Click here to switch to the map view.

The map label for this gene is ipk

Identifier: 21241718

GI number: 21241718

Start: 1110926

End: 1111813

Strand: Direct

Name: ipk

Synonym: XAC0948

Alternate gene names: 21241718

Gene position: 1110926-1111813 (Clockwise)

Preceding gene: 21241717

Following gene: 21241719

Centisome position: 21.46

GC content: 68.47

Gene sequence:

>888_bases
ATGGACCGTATCGCCCTGATGGACGCGCCGGACACGGACTGGTCGGCCTGGCCTGCGCCGGCCAAGCTGAATTTGTTTCT
GCAAATCACCGGGCGCCGGGCCGACGGCTACCACCTGCTGCAGACCGTGTTCCGGCTGCTGGACTGGGGGGACACCGTTC
ATCTTCGCGTGCGCAGCGGCGGCCAGATCCGCCGCGTGGGCGAGAGTTTGCCCGGCGTGGCCGAAGACGATGATCTGGTG
ATCCGCGCCGCGCGCCTGCTGCAGTCGGCAACCGGCGCCCAGGCGGGCGCGGAGATTCGGGTCGACAAACGCATCCCGGC
AGGGGGAGGTTTCGGCGGCGGTTCCTCGGACGCGGCCACCGTGCTGGTGGCGCTCAATGCCTTGTGGGGCCTGGGTCTGG
CGGCCGATGCGCTGGCCGAGCTGGGCTTGCAGCTGGGCGCAGACGTGCCGGTCTTCGTGCGCGGCCACAATGCCTGGGCC
GAAGGCGTGGGCGAACAACTGACCCCGATTTCCCTGCCGGAAGCGGCCTATCTGCTGGTCGATCCCGGCGTTCACGTGCC
GACACCAGCGTTATTTCGATCACAGGAATTGACGCGGGATGCTGCGCCCGCGAAAATAGCGGACTTCGCTTCCGGTTCCC
TGCTCGACAATGCGTTCGAGCCGGTCCTGCGGCGCCGCGAACCCGCCGTCGAGGCCGTGTTCCAGGCGCTTTCCAGGGTC
GGTACACCGCGCTTGACCGGGTCGGGAAGTGGCTGTTTCGTCGAATTCGCCACGCGCGCTGCTGCAGAGCAGGCGCTGGC
GCAGTTGCCGGGCGGCCTGCGGGCGTGGGTGGCGGAGGGTGCATCGCACTCGCCGTTGCTCGACGCACGGGACGCGAGAC
AAGTTTGA

Upstream 100 bases:

>100_bases
ACTTTCTGGCCTGGACGCCAGCCAGCGCCGAGCAGCCCGAGCTGCCGCAGCGGATCGAAGCCCGTAGCGGCGAGGCCAAG
GTGCGCCTGCTGGTCGACCA

Downstream 100 bases:

>100_bases
TGCAGGGGCGTCGCCAAGAGGCCCAAGGCACCAGGTTTTGATCCTGGCATTCGTAGGTTCGAATCCTACCGCCCCTGCCA
GTTTGTCGAGAAAGGCAGGT

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MDRIALMDAPDTDWSAWPAPAKLNLFLQITGRRADGYHLLQTVFRLLDWGDTVHLRVRSGGQIRRVGESLPGVAEDDDLV
IRAARLLQSATGAQAGAEIRVDKRIPAGGGFGGGSSDAATVLVALNALWGLGLAADALAELGLQLGADVPVFVRGHNAWA
EGVGEQLTPISLPEAAYLLVDPGVHVPTPALFRSQELTRDAAPAKIADFASGSLLDNAFEPVLRRREPAVEAVFQALSRV
GTPRLTGSGSGCFVEFATRAAAEQALAQLPGGLRAWVAEGASHSPLLDARDARQV

Sequences:

