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The map label for this gene is lexA

Identifier: 21241950

GI number: 21241950

Start: 1362326

End: 1362931

Strand: Direct

Name: lexA

Synonym: XAC1196

Alternate gene names: 21241950

Gene position: 1362326-1362931 (Clockwise)

Preceding gene: 21241947

Following gene: 21241951

Centisome position: 26.32

GC content: 67.49

Gene sequence:

>606_bases
ATGCCATCGCTTCCTCCCCAACGTGCCGCCGTGCTGGCGTTCCTGCAGGAGCAGGCCCAGGCAGGCGTCTCGCCCAGTCT
GGCCGAGATCGCGCAGGCCTTCGGGTTTGCCTCGCGCAATGCCGCACAAAAGCACGTGCAGGCGCTGGCCGACGCCGGGT
TGATCGAGCTGCTGCCCAATCAGAAACGTGGCATCCGTCTGCCGGGAGGCGCCGGTCGCGATGCATTGTTGGCCTTGCCG
GTGCTGGGGCGGGTGGCAGCAGGCCTGCCGATCGGTGCGGATATCGGCCTGGAGCGTCAGCTCTGGCTGGACCGCGCGCT
GTTTTCGCTGCGCCCGGATTACCTGCTGCAGGTGCAGGGGGATTCGATGATCGATGACGGCATTCTGGATGGCGACCTGG
TTGGCGTGCATCGCAGCAATGAGGCGCGCGACGGACAGATCGTGGTGGCGCGGGTGGATGGCGAAATCACCATCAAGCGC
CTGGAGCGCGGCGCCGAACGGATCCGCCTGCTGCCGCGCAATCGCGCGCATGCGCCGATCGTGGTGGCGGCCGATGCCGA
CTTCGCGATCGAAGGGCTGTACTGCGGCCTGATCCGGCAGGGCTGA

Upstream 100 bases:

>100_bases
GTCGCAAGTGCGTGCTGAAGCCGCTCAGCAAGCCAGTCTCGCCTGCTGCGATCGATGGGTGTACAAATGTACACCTTGTC
CCGTTCTGCTGCCGCGTCTC

Downstream 100 bases:

>100_bases
GATGAGCCAGGAGCCGGCGCGCATCAGCCAGGACGGCAATGCGGCAGTGGCACTGCCGCTGGACGCCCTGCTCGCCGCGC
GCACCGTCTGGCGTGCAGGC

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MPSLPPQRAAVLAFLQEQAQAGVSPSLAEIAQAFGFASRNAAQKHVQALADAGLIELLPNQKRGIRLPGGAGRDALLALP
VLGRVAAGLPIGADIGLERQLWLDRALFSLRPDYLLQVQGDSMIDDGILDGDLVGVHRSNEARDGQIVVARVDGEITIKR
LERGAERIRLLPRNRAHAPIVVAADADFAIEGLYCGLIRQG

Sequences:

>Translated_201_residues
MPSLPPQRAAVLAFLQEQAQAGVSPSLAEIAQAFGFASRNAAQKHVQALADAGLIELLPNQKRGIRLPGGAGRDALLALP
VLGRVAAGLPIGADIGLERQLWLDRALFSLRPDYLLQVQGDSMIDDGILDGDLVGVHRSNEARDGQIVVARVDGEITIKR
LERGAERIRLLPRNRAHAPIVVAADADFAIEGLYCGLIRQG
>Mature_200_residues
PSLPPQRAAVLAFLQEQAQAGVSPSLAEIAQAFGFASRNAAQKHVQALADAGLIELLPNQKRGIRLPGGAGRDALLALPV
LGRVAAGLPIGADIGLERQLWLDRALFSLRPDYLLQVQGDSMIDDGILDGDLVGVHRSNEARDGQIVVARVDGEITIKRL
ERGAERIRLLPRNRAHAPIVVAADADFAIEGLYCGLIRQG

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1790476, Length=203, Percent_Identity=43.8423645320197, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1787431, Length=127, Percent_Identity=33.0708661417323, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEXA1_XANAC (Q8PN77)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641532.1
- ProteinModelPortal:   Q8PN77
- SMR:   Q8PN77
- MEROPS:   S24.001
- GeneID:   1155267
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1196
- NMPDR:   fig|190486.1.peg.1176
- HOGENOM:   HBG679610
- OMA:   EWINGDI
- ProtClustDB:   PRK12423
- BioCyc:   XAXO190486:XAC1196-MONOMER
- BRENDA:   3.4.21.88
- GO:   GO:0006508
- GO:   GO:0006350
- HAMAP:   MF_00015
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.10.109.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00726
- TIGRFAMs:   TIGR00498

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.88

Molecular weight: Translated: 21442; Mature: 21311

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: ACT_SITE 122-122 ACT_SITE 159-159

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSLPPQRAAVLAFLQEQAQAGVSPSLAEIAQAFGFASRNAAQKHVQALADAGLIELLPN
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEECCC
QKRGIRLPGGAGRDALLALPVLGRVAAGLPIGADIGLERQLWLDRALFSLRPDYLLQVQG
CCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECC
DSMIDDGILDGDLVGVHRSNEARDGQIVVARVDGEITIKRLERGAERIRLLPRNRAHAPI
CCCCCCCCCCCCEEEEECCCCCCCCEEEEEEECCCEEHHHHHHHHHHHEECCCCCCCCCE
VVAADADFAIEGLYCGLIRQG
EEEECCCEEHHHHEEEEECCC
>Mature Secondary Structure 
PSLPPQRAAVLAFLQEQAQAGVSPSLAEIAQAFGFASRNAAQKHVQALADAGLIELLPN
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEECCC
QKRGIRLPGGAGRDALLALPVLGRVAAGLPIGADIGLERQLWLDRALFSLRPDYLLQVQG
CCCCEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECC
DSMIDDGILDGDLVGVHRSNEARDGQIVVARVDGEITIKRLERGAERIRLLPRNRAHAPI
CCCCCCCCCCCCEEEEECCCCCCCCEEEEEEECCCEEHHHHHHHHHHHEECCCCCCCCCE
VVAADADFAIEGLYCGLIRQG
EEEECCCEEHHHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217