Click here to switch to the map view.

The map label for this gene is estA [H]

Identifier: 21241390

GI number: 21241390

Start: 734423

End: 735091

Strand: Direct

Name: estA [H]

Synonym: XAC0619

Alternate gene names: 21241390

Gene position: 734423-735091 (Clockwise)

Preceding gene: 77748543

Following gene: 21241391

Centisome position: 14.19

GC content: 69.66

Gene sequence:

>669_bases
ATGATGCTGGAAGTGATCGAACGCGAGACCGGACCGAACCCGCAATGGAGCGTGCTGTGGCTGCACGGCCTGGGCGCCGA
TGGCAGCGACTTCGCCCCGATGGTGCCGGAGCTGGTGCGCCCGCAGTGGCCCGCGCTGCGCTTCGTGTTCCCGCATGCGC
CGATCCGCCCGATCACCATCAACAACGGCGTGCGCATGCGCGGCTGGTACGACATCGTCGGCATGGATTTCGCCCAGCGC
GCCGACAAGGCCGGCATTGCCGAGTCGGTGGCCCAGGTCGAGGCCTTGATCGCCCGTGAGCAGGGCCGCGGCATCGCGCC
GGAGCGCATCCTGCTGGCCGGCTTCTCGCAAGGCGGTGCCGTGACCCTGGCGGTGGGCCTGCAGCGCAGCGTGCCGCTGG
CCGGGCTGATCGCCATGTCCACCTATCTTCCGGATCCGGCCGCGGCCGCCAGCCAGTTGCAGCCGGCCGCCCTGCGCCAA
CCGCTGTTCATGGCGCATGGCACGGCCGACCCGGTGGTGCCGTTGGCGGCCGGCCAGGCCAGCATGCAGACCTTGCGCAC
GCTGGGCTTCGCATTGGATTGGCATACCTACCCGATGGGCCACCAGGTCTGCCTGGAAGAAATCGAGGCCCTGCGCGACT
GGTTGCAGGCGCGCTTTACCGCTGCCTGA

Upstream 100 bases:

>100_bases
AGGAGGCCCGTGGCGATCCGCGGGCCTCAAGCCTCTGGCGCCAGCTGATCTGGCCCACCCCTCGCACAAGGCATAATGCC
CAGCCCGCAAGCGGAGCTGG

Downstream 100 bases:

>100_bases
GCCCATGGCCCAGCGCGCACCGCAGATCGCCTGGATGCCGGACCTGTGCCGGCTGCCGCGGTTGGGCGCGATGCTGGGCC
TGGCCGAGCTGGTGGTGCTG

Product: carboxylesterase

Products: NA

Alternate protein names: Esterase I [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MMLEVIERETGPNPQWSVLWLHGLGADGSDFAPMVPELVRPQWPALRFVFPHAPIRPITINNGVRMRGWYDIVGMDFAQR
ADKAGIAESVAQVEALIAREQGRGIAPERILLAGFSQGGAVTLAVGLQRSVPLAGLIAMSTYLPDPAAAASQLQPAALRQ
PLFMAHGTADPVVPLAAGQASMQTLRTLGFALDWHTYPMGHQVCLEEIEALRDWLQARFTAA

Sequences:

>Translated_222_residues
MMLEVIERETGPNPQWSVLWLHGLGADGSDFAPMVPELVRPQWPALRFVFPHAPIRPITINNGVRMRGWYDIVGMDFAQR
ADKAGIAESVAQVEALIAREQGRGIAPERILLAGFSQGGAVTLAVGLQRSVPLAGLIAMSTYLPDPAAAASQLQPAALRQ
PLFMAHGTADPVVPLAAGQASMQTLRTLGFALDWHTYPMGHQVCLEEIEALRDWLQARFTAA
>Mature_222_residues
MMLEVIERETGPNPQWSVLWLHGLGADGSDFAPMVPELVRPQWPALRFVFPHAPIRPITINNGVRMRGWYDIVGMDFAQR
ADKAGIAESVAQVEALIAREQGRGIAPERILLAGFSQGGAVTLAVGLQRSVPLAGLIAMSTYLPDPAAAASQLQPAALRQ
PLFMAHGTADPVVPLAAGQASMQTLRTLGFALDWHTYPMGHQVCLEEIEALRDWLQARFTAA

Specific function: Hydrolyzes carboxylic ester bonds with relatively broad substrate specificity [H]

COG id: COG0400

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase 2 family [H]

Homologues:

Organism=Homo sapiens, GI9966764, Length=213, Percent_Identity=34.2723004694836, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI5453722, Length=204, Percent_Identity=34.3137254901961, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI20270341, Length=209, Percent_Identity=26.3157894736842, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17508057, Length=205, Percent_Identity=32.6829268292683, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323147, Length=216, Percent_Identity=28.7037037037037, Blast_Score=105, Evalue=6e-24,
Organism=Drosophila melanogaster, GI45553055, Length=201, Percent_Identity=33.8308457711443, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI45553057, Length=201, Percent_Identity=33.8308457711443, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI21357257, Length=201, Percent_Identity=33.8308457711443, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI161078179, Length=214, Percent_Identity=28.5046728971963, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003140 [H]

Pfam domain/function: PF02230 Abhydrolase_2 [H]

EC number: =3.1.1.1 [H]

Molecular weight: Translated: 24067; Mature: 24067

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLEVIERETGPNPQWSVLWLHGLGADGSDFAPMVPELVRPQWPALRFVFPHAPIRPITI
CCHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHCCCCCCEEEECCCCCCCEEEE
NNGVRMRGWYDIVGMDFAQRADKAGIAESVAQVEALIAREQGRGIAPERILLAGFSQGGA
CCCEEECEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCE
VTLAVGLQRSVPLAGLIAMSTYLPDPAAAASQLQPAALRQPLFMAHGTADPVVPLAAGQA
EEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHCCHHHHHCCEEEECCCCCCCEEECCCHH
SMQTLRTLGFALDWHTYPMGHQVCLEEIEALRDWLQARFTAA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMLEVIERETGPNPQWSVLWLHGLGADGSDFAPMVPELVRPQWPALRFVFPHAPIRPITI
CCHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHCCCCCCEEEECCCCCCCEEEE
NNGVRMRGWYDIVGMDFAQRADKAGIAESVAQVEALIAREQGRGIAPERILLAGFSQGGA
CCCEEECEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCE
VTLAVGLQRSVPLAGLIAMSTYLPDPAAAASQLQPAALRQPLFMAHGTADPVVPLAAGQA
EEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHCCHHHHHCCEEEECCCCCCCEEECCCHH
SMQTLRTLGFALDWHTYPMGHQVCLEEIEALRDWLQARFTAA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA