Click here to switch to the map view.

The map label for this gene is rnc

Identifier: 21242078

GI number: 21242078

Start: 1530542

End: 1531222

Strand: Direct

Name: rnc

Synonym: XAC1325

Alternate gene names: 21242078

Gene position: 1530542-1531222 (Clockwise)

Preceding gene: 21242077

Following gene: 21242079

Centisome position: 29.57

GC content: 65.49

Gene sequence:

>681_bases
GTGTCGAATAGAACCTTCCAACGCGGTGATCCGATCGGGCACGCATTCGCCGATCCGGCTCTGCTCGCCCAGGCGCTGCG
GCATCGCAGCGCCGGGACGCCGCACAACGAGCGACTGGAATTTCTCGGCGACGGCATCGTCAACCTGCTGATCGCCGAGG
CGCTGTATCACCGGTGGCCCAAGGCCGATGAAGGCGCATTGACCCGTGCACGTGCCGAGCTCGTACGCGAAGGTGCGCTG
GCAGTCATCGGGCGTACGCTCAATTTGGGCGAACGTCTCACGCTTGGCCCAGGCGAGCTGAAGTCCGGTGGTCACCGGCG
CGATTCGATCCTGGCCGATGCGGTCGAAGCGATCGTCGCTGCCATCTACCTGGACTGCGGTTTCGAGCGTTGCCGTGCGG
TGGTGCTGCCGTGGTTCGAAGCCTCGCTGGCGGCATTGCCGGTGGGCAAGGCAGAGAAGGATCCCAAGACCCGGCTGCAG
GAATGGCTGCAGGCGCGCCAGCTGCCGCTGCCCACTTACGCGCTGATCAGCGAGAGCGGCGACGAGCATGCCAAGCAGTT
CCACGTCGCCTGCATTCTGGAGCAGCCCGTTGCCCGCGCCGAGGGCCAGGGCACCTCGCGTCGCCTCGCAGAGCAACAGG
CGGCGACTCTTGTCATCGCACAACTGGATTCAAACACGTGA

Upstream 100 bases:

>100_bases
GGCTGGCGCATGAAGGTCAATTACGAAGTCCGCCGCGAGCTGGTTGGCAATCTGGATGTGGTCGGCAAGTTCGATACGGC
ACAGGATCTGACGAAGCGCG

Downstream 100 bases:

>100_bases
GCGAAATCACTTCCCCTCACCGCAGCGGTAGCGTTGCGGTGATCGGCCGGCCCAACGTCGGCAAGTCCACCCTGACCAAC
GCCCTGGTCGGCGCGAAGGT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MSNRTFQRGDPIGHAFADPALLAQALRHRSAGTPHNERLEFLGDGIVNLLIAEALYHRWPKADEGALTRARAELVREGAL
AVIGRTLNLGERLTLGPGELKSGGHRRDSILADAVEAIVAAIYLDCGFERCRAVVLPWFEASLAALPVGKAEKDPKTRLQ
EWLQARQLPLPTYALISESGDEHAKQFHVACILEQPVARAEGQGTSRRLAEQQAATLVIAQLDSNT

Sequences:

>Translated_226_residues
MSNRTFQRGDPIGHAFADPALLAQALRHRSAGTPHNERLEFLGDGIVNLLIAEALYHRWPKADEGALTRARAELVREGAL
AVIGRTLNLGERLTLGPGELKSGGHRRDSILADAVEAIVAAIYLDCGFERCRAVVLPWFEASLAALPVGKAEKDPKTRLQ
EWLQARQLPLPTYALISESGDEHAKQFHVACILEQPVARAEGQGTSRRLAEQQAATLVIAQLDSNT
>Mature_225_residues
SNRTFQRGDPIGHAFADPALLAQALRHRSAGTPHNERLEFLGDGIVNLLIAEALYHRWPKADEGALTRARAELVREGALA
VIGRTLNLGERLTLGPGELKSGGHRRDSILADAVEAIVAAIYLDCGFERCRAVVLPWFEASLAALPVGKAEKDPKTRLQE
WLQARQLPLPTYALISESGDEHAKQFHVACILEQPVARAEGQGTSRRLAEQQAATLVIAQLDSNT

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=216, Percent_Identity=29.6296296296296, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI155030236, Length=216, Percent_Identity=29.6296296296296, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1788920, Length=200, Percent_Identity=51, Blast_Score=209, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17506883, Length=227, Percent_Identity=29.9559471365639, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI193202651, Length=227, Percent_Identity=29.9559471365639, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17137682, Length=219, Percent_Identity=29.2237442922374, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_XANAC (Q8PMV0)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641660.1
- ProteinModelPortal:   Q8PMV0
- SMR:   Q8PMV0
- GeneID:   1155396
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1325
- NMPDR:   fig|190486.1.peg.1304
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   PRK00102
- BioCyc:   XAXO190486:XAC1325-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 24621; Mature: 24490

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRTFQRGDPIGHAFADPALLAQALRHRSAGTPHNERLEFLGDGIVNLLIAEALYHRWP
CCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KADEGALTRARAELVREGALAVIGRTLNLGERLTLGPGELKSGGHRRDSILADAVEAIVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHCCCCCHHHHHHHHHHHHHHH
AIYLDCGFERCRAVVLPWFEASLAALPVGKAEKDPKTRLQEWLQARQLPLPTYALISESG
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCC
DEHAKQFHVACILEQPVARAEGQGTSRRLAEQQAATLVIAQLDSNT
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEECCCCC
>Mature Secondary Structure 
SNRTFQRGDPIGHAFADPALLAQALRHRSAGTPHNERLEFLGDGIVNLLIAEALYHRWP
CCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KADEGALTRARAELVREGALAVIGRTLNLGERLTLGPGELKSGGHRRDSILADAVEAIVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHCCCCCHHHHHHHHHHHHHHH
AIYLDCGFERCRAVVLPWFEASLAALPVGKAEKDPKTRLQEWLQARQLPLPTYALISESG
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCC
DEHAKQFHVACILEQPVARAEGQGTSRRLAEQQAATLVIAQLDSNT
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217