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The map label for this gene is pth [H]

Identifier: 21241721

GI number: 21241721

Start: 1113814

End: 1114395

Strand: Direct

Name: pth [H]

Synonym: XAC0952

Alternate gene names: 21241721

Gene position: 1113814-1114395 (Clockwise)

Preceding gene: 21241720

Following gene: 21241722

Centisome position: 21.52

GC content: 64.09

Gene sequence:

>582_bases
ATGACTGCACTCCGCCTGATCGTCGGGCTCGGCAATCCGGGCCCGGAACACGCGCAAACCCGGCATAACGCCGGGTTTCG
TTTCGTCGATGCCCTCATCGAGCGCAGTGGCGCCCGCTGGGCATTGGACAGCAAGTTGTTCGGCGAGACCGCCAAGGTCG
AGGTCGCGGGACAACCGGTCTGGCTGCTCAAGCCGGCTACCTTCATGAATCTCAGCGGCAAGTCGATCACCGCCGCATTG
CGGTTCTGGAAGATCGAGCCCGAACACCTGCTGGTCGCCCACGACGAACTGGATCTGGCGCCCGGTACCGCGCGGCTCAA
GTTCGACGGCGGTCACGGCGGGCAAAACGGCTTGCGCGACACCATTCGCCTGCTCGGGCACGGCAAATTTCACCGTCTAC
GCGTTGGCATCGGTCATCCCGGTCATAAGGATCGCGTGGTGCCCTGGGTGCTGGGGCGGGCAGGGCGCGAGGACGATGCG
GCGATCGGCGCTGCGGTGGACGCCGCCATCGATGTGCTGCCGCTGGCGATGGAAGGCAATTTCAACGAGGCGATGAAACG
CCTGCACACCGAAAAAAAATAG

Upstream 100 bases:

>100_bases
AGACGACGCTGCCGGCGAAGAAGGCAGCGAAGGCGCCGAGACCAAGTAATCCGTCGGCCGATCCCCTGCATTGCGCGCGG
GATCGGCTGCGGTCACTGGC

Downstream 100 bases:

>100_bases
AGAATGGGGAATAGGGAATGGACAGGGCGCTGCTCCTGCCATTCTCCATTCCCGATTCTCCATTCACTGGAAAACCCATG
GGTATCAAATGCGGCATCGT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MTALRLIVGLGNPGPEHAQTRHNAGFRFVDALIERSGARWALDSKLFGETAKVEVAGQPVWLLKPATFMNLSGKSITAAL
RFWKIEPEHLLVAHDELDLAPGTARLKFDGGHGGQNGLRDTIRLLGHGKFHRLRVGIGHPGHKDRVVPWVLGRAGREDDA
AIGAAVDAAIDVLPLAMEGNFNEAMKRLHTEKK

Sequences:

>Translated_193_residues
MTALRLIVGLGNPGPEHAQTRHNAGFRFVDALIERSGARWALDSKLFGETAKVEVAGQPVWLLKPATFMNLSGKSITAAL
RFWKIEPEHLLVAHDELDLAPGTARLKFDGGHGGQNGLRDTIRLLGHGKFHRLRVGIGHPGHKDRVVPWVLGRAGREDDA
AIGAAVDAAIDVLPLAMEGNFNEAMKRLHTEKK
>Mature_192_residues
TALRLIVGLGNPGPEHAQTRHNAGFRFVDALIERSGARWALDSKLFGETAKVEVAGQPVWLLKPATFMNLSGKSITAALR
FWKIEPEHLLVAHDELDLAPGTARLKFDGGHGGQNGLRDTIRLLGHGKFHRLRVGIGHPGHKDRVVPWVLGRAGREDDAA
IGAAVDAAIDVLPLAMEGNFNEAMKRLHTEKK

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=170, Percent_Identity=32.9411764705882, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1787455, Length=191, Percent_Identity=50.261780104712, Blast_Score=164, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321983, Length=157, Percent_Identity=33.1210191082803, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21020; Mature: 20889

Theoretical pI: Translated: 10.36; Mature: 10.36

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALRLIVGLGNPGPEHAQTRHNAGFRFVDALIERSGARWALDSKLFGETAKVEVAGQPV
CCCEEEEEECCCCCCCHHHHHCCCCHHHHHHHHHCCCCCEEECHHHCCCCEEEEECCCCE
WLLKPATFMNLSGKSITAALRFWKIEPEHLLVAHDELDLAPGTARLKFDGGHGGQNGLRD
EEECCCEEEECCCCCEEEEEEEEEECCCEEEEEECCCCCCCCCEEEEEECCCCCCCHHHH
TIRLLGHGKFHRLRVGIGHPGHKDRVVPWVLGRAGREDDAAIGAAVDAAIDVLPLAMEGN
HHHHHCCCCEEEEEEECCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHEEEEEECCC
FNEAMKRLHTEKK
HHHHHHHHHCCCC
>Mature Secondary Structure 
TALRLIVGLGNPGPEHAQTRHNAGFRFVDALIERSGARWALDSKLFGETAKVEVAGQPV
CCEEEEEECCCCCCCHHHHHCCCCHHHHHHHHHCCCCCEEECHHHCCCCEEEEECCCCE
WLLKPATFMNLSGKSITAALRFWKIEPEHLLVAHDELDLAPGTARLKFDGGHGGQNGLRD
EEECCCEEEECCCCCEEEEEEEEEECCCEEEEEECCCCCCCCCEEEEEECCCCCCCHHHH
TIRLLGHGKFHRLRVGIGHPGHKDRVVPWVLGRAGREDDAAIGAAVDAAIDVLPLAMEGN
HHHHHCCCCEEEEEEECCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHEEEEEECCC
FNEAMKRLHTEKK
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA