Click here to switch to the map view.

The map label for this gene is icd [H]

Identifier: 21241811

GI number: 21241811

Start: 1207000

End: 1208007

Strand: Direct

Name: icd [H]

Synonym: XAC1046

Alternate gene names: 21241811

Gene position: 1207000-1208007 (Clockwise)

Preceding gene: 21241810

Following gene: 21241813

Centisome position: 23.32

GC content: 64.58

Gene sequence:

>1008_bases
ATGACGCAGACAATCACGGTCATCCGCGGCGACGGCATCGGCCCGGAGATCATGGATGCCACGCTGTTCGTGCTCGACGC
GCTGCAGGCTGGCCTGACCTACGAATACGCCGACGCCGGCCTGGTTGCGCTGGAAAAGCATGGCGATCTGCTGCCCGAGT
CCACTCTGGCGTCGATCACCAAGAACAAGGTGGCGCTGAAAAGTCCGCTGACCACGCCGGTCGGCGAGGGTTTCAGCTCG
ATCAACGTCGCCATGCGTCGCAAGTTCGACCTGTACGCCAACGTGCGTCCGGCCAAGTCGTTCCCGAACACCAAGTCGCG
TTTTGCCGACGGCGTTGACCTGATCACGGTCCGCGAAAACACCGAAGGTGCGTATCTGAGCGAAGGCCAGACGGTGTCCG
AGGATGGCGAGACCGCGTTCTCCGGCACCCGGATCACCCGCAAGGGCTCCGAGCGCATCGTGCGCTACGCCTTCGAGCTG
GCCAAGAGCACCGGCCGCAAGAAGGTCACCGCCGTGCACAAGGCCAACATCATCAAGTCGACCTCGGGCCTGTTCCTGAA
GGTGGCACGCGATGTGGCCGCGCAGTATCCGGAAATCGAATTCCAGGAAATGATCGTCGACAACACCTGCATGCAGCTGG
TGATGCGTCCCGAGCAATTCGACATCATCGTGACCACCAACCTGTTCGGCGACATCATCTCCGACCTGTGCGCCGGCCTG
GTCGGCGGCCTGGGCCTGGCGCCGGGCGCCAACATCGGTCTGGACGCGGCGATCTTCGAAGCCGTGCACGGCTCGGCGCC
GGATATCGCAGGGCAGGGCAAGGCCAACCCGTGCGCGCTGCTGCTTGGCGCGGCGCAGATGCTCGACCACATCGGTCAGC
CGCAGAATGCCGAGCGCCTGCGCGAAGCCATCGTCGCCACCCTGGAAGCCAAGGATTCGCTGACCCCCGACCTGGGCGGC
ACCGGCAACACCATGGGCTTTGCCAAGGCCATCGCCAGCCGCCTCTGA

Upstream 100 bases:

>100_bases
TTCACCGGCATCGGGCATAATTGCCCGTGAAACCTCCTTGCGCCGCTTTGCCGGGTATTGCGGCTGGCGCTCCCCCCTTC
AAGTTCGGAAACCCAACGTT

Downstream 100 bases:

>100_bases
GCGCACTGGGTGATCGCTTAAACAAAAGGCGCCTAGGCGCCTTTTGTTTTGCTCGGAAGTCGCTGAGAAGCCGTATCTGC
TTATCGATTGCAGGAAATCG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: 3-IPM-DH; IMDH; Beta-IPM dehydrogenase [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTQTITVIRGDGIGPEIMDATLFVLDALQAGLTYEYADAGLVALEKHGDLLPESTLASITKNKVALKSPLTTPVGEGFSS
INVAMRRKFDLYANVRPAKSFPNTKSRFADGVDLITVRENTEGAYLSEGQTVSEDGETAFSGTRITRKGSERIVRYAFEL
AKSTGRKKVTAVHKANIIKSTSGLFLKVARDVAAQYPEIEFQEMIVDNTCMQLVMRPEQFDIIVTTNLFGDIISDLCAGL
VGGLGLAPGANIGLDAAIFEAVHGSAPDIAGQGKANPCALLLGAAQMLDHIGQPQNAERLREAIVATLEAKDSLTPDLGG
TGNTMGFAKAIASRL

Sequences:

>Translated_335_residues
MTQTITVIRGDGIGPEIMDATLFVLDALQAGLTYEYADAGLVALEKHGDLLPESTLASITKNKVALKSPLTTPVGEGFSS
INVAMRRKFDLYANVRPAKSFPNTKSRFADGVDLITVRENTEGAYLSEGQTVSEDGETAFSGTRITRKGSERIVRYAFEL
AKSTGRKKVTAVHKANIIKSTSGLFLKVARDVAAQYPEIEFQEMIVDNTCMQLVMRPEQFDIIVTTNLFGDIISDLCAGL
VGGLGLAPGANIGLDAAIFEAVHGSAPDIAGQGKANPCALLLGAAQMLDHIGQPQNAERLREAIVATLEAKDSLTPDLGG
TGNTMGFAKAIASRL
>Mature_334_residues
TQTITVIRGDGIGPEIMDATLFVLDALQAGLTYEYADAGLVALEKHGDLLPESTLASITKNKVALKSPLTTPVGEGFSSI
NVAMRRKFDLYANVRPAKSFPNTKSRFADGVDLITVRENTEGAYLSEGQTVSEDGETAFSGTRITRKGSERIVRYAFELA
KSTGRKKVTAVHKANIIKSTSGLFLKVARDVAAQYPEIEFQEMIVDNTCMQLVMRPEQFDIIVTTNLFGDIISDLCAGLV
GGLGLAPGANIGLDAAIFEAVHGSAPDIAGQGKANPCALLLGAAQMLDHIGQPQNAERLREAIVATLEAKDSLTPDLGGT
GNTMGFAKAIASRL

