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The map label for this gene is xerC

Identifier: 21241407

GI number: 21241407

Start: 750735

End: 751652

Strand: Direct

Name: xerC

Synonym: XAC0636

Alternate gene names: 21241407

Gene position: 750735-751652 (Clockwise)

Preceding gene: 21241406

Following gene: 21241408

Centisome position: 14.51

GC content: 64.71

Gene sequence:

>918_bases
GTGTCATCGGTCGATGAGTTCCTGACGTACCTGCAGGTCGAGCGGCAAGTATCGGCGCACACGCTGGACGCGTATCGGCG
CGACCTTGCTGCCCTGGTCGTCTGGGCGTCTGAGCAGAAGACAGACGATGGCGTGCAGGACGCTGCAGTGCCTGCCGAGA
CTGCACAGTTCGATAGCGCGCACTTGCGGCAATTCGTTGCGGCAGAACATCGGCGCGGGCTGTCGGCAAAGAGCCTGCAG
CGCCGTCTGTCGGCATGCCGCAGTTATTACGCCTGGTTGCTCAAGCGTGGCCGCATTTCGGCCAGCCCGGCGGCGGCGCT
GCGTGCGCCCAAGGCGCCGCGCAAGTTGCCGCAGGTGCTGGACGCCGACGAAGCAGTGCGTCTGGTGGAAGTGCCGACCG
ATGCGCCACTAGGCCTGCGCGATCGTGCGCTGCTGGAAGTGTTCTACTCGTCCGGGCTGCGCCTGAGCGAGTTATGCGCA
TTACGCTGGCGCGACCTGGACCTGGACAGCGGCCTGGTGATGGTGCTCGGCAAAGGCAGCAAGCAGCGCCTGGTGCCGGT
GGGCTCGCACGCGATCGCCGCCTTGCGCGAATGGCGGCGCGACAGTGGTGCAAGCGCCGACAGCCACGTCTTCCCTGGCC
GTGCCGGCGGTGCGATTTCGCAACGTGCGGTGCAGATCCGCATCAAGCAACTTGCCGTGCGTCAGGGCATGTTCAAGGAC
GTGCATCCGCATATGCTGCGCCACAGTTTCGCCAGCCATATCCTGGAATCGTCCGGCGATCTGCGCGGCGTGCAGGAGTT
GCTGGGCCATTCGGACATCGCCACCACCCAGATCTACACGCATCTGGATTTCCAACACTTGGCCAAGGTCTACGATGCTG
CGCATCCGCGTGCCAGGCGCAAGAAAGCTGCAGAGTGA

Upstream 100 bases:

>100_bases
GGTGGCAGTCGACTATCCGGGTTGTCTGCACCTGCAGGGCGCGCGTTCGCGCGCATGTTGCAGATGACGGCAGTCACGCC
GCGATATCGGAGGCGCTGAC

Downstream 100 bases:

>100_bases
GCGCTAAGCTGTAAGCAGCCGGCAGCCGGCGTCATCGACTCCTGCAGTTCACTGCCGCAGGTCGGTCTGCATGTCGCGTG
CAAACGTGTTGCCGTCTCGC

Product: site-specific tyrosine recombinase XerC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSSVDEFLTYLQVERQVSAHTLDAYRRDLAALVVWASEQKTDDGVQDAAVPAETAQFDSAHLRQFVAAEHRRGLSAKSLQ
RRLSACRSYYAWLLKRGRISASPAAALRAPKAPRKLPQVLDADEAVRLVEVPTDAPLGLRDRALLEVFYSSGLRLSELCA
LRWRDLDLDSGLVMVLGKGSKQRLVPVGSHAIAALREWRRDSGASADSHVFPGRAGGAISQRAVQIRIKQLAVRQGMFKD
VHPHMLRHSFASHILESSGDLRGVQELLGHSDIATTQIYTHLDFQHLAKVYDAAHPRARRKKAAE

Sequences:

>Translated_305_residues
MSSVDEFLTYLQVERQVSAHTLDAYRRDLAALVVWASEQKTDDGVQDAAVPAETAQFDSAHLRQFVAAEHRRGLSAKSLQ
RRLSACRSYYAWLLKRGRISASPAAALRAPKAPRKLPQVLDADEAVRLVEVPTDAPLGLRDRALLEVFYSSGLRLSELCA
LRWRDLDLDSGLVMVLGKGSKQRLVPVGSHAIAALREWRRDSGASADSHVFPGRAGGAISQRAVQIRIKQLAVRQGMFKD
VHPHMLRHSFASHILESSGDLRGVQELLGHSDIATTQIYTHLDFQHLAKVYDAAHPRARRKKAAE
>Mature_304_residues
SSVDEFLTYLQVERQVSAHTLDAYRRDLAALVVWASEQKTDDGVQDAAVPAETAQFDSAHLRQFVAAEHRRGLSAKSLQR
RLSACRSYYAWLLKRGRISASPAAALRAPKAPRKLPQVLDADEAVRLVEVPTDAPLGLRDRALLEVFYSSGLRLSELCAL
RWRDLDLDSGLVMVLGKGSKQRLVPVGSHAIAALREWRRDSGASADSHVFPGRAGGAISQRAVQIRIKQLAVRQGMFKDV
HPHMLRHSFASHILESSGDLRGVQELLGHSDIATTQIYTHLDFQHLAKVYDAAHPRARRKKAAE

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell div

COG id: COG4973

COG function: function code L; Site-specific recombinase XerC

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerC subfamily

Homologues:

Organism=Escherichia coli, GI1790244, Length=303, Percent_Identity=51.1551155115512, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI1789261, Length=307, Percent_Identity=39.0879478827362, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI1790767, Length=194, Percent_Identity=30.4123711340206, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790768, Length=166, Percent_Identity=28.9156626506024, Blast_Score=74, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERC_XANAC (Q8PPP9)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_640989.1
- ProteinModelPortal:   Q8PPP9
- SMR:   Q8PPP9
- GeneID:   1154707
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0636
- NMPDR:   fig|190486.1.peg.633
- HOGENOM:   HBG727654
- OMA:   YLQVERQ
- ProtClustDB:   PRK00236
- BioCyc:   XAXO190486:XAC0636-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01808
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- InterPro:   IPR011931
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10
- TIGRFAMs:   TIGR02224

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 33818; Mature: 33687

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: NA

Important sites: ACT_SITE 154-154 ACT_SITE 178-178 ACT_SITE 244-244 ACT_SITE 247-247 ACT_SITE 270-270 ACT_SITE 279-279

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVDEFLTYLQVERQVSAHTLDAYRRDLAALVVWASEQKTDDGVQDAAVPAETAQFDSA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHCCHH
HLRQFVAAEHRRGLSAKSLQRRLSACRSYYAWLLKRGRISASPAAALRAPKAPRKLPQVL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHH
DADEAVRLVEVPTDAPLGLRDRALLEVFYSSGLRLSELCALRWRDLDLDSGLVMVLGKGS
CHHHCEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEEECCC
KQRLVPVGSHAIAALREWRRDSGASADSHVFPGRAGGAISQRAVQIRIKQLAVRQGMFKD
CCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VHPHMLRHSFASHILESSGDLRGVQELLGHSDIATTQIYTHLDFQHLAKVYDAAHPRARR
CCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCCCHHHH
KKAAE
HCCCC
>Mature Secondary Structure 
SSVDEFLTYLQVERQVSAHTLDAYRRDLAALVVWASEQKTDDGVQDAAVPAETAQFDSA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHCCHH
HLRQFVAAEHRRGLSAKSLQRRLSACRSYYAWLLKRGRISASPAAALRAPKAPRKLPQVL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHH
DADEAVRLVEVPTDAPLGLRDRALLEVFYSSGLRLSELCALRWRDLDLDSGLVMVLGKGS
CHHHCEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEEECCC
KQRLVPVGSHAIAALREWRRDSGASADSHVFPGRAGGAISQRAVQIRIKQLAVRQGMFKD
CCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VHPHMLRHSFASHILESSGDLRGVQELLGHSDIATTQIYTHLDFQHLAKVYDAAHPRARR
CCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCCCHHHH
KKAAE
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217