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The map label for this gene is prpC [H]

Identifier: 21241892

GI number: 21241892

Start: 1287844

End: 1288998

Strand: Direct

Name: prpC [H]

Synonym: XAC1138

Alternate gene names: 21241892

Gene position: 1287844-1288998 (Clockwise)

Preceding gene: 21241891

Following gene: 21241893

Centisome position: 24.88

GC content: 61.65

Gene sequence:

>1155_bases
ATGAACGACACTGCCACTCCTGGTTTCAAGCCGAAAAAGTCCGTCGCCTTGTCCGGCACTGCTGCCGGTAACACGGCCCT
GTGCACGGTGGGGCGCAGCGGCAACGATCTGCATTACCGCGGTTACGACATTCTCGATCTGGCCACCACCAGCGAGTTCG
AAGAGATTGCGTATCTGCTGGTGCACGGCAAGCTGCCCAACCGCGGCGAGCTGCGCGGTTACAAGGCTAAGCTGCGCTCG
CTGCGCGGCGTTCCGGCTGCGGTCAAAACCGCGCTGGAACAGTTGCCTCCGTCGGCGCATCCGATGGACGTGATGCGCAC
CGGCGTGTCGGTGCTGGGCTGCCTGCAGCCGGAAAAAGACGACCATAACCACCCTGGTGCGCGCGACATCGCCGACAAGC
TGATGGCCTCGCTCGGTTCGATGCTGCTGTACTGGTATCACTACAGCCACAACGGCAAGCGCATCGAGGTAGAGACCGAG
GACGATTCCATCGGCGGGCATTTCCTGCACCTGCTGCATGGTTTCGCGCCCAAGGATTCGTGGGTGCGTGCGATGCATAC
CAGCCTGATCCTGTATGCCGAGCACGAATTCAATGCGTCCACCTTTGCGAGCCGCGTGATTGCCGGGACCGGCAGCGATA
TGTACAGCGCCATCGCCGGTGGCATCGGTGCGCTGCGTGGGCCCAAGCATGGCGGCGCCAACGAAGTGGCGTTCGAAGTG
CAGAAGCGCTACGACACCCCGGACGAAGCAGAAGCCGATATCAAGGCGCGCGTGGAACGCAAGGAAGTGGTGATTGGCTT
TGGGCACCCTGTGTACACGGTATCGGATCCGCGCAACAAGGTGATCAAGGTGGTGGCGCGCGAGCTGTCCGATGAACAGG
GCAGCCGCAAGATGTACGACATCGCCGAGCGTTTGGAGAGCGTGATGTGGGACATCAAGAAGATGTTCCCGAACCTGGAT
TGGTTCAGTGCGGTGAGCTACCACATGATGGGCGTGCCGACAGCGATGTTCACCCCCTTGTTCGTGCTGGCGCGCACAGC
CGGCTGGAGCGCGCACATCATCGAGCAGCGCGTGGACGGCAAGATCATTCGCCCCTCGGCCAATTACACCGGGCCGGAAG
ATCAGGTGTTCGTGCCGCTGGATCAGCGTTCTTGA

Upstream 100 bases:

>100_bases
GTTGTTTGCGCGCGAAGGCGCATGATGACGCGTTGCTGATCATCTTCATTGCCACCTCGCACGCCATACCGCGACACCAC
ACAGTTTGGGAGCTCATCGC

Downstream 100 bases:

>100_bases
GTCGCTATGAGGGCGATGCCGGCCCTCATTGCCTTATTCCCTGGTTTCCCCGTTCCCTCATCCGCCCTTCGGGCACCTTC
TCCCGCTTGCGGGAGAAGGA

Product: methylcitrate synthase

Products: NA

Alternate protein names: Citrate synthase 2; Methylcitrate synthase [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MNDTATPGFKPKKSVALSGTAAGNTALCTVGRSGNDLHYRGYDILDLATTSEFEEIAYLLVHGKLPNRGELRGYKAKLRS
LRGVPAAVKTALEQLPPSAHPMDVMRTGVSVLGCLQPEKDDHNHPGARDIADKLMASLGSMLLYWYHYSHNGKRIEVETE
DDSIGGHFLHLLHGFAPKDSWVRAMHTSLILYAEHEFNASTFASRVIAGTGSDMYSAIAGGIGALRGPKHGGANEVAFEV
QKRYDTPDEAEADIKARVERKEVVIGFGHPVYTVSDPRNKVIKVVARELSDEQGSRKMYDIAERLESVMWDIKKMFPNLD
WFSAVSYHMMGVPTAMFTPLFVLARTAGWSAHIIEQRVDGKIIRPSANYTGPEDQVFVPLDQRS

Sequences:

