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The map label for this gene is lon [H]

Identifier: 21241840

GI number: 21241840

Start: 1235046

End: 1237517

Strand: Direct

Name: lon [H]

Synonym: XAC1080

Alternate gene names: 21241840

Gene position: 1235046-1237517 (Clockwise)

Preceding gene: 21241839

Following gene: 21241841

Centisome position: 23.86

GC content: 63.11

Gene sequence:

>2472_bases
ATGGCCCAGTCCCAACCAGAAGTTCTCGATCTGCCGGTGTTGCCGCTGCGCGACGTGGTGGTGTTTCCGCACATGGTGAT
CCCGCTGTTCGTCGGCCGCGACAAGTCGATGCGTGCGCTGGAAAAGGCGATGGAGGCGGACAAGCGCATCCTGCTCGTCG
CGCAGAAGTCGGCCGAGACCGACGACCCGGCTGCCGGCGATCTGTATACCGTCGGTACCCTGGCGCAGGTGCTGCAGCTT
CTCAAGCTCCCCGACGGCACCATCAAGGTGCTGGTCGAGGGTCTGTCACGGGTCACCGTGGACAAGGTTGTCGAGCAGGA
CGGCGCATTGCAGGGGCAGGGCACCGAAATCGAAGCCAGCGACGCGCGTGAGCCGCGCGAGGTGGAAGCGATTGCGCGGT
CGCTGATGTCGCTGTTCGAACAGTACGTCAAGACCAATCGCAAGCTGCCGCCGGAACTGCTGCAGACCTTGGCTGGCATC
GATGAGCCGGGCCGTCTGGCGGACACCATCGCCGCCCACATCGGTGTGCGTCTGGCCGACAAGCAGCGCCTGCTGGAGAT
CACCGACATCGGCGAGCGGCTGGAATTGCTGGTCGGCTTGGTCGATGGCGAAATCGACGTGCAGCAGCTGGAAAAGCGCA
TCCGCGGCCGCGTGAAGTCGCAGATGGAAAAGAGCCAGCGCGAGTACTACCTCAACGAGCAGATGAAGGCGATCCAGAAG
GAGCTGGGCGACCTGGACGATGCGCCTGGCGAGCTGGAAGAGCTGGCGCGCAAGATCGCCGAGGCGGGCATGCCCAAGCC
GGTCGAGACCAAGGCCAAGGCCGAGCTCAACAAACTCAAGCAGATGTCGCCGATGTCCGCTGAGGCAGCCGTGGTGCGCA
ATTACCTGGACTGGCTGCTGGGCGTGCCGTGGAAAAAGCGCACCAAAGTGCGCAAGGACCTCAAGGTTGCCGAAGACACG
CTGGACGCCGATCACTATGGCCTGGACAAGGTCAAGGAGCGCATCCTCGAGTACTTGGCGGTGCAGTCGCGCGTGAAGCA
GATGAAGGGGCCGATCCTGTGCCTGGTCGGTCCGCCGGGCGTGGGCAAGACCTCGCTCGGGCAGTCGATCGCCAAGGCGA
CCAACCGCAAGTTCGTGCGCATGAGCCTGGGCGGCATTCGCGACGAGGCCGAAATCCGTGGCCACCGCCGGACCTATGTC
GGTTCGATGCCGGGCCGCCTGGTGCAGAACCTCAACAAGGTCGGCAGCAAGAACCCGCTGTTCCTGCTGGACGAAATCGA
CAAGATGTCGATGGACTTCCGTGGCGACCCGTCGTCGGCACTGCTGGAAGTGCTCGATCCAGAGCAGAACAATTCGTTCA
ACGACCACTATCTGGAAGTCGATCTGGACCTGTCGGAGGTGATGTTCGTCGCCACCTCCAACTCGCTCAATATCCCGGGC
CCGTTGCTGGACCGCATGGAGGTGATCCGCATCCCCGGCTACACCGAGGATGAGAAGCTCAACATCGCCACGCGCTATCT
GGTGCCCAAGCAGATCAAGGCCAACGGCTTGAAGCCGGAGGAGATCGAGATCGCCAGCGATGCGATCCAGGACATCGTGC
GGTATTACACACGTGAGTCGGGTGTGCGTAATCTCGAACGCGAGGTGGCCAAGATCTGCCGCAAGGTGGTCAAGGAAATC
GCGCTCGCAGGTCCGCAACCGGCGGCCAAGAAGGCGGTCGCCAAGAAGGGCAAGCCGAAGGCGCTGGTCACCGTTAATGC
CAAGAATCTCGACAAGTATCTGGGCGTGCGTCGCTTCGACTTCGGCCGTGCCGAAGAAGAGAACGAGATCGGTCTGGTCA
CGGGTCTGGCATGGACCGAAGTCGGTGGTGAGCTGTTGCAGGTCGAGTCCACGTTGGTGCCAGGCAAGGGCAACCTGATC
CTCACCGGCCAGCTCGGCAATGTCATGAAGGAATCGGCATCGGCTGCATTGTCGGTGGTGCGTTCGCGCGCCGAGCGACT
TGGCATCGATGTGGATTTCCTGCAAAAGCAGGACGTGCATGTGCATGTGCCCGACGGCGCCACGCCCAAGGACGGCCCAA
GCGCAGGTATCGCGATGGTGACCTCGCTGGTGTCGATACTGACCCGGGTGCCGATCCGCGCCGATGTGGCGATGACCGGC
GAGATCACCCTGCGCGGGCGGGTATCGGCAATCGGTGGCTTGAAGGAGAAGTTGCTGGCGGCCCTGCGCGGCGGCATCCG
CACCGTGCTGATCCCCGACGAGAACCGCAAGGATCTGGCCGACATCCCGCCAAACGTGACCCGCGATCTGAAGATCGTGC
CGGTGAAGTGGATCGACGAGGTGCTCGATCTGGCGTTGGAACGTCCGCTTGCGCCGAAGAAGGCCAGCAAGGAAAAGGCA
CGCAAGGCGGCCTCGCGCGTGACCGTGCGCGGCAAGTCGCGTAGCACGCCCGGTACCCGCGTCAAGCACTAA

