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The map label for this gene is pdxA

Identifier: 21241634

GI number: 21241634

Start: 1025204

End: 1026175

Strand: Reverse

Name: pdxA

Synonym: XAC0864

Alternate gene names: 21241634

Gene position: 1026175-1025204 (Counterclockwise)

Preceding gene: 21241635

Following gene: 21241633

Centisome position: 19.83

GC content: 69.75

Gene sequence:

>972_bases
ATGATGGTCCCGTCGCTCGCGCTGGTGCCAGGCGAGCCGGCCGGAATCGGGCCGGAACTCTGCGTCCGGCTTGCCCAGCA
GCCGCGCTCGGACGCGCATCTGATTGCCTACGCCGACCCAGATACCCTGCACAGCGCCGCAACGGCGCTGTCGTTGCCCG
TGCGGCTGCTCGAGCCCGACCAGCCCGCACGCGCGCCCGGCGACCTGCCGCTGCATCCCATTCGCCAAGCCGTGGCCACG
CGCTTCGGCGCACCTGACCCAGCCAATGCCGCAGCGGTGATCGCCGGCCTGCGCAGCGCCGCGGCCGACTGCCTCGCCGG
CCGCCTGCAGGGAATCGTCACTGGCCCGGTGCACAAGGCAGCGATCAACGCCGGCGGCATTGCCTACACCGGCACCACCG
AACTGCTGGCCGAACAAGCCGGTTGCCCGGTGGTGATGATGCTGGCCAACAGCATCGTGCGCGTCGCGCTGGTGACGACC
CATCTGCCGCTGCGTGCGGTGGCCGATGCGATCACGGCCGATGCCCTGCTGCAGTGTCTGCGCATCACCCATGCAGCGAT
GCAGCGCGACTTCGGCCTGGAGCACCCGCGCATCGCCGTGCTCGGCCTCAACCCGCATGCCGGCGAAGATGGTCACCTGG
GCCGCGAGGAACTGGATATCGTCATTCCGGCGCTGGAGCAACTGCGCGGCGAGGGCATGCAGCTGATCGGCCCGCTGCCG
GCGGATACCGCCTTCTTGCCGCAGAAACTGCGTGGTTTCGACGCGGTGGTGGCGATGTATCACGACCAAGGCCTGCCGGT
GCTCAAGTACAGCGGCTTCGAGCAGGCGGTGAATATCACCCTGGGCCTGCCCTACCCGCGCGTGGCGGTGGATCACGGGA
CTGCGCTGGAACTGGCCGGCCGCGGAATCGCGGACCCCTCCAGCCTGATGGCGGCCACTGCGTTGTGCGCGCGATTGGCG
GCGCGCCGCTAA

Upstream 100 bases:

>100_bases
GATGACAACGCCACTGCCGCTCCAGCCAAATCGCCAGACCCTGCAGCGCCCTCGCCGCCGCCGGCAAAGCCGACGCGCTG
AGGGCGGGCGCCCGGATCGC

Downstream 100 bases:

>100_bases
AACCACGCGTGCCTGCTCGCTGCGGGCATGCCGCATGATGCACGCCGCCTATCCGCCAAGCGCGGTGCGCGCGCAAACGA
CACCGCGTGCAGGCGCGGCC

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MMVPSLALVPGEPAGIGPELCVRLAQQPRSDAHLIAYADPDTLHSAATALSLPVRLLEPDQPARAPGDLPLHPIRQAVAT
RFGAPDPANAAAVIAGLRSAAADCLAGRLQGIVTGPVHKAAINAGGIAYTGTTELLAEQAGCPVVMMLANSIVRVALVTT
HLPLRAVADAITADALLQCLRITHAAMQRDFGLEHPRIAVLGLNPHAGEDGHLGREELDIVIPALEQLRGEGMQLIGPLP
ADTAFLPQKLRGFDAVVAMYHDQGLPVLKYSGFEQAVNITLGLPYPRVAVDHGTALELAGRGIADPSSLMAATALCARLA
ARR

