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The map label for this gene is rsbR [H]

Identifier: 21242022

GI number: 21242022

Start: 1452953

End: 1453810

Strand: Direct

Name: rsbR [H]

Synonym: XAC1269

Alternate gene names: 21242022

Gene position: 1452953-1453810 (Clockwise)

Preceding gene: 21242021

Following gene: 21242023

Centisome position: 28.07

GC content: 62.7

Gene sequence:

>858_bases
TTGGTGGGTGATCTCATGGTGGCATTGCAGCAGCGCTCGATCGATGCGATTGGTGACCAGGAACACGCGTTGTTGGCCGC
ATGGTTGGAGTCCAGCCTGGGCAGCGATGCGCGTCTGTCGCGGCAGGAATTCGAAGCGCAGGCCGGCGAATTCCTGCGCT
TGCTGGTGGCGTCGTTGAAGCACGACGGTAGCAGCCTGGACAGTGCCGAATGGAGCGAGGTGCGCCGCTTCCTGGAAAAT
CTCTCGCGCGACCGCGCCACGCGTGGTTTCGATTCGCAGGAAACCGCCAACTTCATCTTTTCGCTCAAGCGTGTGTTGTT
TGCGTTGGTGCAGCGCCAATACGCCAGTCGCCCGGAAGAACTGGGGCAGCAGTTGTGGGCGTTGTCGGAATTGCTCGACC
GCCTGGGCTTGTACACCGTGAAGGTTTTCCAGAAGACCCGCGAAGACATCATCGTGCGTCAGCAGGAAGAGATGCTGGAG
CTGTCCACCCCGGTGGTGAAGCTGTGGGAGGGCGTGCTGGCGCTGCCGATGATCGGCACGCTGGATTCGCAGCGCACCCA
GGTGGTGATGGAATCGCTACTGCAGCGCATTGTCGACACCGGCTCGGAAATCGCCATTATCGACATCACTGGCGTGCCAA
CCGTGGACACCCTCGTGGCGCAGCATCTGCTCAAGACCGTGACCGCGATCCGGCTGATGGGGGCCGACGCCATCATCAGC
GGCGTGCGCCCGCAGATTGCGCAGACCATCGTGCATCTGGGCCTGGACCTGCAGGGGATCGTGACCAAGGCCAACCTGGC
CGATGCGTTGGCGCTGGCGCTCAAGCGCACTGGCGTGGCCGTCAGCAGGGCGGACTGA

Upstream 100 bases:

>100_bases
TGGTTGGCCAATCTGAATTGCTTTATTCTGCTACGCATCGGCGTGGGGGCGCCGCGTCGGTCAGGGCGCAGTCCAGCCCG
CATGCCCAACCTCTTTTCTT

Downstream 100 bases:

>100_bases
CATGGAGCGTATTCCGATCCTGCGGATGGGCCATCTGTTGTTGGTCACCATCCAGGTGGACATGCACGACCAGCTGGCGC
TGCAACTGCAAGACGATCTG

Product: positive regulator of sigma-B

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MVGDLMVALQQRSIDAIGDQEHALLAAWLESSLGSDARLSRQEFEAQAGEFLRLLVASLKHDGSSLDSAEWSEVRRFLEN
LSRDRATRGFDSQETANFIFSLKRVLFALVQRQYASRPEELGQQLWALSELLDRLGLYTVKVFQKTREDIIVRQQEEMLE
LSTPVVKLWEGVLALPMIGTLDSQRTQVVMESLLQRIVDTGSEIAIIDITGVPTVDTLVAQHLLKTVTAIRLMGADAIIS
GVRPQIAQTIVHLGLDLQGIVTKANLADALALALKRTGVAVSRAD

Sequences:

>Translated_285_residues
MVGDLMVALQQRSIDAIGDQEHALLAAWLESSLGSDARLSRQEFEAQAGEFLRLLVASLKHDGSSLDSAEWSEVRRFLEN
LSRDRATRGFDSQETANFIFSLKRVLFALVQRQYASRPEELGQQLWALSELLDRLGLYTVKVFQKTREDIIVRQQEEMLE
LSTPVVKLWEGVLALPMIGTLDSQRTQVVMESLLQRIVDTGSEIAIIDITGVPTVDTLVAQHLLKTVTAIRLMGADAIIS
GVRPQIAQTIVHLGLDLQGIVTKANLADALALALKRTGVAVSRAD
>Mature_285_residues
MVGDLMVALQQRSIDAIGDQEHALLAAWLESSLGSDARLSRQEFEAQAGEFLRLLVASLKHDGSSLDSAEWSEVRRFLEN
LSRDRATRGFDSQETANFIFSLKRVLFALVQRQYASRPEELGQQLWALSELLDRLGLYTVKVFQKTREDIIVRQQEEMLE
LSTPVVKLWEGVLALPMIGTLDSQRTQVVMESLLQRIVDTGSEIAIIDITGVPTVDTLVAQHLLKTVTAIRLMGADAIIS
GVRPQIAQTIVHLGLDLQGIVTKANLADALALALKRTGVAVSRAD

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 31470; Mature: 31470

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGDLMVALQQRSIDAIGDQEHALLAAWLESSLGSDARLSRQEFEAQAGEFLRLLVASLK
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HDGSSLDSAEWSEVRRFLENLSRDRATRGFDSQETANFIFSLKRVLFALVQRQYASRPEE
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LGQQLWALSELLDRLGLYTVKVFQKTREDIIVRQQEEMLELSTPVVKLWEGVLALPMIGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDSQRTQVVMESLLQRIVDTGSEIAIIDITGVPTVDTLVAQHLLKTVTAIRLMGADAIIS
CCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVRPQIAQTIVHLGLDLQGIVTKANLADALALALKRTGVAVSRAD
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCC
>Mature Secondary Structure
MVGDLMVALQQRSIDAIGDQEHALLAAWLESSLGSDARLSRQEFEAQAGEFLRLLVASLK
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HDGSSLDSAEWSEVRRFLENLSRDRATRGFDSQETANFIFSLKRVLFALVQRQYASRPEE
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LGQQLWALSELLDRLGLYTVKVFQKTREDIIVRQQEEMLELSTPVVKLWEGVLALPMIGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDSQRTQVVMESLLQRIVDTGSEIAIIDITGVPTVDTLVAQHLLKTVTAIRLMGADAIIS
CCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVRPQIAQTIVHLGLDLQGIVTKANLADALALALKRTGVAVSRAD
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]