGTGATCACCTGCGGCGGCGTTTCTGCTGGCGAAAAGGATTATCTGCCGCGTCTGAT
CGGCGAATTGGGGCGCATCCATTTCTGGCGTGTGCGAATGCGCCCGGGAATGCCGGCGGTGTTGGGGCAGATTGGTCGCT
GCCTGGTCTTGGGCCTGCCGGGCAACCCGGTCTCGGTGCTGGCAACGCTGATTGCCTACGGCGTGCCGTTGCTGGATGGA
TTGCAGGGACGCAGCGAGCCGCACCCGGTCTGGCATGCGGCCTTGGCAAGCCCATGGGAAAAGCGCCATGAGCGGCTGGA
ATTCCTGCGTGGGCGATTGGAATGCGGCGAAGATGGGCGGCTGACCGCACTGCCGCACCGCGGCGACGCCTCACATCTAC
TGCGTGGCGCGGCCGACAGCAATGCATTGATCGTGCTGCCCGAGCAGGCGCGGCGCTTCGAGGCCGGCGAAATCGTGCGG
GTGATTCCGTACGCGTTGTGA

Upstream 100 bases:

>100_bases
CGCTCGTAGCGCAGCGCGTCATTAAGGCCCATCTCCTGCTTCGGCGGCCGAGTGATGCCGCCATCCTTCGCGTTGGCGAT
GCGCTGGTATCCTGCGCGGC

Downstream 100 bases:

>100_bases
GCGCTTGCTTGATCGATAGTGCCCGGCAGGATGACGCGCGCCTGGTTGGAGTGTTTACGCAATGCGCAGGGCATGCGACG
TGCGGGCGCGACGCGTCAAC

Product: molybdopterin biosynthesis

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MTDYPSRIPYAQALQILHSVATSNRSPDENIAISRADGRISAGDLIAPLALPPFANSAMDGFALRHADIAAGDASLQLVG
EQFAGERWAGTLAAGQCLRITTGAPLPDGADTVIPKEDADERDGMVRFQTAPAPGAAVRLAGSDVRAGDLVIQAGQVLTP
ARIGLAAALGVSRLAVAPRPTIAVLATGDELIEPGMPLGPGQIYNSNRDMLMAQLRALGYAPTAWPTLPDDPQRIGTMLE
DAAAAFDVVITCGGVSAGEKDYLPRLIGELGRIHFWRVRMRPGMPAVLGQIGRCLVLGLPGNPVSVLATLIAYGVPLLDG
LQGRSEPHPVWHAALASPWEKRHERLEFLRGRLECGEDGRLTALPHRGDASHLLRGAADSNALIVLPEQARRFEAGEIVR
VIPYAL

Sequences:

>Translated_406_residues
MTDYPSRIPYAQALQILHSVATSNRSPDENIAISRADGRISAGDLIAPLALPPFANSAMDGFALRHADIAAGDASLQLVG
EQFAGERWAGTLAAGQCLRITTGAPLPDGADTVIPKEDADERDGMVRFQTAPAPGAAVRLAGSDVRAGDLVIQAGQVLTP
ARIGLAAALGVSRLAVAPRPTIAVLATGDELIEPGMPLGPGQIYNSNRDMLMAQLRALGYAPTAWPTLPDDPQRIGTMLE
DAAAAFDVVITCGGVSAGEKDYLPRLIGELGRIHFWRVRMRPGMPAVLGQIGRCLVLGLPGNPVSVLATLIAYGVPLLDG
LQGRSEPHPVWHAALASPWEKRHERLEFLRGRLECGEDGRLTALPHRGDASHLLRGAADSNALIVLPEQARRFEAGEIVR
VIPYAL
>Mature_405_residues
TDYPSRIPYAQALQILHSVATSNRSPDENIAISRADGRISAGDLIAPLALPPFANSAMDGFALRHADIAAGDASLQLVGE
QFAGERWAGTLAAGQCLRITTGAPLPDGADTVIPKEDADERDGMVRFQTAPAPGAAVRLAGSDVRAGDLVIQAGQVLTPA
RIGLAAALGVSRLAVAPRPTIAVLATGDELIEPGMPLGPGQIYNSNRDMLMAQLRALGYAPTAWPTLPDDPQRIGTMLED
AAAAFDVVITCGGVSAGEKDYLPRLIGELGRIHFWRVRMRPGMPAVLGQIGRCLVLGLPGNPVSVLATLIAYGVPLLDGL
QGRSEPHPVWHAALASPWEKRHERLEFLRGRLECGEDGRLTALPHRGDASHLLRGAADSNALIVLPEQARRFEAGEIVRV
IPYAL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=383, Percent_Identity=36.8146214099217, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI10880983, Length=383, Percent_Identity=36.8146214099217, Blast_Score=208, Evalue=8e-54,
Organism=Escherichia coli, GI1787049, Length=363, Percent_Identity=38.5674931129477, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI25147659, Length=333, Percent_Identity=31.5315315315315, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17562606, Length=344, Percent_Identity=26.7441860465116, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17136978, Length=357, Percent_Identity=29.9719887955182, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24638841, Length=357, Percent_Identity=29.9719887955182, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42955; Mature: 42824

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDYPSRIPYAQALQILHSVATSNRSPDENIAISRADGRISAGDLIAPLALPPFANSAMD
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEECCCCCCCCCCCCCC
GFALRHADIAAGDASLQLVGEQFAGERWAGTLAAGQCLRITTGAPLPDGADTVIPKEDAD
CCEEECCCCCCCCCHHEEHHHHHCCCHHCCHHHCCCEEEEECCCCCCCCCCCCCCCCCCC
ERDGMVRFQTAPAPGAAVRLAGSDVRAGDLVIQAGQVLTPARIGLAAALGVSRLAVAPRP
CCCCEEEEEECCCCCCEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHEECCCC
TIAVLATGDELIEPGMPLGPGQIYNSNRDMLMAQLRALGYAPTAWPTLPDDPQRIGTMLE
CEEEEECCHHHHCCCCCCCCCCEECCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
DAAAAFDVVITCGGVSAGEKDYLPRLIGELGRIHFWRVRMRPGMPAVLGQIGRCLVLGLP
HHHHHEEEEEEECCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCHHHHHCCCCEEEEECC
GNPVSVLATLIAYGVPLLDGLQGRSEPHPVWHAALASPWEKRHERLEFLRGRLECGEDGR
CCHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
LTALPHRGDASHLLRGAADSNALIVLPEQARRFEAGEIVRVIPYAL
EEECCCCCCHHHHHHCCCCCCCEEEECHHHCCCCCCCEEEECCCCC
>Mature Secondary Structure 
TDYPSRIPYAQALQILHSVATSNRSPDENIAISRADGRISAGDLIAPLALPPFANSAMD
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEECCCCCCCCCCCCCC
GFALRHADIAAGDASLQLVGEQFAGERWAGTLAAGQCLRITTGAPLPDGADTVIPKEDAD
CCEEECCCCCCCCCHHEEHHHHHCCCHHCCHHHCCCEEEEECCCCCCCCCCCCCCCCCCC
ERDGMVRFQTAPAPGAAVRLAGSDVRAGDLVIQAGQVLTPARIGLAAALGVSRLAVAPRP
CCCCEEEEEECCCCCCEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHEECCCC
TIAVLATGDELIEPGMPLGPGQIYNSNRDMLMAQLRALGYAPTAWPTLPDDPQRIGTMLE
CEEEEECCHHHHCCCCCCCCCCEECCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
DAAAAFDVVITCGGVSAGEKDYLPRLIGELGRIHFWRVRMRPGMPAVLGQIGRCLVLGLP
HHHHHEEEEEEECCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCHHHHHCCCCEEEEECC
GNPVSVLATLIAYGVPLLDGLQGRSEPHPVWHAALASPWEKRHERLEFLRGRLECGEDGR
CCHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
LTALPHRGDASHLLRGAADSNALIVLPEQARRFEAGEIVRVIPYAL
EEECCCCCCHHHHHHCCCCCCCEEEECHHHCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]