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The map label for this gene is tesB [H]

Identifier: 21241997

GI number: 21241997

Start: 1419479

End: 1420384

Strand: Reverse

Name: tesB [H]

Synonym: XAC1243

Alternate gene names: 21241997

Gene position: 1420384-1419479 (Counterclockwise)

Preceding gene: 21241998

Following gene: 21241996

Centisome position: 27.44

GC content: 65.34

Gene sequence:

>906_bases
TTGTCCGCCACCGCCGAACCCGTCGTCTCCGAACTGATCAGCCTGCTGTCGCTGGAGCGCCTGGAAGACAACCTGTTCCG
TGGCCAGAGCCGCGACATCGGCACCAAATACGTGTTCGGTGGGCAGGTGCTGGGCCAGGCGTTGGCGGCAGCGCAGGCGA
CGGTGGAAAACGGCCGCCAGGCGCATTCGCTGCATGCGTATTTCCTGCGTGCCGGCAATATCGACCACCCCATCGTCTAC
GACGTCGACCGCACCCGCGATGGCGGCAGTTTCTCGGTGCGCCGGGTCACCGCGATCCAGCACGGCAAGGTGATCTTTTT
TTGCGCGGCCTCGTTTCAGGAGCACGAAGAAGGCGCCGAGCATCAGTCGGCGATGCCGGTGGTGCCGCCACCGGAAGACA
TCGAACCGGCCGCACCGCTGGCACCGGACGTGTTGGCCAAGCTGCCGGCCAAGGTGCAGCGTTGGCTGTCGCGCGGTGGC
CCGTTCGAGTTTCGCCATGTCTTTCCGCGCGACGAACTCAGGCCGCCCAAGCGCCCGCCGTTCCAGCAGATGTGGCTGCG
CTTGAACGATCCCATCGGAGACGATGTGGGCCTGCATCAAGCGCTCCTTGCGTACGCGTCGGATTTTCAGTTGCTGGGCA
CCTCGACATTTCCGCACGGCATCAGCTATTACACGCCGAACGTGCAGATGGCCTCGCTCGATCATGCCCTGTGGTTCCAT
CGTCCATTCCGTACCGACGACTGGCTGCTGTACTCGCTCGACAGCCCCACCGCGCAGGGCGCGCGCGGTCTGGCTCGCGG
GCAGTTTTTCACCCGCGACGGCGTGCTGGTGGCCAGCACCACGCAGGAAGGCCTGATCCGGGTGGTGCCTGACGGCAGCG
CGATTGCCGTGCCGGCCAAGGAATAG

Upstream 100 bases:

>100_bases
GGCCTGGTGGCGCGCCTGCAAAAGGCCTGAGCCCTGCCGTCGCGGCGCCCCTCGGGCGGGCCGGTATACTCGCTGTCCGT
CGCATGCCCAGGCCAGCCTC

Downstream 100 bases:

>100_bases
ATCTCACATCGCGACAGCACGGCACCCCGCTTGATGGCCAGTGCGCACTCTGGCTGGGTGAAGGCAGCCGAGCACCGCTT
CCCGCGCACTGCAGACACCG

Product: acyl-CoA thiolesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSATAEPVVSELISLLSLERLEDNLFRGQSRDIGTKYVFGGQVLGQALAAAQATVENGRQAHSLHAYFLRAGNIDHPIVY
DVDRTRDGGSFSVRRVTAIQHGKVIFFCAASFQEHEEGAEHQSAMPVVPPPEDIEPAAPLAPDVLAKLPAKVQRWLSRGG
PFEFRHVFPRDELRPPKRPPFQQMWLRLNDPIGDDVGLHQALLAYASDFQLLGTSTFPHGISYYTPNVQMASLDHALWFH
RPFRTDDWLLYSLDSPTAQGARGLARGQFFTRDGVLVASTTQEGLIRVVPDGSAIAVPAKE

Sequences:

>Translated_301_residues
MSATAEPVVSELISLLSLERLEDNLFRGQSRDIGTKYVFGGQVLGQALAAAQATVENGRQAHSLHAYFLRAGNIDHPIVY
DVDRTRDGGSFSVRRVTAIQHGKVIFFCAASFQEHEEGAEHQSAMPVVPPPEDIEPAAPLAPDVLAKLPAKVQRWLSRGG
PFEFRHVFPRDELRPPKRPPFQQMWLRLNDPIGDDVGLHQALLAYASDFQLLGTSTFPHGISYYTPNVQMASLDHALWFH
RPFRTDDWLLYSLDSPTAQGARGLARGQFFTRDGVLVASTTQEGLIRVVPDGSAIAVPAKE
>Mature_300_residues
SATAEPVVSELISLLSLERLEDNLFRGQSRDIGTKYVFGGQVLGQALAAAQATVENGRQAHSLHAYFLRAGNIDHPIVYD
VDRTRDGGSFSVRRVTAIQHGKVIFFCAASFQEHEEGAEHQSAMPVVPPPEDIEPAAPLAPDVLAKLPAKVQRWLSRGGP
FEFRHVFPRDELRPPKRPPFQQMWLRLNDPIGDDVGLHQALLAYASDFQLLGTSTFPHGISYYTPNVQMASLDHALWFHR
PFRTDDWLLYSLDSPTAQGARGLARGQFFTRDGVLVASTTQEGLIRVVPDGSAIAVPAKE

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=290, Percent_Identity=42.4137931034483, Blast_Score=233, Evalue=1e-61,
Organism=Escherichia coli, GI1786657, Length=269, Percent_Identity=49.0706319702602, Blast_Score=270, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI71988741, Length=290, Percent_Identity=40, Blast_Score=207, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI17558508, Length=335, Percent_Identity=37.910447761194, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17531889, Length=278, Percent_Identity=35.2517985611511, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI115532456, Length=278, Percent_Identity=35.2517985611511, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17531885, Length=278, Percent_Identity=35.2517985611511, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71982224, Length=299, Percent_Identity=32.1070234113712, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI212645202, Length=269, Percent_Identity=31.5985130111524, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322480, Length=307, Percent_Identity=26.7100977198697, Blast_Score=99, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 33231; Mature: 33100

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATAEPVVSELISLLSLERLEDNLFRGQSRDIGTKYVFGGQVLGQALAAAQATVENGRQ
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCH
AHSLHAYFLRAGNIDHPIVYDVDRTRDGGSFSVRRVTAIQHGKVIFFCAASFQEHEEGAE
HHHHEEEEEECCCCCCCEEEECCCCCCCCCEEEEEEEEECCCCEEEEEECCHHHHHHCHH
HQSAMPVVPPPEDIEPAAPLAPDVLAKLPAKVQRWLSRGGPFEFRHVFPRDELRPPKRPP
HHCCCCCCCCCCCCCCCCCCCHHHHHHCHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCC
FQQMWLRLNDPIGDDVGLHQALLAYASDFQLLGTSTFPHGISYYTPNVQMASLDHALWFH
HHHHHEECCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCEEECCCEEEECCCHHHHHC
RPFRTDDWLLYSLDSPTAQGARGLARGQFFTRDGVLVASTTQEGLIRVVPDGSAIAVPAK
CCCCCCCEEEEECCCCCHHHHHHHHCCCEEECCCEEEEECCCCCEEEEECCCCEEEECCC
E
C
>Mature Secondary Structure 
SATAEPVVSELISLLSLERLEDNLFRGQSRDIGTKYVFGGQVLGQALAAAQATVENGRQ
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCH
AHSLHAYFLRAGNIDHPIVYDVDRTRDGGSFSVRRVTAIQHGKVIFFCAASFQEHEEGAE
HHHHEEEEEECCCCCCCEEEECCCCCCCCCEEEEEEEEECCCCEEEEEECCHHHHHHCHH
HQSAMPVVPPPEDIEPAAPLAPDVLAKLPAKVQRWLSRGGPFEFRHVFPRDELRPPKRPP
HHCCCCCCCCCCCCCCCCCCCHHHHHHCHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCC
FQQMWLRLNDPIGDDVGLHQALLAYASDFQLLGTSTFPHGISYYTPNVQMASLDHALWFH
HHHHHEECCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCEEECCCEEEECCCHHHHHC
RPFRTDDWLLYSLDSPTAQGARGLARGQFFTRDGVLVASTTQEGLIRVVPDGSAIAVPAK
CCCCCCCEEEEECCCCCHHHHHHHHCCCEEECCCEEEEECCCCCEEEEECCCCEEEECCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]