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The map label for this gene is ubiE [H]

Identifier: 21241414

GI number: 21241414

Start: 757967

End: 758728

Strand: Direct

Name: ubiE [H]

Synonym: XAC0643

Alternate gene names: 21241414

Gene position: 757967-758728 (Clockwise)

Preceding gene: 21241409

Following gene: 21241415

Centisome position: 14.65

GC content: 62.73

Gene sequence:

>762_bases
ATGAGCGAATCCCCCTATACCTCCGGTACTACCCATTTCGGCTTTCGCGATGTCGCTGCCAAGGACAAGCAGAAGCTGGT
CGGTGAAGTGTTCACCTCGGTCGCCCGCAATTACGACCTGATGAACGATCTGATGAGCCTGGGCGTGCACCGCGCATGGA
AACGCTACTTCGTGGCGACCGCGCAGGTGAAGCCAGGCGACCGCGTGCTGGACCTGGCCGGCGGCACCGGCGACATCGCC
GTGCTGCTCAAGGAGCGGGTGGGCAACGAAGGGGCCGTGGTGCTGGGCGACATCAATGCCGGCATGCTGTCGGTGGGCCG
CGACCGGCTGACCAACCGCGGCTTGGTGTCCGGTTTCGACTACGTGCAATGCAACGCCGAAGCGCTGCCGTTCCCGGACC
AGAGTTTCGATCTGCTGACCATTTCCTTCGGCCTGCGCAACGTCACCGACAAGGACGCCGCCTTGCGCGAGATGTACCGC
GTGCTGAAGGTGGGCGGACAGGCGCGCGTGCTGGAATTTTCCGAAGTCACCGCCGACTGGTTCAAGCCGATCTACGACTT
CCACTCGTTCAAGATCCTGCCCAGGCTGGGCCAGCTGTTCGCGCGCGATGCCGATAGCTACCAGTACCTGGCCGAAAGCA
TCCGCAAGCATCCGCCACAGGAATCGCTCAAGGGCATGATGGGCGAGGCCGGGTTTGCGCGTTGCCACTTCAAGAACCTC
ACCGGCGGCATCGTGGCGATCCACTCCGGCTACAAGATCTAA

Upstream 100 bases:

>100_bases
ACTTGTCGCGCACTGAATGCTCGCAGGGCCGGTCGGAGGTGAAAACGCGATTGTGGTCCGGTTGCGGTCATGGTGGCGTC
AGCGGTGCGATAATCCGCCC

Downstream 100 bases:

>100_bases
GCAGGGCGTTTGAGCCGGCTGGTGTCGGCGCGCTTAGCGTGCGCTGGCGCTCGCCCACCGCGTGCACGGGATCGCTTGTT
GAGGCGAACCGGTGCCGCAC

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MSESPYTSGTTHFGFRDVAAKDKQKLVGEVFTSVARNYDLMNDLMSLGVHRAWKRYFVATAQVKPGDRVLDLAGGTGDIA
VLLKERVGNEGAVVLGDINAGMLSVGRDRLTNRGLVSGFDYVQCNAEALPFPDQSFDLLTISFGLRNVTDKDAALREMYR
VLKVGGQARVLEFSEVTADWFKPIYDFHSFKILPRLGQLFARDADSYQYLAESIRKHPPQESLKGMMGEAGFARCHFKNL
TGGIVAIHSGYKI

Sequences:

>Translated_253_residues
MSESPYTSGTTHFGFRDVAAKDKQKLVGEVFTSVARNYDLMNDLMSLGVHRAWKRYFVATAQVKPGDRVLDLAGGTGDIA
VLLKERVGNEGAVVLGDINAGMLSVGRDRLTNRGLVSGFDYVQCNAEALPFPDQSFDLLTISFGLRNVTDKDAALREMYR
VLKVGGQARVLEFSEVTADWFKPIYDFHSFKILPRLGQLFARDADSYQYLAESIRKHPPQESLKGMMGEAGFARCHFKNL
TGGIVAIHSGYKI
>Mature_252_residues
SESPYTSGTTHFGFRDVAAKDKQKLVGEVFTSVARNYDLMNDLMSLGVHRAWKRYFVATAQVKPGDRVLDLAGGTGDIAV
LLKERVGNEGAVVLGDINAGMLSVGRDRLTNRGLVSGFDYVQCNAEALPFPDQSFDLLTISFGLRNVTDKDAALREMYRV
LKVGGQARVLEFSEVTADWFKPIYDFHSFKILPRLGQLFARDADSYQYLAESIRKHPPQESLKGMMGEAGFARCHFKNLT
GGIVAIHSGYKI

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=279, Percent_Identity=43.3691756272401, Blast_Score=224, Evalue=5e-59,
Organism=Escherichia coli, GI48994983, Length=243, Percent_Identity=58.4362139917695, Blast_Score=295, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17557039, Length=244, Percent_Identity=47.9508196721311, Blast_Score=228, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6323526, Length=261, Percent_Identity=43.2950191570881, Blast_Score=182, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24641702, Length=257, Percent_Identity=46.692607003891, Blast_Score=226, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 28008; Mature: 27877

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESPYTSGTTHFGFRDVAAKDKQKLVGEVFTSVARNYDLMNDLMSLGVHRAWKRYFVAT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHEE
AQVKPGDRVLDLAGGTGDIAVLLKERVGNEGAVVLGDINAGMLSVGRDRLTNRGLVSGFD
EEECCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCC
YVQCNAEALPFPDQSFDLLTISFGLRNVTDKDAALREMYRVLKVGGQARVLEFSEVTADW
EEEECCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHH
FKPIYDFHSFKILPRLGQLFARDADSYQYLAESIRKHPPQESLKGMMGEAGFARCHFKNL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCHHEEECCCC
TGGIVAIHSGYKI
CCCEEEECCCCCC
>Mature Secondary Structure 
SESPYTSGTTHFGFRDVAAKDKQKLVGEVFTSVARNYDLMNDLMSLGVHRAWKRYFVAT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHEE
AQVKPGDRVLDLAGGTGDIAVLLKERVGNEGAVVLGDINAGMLSVGRDRLTNRGLVSGFD
EEECCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCC
YVQCNAEALPFPDQSFDLLTISFGLRNVTDKDAALREMYRVLKVGGQARVLEFSEVTADW
EEEECCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHH
FKPIYDFHSFKILPRLGQLFARDADSYQYLAESIRKHPPQESLKGMMGEAGFARCHFKNL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCHHEEECCCC
TGGIVAIHSGYKI
CCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA