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The map label for this gene is hisI

Identifier: 21242579

GI number: 21242579

Start: 2130067

End: 2130687

Strand: Direct

Name: hisI

Synonym: XAC1835

Alternate gene names: 21242579

Gene position: 2130067-2130687 (Clockwise)

Preceding gene: 21242578

Following gene: 77748614

Centisome position: 41.16

GC content: 65.54

Gene sequence:

>621_bases
ATGGGCAGTAACGAAGTGGCGACGGGCGACCCGCTCGCAACGCTGGATTGGAACAAGGGCGAGGGCCTGTTGCCGGTGAT
CGTGCAGGACGCCGACAACCTGCGCGTGCTGATGCTGGGCTACATGAATGCCCAAGCGTTGGCCGTGACCCAGCAGCGTG
GTGAAGTCACCTTCTTCAGCCGCAGCAAGCAGCGCTTGTGGACCAAGGGCGAGAGCTCGGGGAACGTGTTGCGCGTGGTG
TCGATCCAGACCGACTGCGATGCCGACACATTGCTGGTGCAGGCGCGCCCGCATGGCCCGACCTGTCACCTGGGCCGCAC
CAGTTGCTTCCCGTCTGCGCCCGGGCAGTTTCTGGGCAGCCTGGATGCGCTGGTGGCCGAGCGCGAGCGCGAACGCCCGC
ACGGTAGCTACACCACCAAGCTGTTCGAGCAAGGCATCCGTCGCATCGCGCAGAAGGTAGGCGAGGAGGGCGTTGAAACC
GCGCTGGCCGGTGTGGTGCAGGACGATGACGCGTTGCTCGGCGAATCGGCCGATCTGCTGTATCACCTGATCGTGCTGCT
GCGCGCACGTGGGCTGGGGCTTGGCGATGCGGCGGCGTTGCTGGAGTCGCGGCATCAATAA

Upstream 100 bases:

>100_bases
GATGTGGATGGCGCACTGGCGGCCAGCGTATTTCACAGTGGTGCGATTCCGATTCCGGAACTCAAGCAATTCTTGCGCGC
GCAACAGATCGAGGTACGCG

Downstream 100 bases:

>100_bases
CGCGGTCGCGTAGGAGCGCACCCGGGCGCGGCGCGTTATCGGTAACGCCCATCGCGCCCGGGTGCGCTCCTACAGGGTAG
GTGTCGGCGTGTCCTTCGCG

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MGSNEVATGDPLATLDWNKGEGLLPVIVQDADNLRVLMLGYMNAQALAVTQQRGEVTFFSRSKQRLWTKGESSGNVLRVV
SIQTDCDADTLLVQARPHGPTCHLGRTSCFPSAPGQFLGSLDALVAERERERPHGSYTTKLFEQGIRRIAQKVGEEGVET
ALAGVVQDDDALLGESADLLYHLIVLLRARGLGLGDAAALLESRHQ

Sequences:

>Translated_206_residues
MGSNEVATGDPLATLDWNKGEGLLPVIVQDADNLRVLMLGYMNAQALAVTQQRGEVTFFSRSKQRLWTKGESSGNVLRVV
SIQTDCDADTLLVQARPHGPTCHLGRTSCFPSAPGQFLGSLDALVAERERERPHGSYTTKLFEQGIRRIAQKVGEEGVET
ALAGVVQDDDALLGESADLLYHLIVLLRARGLGLGDAAALLESRHQ
>Mature_205_residues
GSNEVATGDPLATLDWNKGEGLLPVIVQDADNLRVLMLGYMNAQALAVTQQRGEVTFFSRSKQRLWTKGESSGNVLRVVS
IQTDCDADTLLVQARPHGPTCHLGRTSCFPSAPGQFLGSLDALVAERERERPHGSYTTKLFEQGIRRIAQKVGEEGVETA
LAGVVQDDDALLGESADLLYHLIVLLRARGLGLGDAAALLESRHQ

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=194, Percent_Identity=59.7938144329897, Blast_Score=225, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6319819, Length=207, Percent_Identity=31.4009661835749, Blast_Score=89, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_XANAC (Q8PLG5)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642161.1
- ProteinModelPortal:   Q8PLG5
- GeneID:   1155906
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1835
- NMPDR:   fig|190486.1.peg.1805
- HOGENOM:   HBG294308
- OMA:   VMACKDD
- ProtClustDB:   PRK02759
- BioCyc:   XAXO190486:XAC1835-MONOMER
- BRENDA:   3.5.4.19
- BRENDA:   3.6.1.31
- GO:   GO:0005737
- HAMAP:   MF_01019
- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH

EC number: =3.5.4.19; =3.6.1.31

Molecular weight: Translated: 22263; Mature: 22131

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSNEVATGDPLATLDWNKGEGLLPVIVQDADNLRVLMLGYMNAQALAVTQQRGEVTFFS
CCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCEEEEEEECCCCEEEEEECCCCCEEEEE
RSKQRLWTKGESSGNVLRVVSIQTDCDADTLLVQARPHGPTCHLGRTSCFPSAPGQFLGS
CCHHHHHCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCEEECCCCCCCCCCCHHHHHH
LDALVAERERERPHGSYTTKLFEQGIRRIAQKVGEEGVETALAGVVQDDDALLGESADLL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHCCHHHHH
YHLIVLLRARGLGLGDAAALLESRHQ
HHHHHHHHHCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
GSNEVATGDPLATLDWNKGEGLLPVIVQDADNLRVLMLGYMNAQALAVTQQRGEVTFFS
CCCCCCCCCCEEEEECCCCCCEEEEEEECCCCEEEEEEECCCCEEEEEECCCCCEEEEE
RSKQRLWTKGESSGNVLRVVSIQTDCDADTLLVQARPHGPTCHLGRTSCFPSAPGQFLGS
CCHHHHHCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCEEECCCCCCCCCCCHHHHHH
LDALVAERERERPHGSYTTKLFEQGIRRIAQKVGEEGVETALAGVVQDDDALLGESADLL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHCCHHHHH
YHLIVLLRARGLGLGDAAALLESRHQ
HHHHHHHHHCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217