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The map label for this gene is hslU

Identifier: 21241409

GI number: 21241409

Start: 752511

End: 753878

Strand: Direct

Name: hslU

Synonym: XAC0638

Alternate gene names: 21241409

Gene position: 752511-753878 (Clockwise)

Preceding gene: 21241408

Following gene: 21241414

Centisome position: 14.54

GC content: 62.43

Gene sequence:

>1368_bases
ATGCCTAATATCGATACCGCCACCATGACTCCGCGCGAAATCGTGCAGGAGCTCGACCGTCATATCGTTGGTCAGCACGA
CGCCAAGCGCGCGGTTGCCATCGCGCTGCGTAACCGCTGGCGCCGCATGCAGTTGCCGGAAGAACTGCGCAACGAAGTGA
TGCCCAAGAACATCCTGATGATCGGCCCTACCGGTGTGGGCAAGACCGAGATCGCACGGCGCCTGGCGACACTGGCCAAC
GCGCCGTTCGTCAAGGTCGAAGCCACGCGCTTCACCGAAGTGGGGTATGTGGGCAAGGATGTGGAGCAGATCATCCGCGA
CCTGGCCGATACCGCCGTCAAGCTGTATCGCGAGCAGGCCAAGGTGCGCGTGCGCAACCAGGCCGAAGAGCGTGCCGAAG
ACCGCATCCTGGACGCATTGCTGCCACGTCGCGCGACCGGTATCGGGTTTGATCCGGAAGCGGCGCGCAACGAGCCCTCC
TCGCAAGATAACGACACCCGCATCAAGTTCCGTCGCATGCTGCGCAACGGCGAGCTGGACGAGCGCGAGATCGAACTGGA
AGTGGCGGTGAACGCCAGCATGGACATCATGACCCCGCCGGGCATGGAAGAAATGGGCCAGCAACTGCGCCAGATGTTTT
CCAATCTGGGCAGCGGCAAATCCCAGAAGCGCAAGCTCACCATCAAGGCAGCGCGCCCGCTGTTGATCGAAGAAGAAGCG
GGCAAATTGGTCAACGAAGACGATGTGCGCACCGCGGCCATCGAAGCGTGCGAGCAGCACGGCATCGTGTTCATCGATGA
GATCGACAAGGTGGCCAAGCGCGGCGAAGCCGGCTCCAGCGGTGGCGATGTCAGTCGCGAAGGCGTGCAGCGCGATCTGT
TGCCGCTGGTGGAAGGCTCCAACGTGTCCACCAAGTACGGCACGGTCAAGACCGACCACATCCTGTTCATTGCATCAGGC
GCGTTTCACCTGGCCAAGCCCAGCGATCTGATCCCGGAGCTGCAGGGCCGCTTCCCGATCCGTGTGGAACTGACCGCGCT
GACCAAGGCCGATTTCGTCCGCATCCTCACCGAGCCCAAGGCCGCCTTGATCAAGCAGTACGAAGCCCTGTTGCAGACCG
AAGGTGTGGCGTTGACGTTTGCGTCCGATGCGGTGGATCGGCTTGCCGAGATTGCCGCGCAGGTCAACGAGCGCCAGGAG
AATATCGGCGCCCGTCGCCTGCACACCGTGTTGGAGCGTTTGCTCGATGTGTTGAGCTACGAAGCGCCCGATCGCGATGG
GCAGAGCGTGACCGTGGACGCCGCCTATGTGGATGCGCAGCTGGGTGAGCTGGTACAGGATCCGGACCTGAGCCGCTACA
TCCTCTGA

Upstream 100 bases:

>100_bases
GGGAATCGGGAATCGCAACAGCGGTTTCGTCCCCACTTCGACGCCATAGGCTCTTGATGTTTGCTTTTGCGATTCCCCTT
TCCCAATTCTCGATTCCCTA

Downstream 100 bases:

>100_bases
CGACGTTGCACGGCAACCTGCGCGTGGGATGGAACAGACCCGCCAATGGCGGGTCTTTTTGTTTGCAGCATGCACGACGG
ACGAGGCGGGCTTTGGCAAT

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MPNIDTATMTPREIVQELDRHIVGQHDAKRAVAIALRNRWRRMQLPEELRNEVMPKNILMIGPTGVGKTEIARRLATLAN
APFVKVEATRFTEVGYVGKDVEQIIRDLADTAVKLYREQAKVRVRNQAEERAEDRILDALLPRRATGIGFDPEAARNEPS
SQDNDTRIKFRRMLRNGELDEREIELEVAVNASMDIMTPPGMEEMGQQLRQMFSNLGSGKSQKRKLTIKAARPLLIEEEA
GKLVNEDDVRTAAIEACEQHGIVFIDEIDKVAKRGEAGSSGGDVSREGVQRDLLPLVEGSNVSTKYGTVKTDHILFIASG
AFHLAKPSDLIPELQGRFPIRVELTALTKADFVRILTEPKAALIKQYEALLQTEGVALTFASDAVDRLAEIAAQVNERQE
NIGARRLHTVLERLLDVLSYEAPDRDGQSVTVDAAYVDAQLGELVQDPDLSRYIL

Sequences:

>Translated_455_residues
MPNIDTATMTPREIVQELDRHIVGQHDAKRAVAIALRNRWRRMQLPEELRNEVMPKNILMIGPTGVGKTEIARRLATLAN
APFVKVEATRFTEVGYVGKDVEQIIRDLADTAVKLYREQAKVRVRNQAEERAEDRILDALLPRRATGIGFDPEAARNEPS
SQDNDTRIKFRRMLRNGELDEREIELEVAVNASMDIMTPPGMEEMGQQLRQMFSNLGSGKSQKRKLTIKAARPLLIEEEA
GKLVNEDDVRTAAIEACEQHGIVFIDEIDKVAKRGEAGSSGGDVSREGVQRDLLPLVEGSNVSTKYGTVKTDHILFIASG
AFHLAKPSDLIPELQGRFPIRVELTALTKADFVRILTEPKAALIKQYEALLQTEGVALTFASDAVDRLAEIAAQVNERQE
NIGARRLHTVLERLLDVLSYEAPDRDGQSVTVDAAYVDAQLGELVQDPDLSRYIL
>Mature_454_residues
PNIDTATMTPREIVQELDRHIVGQHDAKRAVAIALRNRWRRMQLPEELRNEVMPKNILMIGPTGVGKTEIARRLATLANA
PFVKVEATRFTEVGYVGKDVEQIIRDLADTAVKLYREQAKVRVRNQAEERAEDRILDALLPRRATGIGFDPEAARNEPSS
QDNDTRIKFRRMLRNGELDEREIELEVAVNASMDIMTPPGMEEMGQQLRQMFSNLGSGKSQKRKLTIKAARPLLIEEEAG
KLVNEDDVRTAAIEACEQHGIVFIDEIDKVAKRGEAGSSGGDVSREGVQRDLLPLVEGSNVSTKYGTVKTDHILFIASGA
FHLAKPSDLIPELQGRFPIRVELTALTKADFVRILTEPKAALIKQYEALLQTEGVALTFASDAVDRLAEIAAQVNERQEN
IGARRLHTVLERLLDVLSYEAPDRDGQSVTVDAAYVDAQLGELVQDPDLSRYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily

Homologues:

Organism=Homo sapiens, GI7242140, Length=111, Percent_Identity=37.8378378378378, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790366, Length=448, Percent_Identity=66.2946428571429, Blast_Score=577, Evalue=1e-166,
Organism=Escherichia coli, GI1786642, Length=236, Percent_Identity=34.3220338983051, Blast_Score=101, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI71988663, Length=245, Percent_Identity=27.3469387755102, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319704, Length=303, Percent_Identity=27.7227722772277, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24648291, Length=249, Percent_Identity=31.7269076305221, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24648289, Length=249, Percent_Identity=31.7269076305221, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSLU_XANAC (Q8PPP7)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_640991.1
- ProteinModelPortal:   Q8PPP7
- SMR:   Q8PPP7
- GeneID:   1154709
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0638
- NMPDR:   fig|190486.1.peg.635
- HOGENOM:   HBG745965
- OMA:   EASKFTE
- ProtClustDB:   PRK05201
- BioCyc:   XAXO190486:XAC0638-MONOMER
- HAMAP:   MF_00249
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491
- PANTHER:   PTHR11262:SF3
- SMART:   SM00382
- TIGRFAMs:   TIGR00390

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 50714; Mature: 50582

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: BINDING 23-23 BINDING 266-266 BINDING 333-333 BINDING 405-405

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNIDTATMTPREIVQELDRHIVGQHDAKRAVAIALRNRWRRMQLPEELRNEVMPKNILM
CCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEE
IGPTGVGKTEIARRLATLANAPFVKVEATRFTEVGYVGKDVEQIIRDLADTAVKLYREQA
ECCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
KVRVRNQAEERAEDRILDALLPRRATGIGFDPEAARNEPSSQDNDTRIKFRRMLRNGELD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCCC
EREIELEVAVNASMDIMTPPGMEEMGQQLRQMFSNLGSGKSQKRKLTIKAARPLLIEEEA
CCEEEEEEEECCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEHHH
GKLVNEDDVRTAAIEACEQHGIVFIDEIDKVAKRGEAGSSGGDVSREGVQRDLLPLVEGS
CCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCC
NVSTKYGTVKTDHILFIASGAFHLAKPSDLIPELQGRFPIRVELTALTKADFVRILTEPK
CCCCCCCCEEECEEEEEECCCEECCCCHHHHHHHCCCCCEEEEEEEHHHHHHHHHHCCCH
AALIKQYEALLQTEGVALTFASDAVDRLAEIAAQVNERQENIGARRLHTVLERLLDVLSY
HHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EAPDRDGQSVTVDAAYVDAQLGELVQDPDLSRYIL
CCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PNIDTATMTPREIVQELDRHIVGQHDAKRAVAIALRNRWRRMQLPEELRNEVMPKNILM
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEE
IGPTGVGKTEIARRLATLANAPFVKVEATRFTEVGYVGKDVEQIIRDLADTAVKLYREQA
ECCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
KVRVRNQAEERAEDRILDALLPRRATGIGFDPEAARNEPSSQDNDTRIKFRRMLRNGELD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCCC
EREIELEVAVNASMDIMTPPGMEEMGQQLRQMFSNLGSGKSQKRKLTIKAARPLLIEEEA
CCEEEEEEEECCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEHHH
GKLVNEDDVRTAAIEACEQHGIVFIDEIDKVAKRGEAGSSGGDVSREGVQRDLLPLVEGS
CCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCC
NVSTKYGTVKTDHILFIASGAFHLAKPSDLIPELQGRFPIRVELTALTKADFVRILTEPK
CCCCCCCCEEECEEEEEECCCEECCCCHHHHHHHCCCCCEEEEEEEHHHHHHHHHHCCCH
AALIKQYEALLQTEGVALTFASDAVDRLAEIAAQVNERQENIGARRLHTVLERLLDVLSY
HHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EAPDRDGQSVTVDAAYVDAQLGELVQDPDLSRYIL
CCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217