Sequences:

>Translated_323_residues
MMVPSLALVPGEPAGIGPELCVRLAQQPRSDAHLIAYADPDTLHSAATALSLPVRLLEPDQPARAPGDLPLHPIRQAVAT
RFGAPDPANAAAVIAGLRSAAADCLAGRLQGIVTGPVHKAAINAGGIAYTGTTELLAEQAGCPVVMMLANSIVRVALVTT
HLPLRAVADAITADALLQCLRITHAAMQRDFGLEHPRIAVLGLNPHAGEDGHLGREELDIVIPALEQLRGEGMQLIGPLP
ADTAFLPQKLRGFDAVVAMYHDQGLPVLKYSGFEQAVNITLGLPYPRVAVDHGTALELAGRGIADPSSLMAATALCARLA
ARR
>Mature_323_residues
MMVPSLALVPGEPAGIGPELCVRLAQQPRSDAHLIAYADPDTLHSAATALSLPVRLLEPDQPARAPGDLPLHPIRQAVAT
RFGAPDPANAAAVIAGLRSAAADCLAGRLQGIVTGPVHKAAINAGGIAYTGTTELLAEQAGCPVVMMLANSIVRVALVTT
HLPLRAVADAITADALLQCLRITHAAMQRDFGLEHPRIAVLGLNPHAGEDGHLGREELDIVIPALEQLRGEGMQLIGPLP
ADTAFLPQKLRGFDAVVAMYHDQGLPVLKYSGFEQAVNITLGLPYPRVAVDHGTALELAGRGIADPSSLMAATALCARLA
ARR

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=319, Percent_Identity=50.4702194357367, Blast_Score=286, Evalue=1e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_XANAC (Q8PP24)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641216.1
- ProteinModelPortal:   Q8PP24
- SMR:   Q8PP24
- GeneID:   1154935
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0864
- NMPDR:   fig|190486.1.peg.860
- HOGENOM:   HBG451136
- OMA:   NPANAAY
- ProtClustDB:   PRK00232
- BioCyc:   XAXO190486:XAC0864-MONOMER
- BRENDA:   1.1.1.262
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 33650; Mature: 33650

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: BINDING 133-133 BINDING 269-269 BINDING 278-278 BINDING 287-287

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMVPSLALVPGEPAGIGPELCVRLAQQPRSDAHLIAYADPDTLHSAATALSLPVRLLEPD
CCCCCEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCEEECCC
QPARAPGDLPLHPIRQAVATRFGAPDPANAAAVIAGLRSAAADCLAGRLQGIVTGPVHKA
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCHHHH
AINAGGIAYTGTTELLAEQAGCPVVMMLANSIVRVALVTTHLPLRAVADAITADALLQCL
HCCCCCEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
RITHAAMQRDFGLEHPRIAVLGLNPHAGEDGHLGREELDIVIPALEQLRGEGMQLIGPLP
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCC
ADTAFLPQKLRGFDAVVAMYHDQGLPVLKYSGFEQAVNITLGLPYPRVAVDHGTALELAG
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCEEECCCCEEEECC
RGIADPSSLMAATALCARLAARR
CCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMVPSLALVPGEPAGIGPELCVRLAQQPRSDAHLIAYADPDTLHSAATALSLPVRLLEPD
CCCCCEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCEEECCC
QPARAPGDLPLHPIRQAVATRFGAPDPANAAAVIAGLRSAAADCLAGRLQGIVTGPVHKA
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCHHHH
AINAGGIAYTGTTELLAEQAGCPVVMMLANSIVRVALVTTHLPLRAVADAITADALLQCL
HCCCCCEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
RITHAAMQRDFGLEHPRIAVLGLNPHAGEDGHLGREELDIVIPALEQLRGEGMQLIGPLP
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCC
ADTAFLPQKLRGFDAVVAMYHDQGLPVLKYSGFEQAVNITLGLPYPRVAVDHGTALELAG
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCEEECCCCEEEECC
RGIADPSSLMAATALCARLAARR
CCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217