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The map label for this gene is acdA [H]

Identifier: 21242313

GI number: 21242313

Start: 1805539

End: 1806687

Strand: Direct

Name: acdA [H]

Synonym: XAC1562

Alternate gene names: 21242313

Gene position: 1805539-1806687 (Clockwise)

Preceding gene: 21242309

Following gene: 21242315

Centisome position: 34.89

GC content: 62.14

Gene sequence:

>1149_bases
GTGGATTTCAGCTTCACCGAAGAACAATTAATGATCCAGGATGTGGCGCGCCGCATCGCGCAGGAAAAGATCGCGCCCAG
CGCCGAGCAATTCGACCGTAGCGGCGAATTCCCGCTCGAAAATATCCGCCTGTTGGGCGAAAACGGCCTGATGGGCATCG
AGGTGCCGGTCGAATACGGCGGCGCCGGCATGGACCCGATCAGCTACGCGCTGGCGATGATCGAAATCGCCGCGGCCGAC
GGCGCGCATTCCACCATCGTTTCGGTCAACAACTCGCTGTTTTGCACCGGTATTCTGAAGAACGGCAGCGAAGCGCAAAA
GCAGCTCTACGTGCGCGCGATCGCCGAAGGCGCGCACATCGGTGCGTTCGCGCTGACCGAGCCGCAGTCCGGCTCGGATG
CCTCGGCAATGCGCTGCCGCGCGGTCAAGCAGGCCGATGGCAGCTTCCTCATCAACGGCAAGAAGAGCTGGATCACCTCC
GGCCCGGTGGCCAAGTACATCGTCTTGTTTGCAATGACCGAGCCGGACAAGGGTTCGCGCGGCATCACTGCGTTCATGGT
CGACACCGATCGCGCCGGTTTTCATCGCGGCAAGACCGAGCCCAAGCTCGGCATTCGCGCCTCGGCCACCTGCGAAATCG
AGTTTGCCGATTACGTTGCGCAGCCCGATGAAGTGCTGGGCGTGGAAGGCGAGGGCTTCAAGACTGCGATGAGCGTTCTG
GACGCCGGGCGCATCGGTATTGCCTCGCAAGCGGTCGGGATTGCACGTGCGGCTTATGAGGCCACGCTGGCCTACGTCAA
GGAGCGCAAGGCATTCGGCGCGGCGATCGGCACGTTCCAGATGACCCAGGCCAAGATCGCCGACATGAAGTGCAAGCTGG
ATGCAGCGCTGCTGCTGACGCTGCGCGCCGCGTGGTTGAAAGGGCAGGGGCAGAAGTTCGGCACCGAAGCGGCAGTGGCC
AAGCTCACTGCATCCGAGGCGGCGATGTGGATCACCCATCAGGCCGTGCAAATCCATGGCGGCATGGGGTATTCGAAAGA
AATGCCGCTGGAGCGCTACTTTCGCGATGCAAAGATCACCGAAATCTACGAGGGCACCTCGGAAATCCAGCGCCTGGTGA
TTGCACGCGGCGAGACTGGCTTGCGCTGA

Upstream 100 bases:

>100_bases
TGGAGATATTTTCGACCCGGCGCCAGGTGCGGTCAACTACATACGCATGCGAATGGTTGGCGCTACAATGGGGCTCAGCT
CAGGCCTGAAGGGGTGCGAC

Downstream 100 bases:

>100_bases
AGTCGACCGCGCTCCAGCGCTGCCGCCACGCGCGGCAACGCTGGAGCGCTCTCCGCGATGCAAAGATCACCGAAATCTAC
GAGGGCACCTCGGAAATCCA

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MDFSFTEEQLMIQDVARRIAQEKIAPSAEQFDRSGEFPLENIRLLGENGLMGIEVPVEYGGAGMDPISYALAMIEIAAAD
GAHSTIVSVNNSLFCTGILKNGSEAQKQLYVRAIAEGAHIGAFALTEPQSGSDASAMRCRAVKQADGSFLINGKKSWITS
GPVAKYIVLFAMTEPDKGSRGITAFMVDTDRAGFHRGKTEPKLGIRASATCEIEFADYVAQPDEVLGVEGEGFKTAMSVL
DAGRIGIASQAVGIARAAYEATLAYVKERKAFGAAIGTFQMTQAKIADMKCKLDAALLLTLRAAWLKGQGQKFGTEAAVA
KLTASEAAMWITHQAVQIHGGMGYSKEMPLERYFRDAKITEIYEGTSEIQRLVIARGETGLR

Sequences:

>Translated_382_residues
MDFSFTEEQLMIQDVARRIAQEKIAPSAEQFDRSGEFPLENIRLLGENGLMGIEVPVEYGGAGMDPISYALAMIEIAAAD
GAHSTIVSVNNSLFCTGILKNGSEAQKQLYVRAIAEGAHIGAFALTEPQSGSDASAMRCRAVKQADGSFLINGKKSWITS
GPVAKYIVLFAMTEPDKGSRGITAFMVDTDRAGFHRGKTEPKLGIRASATCEIEFADYVAQPDEVLGVEGEGFKTAMSVL
DAGRIGIASQAVGIARAAYEATLAYVKERKAFGAAIGTFQMTQAKIADMKCKLDAALLLTLRAAWLKGQGQKFGTEAAVA
KLTASEAAMWITHQAVQIHGGMGYSKEMPLERYFRDAKITEIYEGTSEIQRLVIARGETGLR
>Mature_382_residues
MDFSFTEEQLMIQDVARRIAQEKIAPSAEQFDRSGEFPLENIRLLGENGLMGIEVPVEYGGAGMDPISYALAMIEIAAAD
GAHSTIVSVNNSLFCTGILKNGSEAQKQLYVRAIAEGAHIGAFALTEPQSGSDASAMRCRAVKQADGSFLINGKKSWITS
GPVAKYIVLFAMTEPDKGSRGITAFMVDTDRAGFHRGKTEPKLGIRASATCEIEFADYVAQPDEVLGVEGEGFKTAMSVL
DAGRIGIASQAVGIARAAYEATLAYVKERKAFGAAIGTFQMTQAKIADMKCKLDAALLLTLRAAWLKGQGQKFGTEAAVA
KLTASEAAMWITHQAVQIHGGMGYSKEMPLERYFRDAKITEIYEGTSEIQRLVIARGETGLR

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=371, Percent_Identity=49.0566037735849, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=41.2868632707775, Blast_Score=284, Evalue=1e-76,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=37.8306878306878, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=37.4005305039788, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=37.4005305039788, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI226958414, Length=334, Percent_Identity=38.3233532934132, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI21361497, Length=362, Percent_Identity=39.5027624309392, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI4557235, Length=339, Percent_Identity=37.7581120943953, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI76496475, Length=339, Percent_Identity=37.7581120943953, Blast_Score=198, Evalue=9e-51,
Organism=Homo sapiens, GI4501857, Length=375, Percent_Identity=31.4666666666667, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=30.9333333333333, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI4503943, Length=383, Percent_Identity=31.0704960835509, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI7669494, Length=365, Percent_Identity=30.6849315068493, Blast_Score=158, Evalue=6e-39,
Organism=Homo sapiens, GI211971008, Length=353, Percent_Identity=29.4617563739377, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI48976061, Length=353, Percent_Identity=29.4617563739377, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI38505218, Length=303, Percent_Identity=27.7227722772277, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI87081958, Length=381, Percent_Identity=32.2834645669291, Blast_Score=181, Evalue=5e-47,
Organism=Escherichia coli, GI1786223, Length=379, Percent_Identity=29.5514511873351, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI87082384, Length=258, Percent_Identity=27.906976744186, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87081702, Length=371, Percent_Identity=25.8760107816712, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=41.3978494623656, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17506239, Length=372, Percent_Identity=37.3655913978495, Blast_Score=255, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17538396, Length=378, Percent_Identity=35.7142857142857, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=37.7308707124011, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=37.696335078534, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=34.3007915567282, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI71990804, Length=294, Percent_Identity=41.156462585034, Blast_Score=217, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI71985184, Length=352, Percent_Identity=36.0795454545455, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17533517, Length=371, Percent_Identity=30.9973045822102, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17534353, Length=379, Percent_Identity=30.8707124010554, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=32.967032967033, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17551932, Length=379, Percent_Identity=29.023746701847, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71985192, Length=333, Percent_Identity=32.7327327327327, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=36.3636363636364, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17505929, Length=381, Percent_Identity=28.6089238845144, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17531909, Length=238, Percent_Identity=32.3529411764706, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI86563383, Length=334, Percent_Identity=27.2455089820359, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI86563381, Length=334, Percent_Identity=27.2455089820359, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17531913, Length=174, Percent_Identity=31.6091954022989, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562446, Length=294, Percent_Identity=26.1904761904762, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356377, Length=372, Percent_Identity=48.1182795698925, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=45.1612903225806, Blast_Score=322, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24666513, Length=374, Percent_Identity=41.4438502673797, Blast_Score=277, Evalue=7e-75,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=39.0501319261214, Blast_Score=254, Evalue=5e-68,
Organism=Drosophila melanogaster, GI281363737, Length=371, Percent_Identity=36.3881401617251, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI21355753, Length=382, Percent_Identity=34.8167539267016, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI19920834, Length=384, Percent_Identity=33.3333333333333, Blast_Score=183, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 41070; Mature: 41070

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSFTEEQLMIQDVARRIAQEKIAPSAEQFDRSGEFPLENIRLLGENGLMGIEVPVEYG
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHEEEECCCCEEEEEEEHCCC
GAGMDPISYALAMIEIAAADGAHSTIVSVNNSLFCTGILKNGSEAQKQLYVRAIAEGAHI
CCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEEECCCHHHHHHHHHHHHHCCCCC
GAFALTEPQSGSDASAMRCRAVKQADGSFLINGKKSWITSGPVAKYIVLFAMTEPDKGSR
CEEEEECCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHEEEEEEEEECCCCCCC
GITAFMVDTDRAGFHRGKTEPKLGIRASATCEIEFADYVAQPDEVLGVEGEGFKTAMSVL
CEEEEEEECCCCCCCCCCCCCCCCEEECCEEEEEHHHHHCCCCCEECCCCCCHHHHHHHH
DAGRIGIASQAVGIARAAYEATLAYVKERKAFGAAIGTFQMTQAKIADMKCKLDAALLLT
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRAAWLKGQGQKFGTEAAVAKLTASEAAMWITHQAVQIHGGMGYSKEMPLERYFRDAKIT
HHHHHHCCCCCCCCCHHHHHHHHHHHHEEEEEEEEEEEECCCCCCCCCCHHHHHCCCHHH
EIYEGTSEIQRLVIARGETGLR
HHHCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDFSFTEEQLMIQDVARRIAQEKIAPSAEQFDRSGEFPLENIRLLGENGLMGIEVPVEYG
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHEEEECCCCEEEEEEEHCCC
GAGMDPISYALAMIEIAAADGAHSTIVSVNNSLFCTGILKNGSEAQKQLYVRAIAEGAHI
CCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEEECCCHHHHHHHHHHHHHCCCCC
GAFALTEPQSGSDASAMRCRAVKQADGSFLINGKKSWITSGPVAKYIVLFAMTEPDKGSR
CEEEEECCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHEEEEEEEEECCCCCCC
GITAFMVDTDRAGFHRGKTEPKLGIRASATCEIEFADYVAQPDEVLGVEGEGFKTAMSVL
CEEEEEEECCCCCCCCCCCCCCCCEEECCEEEEEHHHHHCCCCCEECCCCCCHHHHHHHH
DAGRIGIASQAVGIARAAYEATLAYVKERKAFGAAIGTFQMTQAKIADMKCKLDAALLLT
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRAAWLKGQGQKFGTEAAVAKLTASEAAMWITHQAVQIHGGMGYSKEMPLERYFRDAKIT
HHHHHHCCCCCCCCCHHHHHHHHHHHHEEEEEEEEEEEECCCCCCCCCCHHHHHCCCHHH
EIYEGTSEIQRLVIARGETGLR
HHHCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]