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The map label for this gene is engA

Identifier: 21242765

GI number: 21242765

Start: 2363708

End: 2365105

Strand: Direct

Name: engA

Synonym: XAC2021

Alternate gene names: 21242765

Gene position: 2363708-2365105 (Clockwise)

Preceding gene: 21242764

Following gene: 21242766

Centisome position: 45.67

GC content: 64.38

Gene sequence:

>1398_bases
ATGCTGCCCCTGGTCGCCCTGGTTGGACGGCCCAATGTCGGCAAGTCCACCATCTTCAATGCGCTGACGCGCACCCGTGA
CGCGCTGGTTCACGACCAGCCAGGCGTCACTCGCGACCGCAACTACGGGGTCTGCCGTCTCGACGAGCAGCAGCCGTTCA
TCGTCGTCGATACCGGTGGTATCGCCGGCGACGAGGAAGGTCTTGCCGGGGCCACGGCCCGCCAGGCACGGGCCGCCGCC
GGCGAAGCCGATCTGGTGCTGTTCGTGGTCGATGGCCGCGAAGGCGCGTCCTCGCTCGATGACGAGATTCTGGCCTGGTT
GCGCAAATTGGCGCGGCCGACCGTGCTGGTGATCAACAAGATCGACGGCACCGACGAAGAAACCGTGCGCTCGGAATTCG
CGCGCTACGGCTTCTCCGACGTGGTGGCGTTGTCTGCTGCGCATCGGCAGGGCATCGACGAATTGCTTGACGAGGTGGGT
GCGCGCTTGCCCGAGGAAGGGGCCGGCGAGCTGCTGGACAACGACCCGGCGCGCGTACGCATCGCCTTCGTGGGGCGCCC
GAATGTGGGCAAGTCGACCCTGGTCAATCGCCTGCTGGGCGAAGAACGCATGATCGCCTCGGAAGTGCCGGGTACCACGC
GCGATTCGATCGCCGTGGACCTGGAGCGCGATGGCCGTCAGTACCGCCTGATCGACACCGCCGGCCTGCGACGGCGCGGC
AAGGTGGAAGAGGCGGTCGAGAAATTCAGCGCGTTCAAGACGCTGCAGGCGATCGAACAATGCCAGGTCGCGGTGCTGAT
GCTGGACGCCACTGAAGGCGTGACCGATCAGGACGCGACGATTCTCGGCGCAATCCTGGATGCCGGGCGTGCCTTGGTCG
TGGCGATCAACAAATGGGACGGGCAAAGCGATTACCAGCGTGCGCAGGCCGAAGATCTGCTGTCGCGCAAGCTGGGCTTC
GTCAACTGGGCCGAGGCGGTGCGGATTTCCGCATTGCACGGCTCGGGCATGCGCGAGCTGTTCCAGGCGATTCACCGCGC
CCATGCATCGGCCACGCATGAGTTCAGCACCAGTGAAGTGAACCAGGCGCTGGAAATCGCTTATGAGACCAACCCGCCGC
CGAGCATTCGCGGGCATGTCTCCAAGCTGCGGTATGTGCACCCGGGCGGCGCGAATCCGCCGACCTTCATCGTGCATGGC
ACGCGCCTGAAGGTGCTGCCGGAATCGTACAAGCGCTATCTGGAAAACTTCTTCCGGAAGCGTTTCAAGCTGGTTGGTAC
GCCGGTGCGTTTCATCTTCCGTGAGGGCGCCAATCCGTACGAGGGCAAGAAGAATCCGCTTTCCGATCGTCAGGTGGCCC
GCAAGCGGCGCCTGATGCGGCATGTCAAAGGGAAGTAA

Upstream 100 bases:

>100_bases
ACGCTGCTGGCGCAGCCGCAGGTGGTCGACGGCATTTTGCTGGTACAAAACACCGACGGCGATCTCACCGCCTTCCGGTT
GGCACAATAAGGACCTTGCG

Downstream 100 bases:

>100_bases
CGGCGCGCAGGCCGCCTGAGGCGTGATGTCCAGGCGGTGCGGGAGGCGTGTGGCTCTGTGGCCTGTGCGCGGTAAGTCGT
TCTTAGAGCCCGGGATTTGC

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MLPLVALVGRPNVGKSTIFNALTRTRDALVHDQPGVTRDRNYGVCRLDEQQPFIVVDTGGIAGDEEGLAGATARQARAAA
GEADLVLFVVDGREGASSLDDEILAWLRKLARPTVLVINKIDGTDEETVRSEFARYGFSDVVALSAAHRQGIDELLDEVG
ARLPEEGAGELLDNDPARVRIAFVGRPNVGKSTLVNRLLGEERMIASEVPGTTRDSIAVDLERDGRQYRLIDTAGLRRRG
KVEEAVEKFSAFKTLQAIEQCQVAVLMLDATEGVTDQDATILGAILDAGRALVVAINKWDGQSDYQRAQAEDLLSRKLGF
VNWAEAVRISALHGSGMRELFQAIHRAHASATHEFSTSEVNQALEIAYETNPPPSIRGHVSKLRYVHPGGANPPTFIVHG
TRLKVLPESYKRYLENFFRKRFKLVGTPVRFIFREGANPYEGKKNPLSDRQVARKRRLMRHVKGK

Sequences:

>Translated_465_residues
MLPLVALVGRPNVGKSTIFNALTRTRDALVHDQPGVTRDRNYGVCRLDEQQPFIVVDTGGIAGDEEGLAGATARQARAAA
GEADLVLFVVDGREGASSLDDEILAWLRKLARPTVLVINKIDGTDEETVRSEFARYGFSDVVALSAAHRQGIDELLDEVG
ARLPEEGAGELLDNDPARVRIAFVGRPNVGKSTLVNRLLGEERMIASEVPGTTRDSIAVDLERDGRQYRLIDTAGLRRRG
KVEEAVEKFSAFKTLQAIEQCQVAVLMLDATEGVTDQDATILGAILDAGRALVVAINKWDGQSDYQRAQAEDLLSRKLGF
VNWAEAVRISALHGSGMRELFQAIHRAHASATHEFSTSEVNQALEIAYETNPPPSIRGHVSKLRYVHPGGANPPTFIVHG
TRLKVLPESYKRYLENFFRKRFKLVGTPVRFIFREGANPYEGKKNPLSDRQVARKRRLMRHVKGK
>Mature_465_residues
MLPLVALVGRPNVGKSTIFNALTRTRDALVHDQPGVTRDRNYGVCRLDEQQPFIVVDTGGIAGDEEGLAGATARQARAAA
GEADLVLFVVDGREGASSLDDEILAWLRKLARPTVLVINKIDGTDEETVRSEFARYGFSDVVALSAAHRQGIDELLDEVG
ARLPEEGAGELLDNDPARVRIAFVGRPNVGKSTLVNRLLGEERMIASEVPGTTRDSIAVDLERDGRQYRLIDTAGLRRRG
KVEEAVEKFSAFKTLQAIEQCQVAVLMLDATEGVTDQDATILGAILDAGRALVVAINKWDGQSDYQRAQAEDLLSRKLGF
VNWAEAVRISALHGSGMRELFQAIHRAHASATHEFSTSEVNQALEIAYETNPPPSIRGHVSKLRYVHPGGANPPTFIVHG
TRLKVLPESYKRYLENFFRKRFKLVGTPVRFIFREGANPYEGKKNPLSDRQVARKRRLMRHVKGK

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Escherichia coli, GI87082120, Length=488, Percent_Identity=47.9508196721311, Blast_Score=460, Evalue=1e-131,
Organism=Escherichia coli, GI1788919, Length=168, Percent_Identity=30.952380952381, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI2367268, Length=185, Percent_Identity=31.8918918918919, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6323665, Length=195, Percent_Identity=25.1282051282051, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_XANAC (Q8PKY6)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642347.1
- ProteinModelPortal:   Q8PKY6
- SMR:   Q8PKY6
- GeneID:   1156092
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2021
- NMPDR:   fig|190486.1.peg.1991
- HOGENOM:   HBG592135
- OMA:   KCEKAFD
- ProtClustDB:   PRK00093
- BioCyc:   XAXO190486:XAC2021-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00326
- SMART:   SM00382
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 51259; Mature: 51259

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPLVALVGRPNVGKSTIFNALTRTRDALVHDQPGVTRDRNYGVCRLDEQQPFIVVDTGG
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCEEEEECCC
IAGDEEGLAGATARQARAAAGEADLVLFVVDGREGASSLDDEILAWLRKLARPTVLVINK
CCCCCCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEC
IDGTDEETVRSEFARYGFSDVVALSAAHRQGIDELLDEVGARLPEEGAGELLDNDPARVR
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEE
IAFVGRPNVGKSTLVNRLLGEERMIASEVPGTTRDSIAVDLERDGRQYRLIDTAGLRRRG
EEEECCCCCCHHHHHHHHHCHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCC
KVEEAVEKFSAFKTLQAIEQCQVAVLMLDATEGVTDQDATILGAILDAGRALVVAINKWD
CHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCHHHHHHHHHCCCEEEEEEECCC
GQSDYQRAQAEDLLSRKLGFVNWAEAVRISALHGSGMRELFQAIHRAHASATHEFSTSEV
CCHHHHHHHHHHHHHHHCCCCCHHHHHEEEHHCCCCHHHHHHHHHHHHHHHCCCCCHHHH
NQALEIAYETNPPPSIRGHVSKLRYVHPGGANPPTFIVHGTRLKVLPESYKRYLENFFRK
HHHHEEEECCCCCCCHHHHHHHHEEECCCCCCCCEEEEECCEEEECHHHHHHHHHHHHHH
RFKLVGTPVRFIFREGANPYEGKKNPLSDRQVARKRRLMRHVKGK
HHHHCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLPLVALVGRPNVGKSTIFNALTRTRDALVHDQPGVTRDRNYGVCRLDEQQPFIVVDTGG
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCEEEEECCC
IAGDEEGLAGATARQARAAAGEADLVLFVVDGREGASSLDDEILAWLRKLARPTVLVINK
CCCCCCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEC
IDGTDEETVRSEFARYGFSDVVALSAAHRQGIDELLDEVGARLPEEGAGELLDNDPARVR
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEE
IAFVGRPNVGKSTLVNRLLGEERMIASEVPGTTRDSIAVDLERDGRQYRLIDTAGLRRRG
EEEECCCCCCHHHHHHHHHCHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCC
KVEEAVEKFSAFKTLQAIEQCQVAVLMLDATEGVTDQDATILGAILDAGRALVVAINKWD
CHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCHHHHHHHHHCCCEEEEEEECCC
GQSDYQRAQAEDLLSRKLGFVNWAEAVRISALHGSGMRELFQAIHRAHASATHEFSTSEV
CCHHHHHHHHHHHHHHHCCCCCHHHHHEEEHHCCCCHHHHHHHHHHHHHHHCCCCCHHHH
NQALEIAYETNPPPSIRGHVSKLRYVHPGGANPPTFIVHGTRLKVLPESYKRYLENFFRK
HHHHEEEECCCCCCCHHHHHHHHEEECCCCCCCCEEEEECCEEEECHHHHHHHHHHHHHH
RFKLVGTPVRFIFREGANPYEGKKNPLSDRQVARKRRLMRHVKGK
HHHHCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217