>Translated_384_residues
MNDTATPGFKPKKSVALSGTAAGNTALCTVGRSGNDLHYRGYDILDLATTSEFEEIAYLLVHGKLPNRGELRGYKAKLRS
LRGVPAAVKTALEQLPPSAHPMDVMRTGVSVLGCLQPEKDDHNHPGARDIADKLMASLGSMLLYWYHYSHNGKRIEVETE
DDSIGGHFLHLLHGFAPKDSWVRAMHTSLILYAEHEFNASTFASRVIAGTGSDMYSAIAGGIGALRGPKHGGANEVAFEV
QKRYDTPDEAEADIKARVERKEVVIGFGHPVYTVSDPRNKVIKVVARELSDEQGSRKMYDIAERLESVMWDIKKMFPNLD
WFSAVSYHMMGVPTAMFTPLFVLARTAGWSAHIIEQRVDGKIIRPSANYTGPEDQVFVPLDQRS
>Mature_384_residues
MNDTATPGFKPKKSVALSGTAAGNTALCTVGRSGNDLHYRGYDILDLATTSEFEEIAYLLVHGKLPNRGELRGYKAKLRS
LRGVPAAVKTALEQLPPSAHPMDVMRTGVSVLGCLQPEKDDHNHPGARDIADKLMASLGSMLLYWYHYSHNGKRIEVETE
DDSIGGHFLHLLHGFAPKDSWVRAMHTSLILYAEHEFNASTFASRVIAGTGSDMYSAIAGGIGALRGPKHGGANEVAFEV
QKRYDTPDEAEADIKARVERKEVVIGFGHPVYTVSDPRNKVIKVVARELSDEQGSRKMYDIAERLESVMWDIKKMFPNLD
WFSAVSYHMMGVPTAMFTPLFVLARTAGWSAHIIEQRVDGKIIRPSANYTGPEDQVFVPLDQRS

Specific function: Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786527, Length=389, Percent_Identity=75.0642673521851, Blast_Score=600, Evalue=1e-173,
Organism=Escherichia coli, GI1786939, Length=389, Percent_Identity=31.1053984575836, Blast_Score=180, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319850, Length=344, Percent_Identity=24.4186046511628, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324328, Length=345, Percent_Identity=25.2173913043478, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24640124, Length=341, Percent_Identity=23.4604105571848, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24640126, Length=344, Percent_Identity=23.546511627907, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.5 [H]

Molecular weight: Translated: 42382; Mature: 42382

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDTATPGFKPKKSVALSGTAAGNTALCTVGRSGNDLHYRGYDILDLATTSEFEEIAYLL
CCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCEECCCEEEEECCHHHHHHHEEHE
VHGKLPNRGELRGYKAKLRSLRGVPAAVKTALEQLPPSAHPMDVMRTGVSVLGCLQPEKD
EECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
DHNHPGARDIADKLMASLGSMLLYWYHYSHNGKRIEVETEDDSIGGHFLHLLHGFAPKDS
CCCCCCHHHHHHHHHHHHHHHHEEHEEEECCCCEEEEECCCCCCCHHHHHHHHCCCCCHH
WVRAMHTSLILYAEHEFNASTFASRVIAGTGSDMYSAIAGGIGALRGPKHGGANEVAFEV
HHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHCCHHHCCCCCCCCCCHHHHHH
QKRYDTPDEAEADIKARVERKEVVIGFGHPVYTVSDPRNKVIKVVARELSDEQGSRKMYD
HHHCCCCCCCCCHHHHHCCEEEEEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHH
IAERLESVMWDIKKMFPNLDWFSAVSYHMMGVPTAMFTPLFVLARTAGWSAHIIEQRVDG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHCCC
KIIRPSANYTGPEDQVFVPLDQRS
EEECCCCCCCCCCCCEEEECCCCC
>Mature Secondary Structure
MNDTATPGFKPKKSVALSGTAAGNTALCTVGRSGNDLHYRGYDILDLATTSEFEEIAYLL
CCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCEECCCEEEEECCHHHHHHHEEHE
VHGKLPNRGELRGYKAKLRSLRGVPAAVKTALEQLPPSAHPMDVMRTGVSVLGCLQPEKD
EECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
DHNHPGARDIADKLMASLGSMLLYWYHYSHNGKRIEVETEDDSIGGHFLHLLHGFAPKDS
CCCCCCHHHHHHHHHHHHHHHHEEHEEEECCCCEEEEECCCCCCCHHHHHHHHCCCCCHH
WVRAMHTSLILYAEHEFNASTFASRVIAGTGSDMYSAIAGGIGALRGPKHGGANEVAFEV
HHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHCCHHHCCCCCCCCCCHHHHHH
QKRYDTPDEAEADIKARVERKEVVIGFGHPVYTVSDPRNKVIKVVARELSDEQGSRKMYD
HHHCCCCCCCCCHHHHHCCEEEEEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHH
IAERLESVMWDIKKMFPNLDWFSAVSYHMMGVPTAMFTPLFVLARTAGWSAHIIEQRVDG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHCCC
KIIRPSANYTGPEDQVFVPLDQRS
EEECCCCCCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 8508809; 9325432 [H]