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The map label for this gene is rpfC [H]

Identifier: 21242622

GI number: 21242622

Start: 2179302

End: 2181479

Strand: Direct

Name: rpfC [H]

Synonym: XAC1878

Alternate gene names: 21242622

Gene position: 2179302-2181479 (Clockwise)

Preceding gene: 21242621

Following gene: 21242625

Centisome position: 42.11

GC content: 66.67

Gene sequence:

>2178_bases
ATGAATCCGTTCGCCAGGATCCGGCAAACGCTGATGAATCGGCCCGATAGCGAACATGGCCAGGCCATCGTCCGTATCGT
GCTGATCACCCTGATCCTGTCGTATGTGTTGTTGCCGCACGTGCGCAACAGTTTGCCGATGCACCAATACACCGATGTGC
TGGCCGTGGTGCTGGTCGGGCTGAGCCTTGGGCTGGGACTGTTCGTGTGGTTGCTCTCGCGGCCGGGCCGCTCCGACCCG
CGCCGGATCATCGGCATGCTGGCCGATTACGGCCTGATGGCGGCCGGCATGGTCCAGATGGGCGAGCCGCTGGCCTGGGT
CTACGTGGTGGTGATGTGGGTCACCGTGGGCAACGGCTTGCGCTACGGCAACCGCTATCTGTATCTGGCCGTCGGCATGG
CGGTGAGCAGTTTCGCCACGACCCTGGCCATGACCGAGTACTGGCATGAGAATCTCAGTCTTGGCATCGGTCTCGCGGTT
GGCCTGGCCGCGGTTCCGCTGTACTTCGCCAGCCTGCTGCGCCAGCTGACGCGCGCCACCGTGGAAGCGCGTCGTGCCAG
CGAAGCCAAGAGCCGGTTTCTGGCCAACATGAGCCATGAGTTCCGCACGCCGCTCAACGGCCTGTCCGGCATGACCGAGG
TGCTGGCCACCACGCGCATGGACAGCGAGCAGCGCGAATGCCTGAAGACCATCCAGGCGTCCACGCGCAGCCTGCTCGCG
CTGGTGGAGGAAGTGCTGGACATCTCGGCCATCGAAGCCGGCAAGCTGCGCATCAACACTTCCGACTTCGCGCTGCACGA
CACGCTGCAGGCGATTGGCCTGATTCTCGAGCCGCAGTCCAGGGCGAAGGCGCTCAACTACCAGGTGAGCGTGGCGGCGG
ACGTGCCCGCCCGCCTGCATGGCGATGCCGGGCACCTGCGCCAGATCCTGCTCAATCTGGTCGGCAATGCGGTCAAGTTC
ACCGACCAGGGCAGCGTCCAGCTGAAGGTGGCGGCAACCGGAACCAATGGGCGCGTCGGTGTGCTGCTGCGCTTCGAGGT
GATCGATACCGGCATCGGCGTGCCGGTGGACATGCGCCCGCGGCTGTTCGAGGCATTCGAGCAGGCGGACACCGGGCTGG
CGCGGCGTTTCGAAGGCAGCGGCCTCGGCACGACGATCGCCAAGGGGTTGGTGCAGTCGATGGGCGGTGCGATCGGGTTC
GAGGAGAACCCCGAGGGCGGCAGCCAGTTCTGGTTCGAGCTTCCGTTCGGCCTGGCGGCCGCCGTGCCCGCATCCGCGTC
GCTCCCCGCGTTGCAGGATGCCGACACCACCGCCATTCCCGGCAACGTCATCGCTTTCGCCGATCCGTTCCTGCGCCATC
GTGCCCGCGTGCGCAGCATGCAGATCCTGGTGGCCGACGATCACCTGGCGAACCGGCTGGTGTTGCAGCGATTGCTGCAG
AAGGCCGGGCATCGGGTCACCTGCGTCGATGGTGGCGAGGCGGTACTGGATGCGCTTGCCGACACCGATTACGACGCCGC
CATCGTCGATCTGCACATGCCGGGCGTCAGCGGGCTGGACATGCTGAAACAGCTGCGGGTCATGCAGGCCGGCGGCGCCT
CGGTCACGCAGGTGGTGGTGCTCAGCGCCGATGTCACCCCGGAGTCGATCCGCAGTTGCGAACAGGCCGGCGCCTACGCG
TTCCTGGCCAAGCCGGTCGCGGCGGTCAAGCTGCTCGATACGCTGGCCGAGATCGCCCTCAACCAGAAGGTGCGCCAGAC
CGATGCGGCGATCGGCAAGCGCGGTCCGGCCACGAACGGAGCCGTGCTCGATCCGGCGGTGCTGGACGAGCTGGCGGAAC
TGGGGATGGGCGAGGAATTCGAGCGCGAGTTCATCCAGCAATGCCTCAGCGATGCGACCGCGTGTGTCGTCGAACTCGGC
AAGGCCGCCGCGGACGAGGACTGGGGGCGTCTGCGCGAGCATGCGCATGCGGTGAAAGGAGTGTCCAGCAATCTGGGGCT
GGTGATCCTGGCCGAGCAGGGCGGCGAATTGATGCGGCTGCCGGAAGCGCAATTGCGCAGTGAATGGCGGCAGCGGCTGG
AACAGTTGAAGACCGGACTGGCGCAGGGGCGCGAGGCGTTGGCGCAGCGTGCGCGACGCAAGACCGAGGGCGGGGCCAGC
GGTAATGGCGATCCCTGA

Upstream 100 bases:

>100_bases
CGATCCGCGTTGCGTGGATGCGCTGCTGCGCGGACGGGCGCAGTTGGATCAGGTCTGCAACCAGTTCTCTACCGCATCGG
TGCGTCCAGGAGCATAGGCC

Downstream 100 bases:

>100_bases
TTAAGTAAAGCCCGGCATCCGGCCGGGCCTGATTCCCCCTGAAGATGCGACGTATCAAAAATCAGGCGACGCCCATGCCG
ACGCGCCGGTTCTGCGCCTT

Product: RpfC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 725; Mature: 725

Protein sequence:

>725_residues
MNPFARIRQTLMNRPDSEHGQAIVRIVLITLILSYVLLPHVRNSLPMHQYTDVLAVVLVGLSLGLGLFVWLLSRPGRSDP
RRIIGMLADYGLMAAGMVQMGEPLAWVYVVVMWVTVGNGLRYGNRYLYLAVGMAVSSFATTLAMTEYWHENLSLGIGLAV
GLAAVPLYFASLLRQLTRATVEARRASEAKSRFLANMSHEFRTPLNGLSGMTEVLATTRMDSEQRECLKTIQASTRSLLA
LVEEVLDISAIEAGKLRINTSDFALHDTLQAIGLILEPQSRAKALNYQVSVAADVPARLHGDAGHLRQILLNLVGNAVKF
TDQGSVQLKVAATGTNGRVGVLLRFEVIDTGIGVPVDMRPRLFEAFEQADTGLARRFEGSGLGTTIAKGLVQSMGGAIGF
EENPEGGSQFWFELPFGLAAAVPASASLPALQDADTTAIPGNVIAFADPFLRHRARVRSMQILVADDHLANRLVLQRLLQ
KAGHRVTCVDGGEAVLDALADTDYDAAIVDLHMPGVSGLDMLKQLRVMQAGGASVTQVVVLSADVTPESIRSCEQAGAYA
FLAKPVAAVKLLDTLAEIALNQKVRQTDAAIGKRGPATNGAVLDPAVLDELAELGMGEEFEREFIQQCLSDATACVVELG
KAAADEDWGRLREHAHAVKGVSSNLGLVILAEQGGELMRLPEAQLRSEWRQRLEQLKTGLAQGREALAQRARRKTEGGAS
GNGDP

Sequences:

>Translated_725_residues
MNPFARIRQTLMNRPDSEHGQAIVRIVLITLILSYVLLPHVRNSLPMHQYTDVLAVVLVGLSLGLGLFVWLLSRPGRSDP
RRIIGMLADYGLMAAGMVQMGEPLAWVYVVVMWVTVGNGLRYGNRYLYLAVGMAVSSFATTLAMTEYWHENLSLGIGLAV
GLAAVPLYFASLLRQLTRATVEARRASEAKSRFLANMSHEFRTPLNGLSGMTEVLATTRMDSEQRECLKTIQASTRSLLA
LVEEVLDISAIEAGKLRINTSDFALHDTLQAIGLILEPQSRAKALNYQVSVAADVPARLHGDAGHLRQILLNLVGNAVKF
TDQGSVQLKVAATGTNGRVGVLLRFEVIDTGIGVPVDMRPRLFEAFEQADTGLARRFEGSGLGTTIAKGLVQSMGGAIGF
EENPEGGSQFWFELPFGLAAAVPASASLPALQDADTTAIPGNVIAFADPFLRHRARVRSMQILVADDHLANRLVLQRLLQ
KAGHRVTCVDGGEAVLDALADTDYDAAIVDLHMPGVSGLDMLKQLRVMQAGGASVTQVVVLSADVTPESIRSCEQAGAYA
FLAKPVAAVKLLDTLAEIALNQKVRQTDAAIGKRGPATNGAVLDPAVLDELAELGMGEEFEREFIQQCLSDATACVVELG
KAAADEDWGRLREHAHAVKGVSSNLGLVILAEQGGELMRLPEAQLRSEWRQRLEQLKTGLAQGREALAQRARRKTEGGAS
GNGDP
>Mature_725_residues
MNPFARIRQTLMNRPDSEHGQAIVRIVLITLILSYVLLPHVRNSLPMHQYTDVLAVVLVGLSLGLGLFVWLLSRPGRSDP
RRIIGMLADYGLMAAGMVQMGEPLAWVYVVVMWVTVGNGLRYGNRYLYLAVGMAVSSFATTLAMTEYWHENLSLGIGLAV
GLAAVPLYFASLLRQLTRATVEARRASEAKSRFLANMSHEFRTPLNGLSGMTEVLATTRMDSEQRECLKTIQASTRSLLA
LVEEVLDISAIEAGKLRINTSDFALHDTLQAIGLILEPQSRAKALNYQVSVAADVPARLHGDAGHLRQILLNLVGNAVKF
TDQGSVQLKVAATGTNGRVGVLLRFEVIDTGIGVPVDMRPRLFEAFEQADTGLARRFEGSGLGTTIAKGLVQSMGGAIGF
EENPEGGSQFWFELPFGLAAAVPASASLPALQDADTTAIPGNVIAFADPFLRHRARVRSMQILVADDHLANRLVLQRLLQ
KAGHRVTCVDGGEAVLDALADTDYDAAIVDLHMPGVSGLDMLKQLRVMQAGGASVTQVVVLSADVTPESIRSCEQAGAYA
FLAKPVAAVKLLDTLAEIALNQKVRQTDAAIGKRGPATNGAVLDPAVLDELAELGMGEEFEREFIQQCLSDATACVVELG
KAAADEDWGRLREHAHAVKGVSSNLGLVILAEQGGELMRLPEAQLRSEWRQRLEQLKTGLAQGREALAQRARRKTEGGAS
GNGDP

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=325, Percent_Identity=37.8461538461538, Blast_Score=203, Evalue=3e-53,
Organism=Escherichia coli, GI87081816, Length=507, Percent_Identity=28.7968441814596, Blast_Score=179, Evalue=6e-46,
Organism=Escherichia coli, GI48994928, Length=534, Percent_Identity=26.2172284644195, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI145693157, Length=281, Percent_Identity=32.7402135231317, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1788713, Length=365, Percent_Identity=30.1369863013699, Blast_Score=146, Evalue=5e-36,
Organism=Escherichia coli, GI1786600, Length=271, Percent_Identity=29.1512915129151, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1786912, Length=252, Percent_Identity=29.7619047619048, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1788393, Length=231, Percent_Identity=28.1385281385281, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082128, Length=230, Percent_Identity=27.8260869565217, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1786783, Length=253, Percent_Identity=24.1106719367589, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790436, Length=253, Percent_Identity=24.1106719367589, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790346, Length=260, Percent_Identity=25.3846153846154, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 78050; Mature: 78050

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPFARIRQTLMNRPDSEHGQAIVRIVLITLILSYVLLPHVRNSLPMHQYTDVLAVVLVG
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LSLGLGLFVWLLSRPGRSDPRRIIGMLADYGLMAAGMVQMGEPLAWVYVVVMWVTVGNGL
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
RYGNRYLYLAVGMAVSSFATTLAMTEYWHENLSLGIGLAVGLAAVPLYFASLLRQLTRAT
EECCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEARRASEAKSRFLANMSHEFRTPLNGLSGMTEVLATTRMDSEQRECLKTIQASTRSLLA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LVEEVLDISAIEAGKLRINTSDFALHDTLQAIGLILEPQSRAKALNYQVSVAADVPARLH
HHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHHCEEEEEEECCCHHHC
GDAGHLRQILLNLVGNAVKFTDQGSVQLKVAATGTNGRVGVLLRFEVIDTGIGVPVDMRP
CCHHHHHHHHHHHHCCCEEECCCCCEEEEEEEECCCCCEEEEEEEEEECCCCCCCCCCCH
RLFEAFEQADTGLARRFEGSGLGTTIAKGLVQSMGGAIGFEENPEGGSQFWFELPFGLAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCHHHH
AVPASASLPALQDADTTAIPGNVIAFADPFLRHRARVRSMQILVADDHLANRLVLQRLLQ
HCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHH
KAGHRVTCVDGGEAVLDALADTDYDAAIVDLHMPGVSGLDMLKQLRVMQAGGASVTQVVV
HCCCEEEEECCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEE
LSADVTPESIRSCEQAGAYAFLAKPVAAVKLLDTLAEIALNQKVRQTDAAIGKRGPATNG
EECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
AVLDPAVLDELAELGMGEEFEREFIQQCLSDATACVVELGKAAADEDWGRLREHAHAVKG
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
VSSNLGLVILAEQGGELMRLPEAQLRSEWRQRLEQLKTGLAQGREALAQRARRKTEGGAS
CCCCCCEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GNGDP
CCCCC
>Mature Secondary Structure
MNPFARIRQTLMNRPDSEHGQAIVRIVLITLILSYVLLPHVRNSLPMHQYTDVLAVVLVG
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LSLGLGLFVWLLSRPGRSDPRRIIGMLADYGLMAAGMVQMGEPLAWVYVVVMWVTVGNGL
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
RYGNRYLYLAVGMAVSSFATTLAMTEYWHENLSLGIGLAVGLAAVPLYFASLLRQLTRAT
EECCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEARRASEAKSRFLANMSHEFRTPLNGLSGMTEVLATTRMDSEQRECLKTIQASTRSLLA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LVEEVLDISAIEAGKLRINTSDFALHDTLQAIGLILEPQSRAKALNYQVSVAADVPARLH
HHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHHCEEEEEEECCCHHHC
GDAGHLRQILLNLVGNAVKFTDQGSVQLKVAATGTNGRVGVLLRFEVIDTGIGVPVDMRP
CCHHHHHHHHHHHHCCCEEECCCCCEEEEEEEECCCCCEEEEEEEEEECCCCCCCCCCCH
RLFEAFEQADTGLARRFEGSGLGTTIAKGLVQSMGGAIGFEENPEGGSQFWFELPFGLAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCHHHH
AVPASASLPALQDADTTAIPGNVIAFADPFLRHRARVRSMQILVADDHLANRLVLQRLLQ
HCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHH
KAGHRVTCVDGGEAVLDALADTDYDAAIVDLHMPGVSGLDMLKQLRVMQAGGASVTQVVV
HCCCEEEEECCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEE
LSADVTPESIRSCEQAGAYAFLAKPVAAVKLLDTLAEIALNQKVRQTDAAIGKRGPATNG
EECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
AVLDPAVLDELAELGMGEEFEREFIQQCLSDATACVVELGKAAADEDWGRLREHAHAVKG
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
VSSNLGLVILAEQGGELMRLPEAQLRSEWRQRLEQLKTGLAQGREALAQRARRKTEGGAS
CCCCCCEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GNGDP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]