Specific function: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate [H]

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=334, Percent_Identity=46.7065868263473, Blast_Score=295, Evalue=3e-80,
Organism=Homo sapiens, GI4758582, Length=326, Percent_Identity=45.0920245398773, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI28178838, Length=318, Percent_Identity=44.3396226415094, Blast_Score=238, Evalue=4e-63,
Organism=Homo sapiens, GI28178821, Length=338, Percent_Identity=39.9408284023669, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI28178816, Length=338, Percent_Identity=39.6449704142012, Blast_Score=224, Evalue=6e-59,
Organism=Homo sapiens, GI28178819, Length=193, Percent_Identity=44.559585492228, Blast_Score=166, Evalue=2e-41,
Organism=Escherichia coli, GI1788101, Length=355, Percent_Identity=36.056338028169, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI1787381, Length=359, Percent_Identity=35.0974930362117, Blast_Score=194, Evalue=9e-51,
Organism=Escherichia coli, GI87081683, Length=307, Percent_Identity=36.8078175895765, Blast_Score=185, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI71986051, Length=334, Percent_Identity=45.5089820359281, Blast_Score=297, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI25144293, Length=334, Percent_Identity=42.5149700598802, Blast_Score=247, Evalue=8e-66,
Organism=Caenorhabditis elegans, GI17550882, Length=339, Percent_Identity=41.2979351032448, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17505779, Length=322, Percent_Identity=40.3726708074534, Blast_Score=219, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6324709, Length=336, Percent_Identity=43.1547619047619, Blast_Score=273, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6324291, Length=338, Percent_Identity=39.6449704142012, Blast_Score=227, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6322097, Length=352, Percent_Identity=37.7840909090909, Blast_Score=211, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6319830, Length=360, Percent_Identity=29.1666666666667, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24643270, Length=335, Percent_Identity=45.6716417910448, Blast_Score=301, Evalue=6e-82,
Organism=Drosophila melanogaster, GI24643268, Length=335, Percent_Identity=45.6716417910448, Blast_Score=300, Evalue=7e-82,
Organism=Drosophila melanogaster, GI24661184, Length=339, Percent_Identity=41.5929203539823, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI161078637, Length=333, Percent_Identity=39.3393393393393, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI161078633, Length=333, Percent_Identity=39.3393393393393, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24650122, Length=333, Percent_Identity=39.3393393393393, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI161078635, Length=333, Percent_Identity=39.3393393393393, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI161078639, Length=326, Percent_Identity=39.8773006134969, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI281362242, Length=335, Percent_Identity=40.8955223880597, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24648872, Length=335, Percent_Identity=40.8955223880597, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI20130355, Length=335, Percent_Identity=28.3582089552239, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI45550436, Length=233, Percent_Identity=24.4635193133047, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011828 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.85 [H]

Molecular weight: Translated: 35590; Mature: 35459

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTITVIRGDGIGPEIMDATLFVLDALQAGLTYEYADAGLVALEKHGDLLPESTLASIT
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEECCCCEEEEECCCCCCCHHHHHHHH
KNKVALKSPLTTPVGEGFSSINVAMRRKFDLYANVRPAKSFPNTKSRFADGVDLITVREN
HCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCEEEEEEEC
TEGAYLSEGQTVSEDGETAFSGTRITRKGSERIVRYAFELAKSTGRKKVTAVHKANIIKS
CCCCEECCCCEECCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
TSGLFLKVARDVAAQYPEIEFQEMIVDNTCMQLVMRPEQFDIIVTTNLFGDIISDLCAGL
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHH
VGGLGLAPGANIGLDAAIFEAVHGSAPDIAGQGKANPCALLLGAAQMLDHIGQPQNAERL
HCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHH
REAIVATLEAKDSLTPDLGGTGNTMGFAKAIASRL
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TQTITVIRGDGIGPEIMDATLFVLDALQAGLTYEYADAGLVALEKHGDLLPESTLASIT
CCEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEECCCCEEEEECCCCCCCHHHHHHHH
KNKVALKSPLTTPVGEGFSSINVAMRRKFDLYANVRPAKSFPNTKSRFADGVDLITVREN
HCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCEEEEEEEC
TEGAYLSEGQTVSEDGETAFSGTRITRKGSERIVRYAFELAKSTGRKKVTAVHKANIIKS
CCCCEECCCCEECCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
TSGLFLKVARDVAAQYPEIEFQEMIVDNTCMQLVMRPEQFDIIVTTNLFGDIISDLCAGL
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHH
VGGLGLAPGANIGLDAAIFEAVHGSAPDIAGQGKANPCALLLGAAQMLDHIGQPQNAERL
HCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHH
REAIVATLEAKDSLTPDLGGTGNTMGFAKAIASRL
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]