Upstream 100 bases:

>100_bases
CCGCTTTCCTAACGCTACTTGCAACACCTCGCCGATGGCCCCATAACGGGGCCATCGGCTTTTTACTGCCCCAAAAACCC
CCATTCCTGCGGAGTGCCCC

Downstream 100 bases:

>100_bases
CGAGGGCTGTCTGGGCCTCGCCAAAACAAGCCAAAACCCGCGTCGTTATTGGGTTTTGGCTTGCGTGCTGTTGGGGGCGC
TGGTATAAATGCACGACTCG

Product: ATP-dependent serine proteinase La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 823; Mature: 822

Protein sequence:

>823_residues
MAQSQPEVLDLPVLPLRDVVVFPHMVIPLFVGRDKSMRALEKAMEADKRILLVAQKSAETDDPAAGDLYTVGTLAQVLQL
LKLPDGTIKVLVEGLSRVTVDKVVEQDGALQGQGTEIEASDAREPREVEAIARSLMSLFEQYVKTNRKLPPELLQTLAGI
DEPGRLADTIAAHIGVRLADKQRLLEITDIGERLELLVGLVDGEIDVQQLEKRIRGRVKSQMEKSQREYYLNEQMKAIQK
ELGDLDDAPGELEELARKIAEAGMPKPVETKAKAELNKLKQMSPMSAEAAVVRNYLDWLLGVPWKKRTKVRKDLKVAEDT
LDADHYGLDKVKERILEYLAVQSRVKQMKGPILCLVGPPGVGKTSLGQSIAKATNRKFVRMSLGGIRDEAEIRGHRRTYV
GSMPGRLVQNLNKVGSKNPLFLLDEIDKMSMDFRGDPSSALLEVLDPEQNNSFNDHYLEVDLDLSEVMFVATSNSLNIPG
PLLDRMEVIRIPGYTEDEKLNIATRYLVPKQIKANGLKPEEIEIASDAIQDIVRYYTRESGVRNLEREVAKICRKVVKEI
ALAGPQPAAKKAVAKKGKPKALVTVNAKNLDKYLGVRRFDFGRAEEENEIGLVTGLAWTEVGGELLQVESTLVPGKGNLI
LTGQLGNVMKESASAALSVVRSRAERLGIDVDFLQKQDVHVHVPDGATPKDGPSAGIAMVTSLVSILTRVPIRADVAMTG
EITLRGRVSAIGGLKEKLLAALRGGIRTVLIPDENRKDLADIPPNVTRDLKIVPVKWIDEVLDLALERPLAPKKASKEKA
RKAASRVTVRGKSRSTPGTRVKH

Sequences:

>Translated_823_residues
MAQSQPEVLDLPVLPLRDVVVFPHMVIPLFVGRDKSMRALEKAMEADKRILLVAQKSAETDDPAAGDLYTVGTLAQVLQL
LKLPDGTIKVLVEGLSRVTVDKVVEQDGALQGQGTEIEASDAREPREVEAIARSLMSLFEQYVKTNRKLPPELLQTLAGI
DEPGRLADTIAAHIGVRLADKQRLLEITDIGERLELLVGLVDGEIDVQQLEKRIRGRVKSQMEKSQREYYLNEQMKAIQK
ELGDLDDAPGELEELARKIAEAGMPKPVETKAKAELNKLKQMSPMSAEAAVVRNYLDWLLGVPWKKRTKVRKDLKVAEDT
LDADHYGLDKVKERILEYLAVQSRVKQMKGPILCLVGPPGVGKTSLGQSIAKATNRKFVRMSLGGIRDEAEIRGHRRTYV
GSMPGRLVQNLNKVGSKNPLFLLDEIDKMSMDFRGDPSSALLEVLDPEQNNSFNDHYLEVDLDLSEVMFVATSNSLNIPG
PLLDRMEVIRIPGYTEDEKLNIATRYLVPKQIKANGLKPEEIEIASDAIQDIVRYYTRESGVRNLEREVAKICRKVVKEI
ALAGPQPAAKKAVAKKGKPKALVTVNAKNLDKYLGVRRFDFGRAEEENEIGLVTGLAWTEVGGELLQVESTLVPGKGNLI
LTGQLGNVMKESASAALSVVRSRAERLGIDVDFLQKQDVHVHVPDGATPKDGPSAGIAMVTSLVSILTRVPIRADVAMTG
EITLRGRVSAIGGLKEKLLAALRGGIRTVLIPDENRKDLADIPPNVTRDLKIVPVKWIDEVLDLALERPLAPKKASKEKA
RKAASRVTVRGKSRSTPGTRVKH
>Mature_822_residues
AQSQPEVLDLPVLPLRDVVVFPHMVIPLFVGRDKSMRALEKAMEADKRILLVAQKSAETDDPAAGDLYTVGTLAQVLQLL
KLPDGTIKVLVEGLSRVTVDKVVEQDGALQGQGTEIEASDAREPREVEAIARSLMSLFEQYVKTNRKLPPELLQTLAGID
EPGRLADTIAAHIGVRLADKQRLLEITDIGERLELLVGLVDGEIDVQQLEKRIRGRVKSQMEKSQREYYLNEQMKAIQKE
LGDLDDAPGELEELARKIAEAGMPKPVETKAKAELNKLKQMSPMSAEAAVVRNYLDWLLGVPWKKRTKVRKDLKVAEDTL
DADHYGLDKVKERILEYLAVQSRVKQMKGPILCLVGPPGVGKTSLGQSIAKATNRKFVRMSLGGIRDEAEIRGHRRTYVG
SMPGRLVQNLNKVGSKNPLFLLDEIDKMSMDFRGDPSSALLEVLDPEQNNSFNDHYLEVDLDLSEVMFVATSNSLNIPGP
LLDRMEVIRIPGYTEDEKLNIATRYLVPKQIKANGLKPEEIEIASDAIQDIVRYYTRESGVRNLEREVAKICRKVVKEIA
LAGPQPAAKKAVAKKGKPKALVTVNAKNLDKYLGVRRFDFGRAEEENEIGLVTGLAWTEVGGELLQVESTLVPGKGNLIL
TGQLGNVMKESASAALSVVRSRAERLGIDVDFLQKQDVHVHVPDGATPKDGPSAGIAMVTSLVSILTRVPIRADVAMTGE
ITLRGRVSAIGGLKEKLLAALRGGIRTVLIPDENRKDLADIPPNVTRDLKIVPVKWIDEVLDLALERPLAPKKASKEKAR
KAASRVTVRGKSRSTPGTRVKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=782, Percent_Identity=39.2583120204604, Blast_Score=525, Evalue=1e-148,
Organism=Homo sapiens, GI21396489, Length=846, Percent_Identity=37.7068557919622, Blast_Score=514, Evalue=1e-145,
Organism=Escherichia coli, GI1786643, Length=787, Percent_Identity=65.9466327827192, Blast_Score=1048, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=655, Percent_Identity=41.2213740458015, Blast_Score=499, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17556486, Length=814, Percent_Identity=32.5552825552826, Blast_Score=416, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6319449, Length=722, Percent_Identity=40.9972299168975, Blast_Score=517, Evalue=1e-147,
Organism=Drosophila melanogaster, GI221513036, Length=692, Percent_Identity=41.907514450867, Blast_Score=527, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24666867, Length=692, Percent_Identity=41.907514450867, Blast_Score=526, Evalue=1e-149,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 90640; Mature: 90509

