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The map label for this gene is ftsJ

Identifier: 21242480

GI number: 21242480

Start: 1989624

End: 1990256

Strand: Direct

Name: ftsJ

Synonym: XAC1731

Alternate gene names: 21242480

Gene position: 1989624-1990256 (Clockwise)

Preceding gene: 21242477

Following gene: 21242481

Centisome position: 38.44

GC content: 63.51

Gene sequence:

>633_bases
ATGCCTTCCCGCAGTAAAAGCAGCCAGCGCTGGCTCAAGGAACACTTCGCCGACCCTTACGTGAAGAAGGCCCAGGCCGA
GGGCATGCGCTCGCGCGCGGCCTACAAGCTGGAAGAGTTGCTGCAGCGCGACCGCCTGCTCAAGCCGGGCATGGTGGTGG
TCGATCTGGGCGCGGCGCCGGGTGGCTGGTCGCAACAGGTACGCAAGTCAATGGGCGACAGCGGCCGGGTGGTGGCGCTG
GATATCCTGGACATGCCGGCCCTGGCAGGCGTGGAGTTCCTTCACGGCGACTTCAGGGAGCAGGCCGTCCTATCCCAATT
CGAAGCGATGCTGGGCGATGTGCCGGTGGACCTTGTGCTGTCGGATATGGCCCCCAATAAGAGTGGCATGGATGCGGTCG
ACCAACCGCGGATGATGCACCTGGCGGAATTGGCCATGGAATTTGCCGACACCCACCTCAAGCCGGGCGGGGCGTTCCTG
ATCAAGCTGTTCCAGGGTGTCGGGTCCGACGACTACATTCGCGAGCTTCGCCGCCGCTATGAAAAGGTGACGATTCGCAA
GCCGGCGGCCTCGCGCAAGCGCTCCCCGGAAGTTTATGCGCTCGGTCAGGGCAAGCGTGTCCAGATCAAGTAA

Upstream 100 bases:

>100_bases
AAACGGTTCTGGGCGGAGGTGAGAACAATGGACATGCAGGATCGAAGGGAAGCAAAGGGTGTTCAGGGTATCATGGCGAC
CCGTTCGGACCCCTCTGCCA

Downstream 100 bases:

>100_bases
GCTGCCAATGACCGCCGTATTTCAAGCATTGAAGAGTAGAGGGCACCGGAGCCAATGAGGATGAACGACTTGACCAAGAA
TCTGCTGCTGTGGGTGGTCG

Product: cell division protein

Products: NA

Alternate protein names: 23S rRNA Um2552 methyltransferase; rRNA (uridine-2'-O-)-methyltransferase

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MPSRSKSSQRWLKEHFADPYVKKAQAEGMRSRAAYKLEELLQRDRLLKPGMVVVDLGAAPGGWSQQVRKSMGDSGRVVAL
DILDMPALAGVEFLHGDFREQAVLSQFEAMLGDVPVDLVLSDMAPNKSGMDAVDQPRMMHLAELAMEFADTHLKPGGAFL
IKLFQGVGSDDYIRELRRRYEKVTIRKPAASRKRSPEVYALGQGKRVQIK

Sequences:

>Translated_210_residues
MPSRSKSSQRWLKEHFADPYVKKAQAEGMRSRAAYKLEELLQRDRLLKPGMVVVDLGAAPGGWSQQVRKSMGDSGRVVAL
DILDMPALAGVEFLHGDFREQAVLSQFEAMLGDVPVDLVLSDMAPNKSGMDAVDQPRMMHLAELAMEFADTHLKPGGAFL
IKLFQGVGSDDYIRELRRRYEKVTIRKPAASRKRSPEVYALGQGKRVQIK
>Mature_209_residues
PSRSKSSQRWLKEHFADPYVKKAQAEGMRSRAAYKLEELLQRDRLLKPGMVVVDLGAAPGGWSQQVRKSMGDSGRVVALD
ILDMPALAGVEFLHGDFREQAVLSQFEAMLGDVPVDLVLSDMAPNKSGMDAVDQPRMMHLAELAMEFADTHLKPGGAFLI
KLFQGVGSDDYIRELRRRYEKVTIRKPAASRKRSPEVYALGQGKRVQIK

Specific function: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit

COG id: COG0293

COG function: function code J; 23S rRNA methylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RlmE family

Homologues:

Organism=Homo sapiens, GI7019377, Length=209, Percent_Identity=36.3636363636364, Blast_Score=133, Evalue=9e-32,
Organism=Homo sapiens, GI29029591, Length=189, Percent_Identity=35.4497354497354, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI29029589, Length=189, Percent_Identity=35.4497354497354, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI7110661, Length=189, Percent_Identity=35.4497354497354, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI194097365, Length=187, Percent_Identity=32.0855614973262, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1789569, Length=203, Percent_Identity=54.679802955665, Blast_Score=235, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17553474, Length=201, Percent_Identity=30.3482587064677, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71987561, Length=190, Percent_Identity=34.7368421052632, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17553860, Length=190, Percent_Identity=34.7368421052632, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17554650, Length=187, Percent_Identity=31.0160427807487, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71987550, Length=188, Percent_Identity=35.1063829787234, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319535, Length=197, Percent_Identity=30.9644670050761, Blast_Score=96, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319796, Length=188, Percent_Identity=28.1914893617021, Blast_Score=75, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321302, Length=96, Percent_Identity=35.4166666666667, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356387, Length=213, Percent_Identity=34.2723004694836, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI18859957, Length=187, Percent_Identity=32.0855614973262, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24647580, Length=197, Percent_Identity=29.9492385786802, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648639, Length=194, Percent_Identity=27.8350515463918, Blast_Score=87, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RLME_XANAC (Q8PLQ8)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642062.1
- ProteinModelPortal:   Q8PLQ8
- SMR:   Q8PLQ8
- GeneID:   1155802
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1731
- HOGENOM:   HBG398270
- OMA:   SDMAANT
- ProtClustDB:   CLSK445916
- BioCyc:   XAXO190486:XAC1731-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01547
- InterPro:   IPR015507
- InterPro:   IPR002877
- PANTHER:   PTHR10920
- PIRSF:   PIRSF005461

Pfam domain/function: PF01728 FtsJ

EC number: =2.1.1.166

Molecular weight: Translated: 23455; Mature: 23323

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: NA

Important sites: ACT_SITE 162-162 BINDING 61-61 BINDING 63-63 BINDING 81-81 BINDING 97-97 BINDING 122-122

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSRSKSSQRWLKEHFADPYVKKAQAEGMRSRAAYKLEELLQRDRLLKPGMVVVDLGAAP
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
GGWSQQVRKSMGDSGRVVALDILDMPALAGVEFLHGDFREQAVLSQFEAMLGDVPVDLVL
CCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
SDMAPNKSGMDAVDQPRMMHLAELAMEFADTHLKPGGAFLIKLFQGVGSDDYIRELRRRY
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
EKVTIRKPAASRKRSPEVYALGQGKRVQIK
HHHHCCCCCHHCCCCCCEEEECCCCEEECC
>Mature Secondary Structure 
PSRSKSSQRWLKEHFADPYVKKAQAEGMRSRAAYKLEELLQRDRLLKPGMVVVDLGAAP
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
GGWSQQVRKSMGDSGRVVALDILDMPALAGVEFLHGDFREQAVLSQFEAMLGDVPVDLVL
CCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
SDMAPNKSGMDAVDQPRMMHLAELAMEFADTHLKPGGAFLIKLFQGVGSDDYIRELRRRY
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
EKVTIRKPAASRKRSPEVYALGQGKRVQIK
HHHHCCCCCHHCCCCCCEEEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217