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The map label for this gene is pcm

Identifier: 21242475

GI number: 21242475

Start: 1986630

End: 1987307

Strand: Direct

Name: pcm

Synonym: XAC1726

Alternate gene names: 21242475

Gene position: 1986630-1987307 (Clockwise)

Preceding gene: 21242474

Following gene: 21242476

Centisome position: 38.38

GC content: 68.58

Gene sequence:

>678_bases
ATGACGCCGAGGCTGCGCCTGCAACCGGAATCGGTCGGGATCGGCATGACCTCGCAGCGCGTGCGCGACCGCCTGGTCGA
GCGCCTGCGCGAGGCCGGCATCCAGGACGAGTCCACGCTCAATGCAATGCGCACCGTGCCGCGGCATCTGTTCATCGATG
AAGCGCTGGCCTCGCGCGCCTACGAAGACACCGCGCTGCCAATCGGCCATGGCCAGACCATCTCCCAGCCCTGGGTGGTG
GCGCGCATGACCGAAGCGGTGCTGCAGGTTGCCCCGACCAAGGTGCTCGAAGTGGGCACCGGCTCCGGCTACCAGGGCGC
GATCCTGGCGGCGCTGGGGTTGGAGGTCTACACCGTCGAGCGCATCGGCGACCTGCTGCGGCAGGCGCGCAAGCGCTTCC
GGCATCTGGGCATGAATGTGCGCAGCAAGCACGACGACGGCCGCATCGGCTGGCCCGAGCATGGTCCGTACGACGCCATC
GTGGTGACCGCCGCGGCACCGGCGTTGGTCGATGCACTGATCGATCAGCTGGCGGTCGGCGGACGCCTGGTCGCGCCGGT
CGGCGGTGCTTCCTCGCAATCGTTGGTGCAACTCACCCGCGGGGCCGATGGCGCGATCGAACAACAGGTTCTGGCGCCGG
TCACGTTCGTCCCGCTGTTGTCGGGCATGCTGGATTGA

Upstream 100 bases:

>100_bases
TCTCGATCACGCCGATCCACGTCGATCTCACCCGTTACCAGGCACTGGACACCGTTGCCGGCTGGGTGGGTGGGCTGACC
GCAGCGCTGGACGGCCCGGC

Downstream 100 bases:

>100_bases
ATCCATGAGAGTCCTTCGATGAAGATTTTTGGGCCGTTGTACGACGTGGCCATCCGTTGGTCGCGCCATCGCCGCGCACC
CGCGCTGCTGACCGGTCTCA

Product: L-isoaspartate protein carboxylmethyltransferase type II

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MTPRLRLQPESVGIGMTSQRVRDRLVERLREAGIQDESTLNAMRTVPRHLFIDEALASRAYEDTALPIGHGQTISQPWVV
ARMTEAVLQVAPTKVLEVGTGSGYQGAILAALGLEVYTVERIGDLLRQARKRFRHLGMNVRSKHDDGRIGWPEHGPYDAI
VVTAAAPALVDALIDQLAVGGRLVAPVGGASSQSLVQLTRGADGAIEQQVLAPVTFVPLLSGMLD

Sequences:

>Translated_225_residues
MTPRLRLQPESVGIGMTSQRVRDRLVERLREAGIQDESTLNAMRTVPRHLFIDEALASRAYEDTALPIGHGQTISQPWVV
ARMTEAVLQVAPTKVLEVGTGSGYQGAILAALGLEVYTVERIGDLLRQARKRFRHLGMNVRSKHDDGRIGWPEHGPYDAI
VVTAAAPALVDALIDQLAVGGRLVAPVGGASSQSLVQLTRGADGAIEQQVLAPVTFVPLLSGMLD
>Mature_224_residues
TPRLRLQPESVGIGMTSQRVRDRLVERLREAGIQDESTLNAMRTVPRHLFIDEALASRAYEDTALPIGHGQTISQPWVVA
RMTEAVLQVAPTKVLEVGTGSGYQGAILAALGLEVYTVERIGDLLRQARKRFRHLGMNVRSKHDDGRIGWPEHGPYDAIV
VTAAAPALVDALIDQLAVGGRLVAPVGGASSQSLVQLTRGADGAIEQQVLAPVTFVPLLSGMLD

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family

Homologues:

Organism=Homo sapiens, GI226530908, Length=212, Percent_Identity=34.4339622641509, Blast_Score=84, Evalue=7e-17,
Organism=Escherichia coli, GI1789100, Length=211, Percent_Identity=49.7630331753554, Blast_Score=179, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71983477, Length=218, Percent_Identity=32.5688073394495, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193207222, Length=219, Percent_Identity=31.9634703196347, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17981723, Length=216, Percent_Identity=34.7222222222222, Blast_Score=91, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PIMT_XANAC (Q8PLR3)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642057.1
- HSSP:   Q8TZR3
- ProteinModelPortal:   Q8PLR3
- SMR:   Q8PLR3
- GeneID:   1155797
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1726
- NMPDR:   fig|190486.1.peg.1701
- HOGENOM:   HBG699907
- OMA:   YSVERIR
- ProtClustDB:   CLSK446106
- BioCyc:   XAXO190486:XAC1726-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00090
- InterPro:   IPR000682
- PANTHER:   PTHR11579
- TIGRFAMs:   TIGR00080

Pfam domain/function: PF01135 PCMT

EC number: =2.1.1.77

Molecular weight: Translated: 24227; Mature: 24096

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS01279 PCMT

Important sites: ACT_SITE 75-75

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPRLRLQPESVGIGMTSQRVRDRLVERLREAGIQDESTLNAMRTVPRHLFIDEALASRA
CCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YEDTALPIGHGQTISQPWVVARMTEAVLQVAPTKVLEVGTGSGYQGAILAALGLEVYTVE
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHCCHHHHHH
RIGDLLRQARKRFRHLGMNVRSKHDDGRIGWPEHGPYDAIVVTAAAPALVDALIDQLAVG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHC
GRLVAPVGGASSQSLVQLTRGADGAIEQQVLAPVTFVPLLSGMLD
CEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPRLRLQPESVGIGMTSQRVRDRLVERLREAGIQDESTLNAMRTVPRHLFIDEALASRA
CCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YEDTALPIGHGQTISQPWVVARMTEAVLQVAPTKVLEVGTGSGYQGAILAALGLEVYTVE
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHCCHHHHHH
RIGDLLRQARKRFRHLGMNVRSKHDDGRIGWPEHGPYDAIVVTAAAPALVDALIDQLAVG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHC
GRLVAPVGGASSQSLVQLTRGADGAIEQQVLAPVTFVPLLSGMLD
CEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217