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The map label for this gene is mdh [H]

Identifier: 21241771

GI number: 21241771

Start: 1160899

End: 1161885

Strand: Direct

Name: mdh [H]

Synonym: XAC1006

Alternate gene names: 21241771

Gene position: 1160899-1161885 (Clockwise)

Preceding gene: 21241770

Following gene: 21241774

Centisome position: 22.43

GC content: 64.34

Gene sequence:

>987_bases
ATGAAAGCACCTGTTCGTGTTGCTGTGACCGGCGCTGCCGGCCAGATCGGCTATGCCCTGCTGTTCCGCATCGCTTCCGG
CGAAATGCTGGGCAAGGACCAACCGGTCATTCTGCAGTTGCTTGAACTGCCGATTGAGAAGGCCCAGGCCGCCCTCAAGG
GCGTGATGATGGAACTGGAAGACTGCGCGTTCCCGTTGCTGGCCGGCATGGTCGGTACCGACGACGCCGAAGTGGCCTTC
AAGGACGTCGATGTCGCCCTGCTGGTCGGTTCGCGTCCGCGCGGCCCGGGCATGGAGCGCAAGGACCTGCTGCTGGCCAA
TGCGGAGATCTTCACCGCACAGGGCGCGGCCCTGAACAAGGTCGCCAAGCGCGACGTGAAGGTGCTGGTGGTCGGCAATC
CGGCCAACACCAACGCCTACATCGCCATGAAGTCGGCGCCGGACCTGGACCCGAAGAATTTCACCGCCATGCTGCGCCTG
GACCACAACCGTGCGCTGAGCCAGCTCTCGGCCAAGCTCGGCAAGCCGGTGGCCGGCATCGAGAAGCTGGCGGTGTGGGG
TAACCACAGCCCGACCATGTACCCGGATTATCGTTTCGCCACCGCCGATGGCGCCTCCATCGGCGATGCGATCAACGACC
AGGAGTGGAACGCTTCCACGTTCATCCCGACCGTGGGCAAGCGCGGCGCGGCGATCATCGAAGCGCGTGGCCTGTCCTCG
GCTGCCTCCGCGGCCAATGCCGCCATCGACCACATCCGTGACTGGGTGCTGGGCACCAGCGGTAAGTGGGTGACGATGGG
CGTGCCGTCGGACGGCTCCTACGGCATTCCGGAAGGCGTGATGTTCGGCTTCCCGGTCACCACCGAAAATGGCAAGTACA
CCATCGTCAAGGATCTGCCGATCGACGACTTCAGCCAGAAGTACATCGACAAGACCCTGGCCGAGCTGGAAGAAGAGCGC
AGCGGCGTGGCGCACCTGCTGGGCTGA

Upstream 100 bases:

>100_bases
CCGCCATGTGCGGCCGTTCGCTTGTCAATGCGCGCCGCCAGGCCTTGCGCCCCGCCAGCGTACGACCCTTACCAACGTTT
TTTAGCAGAGGAAACACCCC

Downstream 100 bases:

>100_bases
GTTGGTCGATCACGGCAGTCATGAAAACGCCGGGCATTGCCCGGCGTTTTTGTTATTACGCGTCGTGTGGCAAACGGCTG
CGCTGCCAGGCCAGACCCTC

Product: malate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MKAPVRVAVTGAAGQIGYALLFRIASGEMLGKDQPVILQLLELPIEKAQAALKGVMMELEDCAFPLLAGMVGTDDAEVAF
KDVDVALLVGSRPRGPGMERKDLLLANAEIFTAQGAALNKVAKRDVKVLVVGNPANTNAYIAMKSAPDLDPKNFTAMLRL
DHNRALSQLSAKLGKPVAGIEKLAVWGNHSPTMYPDYRFATADGASIGDAINDQEWNASTFIPTVGKRGAAIIEARGLSS
AASAANAAIDHIRDWVLGTSGKWVTMGVPSDGSYGIPEGVMFGFPVTTENGKYTIVKDLPIDDFSQKYIDKTLAELEEER
SGVAHLLG

Sequences:

>Translated_328_residues
MKAPVRVAVTGAAGQIGYALLFRIASGEMLGKDQPVILQLLELPIEKAQAALKGVMMELEDCAFPLLAGMVGTDDAEVAF
KDVDVALLVGSRPRGPGMERKDLLLANAEIFTAQGAALNKVAKRDVKVLVVGNPANTNAYIAMKSAPDLDPKNFTAMLRL
DHNRALSQLSAKLGKPVAGIEKLAVWGNHSPTMYPDYRFATADGASIGDAINDQEWNASTFIPTVGKRGAAIIEARGLSS
AASAANAAIDHIRDWVLGTSGKWVTMGVPSDGSYGIPEGVMFGFPVTTENGKYTIVKDLPIDDFSQKYIDKTLAELEEER
SGVAHLLG
>Mature_328_residues
MKAPVRVAVTGAAGQIGYALLFRIASGEMLGKDQPVILQLLELPIEKAQAALKGVMMELEDCAFPLLAGMVGTDDAEVAF
KDVDVALLVGSRPRGPGMERKDLLLANAEIFTAQGAALNKVAKRDVKVLVVGNPANTNAYIAMKSAPDLDPKNFTAMLRL
DHNRALSQLSAKLGKPVAGIEKLAVWGNHSPTMYPDYRFATADGASIGDAINDQEWNASTFIPTVGKRGAAIIEARGLSS
AASAANAAIDHIRDWVLGTSGKWVTMGVPSDGSYGIPEGVMFGFPVTTENGKYTIVKDLPIDDFSQKYIDKTLAELEEER
SGVAHLLG

Specific function: Catalyzes the reversible oxidation of malate to oxaloacetate [H]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. MDH type 2 family [H]

Homologues:

Organism=Homo sapiens, GI5174539, Length=333, Percent_Identity=52.2522522522522, Blast_Score=341, Evalue=7e-94,
Organism=Homo sapiens, GI89886456, Length=337, Percent_Identity=24.6290801186944, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17561064, Length=326, Percent_Identity=53.680981595092, Blast_Score=319, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI32566798, Length=264, Percent_Identity=53.030303030303, Blast_Score=249, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI32566800, Length=169, Percent_Identity=51.4792899408284, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24583394, Length=325, Percent_Identity=54.7692307692308, Blast_Score=328, Evalue=3e-90,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR010945
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.37 [H]

Molecular weight: Translated: 34851; Mature: 34851

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAPVRVAVTGAAGQIGYALLFRIASGEMLGKDQPVILQLLELPIEKAQAALKGVMMELE
CCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
DCAFPLLAGMVGTDDAEVAFKDVDVALLVGSRPRGPGMERKDLLLANAEIFTAQGAALNK
HHHHHHHHHHCCCCCCCEEEEECCEEEEECCCCCCCCCCCCCEEEECCEEEEECCHHHHH
VAKRDVKVLVVGNPANTNAYIAMKSAPDLDPKNFTAMLRLDHNRALSQLSAKLGKPVAGI
HHHCCEEEEEECCCCCCCEEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCHHCH
EKLAVWGNHSPTMYPDYRFATADGASIGDAINDQEWNASTFIPTVGKRGAAIIEARGLSS
HHEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCH
AASAANAAIDHIRDWVLGTSGKWVTMGVPSDGSYGIPEGVMFGFPVTTENGKYTIVKDLP
HHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEECEEECCCCCEEEEECCC
IDDFSQKYIDKTLAELEEERSGVAHLLG
CCHHHHHHHHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure
MKAPVRVAVTGAAGQIGYALLFRIASGEMLGKDQPVILQLLELPIEKAQAALKGVMMELE
CCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
DCAFPLLAGMVGTDDAEVAFKDVDVALLVGSRPRGPGMERKDLLLANAEIFTAQGAALNK
HHHHHHHHHHCCCCCCCEEEEECCEEEEECCCCCCCCCCCCCEEEECCEEEEECCHHHHH
VAKRDVKVLVVGNPANTNAYIAMKSAPDLDPKNFTAMLRLDHNRALSQLSAKLGKPVAGI
HHHCCEEEEEECCCCCCCEEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCHHCH
EKLAVWGNHSPTMYPDYRFATADGASIGDAINDQEWNASTFIPTVGKRGAAIIEARGLSS
HHEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCH
AASAANAAIDHIRDWVLGTSGKWVTMGVPSDGSYGIPEGVMFGFPVTTENGKYTIVKDLP
HHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEECEEECCCCCEEEEECCC
IDDFSQKYIDKTLAELEEERSGVAHLLG
CCHHHHHHHHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA