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The map label for this gene is gcdH [H]

Identifier: 21242224

GI number: 21242224

Start: 1696904

End: 1698079

Strand: Direct

Name: gcdH [H]

Synonym: XAC1472

Alternate gene names: 21242224

Gene position: 1696904-1698079 (Clockwise)

Preceding gene: 21242223

Following gene: 21242225

Centisome position: 32.79

GC content: 67.52

Gene sequence:

>1176_bases
ATGGAAGCCAACATGCCGGTGCACCCCGATGACCTGTTCGACGTACGCGCGCTGCTCACCGACGAAGAGCGGGCGGTGCA
GGACGCGGTCGCGCGCTTTACCGATACGCGGGTTGTACCGGCCATCGGCGACGCCTTCGATGCCGGGCGCTTTCCGCGCG
AGTGGATTCCGGAGCTGGCGGAACTGGGGCTGCTGGGTGCCAGCCTGCCGGTACGCGACGGCGGTGCGGGCCTTGGCGCG
GTGTCCTACGGATTGATCTGCCAGGAACTGGAGCGCGGCGACAGTGGCCTGCGCAGCTTCGTCAGCGTGCAATCGTCGTT
GTGCATGTATCCCATCCACGCCTACGGCAGCGACGAACAGCGGCAGCGCTGGCTGCCGGAGATGGCGGCAGGCCGGGTCA
TCGGCTGTTTCGGCCTGAGCGAGGCGCAGGGCGGATCGGACCCGGCCGCGATGACCACCCGCGCGGTGCGCGAGGGCGAG
GGCTGGCGTTTGAACGGCGCCAAGATGTGGATCACCAACGGCAGCATCGCCGGGCTGGCGATCATCTGGGCGCAGACCGA
CGATGGCGTGCGCGGCTTTCTGGTCCAGACCGACAGCGCCGGTTTCAGCGCGCACGACATCAGCCACAAGATGAGCCTGC
GTGCGTCGGTCACCTCGGGCCTGTTCCTGGACAACGTGTTCGTGCCCGAGCAGATGCGGTTGCCGCAGGCGGCCGGTTTG
AAGGCGCCGCTGAGTTGCCTCAACCAGGCACGCTACGGCATCGCCTGGGGCGCCATTGGCGCGGCAGTGGCCTGCCTGCG
CGAGGCGCTGGCCTATGCCGGCGAGCGCATCCTGTTCGGCCGCCCGTTGGCGGCCACGCAAAGCGCGCAGATCAAACTGG
CCGACATGGCGCGGCGGATTTCCACCGCCCAGCTGCTGGCATTGCAGCTTGGGCGCTTGAAGGAAGCCGGGACGCTGCAG
CCGGAGCAGGTCTCGCTGGCAAAATGGAATAATTGCCGCATGGCGCTGGATGTGGCGCGCGAATGCCGCGACCTGCTGGG
CGCGGCCGGCATCACCACCGAGCATGTGGCGATCCGGCATGCGCTGAACCTGGAATCGGTGATCACCTACGAAGGCACCG
AAACCGTGCACCAGCTGGTGGTGGGCCGTGCGCTGACAGGACTCAATGCGTTTTGA

Upstream 100 bases:

>100_bases
GAGCCGGCATTGCCGGCTCTTTTCGTCTGCGCCATCCCCTGGAGCGGTGCACTGCCATGTTGGTCCGGCAACTGGCAGAT
AATCGCGCTTTCAGCTTGCG

Downstream 100 bases:

>100_bases
CGAGGAGTGGGGGTTTGATCAGCAAGGATGTGATGCGACGCCTGTTCGGCGTCTTCTGGACCATGTGTCTGCTGGTCGGC
GCGAGCCTCGTGCCAGCACG

Product: glutaryl-CoA dehydrogenase

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MEANMPVHPDDLFDVRALLTDEERAVQDAVARFTDTRVVPAIGDAFDAGRFPREWIPELAELGLLGASLPVRDGGAGLGA
VSYGLICQELERGDSGLRSFVSVQSSLCMYPIHAYGSDEQRQRWLPEMAAGRVIGCFGLSEAQGGSDPAAMTTRAVREGE
GWRLNGAKMWITNGSIAGLAIIWAQTDDGVRGFLVQTDSAGFSAHDISHKMSLRASVTSGLFLDNVFVPEQMRLPQAAGL
KAPLSCLNQARYGIAWGAIGAAVACLREALAYAGERILFGRPLAATQSAQIKLADMARRISTAQLLALQLGRLKEAGTLQ
PEQVSLAKWNNCRMALDVARECRDLLGAAGITTEHVAIRHALNLESVITYEGTETVHQLVVGRALTGLNAF

Sequences:

>Translated_391_residues
MEANMPVHPDDLFDVRALLTDEERAVQDAVARFTDTRVVPAIGDAFDAGRFPREWIPELAELGLLGASLPVRDGGAGLGA
VSYGLICQELERGDSGLRSFVSVQSSLCMYPIHAYGSDEQRQRWLPEMAAGRVIGCFGLSEAQGGSDPAAMTTRAVREGE
GWRLNGAKMWITNGSIAGLAIIWAQTDDGVRGFLVQTDSAGFSAHDISHKMSLRASVTSGLFLDNVFVPEQMRLPQAAGL
KAPLSCLNQARYGIAWGAIGAAVACLREALAYAGERILFGRPLAATQSAQIKLADMARRISTAQLLALQLGRLKEAGTLQ
PEQVSLAKWNNCRMALDVARECRDLLGAAGITTEHVAIRHALNLESVITYEGTETVHQLVVGRALTGLNAF
>Mature_391_residues
MEANMPVHPDDLFDVRALLTDEERAVQDAVARFTDTRVVPAIGDAFDAGRFPREWIPELAELGLLGASLPVRDGGAGLGA
VSYGLICQELERGDSGLRSFVSVQSSLCMYPIHAYGSDEQRQRWLPEMAAGRVIGCFGLSEAQGGSDPAAMTTRAVREGE
GWRLNGAKMWITNGSIAGLAIIWAQTDDGVRGFLVQTDSAGFSAHDISHKMSLRASVTSGLFLDNVFVPEQMRLPQAAGL
KAPLSCLNQARYGIAWGAIGAAVACLREALAYAGERILFGRPLAATQSAQIKLADMARRISTAQLLALQLGRLKEAGTLQ
PEQVSLAKWNNCRMALDVARECRDLLGAAGITTEHVAIRHALNLESVITYEGTETVHQLVVGRALTGLNAF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=376, Percent_Identity=50.531914893617, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI7669494, Length=356, Percent_Identity=50.2808988764045, Blast_Score=335, Evalue=6e-92,
Organism=Homo sapiens, GI4557233, Length=355, Percent_Identity=34.0845070422535, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=31.6353887399464, Blast_Score=194, Evalue=8e-50,
Organism=Homo sapiens, GI187960098, Length=374, Percent_Identity=29.144385026738, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI4557231, Length=374, Percent_Identity=29.144385026738, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI226958412, Length=381, Percent_Identity=28.0839895013123, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4501857, Length=380, Percent_Identity=28.1578947368421, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI226958414, Length=342, Percent_Identity=28.0701754385965, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI76496475, Length=412, Percent_Identity=26.4563106796117, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI4557235, Length=412, Percent_Identity=26.4563106796117, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI21361497, Length=398, Percent_Identity=25.6281407035176, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI7656849, Length=378, Percent_Identity=24.6031746031746, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI87081958, Length=345, Percent_Identity=25.7971014492754, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786223, Length=343, Percent_Identity=22.4489795918367, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17534353, Length=387, Percent_Identity=44.4444444444444, Blast_Score=346, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI17508101, Length=365, Percent_Identity=30.1369863013699, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=30.2631578947368, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17534899, Length=376, Percent_Identity=29.2553191489362, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17569725, Length=378, Percent_Identity=27.7777777777778, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17506239, Length=374, Percent_Identity=28.0748663101604, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17570075, Length=376, Percent_Identity=27.9255319148936, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI71990804, Length=274, Percent_Identity=29.9270072992701, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71985192, Length=356, Percent_Identity=25.2808988764045, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI71985184, Length=394, Percent_Identity=25.6345177664975, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17533517, Length=382, Percent_Identity=23.8219895287958, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17551932, Length=351, Percent_Identity=26.4957264957265, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI32563615, Length=229, Percent_Identity=30.1310043668122, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71982178, Length=271, Percent_Identity=27.6752767527675, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17505929, Length=348, Percent_Identity=25.2873563218391, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI19920834, Length=386, Percent_Identity=47.4093264248705, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI21356377, Length=337, Percent_Identity=33.2344213649852, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24660351, Length=377, Percent_Identity=30.5039787798408, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=31.7333333333333, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24666513, Length=374, Percent_Identity=28.8770053475936, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI281363737, Length=344, Percent_Identity=29.9418604651163, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI21355753, Length=394, Percent_Identity=27.6649746192893, Blast_Score=142, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 41957; Mature: 41957

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEANMPVHPDDLFDVRALLTDEERAVQDAVARFTDTRVVPAIGDAFDAGRFPREWIPELA
CCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCHHHHHHHH
ELGLLGASLPVRDGGAGLGAVSYGLICQELERGDSGLRSFVSVQSSLCMYPIHAYGSDEQ
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEECCCCCHH
RQRWLPEMAAGRVIGCFGLSEAQGGSDPAAMTTRAVREGEGWRLNGAKMWITNGSIAGLA
HHHHCHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEECCEEEEEECCCEEEEE
IIWAQTDDGVRGFLVQTDSAGFSAHDISHKMSLRASVTSGLFLDNVFVPEQMRLPQAAGL
EEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCHHHCCCHHCCC
KAPLSCLNQARYGIAWGAIGAAVACLREALAYAGERILFGRPLAATQSAQIKLADMARRI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEHHHHHHHH
STAQLLALQLGRLKEAGTLQPEQVSLAKWNNCRMALDVARECRDLLGAAGITTEHVAIRH
HHHHHHHHHHHCCCCCCCCCCCCCHHECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
ALNLESVITYEGTETVHQLVVGRALTGLNAF
HCCCCCEEEECCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEANMPVHPDDLFDVRALLTDEERAVQDAVARFTDTRVVPAIGDAFDAGRFPREWIPELA
CCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCHHHHHHHH
ELGLLGASLPVRDGGAGLGAVSYGLICQELERGDSGLRSFVSVQSSLCMYPIHAYGSDEQ
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEECCCCCHH
RQRWLPEMAAGRVIGCFGLSEAQGGSDPAAMTTRAVREGEGWRLNGAKMWITNGSIAGLA
HHHHCHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEECCEEEEEECCCEEEEE
IIWAQTDDGVRGFLVQTDSAGFSAHDISHKMSLRASVTSGLFLDNVFVPEQMRLPQAAGL
EEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCHHHCCCHHCCC
KAPLSCLNQARYGIAWGAIGAAVACLREALAYAGERILFGRPLAATQSAQIKLADMARRI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEHHHHHHHH
STAQLLALQLGRLKEAGTLQPEQVSLAKWNNCRMALDVARECRDLLGAAGITTEHVAIRH
HHHHHHHHHHHCCCCCCCCCCCCCHHECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
ALNLESVITYEGTETVHQLVVGRALTGLNAF
HCCCCCEEEECCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]