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The map label for this gene is serS

Identifier: 21242403

GI number: 21242403

Start: 1904872

End: 1906152

Strand: Direct

Name: serS

Synonym: XAC1653

Alternate gene names: 21242403

Gene position: 1904872-1906152 (Clockwise)

Preceding gene: 21242400

Following gene: 21242405

Centisome position: 36.81

GC content: 63.7

Gene sequence:

>1281_bases
ATGCTAGATCCGGCCCTGCTTCGCCAACACCCTGCCGACCTTGCCGAGCGCCTGCGCAGCACGCGCGGTTTCTCCCTGGA
CACTGCGGAACTGGAGTCGCTGGAGAGCGAGCGCAAGCGTATCCAGGTGCGCACGCAGGAACTGCAGAGCCAGCGCAATT
CCAAATCCAAGGCGATCGGGCAGGCCAAGGCCAAGGGCGAAGACGTGGCCGCGCTGATGGCCGAAGTGGCCGGGTTCGGC
GATGAGCTCAAGGCGTCCGAAGACGCGCTGGATGCGATTCGCGCCAAGCTCGAAGGCATCGCGCTTGGCCTGCCCAATCT
GCCGGCCGAGGGTGTGCCGCTTGGCAAGGACGAGAGCGAGAACCTCGAGCAATCGCGTTGGGGTACGCCGCGTCAGTTCG
ATTTCGCCGTCAAGGACCATGTGGAACTCGGTGCGCCGCACGGCTGGCTGGATGGCGAAACGGCAGCCAAATTGTCGGGT
GCGCGGTTCACCGTGCTGCGTGGTCCGGTCGCGCGTCTGCACCGTGCGCTGGCGCAGTTCATGCTGGACCTGCATGTGGG
CGAACACGGTTACGAAGAAACCAACGTGCCGCTGCTGGTCAATGCCGATTCGATGCGCGGCACCGGTCAGCTGCCGAAAT
TCGAAGACGATTTGTTTCAGACCGAAGTGGGCGAGTCGCGCCGTTATCTGATCCCCACCTCCGAAGTGCCGCTGACCAAT
ATCGTGCGCGAGGAGATCGTCGACGCCGAGCGTCTGCCATTGCGCATGACCGCCCATTCGATGTGTTTCCGCGCCGAAGC
CGGCAGTGGTGGCCGCGATACGCGCGGCATGATCCGCCAGCACCAGTTCGAAAAGGTGGAGCTGGTGACCGCCTGTGCGC
CGGAAGACAGCGATGCCGAGCATCAGCGCATGACGCGCTGCGCCGAAGTGGTGCTGGAACAACTCGGTCTGCCGTATCGC
AAGGTGTTGCTGTGCACCGGCGACATGGGGTTTTCCGCGATCAAGACCTACGATCTGGAGGTGTGGTTGCCGTCGCAGAA
CACCTATCGCGAAATTTCGTCCTGCTCCAATTGCGGCGATTTCCAGGCGCGGCGCATGCAGGCGCGCTGGCGCAACCCGG
TCAGCGGCAAGCCGGAGTTGCTGCACACGCTCAACGGCTCGGGCACTGCCGTGGGTCGCGCGATGATCGCGGTCATGGAG
AACTACCAGAATGCCGATGGCTCGATCGATGTACCGCAGGTGCTGCGTCCGTACATGGGCGGGATCGAGCGTATCGGCTG
A

Upstream 100 bases:

>100_bases
GAAGAATCGTCGCAATTCTGGCATAGCCGTAGTGAATCGATCGCAGCAGGTGGCGGAACAGGCGATAATCTCGCGCTATT
CCACTGACGCACATATTCCG

Downstream 100 bases:

>100_bases
GCGCCGCTAACAGGAAGGCGGCGCCCATCAGCAGGCGGCGTGGGCGGTGTTCGGTGCGCATGTCGCGTTCGGGCACTGCG
GTTGCCCGGCTAGACCCGCG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLDPALLRQHPADLAERLRSTRGFSLDTAELESLESERKRIQVRTQELQSQRNSKSKAIGQAKAKGEDVAALMAEVAGFG
DELKASEDALDAIRAKLEGIALGLPNLPAEGVPLGKDESENLEQSRWGTPRQFDFAVKDHVELGAPHGWLDGETAAKLSG
ARFTVLRGPVARLHRALAQFMLDLHVGEHGYEETNVPLLVNADSMRGTGQLPKFEDDLFQTEVGESRRYLIPTSEVPLTN
IVREEIVDAERLPLRMTAHSMCFRAEAGSGGRDTRGMIRQHQFEKVELVTACAPEDSDAEHQRMTRCAEVVLEQLGLPYR
KVLLCTGDMGFSAIKTYDLEVWLPSQNTYREISSCSNCGDFQARRMQARWRNPVSGKPELLHTLNGSGTAVGRAMIAVME
NYQNADGSIDVPQVLRPYMGGIERIG

Sequences:

>Translated_426_residues
MLDPALLRQHPADLAERLRSTRGFSLDTAELESLESERKRIQVRTQELQSQRNSKSKAIGQAKAKGEDVAALMAEVAGFG
DELKASEDALDAIRAKLEGIALGLPNLPAEGVPLGKDESENLEQSRWGTPRQFDFAVKDHVELGAPHGWLDGETAAKLSG
ARFTVLRGPVARLHRALAQFMLDLHVGEHGYEETNVPLLVNADSMRGTGQLPKFEDDLFQTEVGESRRYLIPTSEVPLTN
IVREEIVDAERLPLRMTAHSMCFRAEAGSGGRDTRGMIRQHQFEKVELVTACAPEDSDAEHQRMTRCAEVVLEQLGLPYR
KVLLCTGDMGFSAIKTYDLEVWLPSQNTYREISSCSNCGDFQARRMQARWRNPVSGKPELLHTLNGSGTAVGRAMIAVME
NYQNADGSIDVPQVLRPYMGGIERIG
>Mature_426_residues
MLDPALLRQHPADLAERLRSTRGFSLDTAELESLESERKRIQVRTQELQSQRNSKSKAIGQAKAKGEDVAALMAEVAGFG
DELKASEDALDAIRAKLEGIALGLPNLPAEGVPLGKDESENLEQSRWGTPRQFDFAVKDHVELGAPHGWLDGETAAKLSG
ARFTVLRGPVARLHRALAQFMLDLHVGEHGYEETNVPLLVNADSMRGTGQLPKFEDDLFQTEVGESRRYLIPTSEVPLTN
IVREEIVDAERLPLRMTAHSMCFRAEAGSGGRDTRGMIRQHQFEKVELVTACAPEDSDAEHQRMTRCAEVVLEQLGLPYR
KVLLCTGDMGFSAIKTYDLEVWLPSQNTYREISSCSNCGDFQARRMQARWRNPVSGKPELLHTLNGSGTAVGRAMIAVME
NYQNADGSIDVPQVLRPYMGGIERIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=461, Percent_Identity=32.7548806941432, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI8923421, Length=324, Percent_Identity=31.4814814814815, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI225579074, Length=324, Percent_Identity=31.4814814814815, Blast_Score=157, Evalue=3e-38,
Organism=Escherichia coli, GI1787120, Length=431, Percent_Identity=62.4129930394432, Blast_Score=553, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17539260, Length=436, Percent_Identity=31.1926605504587, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=333, Percent_Identity=28.5285285285285, Blast_Score=148, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6320226, Length=436, Percent_Identity=31.1926605504587, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321799, Length=390, Percent_Identity=31.2820512820513, Blast_Score=186, Evalue=8e-48,
Organism=Drosophila melanogaster, GI24581334, Length=437, Percent_Identity=31.8077803203661, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI17737985, Length=333, Percent_Identity=33.3333333333333, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_XANAC (Q8PLY2)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641985.1
- ProteinModelPortal:   Q8PLY2
- SMR:   Q8PLY2
- GeneID:   1155724
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1653
- NMPDR:   fig|190486.1.peg.1629
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- ProtClustDB:   PRK05431
- BioCyc:   XAXO190486:XAC1653-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47119; Mature: 47119

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 287-287 BINDING 387-387

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDPALLRQHPADLAERLRSTRGFSLDTAELESLESERKRIQVRTQELQSQRNSKSKAIG
CCCHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAKAKGEDVAALMAEVAGFGDELKASEDALDAIRAKLEGIALGLPNLPAEGVPLGKDESE
HHHCCCHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCC
NLEQSRWGTPRQFDFAVKDHVELGAPHGWLDGETAAKLSGARFTVLRGPVARLHRALAQF
CHHHHHCCCCCEECHHHHHHHHCCCCCCCCCCCHHHHCCCCEEEEECCCHHHHHHHHHHH
MLDLHVGEHGYEETNVPLLVNADSMRGTGQLPKFEDDLFQTEVGESRRYLIPTSEVPLTN
HHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCHHH
IVREEIVDAERLPLRMTAHSMCFRAEAGSGGRDTRGMIRQHQFEKVELVTACAPEDSDAE
HHHHHHHCHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCCHH
HQRMTRCAEVVLEQLGLPYRKVLLCTGDMGFSAIKTYDLEVWLPSQNTYREISSCSNCGD
HHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEEEEECCCHHHHHHHHCCCCCH
FQARRMQARWRNPVSGKPELLHTLNGSGTAVGRAMIAVMENYQNADGSIDVPQVLRPYMG
HHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
GIERIG
HHHHCC
>Mature Secondary Structure
MLDPALLRQHPADLAERLRSTRGFSLDTAELESLESERKRIQVRTQELQSQRNSKSKAIG
CCCHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAKAKGEDVAALMAEVAGFGDELKASEDALDAIRAKLEGIALGLPNLPAEGVPLGKDESE
HHHCCCHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCC
NLEQSRWGTPRQFDFAVKDHVELGAPHGWLDGETAAKLSGARFTVLRGPVARLHRALAQF
CHHHHHCCCCCEECHHHHHHHHCCCCCCCCCCCHHHHCCCCEEEEECCCHHHHHHHHHHH
MLDLHVGEHGYEETNVPLLVNADSMRGTGQLPKFEDDLFQTEVGESRRYLIPTSEVPLTN
HHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCHHH
IVREEIVDAERLPLRMTAHSMCFRAEAGSGGRDTRGMIRQHQFEKVELVTACAPEDSDAE
HHHHHHHCHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCCHH
HQRMTRCAEVVLEQLGLPYRKVLLCTGDMGFSAIKTYDLEVWLPSQNTYREISSCSNCGD
HHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEEEEECCCHHHHHHHHCCCCCH
FQARRMQARWRNPVSGKPELLHTLNGSGTAVGRAMIAVMENYQNADGSIDVPQVLRPYMG
HHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
GIERIG
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217