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQSQPEVLDLPVLPLRDVVVFPHMVIPLFVGRDKSMRALEKAMEADKRILLVAQKSAET
CCCCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCC
DDPAAGDLYTVGTLAQVLQLLKLPDGTIKVLVEGLSRVTVDKVVEQDGALQGQGTEIEAS
CCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCC
DAREPREVEAIARSLMSLFEQYVKTNRKLPPELLQTLAGIDEPGRLADTIAAHIGVRLAD
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCEEEC
KQRLLEITDIGERLELLVGLVDGEIDVQQLEKRIRGRVKSQMEKSQREYYLNEQMKAIQK
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELGDLDDAPGELEELARKIAEAGMPKPVETKAKAELNKLKQMSPMSAEAAVVRNYLDWLL
HHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
GVPWKKRTKVRKDLKVAEDTLDADHYGLDKVKERILEYLAVQSRVKQMKGPILCLVGPPG
CCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
VGKTSLGQSIAKATNRKFVRMSLGGIRDEAEIRGHRRTYVGSMPGRLVQNLNKVGSKNPL
CCHHHHHHHHHHHHCCEEEEEHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCCE
FLLDEIDKMSMDFRGDPSSALLEVLDPEQNNSFNDHYLEVDLDLSEVMFVATSNSLNIPG
EEEECHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCHHHEEEEEECCCCCCCC
PLLDRMEVIRIPGYTEDEKLNIATRYLVPKQIKANGLKPEEIEIASDAIQDIVRYYTRES
HHHCCHHEEECCCCCCCCCCCHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
GVRNLEREVAKICRKVVKEIALAGPQPAAKKAVAKKGKPKALVTVNAKNLDKYLGVRRFD
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHCCHHCC
FGRAEEENEIGLVTGLAWTEVGGELLQVESTLVPGKGNLILTGQLGNVMKESASAALSVV
CCCCCCCCCCEEEECCHHHHHCCHHEEEHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHH
RSRAERLGIDVDFLQKQDVHVHVPDGATPKDGPSAGIAMVTSLVSILTRVPIRADVAMTG
HHHHHHHCCCHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECEEEEC
EITLRGRVSAIGGLKEKLLAALRGGIRTVLIPDENRKDLADIPPNVTRDLKIVPVKWIDE
EEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHCCCCCCCCCCEEEEHHHHHH
VLDLALERPLAPKKASKEKARKAASRVTVRGKSRSTPGTRVKH
HHHHHHHCCCCCCCCHHHHHHHHHHHEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
AQSQPEVLDLPVLPLRDVVVFPHMVIPLFVGRDKSMRALEKAMEADKRILLVAQKSAET
CCCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCC
DDPAAGDLYTVGTLAQVLQLLKLPDGTIKVLVEGLSRVTVDKVVEQDGALQGQGTEIEAS
CCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCC
DAREPREVEAIARSLMSLFEQYVKTNRKLPPELLQTLAGIDEPGRLADTIAAHIGVRLAD
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCEEEC
KQRLLEITDIGERLELLVGLVDGEIDVQQLEKRIRGRVKSQMEKSQREYYLNEQMKAIQK
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELGDLDDAPGELEELARKIAEAGMPKPVETKAKAELNKLKQMSPMSAEAAVVRNYLDWLL
HHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
GVPWKKRTKVRKDLKVAEDTLDADHYGLDKVKERILEYLAVQSRVKQMKGPILCLVGPPG
CCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
VGKTSLGQSIAKATNRKFVRMSLGGIRDEAEIRGHRRTYVGSMPGRLVQNLNKVGSKNPL
CCHHHHHHHHHHHHCCEEEEEHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCCE
FLLDEIDKMSMDFRGDPSSALLEVLDPEQNNSFNDHYLEVDLDLSEVMFVATSNSLNIPG
EEEECHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCHHHEEEEEECCCCCCCC
PLLDRMEVIRIPGYTEDEKLNIATRYLVPKQIKANGLKPEEIEIASDAIQDIVRYYTRES
HHHCCHHEEECCCCCCCCCCCHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
GVRNLEREVAKICRKVVKEIALAGPQPAAKKAVAKKGKPKALVTVNAKNLDKYLGVRRFD
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHCCHHCC
FGRAEEENEIGLVTGLAWTEVGGELLQVESTLVPGKGNLILTGQLGNVMKESASAALSVV
CCCCCCCCCCEEEECCHHHHHCCHHEEEHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHH
RSRAERLGIDVDFLQKQDVHVHVPDGATPKDGPSAGIAMVTSLVSILTRVPIRADVAMTG
HHHHHHHCCCHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECEEEEC
EITLRGRVSAIGGLKEKLLAALRGGIRTVLIPDENRKDLADIPPNVTRDLKIVPVKWIDE
EEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHCCCCCCCCCCEEEEHHHHHH
VLDLALERPLAPKKASKEKARKAASRVTVRGKSRSTPGTRVKH
HHHHHHHCCCCCCCCHHHHHHHHHHHEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA