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The map label for this gene is rlmM

Identifier: 21241659

GI number: 21241659

Start: 1050922

End: 1051965

Strand: Reverse

Name: rlmM

Synonym: XAC0889

Alternate gene names: 21241659

Gene position: 1051965-1050922 (Counterclockwise)

Preceding gene: 21241660

Following gene: 21241657

Centisome position: 20.33

GC content: 65.61

Gene sequence:

>1044_bases
ATGAGCGGCCTGCTGTGTTACTGCCGGCCGGGTTTCGAACCTGAGCTGGCCGCAGAATTGAGTGTGCGCGCCGCATTCGT
CGGCATTGCCGGCTATGCGCGCACCCAACGCAACGACGGCTATGTATTGTTCGTCTGCGACGAAGCCGCGCAACTTGCAG
CAAAACTGCAGTGGCGCGAGTTGATCTTCGCCCGGCAGAAGCTGGTGGTGATTGCCGAGCTGAAAGGTATCGACCCCAAG
GACCGCATCACGCCGATCCTGGCCGCGTTGGACGGGCAGCAGCGCTTTGGCGATCTGTGGGTGGAACACCCGGATTCGGA
CGCGGGCAAGCCGCTGGCGGGCCTGGCGCGCAGCTTCGGCAATGCGCTGCGCCCGGCTCTGCGCAAGGCCGGCCTGCTCA
CCGACAAGCCGCAGCCGCGCCAACCTCGGTTGCACGTCTGTTTTCTCGACGGCGACCACGCCTTGCTTGCGGTGGCCGAC
AGCGCCGACAGCGCCCCGTGGCCACTGGGCATTCCACGCCTGAAATTGCTGCCGGAAGCGCCCTCGCGCTCTGCCCTCAA
GCTCGACGAAGCCTTGCTGACGCTGCTCACGCCCGAAGAACGCGATGCACTGGTCAAGCCGGGCATGCGTGCGGCCGATC
TGGGCGCTGCGCCCGGCGGCTGGACCTGGGTACTGACGCGGCAGCACGTGCACGTCACCAGCGTGGACAACGGCCCGCTG
CGCGAGCATGTGCTGGAGACCGGGCTGGTGGAACACCTGCGTGCCGACGGCTTTCACTGGAAGCCCGCGCAACCGCTGGA
CTGGATGGTCTGCGACATGGTCGAGCAACCGCGCCGCGTGGCCGAACGCATGGCGACCTGGGTGCGCGAAGGTTGGTGCC
GCAACACCATCTTCAACCTCAAGCTACCGATGAAAAAGCGCTGGGACGAGACCCGTCTGTGCCTGGACCTGTTCGAGCAA
CAGGCCGAGAGATCATTGAGCGTGCGCGCCAAGCAGCTGTATCACGATCGCGAGGAGATCACGGTGCTGGCGATGCGGGA
TTGA

Upstream 100 bases:

>100_bases
ACTGCGCGACCAGGCGTGTGCAGTGCTGCGCAACTACGGCGAGGGCGGCGGTGACCATTACTGATGTCGCGGGCGCAGCG
GGCGCCCTGCAGGTGCAGCG

Downstream 100 bases:

>100_bases
GCTGAATCGGAATTCGGAAAAGGGTGGGGCTGGGACGGAGAGTCATCAAGAGTGCTTCGATCATGCGATCGATCGGCGAT
GCAGTCCGCCGTGCGCTGGG

Product: RNA 2'-O-ribose methyltransferase

Products: NA

Alternate protein names: 23S rRNA 2'-O-ribose methyltransferase rlmM

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MSGLLCYCRPGFEPELAAELSVRAAFVGIAGYARTQRNDGYVLFVCDEAAQLAAKLQWRELIFARQKLVVIAELKGIDPK
DRITPILAALDGQQRFGDLWVEHPDSDAGKPLAGLARSFGNALRPALRKAGLLTDKPQPRQPRLHVCFLDGDHALLAVAD
SADSAPWPLGIPRLKLLPEAPSRSALKLDEALLTLLTPEERDALVKPGMRAADLGAAPGGWTWVLTRQHVHVTSVDNGPL
REHVLETGLVEHLRADGFHWKPAQPLDWMVCDMVEQPRRVAERMATWVREGWCRNTIFNLKLPMKKRWDETRLCLDLFEQ
QAERSLSVRAKQLYHDREEITVLAMRD

Sequences:

>Translated_347_residues
MSGLLCYCRPGFEPELAAELSVRAAFVGIAGYARTQRNDGYVLFVCDEAAQLAAKLQWRELIFARQKLVVIAELKGIDPK
DRITPILAALDGQQRFGDLWVEHPDSDAGKPLAGLARSFGNALRPALRKAGLLTDKPQPRQPRLHVCFLDGDHALLAVAD
SADSAPWPLGIPRLKLLPEAPSRSALKLDEALLTLLTPEERDALVKPGMRAADLGAAPGGWTWVLTRQHVHVTSVDNGPL
REHVLETGLVEHLRADGFHWKPAQPLDWMVCDMVEQPRRVAERMATWVREGWCRNTIFNLKLPMKKRWDETRLCLDLFEQ
QAERSLSVRAKQLYHDREEITVLAMRD
>Mature_346_residues
SGLLCYCRPGFEPELAAELSVRAAFVGIAGYARTQRNDGYVLFVCDEAAQLAAKLQWRELIFARQKLVVIAELKGIDPKD
RITPILAALDGQQRFGDLWVEHPDSDAGKPLAGLARSFGNALRPALRKAGLLTDKPQPRQPRLHVCFLDGDHALLAVADS
ADSAPWPLGIPRLKLLPEAPSRSALKLDEALLTLLTPEERDALVKPGMRAADLGAAPGGWTWVLTRQHVHVTSVDNGPLR
EHVLETGLVEHLRADGFHWKPAQPLDWMVCDMVEQPRRVAERMATWVREGWCRNTIFNLKLPMKKRWDETRLCLDLFEQQ
AERSLSVRAKQLYHDREEITVLAMRD

Specific function: Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA

COG id: COG2933

COG function: function code R; Predicted SAM-dependent methyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RlmE family. RlmM subfamily

Homologues:

Organism=Escherichia coli, GI1789171, Length=354, Percent_Identity=44.6327683615819, Blast_Score=295, Evalue=4e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RLMM_XANAC (Q8PNZ9)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641241.1
- ProteinModelPortal:   Q8PNZ9
- SMR:   Q8PNZ9
- GeneID:   1154960
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0889
- NMPDR:   fig|190486.1.peg.885
- HOGENOM:   HBG681972
- OMA:   LYCRPGF
- ProtClustDB:   PRK11760
- BioCyc:   XAXO190486:XAC0889-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01551
- InterPro:   IPR011224
- InterPro:   IPR002877
- PIRSF:   PIRSF028774

Pfam domain/function: PF01728 FtsJ

EC number: NA

Molecular weight: Translated: 38959; Mature: 38828

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLLCYCRPGFEPELAAELSVRAAFVGIAGYARTQRNDGYVLFVCDEAAQLAAKLQWRE
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHH
LIFARQKLVVIAELKGIDPKDRITPILAALDGQQRFGDLWVEHPDSDAGKPLAGLARSFG
HHHHHHHEEEEEEECCCCCHHHHHHHHHHCCCCHHHCCCEEECCCCCCCCCHHHHHHHHH
NALRPALRKAGLLTDKPQPRQPRLHVCFLDGDHALLAVADSADSAPWPLGIPRLKLLPEA
HHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCCCCEEECCCC
PSRSALKLDEALLTLLTPEERDALVKPGMRAADLGAAPGGWTWVLTRQHVHVTSVDNGPL
CCCCHHHHHHHHHHHCCCCCCCHHHCCCCCHHHCCCCCCCEEEEEEECEEEEEECCCCHH
REHVLETGLVEHLRADGFHWKPAQPLDWMVCDMVEQPRRVAERMATWVREGWCRNTIFNL
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCEEEE
KLPMKKRWDETRLCLDLFEQQAERSLSVRAKQLYHDREEITVLAMRD
ECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure 
SGLLCYCRPGFEPELAAELSVRAAFVGIAGYARTQRNDGYVLFVCDEAAQLAAKLQWRE
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHH
LIFARQKLVVIAELKGIDPKDRITPILAALDGQQRFGDLWVEHPDSDAGKPLAGLARSFG
HHHHHHHEEEEEEECCCCCHHHHHHHHHHCCCCHHHCCCEEECCCCCCCCCHHHHHHHHH
NALRPALRKAGLLTDKPQPRQPRLHVCFLDGDHALLAVADSADSAPWPLGIPRLKLLPEA
HHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCCCCEEECCCC
PSRSALKLDEALLTLLTPEERDALVKPGMRAADLGAAPGGWTWVLTRQHVHVTSVDNGPL
CCCCHHHHHHHHHHHCCCCCCCHHHCCCCCHHHCCCCCCCEEEEEEECEEEEEECCCCHH
REHVLETGLVEHLRADGFHWKPAQPLDWMVCDMVEQPRRVAERMATWVREGWCRNTIFNL
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCEEEE
KLPMKKRWDETRLCLDLFEQQAERSLSVRAKQLYHDREEITVLAMRD
ECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217