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The map label for this gene is thiD [H]

Identifier: 21242499

GI number: 21242499

Start: 2012651

End: 2013475

Strand: Reverse

Name: thiD [H]

Synonym: XAC1753

Alternate gene names: 21242499

Gene position: 2013475-2012651 (Counterclockwise)

Preceding gene: 77748608

Following gene: 21242498

Centisome position: 38.9

GC content: 67.76

Gene sequence:

>825_bases
GTGCAGAATCGCCACATGACTACGCCCAGTACGCTGTCTGCATTGAGCATCGCCGGCTCCGACTCCGGCGGGGGCGCCGG
CGTCCAGGCCGACCTCAAGACCTTCGCCGCGCACCGCGTGCACGGGTTGTCGGCGATTACCGCATTGACCGCGCAACACA
CCCGCGCCGTCACCGCCGTGCATCTTCCACCACTGCCCTTTCTGCAGGCGCAGGTGGATGCATGCTTCGCCGATTTCGAG
ATCCAGGCGGTCAAACTCGGCATGCTGGCCAATGCCGACATCATTCATTGCGTGGCCGACCTGCTTGAGCGGTATCGCCC
GCCGTTCGTGGTGCTCGACCCGGTGATGGTGTCCACCAGCGGCGCGCGCCTGCTCGAAGATGCGGCATTGGATGCGCTGC
GCACGCGCTTGCTGCCGCTGGCCACCCTGGTGACCCCCAATACGCCCGAAGCCGAGCTGCTGACAGGCCACCGCATCGAC
AGCGCCGACGCCGCCGAACATGCCACCGCCGCCTTGCTCGACCTGGGTGCCAACGCGGTGCTGCTCAAGGGCGGACATCT
GCACGAGGGCGCACGCGTGCTCGACCGCTTCGATGACGGCGTGACCCAGGACGTGTTCATGCATCCGCGCCTGCAGGTCG
ATGCGCACGGCACCGGCTGCAGCCTGTCGGCAGCCATCGCCGCGCAGCTGTGCCAGGGCCTGTCGCTGCTCAATGCCTGC
GAAGCGGCGATCGATTACGTTGCCCGCGCCATTCGCATCGGCCAACGCCCGGGCCAGAGCGATGTGCTGGTGCTCGACCA
CTTCGGCGCCGCGCGCGGCGCATGA

Upstream 100 bases:

>100_bases
CTGCCCGCCAGCCTCACCGGATCGACCGGCGCTGGCTATGTCGCCTACCTGCAATGGCGTCGCTGGCGCACAGGATGATG
TGCACATCCTCCAGCCAGCA

Downstream 100 bases:

>100_bases
GCGTGCAGACCGACACCCTGCTCGCCAGCGCTGCAGATGGGCACCGCTGGCAAATCATCCGTTGCGCGCCGCCGCACCCG
ACCGCAACGCTGCTGTGGCT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MQNRHMTTPSTLSALSIAGSDSGGGAGVQADLKTFAAHRVHGLSAITALTAQHTRAVTAVHLPPLPFLQAQVDACFADFE
IQAVKLGMLANADIIHCVADLLERYRPPFVVLDPVMVSTSGARLLEDAALDALRTRLLPLATLVTPNTPEAELLTGHRID
SADAAEHATAALLDLGANAVLLKGGHLHEGARVLDRFDDGVTQDVFMHPRLQVDAHGTGCSLSAAIAAQLCQGLSLLNAC
EAAIDYVARAIRIGQRPGQSDVLVLDHFGAARGA

Sequences:

>Translated_274_residues
MQNRHMTTPSTLSALSIAGSDSGGGAGVQADLKTFAAHRVHGLSAITALTAQHTRAVTAVHLPPLPFLQAQVDACFADFE
IQAVKLGMLANADIIHCVADLLERYRPPFVVLDPVMVSTSGARLLEDAALDALRTRLLPLATLVTPNTPEAELLTGHRID
SADAAEHATAALLDLGANAVLLKGGHLHEGARVLDRFDDGVTQDVFMHPRLQVDAHGTGCSLSAAIAAQLCQGLSLLNAC
EAAIDYVARAIRIGQRPGQSDVLVLDHFGAARGA
>Mature_274_residues
MQNRHMTTPSTLSALSIAGSDSGGGAGVQADLKTFAAHRVHGLSAITALTAQHTRAVTAVHLPPLPFLQAQVDACFADFE
IQAVKLGMLANADIIHCVADLLERYRPPFVVLDPVMVSTSGARLLEDAALDALRTRLLPLATLVTPNTPEAELLTGHRID
SADAAEHATAALLDLGANAVLLKGGHLHEGARVLDRFDDGVTQDVFMHPRLQVDAHGTGCSLSAAIAAQLCQGLSLLNAC
EAAIDYVARAIRIGQRPGQSDVLVLDHFGAARGA

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=258, Percent_Identity=41.4728682170543, Blast_Score=173, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6325378, Length=254, Percent_Identity=31.8897637795276, Blast_Score=115, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6324997, Length=254, Percent_Identity=35.4330708661417, Blast_Score=115, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6324517, Length=255, Percent_Identity=32.9411764705882, Blast_Score=109, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28701; Mature: 28701

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNRHMTTPSTLSALSIAGSDSGGGAGVQADLKTFAAHRVHGLSAITALTAQHTRAVTAV
CCCCCCCCCCHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
HLPPLPFLQAQVDACFADFEIQAVKLGMLANADIIHCVADLLERYRPPFVVLDPVMVSTS
ECCCCCHHHHHHHHHHHCCEEEEEEECHHCCCHHHHHHHHHHHHCCCCEEEECCEEECCC
GARLLEDAALDALRTRLLPLATLVTPNTPEAELLTGHRIDSADAAEHATAALLDLGANAV
CHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHEECCCCCCCHHHHHHHHHHHHCCCCEE
LLKGGHLHEGARVLDRFDDGVTQDVFMHPRLQVDAHGTGCSLSAAIAAQLCQGLSLLNAC
EEECCCCCHHHHHHHHHCCCCCHHHEECCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
EAAIDYVARAIRIGQRPGQSDVLVLDHFGAARGA
HHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MQNRHMTTPSTLSALSIAGSDSGGGAGVQADLKTFAAHRVHGLSAITALTAQHTRAVTAV
CCCCCCCCCCHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
HLPPLPFLQAQVDACFADFEIQAVKLGMLANADIIHCVADLLERYRPPFVVLDPVMVSTS
ECCCCCHHHHHHHHHHHCCEEEEEEECHHCCCHHHHHHHHHHHHCCCCEEEECCEEECCC
GARLLEDAALDALRTRLLPLATLVTPNTPEAELLTGHRIDSADAAEHATAALLDLGANAV
CHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHEECCCCCCCHHHHHHHHHHHHCCCCEE
LLKGGHLHEGARVLDRFDDGVTQDVFMHPRLQVDAHGTGCSLSAAIAAQLCQGLSLLNAC
EEECCCCCHHHHHHHHHCCCCCHHHEECCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
EAAIDYVARAIRIGQRPGQSDVLVLDHFGAARGA
HHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]