>Translated_295_residues
MDRIALMDAPDTDWSAWPAPAKLNLFLQITGRRADGYHLLQTVFRLLDWGDTVHLRVRSGGQIRRVGESLPGVAEDDDLV
IRAARLLQSATGAQAGAEIRVDKRIPAGGGFGGGSSDAATVLVALNALWGLGLAADALAELGLQLGADVPVFVRGHNAWA
EGVGEQLTPISLPEAAYLLVDPGVHVPTPALFRSQELTRDAAPAKIADFASGSLLDNAFEPVLRRREPAVEAVFQALSRV
GTPRLTGSGSGCFVEFATRAAAEQALAQLPGGLRAWVAEGASHSPLLDARDARQV
>Mature_295_residues
MDRIALMDAPDTDWSAWPAPAKLNLFLQITGRRADGYHLLQTVFRLLDWGDTVHLRVRSGGQIRRVGESLPGVAEDDDLV
IRAARLLQSATGAQAGAEIRVDKRIPAGGGFGGGSSDAATVLVALNALWGLGLAADALAELGLQLGADVPVFVRGHNAWA
EGVGEQLTPISLPEAAYLLVDPGVHVPTPALFRSQELTRDAAPAKIADFASGSLLDNAFEPVLRRREPAVEAVFQALSRV
GTPRLTGSGSGCFVEFATRAAAEQALAQLPGGLRAWVAEGASHSPLLDARDARQV

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily

Homologues:

Organism=Escherichia coli, GI1787459, Length=278, Percent_Identity=51.4388489208633, Blast_Score=252, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPE_XANAC (Q8PNU1)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641300.1
- ProteinModelPortal:   Q8PNU1
- SMR:   Q8PNU1
- GeneID:   1155019
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0948
- NMPDR:   fig|190486.1.peg.944
- HOGENOM:   HBG734593
- OMA:   LNLFLHV
- ProtClustDB:   PRK00343
- BioCyc:   XAXO190486:XAC0948-MONOMER
- BRENDA:   2.7.1.148
- HAMAP:   MF_00061
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR20861:SF2
- PIRSF:   PIRSF010376
- TIGRFAMs:   TIGR00154

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.148

Molecular weight: Translated: 31058; Mature: 31058

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: ACT_SITE 22-22 ACT_SITE 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRIALMDAPDTDWSAWPAPAKLNLFLQITGRRADGYHLLQTVFRLLDWGDTVHLRVRSG
CCCEEEECCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCC
GQIRRVGESLPGVAEDDDLVIRAARLLQSATGAQAGAEIRVDKRIPAGGGFGGGSSDAAT
CHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCHHHH
VLVALNALWGLGLAADALAELGLQLGADVPVFVRGHNAWAEGVGEQLTPISLPEAAYLLV
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCCCCCCCCCEEEEE
DPGVHVPTPALFRSQELTRDAAPAKIADFASGSLLDNAFEPVLRRREPAVEAVFQALSRV
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHC
GTPRLTGSGSGCFVEFATRAAAEQALAQLPGGLRAWVAEGASHSPLLDARDARQV
CCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDRIALMDAPDTDWSAWPAPAKLNLFLQITGRRADGYHLLQTVFRLLDWGDTVHLRVRSG
CCCEEEECCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCC
GQIRRVGESLPGVAEDDDLVIRAARLLQSATGAQAGAEIRVDKRIPAGGGFGGGSSDAAT
CHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCHHHH
VLVALNALWGLGLAADALAELGLQLGADVPVFVRGHNAWAEGVGEQLTPISLPEAAYLLV
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCCCCCCCCCEEEEE
DPGVHVPTPALFRSQELTRDAAPAKIADFASGSLLDNAFEPVLRRREPAVEAVFQALSRV
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHC
GTPRLTGSGSGCFVEFATRAAAEQALAQLPGGLRAWVAEGASHSPLLDARDARQV
CCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217