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The map label for this gene is hmgA

Identifier: 21241227

GI number: 21241227

Start: 543202

End: 544578

Strand: Direct

Name: hmgA

Synonym: XAC0454

Alternate gene names: 21241227

Gene position: 543202-544578 (Clockwise)

Preceding gene: 21241226

Following gene: 21241229

Centisome position: 10.5

GC content: 63.98

Gene sequence:

>1377_bases
TTGATCCAACGCGATCCCAACCTTCTGCTGTCATGGAGGGCGGATCAACATCCGGACGCACCCATGCACAACGACCAGCG
TTACATGACCGGCTTCGGCAATGAGTTCGCAACCGAGGCGGTGGCCGGCAGTCTACCGATCGGCCAGAACTCACCGCAGC
GTGTGGCGCACGGCCTGTATGCCGAGCAGCTATCCGGCACCGCGTTCACGGCGCCGCGTGGTCAAAATCGGCGCAGCTGG
CTGTATCGCATTCGCCCTGCCGCCGTGCATGGCAGCTTCTCGCTGGTCGAGCAGTCGCACTTCCATAACGATTTCGGTGC
GGGCCCGGTGCCGCCGGATCAGTTGCGCTGGAGCCCATTGCCACTGCCGTCGGTGCCCACCGATTTTGTCGACGGCCTCT
ACACCATGGCCGGCAATGGCGGGCCCGAAGCGATGTCCGGCGTTGGCGTGCATGTGTATGCGGCCAACGCCTCCATGCAG
GATCGCTTCTTCTACGACGCCGACGGCGAGCTGCTGCTGGTGCCGCAGCAGGGCCGGCTGCGCGTGCATACCGAGCTGGG
CGTGCTGGCGCTGGAACCGCAGCAGATTGGTGTGATTCCACGCGGCATGCGCTTTCGCGTCGAGTTGCTGGACGCCGCCG
CGCGCGGCTATGTGTGCGAAAACTTTGGCGGCCTGCTGCGCCTGCCCGATCTGGGGCCGATCGGCGCCAATGGCCTGGCC
AATCCGCGCGATTTCGAAACGCCGCATGCCGCCTTCGAACAACGCGAAGGCACGTTCGAACTGGTGGCCAAATTCCAGGG
CCATCTCTGGCGTGCCGACATCGGTCACTCGCCGCTGGATGTCGTCGCCTGGCACGGCAATTACGCGCCCTATCGTTACG
ACCTGCGTCGCTTCAACACCATCGGCTCGATCAGTTTCGATCATCCCGATCCCAGCATCTTCACCGTGCTGACCTCGCCC
AGCGACACGCACGGGACTGCGAACATGGATTTTGCGATCTTCCCGCCGCGTTGGCTGGTAGCACAGCACACCTTCCGCCC
GCCGTGGTTCCATCGCAATGTCGCCAGCGAATTCATGGGCCTGGTGCATGGCGTCTACGATGCCAAGGCCGAAGGCTTCG
CGCCCGGTGGCGCCTCGTTGCATAACTGCATGAGCGGGCACGGCCCGGATGCGGCCACCTTCGACAAGGCTTCACAGGCA
GATCTCACGCGCCCGGACGTGATCGCCGACACCATGGCCTTCATGTTCGAAACGCGTGCGGTGTTGCGCCCTACGCAGCA
GGCATTGAGCGCCGCCCATCGGCAAGCCGATTACCAGCAGTGCTGGTCCGGACTACGCGCTGCATTTCAACCGCCGATAA
CGGAAGACGCAACCTAG

Upstream 100 bases:

>100_bases
CTGCAAGATGGTCGCTACGCCGTACCCTCACCCCAACCCCTCTCCCGGTGGGAGAGGGGCTTGATTCGCCAGGCTTCAGC
TCTTTTTCGGTAAGAGCGGC

Downstream 100 bases:

>100_bases
CGCGCAACCAAAATCTCGTAAGCAATTGTCAGTTGGTGCGGACGTTGCTCAGGCACAGAGTGCATGGCGTGGATGGCGGC
TAGATACCTGTCCCGAGTAC

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MIQRDPNLLLSWRADQHPDAPMHNDQRYMTGFGNEFATEAVAGSLPIGQNSPQRVAHGLYAEQLSGTAFTAPRGQNRRSW
LYRIRPAAVHGSFSLVEQSHFHNDFGAGPVPPDQLRWSPLPLPSVPTDFVDGLYTMAGNGGPEAMSGVGVHVYAANASMQ
DRFFYDADGELLLVPQQGRLRVHTELGVLALEPQQIGVIPRGMRFRVELLDAAARGYVCENFGGLLRLPDLGPIGANGLA
NPRDFETPHAAFEQREGTFELVAKFQGHLWRADIGHSPLDVVAWHGNYAPYRYDLRRFNTIGSISFDHPDPSIFTVLTSP
SDTHGTANMDFAIFPPRWLVAQHTFRPPWFHRNVASEFMGLVHGVYDAKAEGFAPGGASLHNCMSGHGPDAATFDKASQA
DLTRPDVIADTMAFMFETRAVLRPTQQALSAAHRQADYQQCWSGLRAAFQPPITEDAT

Sequences:

>Translated_458_residues
MIQRDPNLLLSWRADQHPDAPMHNDQRYMTGFGNEFATEAVAGSLPIGQNSPQRVAHGLYAEQLSGTAFTAPRGQNRRSW
LYRIRPAAVHGSFSLVEQSHFHNDFGAGPVPPDQLRWSPLPLPSVPTDFVDGLYTMAGNGGPEAMSGVGVHVYAANASMQ
DRFFYDADGELLLVPQQGRLRVHTELGVLALEPQQIGVIPRGMRFRVELLDAAARGYVCENFGGLLRLPDLGPIGANGLA
NPRDFETPHAAFEQREGTFELVAKFQGHLWRADIGHSPLDVVAWHGNYAPYRYDLRRFNTIGSISFDHPDPSIFTVLTSP
SDTHGTANMDFAIFPPRWLVAQHTFRPPWFHRNVASEFMGLVHGVYDAKAEGFAPGGASLHNCMSGHGPDAATFDKASQA
DLTRPDVIADTMAFMFETRAVLRPTQQALSAAHRQADYQQCWSGLRAAFQPPITEDAT
>Mature_458_residues
MIQRDPNLLLSWRADQHPDAPMHNDQRYMTGFGNEFATEAVAGSLPIGQNSPQRVAHGLYAEQLSGTAFTAPRGQNRRSW
LYRIRPAAVHGSFSLVEQSHFHNDFGAGPVPPDQLRWSPLPLPSVPTDFVDGLYTMAGNGGPEAMSGVGVHVYAANASMQ
DRFFYDADGELLLVPQQGRLRVHTELGVLALEPQQIGVIPRGMRFRVELLDAAARGYVCENFGGLLRLPDLGPIGANGLA
NPRDFETPHAAFEQREGTFELVAKFQGHLWRADIGHSPLDVVAWHGNYAPYRYDLRRFNTIGSISFDHPDPSIFTVLTSP
SDTHGTANMDFAIFPPRWLVAQHTFRPPWFHRNVASEFMGLVHGVYDAKAEGFAPGGASLHNCMSGHGPDAATFDKASQA
DLTRPDVIADTMAFMFETRAVLRPTQQALSAAHRQADYQQCWSGLRAAFQPPITEDAT

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family

Homologues:

Organism=Homo sapiens, GI115527117, Length=434, Percent_Identity=49.7695852534562, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17507969, Length=434, Percent_Identity=52.7649769585253, Blast_Score=465, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24583650, Length=435, Percent_Identity=50.3448275862069, Blast_Score=439, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HGD_XANAC (Q8PQ74)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_640809.1
- ProteinModelPortal:   Q8PQ74
- GeneID:   1154525
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0454
- NMPDR:   fig|190486.1.peg.453
- HOGENOM:   HBG293508
- OMA:   RNCMSEF
- ProtClustDB:   PRK05341
- BioCyc:   XAXO190486:XAC0454-MONOMER
- BRENDA:   1.13.11.5
- HAMAP:   MF_00334
- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950
- PANTHER:   PTHR11056
- TIGRFAMs:   TIGR01015

Pfam domain/function: PF04209 HgmA; SSF51182 RmlC_like_cupin

EC number: =1.13.11.5

Molecular weight: Translated: 50450; Mature: 50450

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQRDPNLLLSWRADQHPDAPMHNDQRYMTGFGNEFATEAVAGSLPIGQNSPQRVAHGLY
CCCCCCCEEEEECCCCCCCCCCCCCCHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHH
AEQLSGTAFTAPRGQNRRSWLYRIRPAAVHGSFSLVEQSHFHNDFGAGPVPPDQLRWSPL
HHHHCCCEEECCCCCCCCCEEEEEEEHHCCCCHHHHHHHHCCCCCCCCCCCHHHCCCCCC
PLPSVPTDFVDGLYTMAGNGGPEAMSGVGVHVYAANASMQDRFFYDADGELLLVPQQGRL
CCCCCCHHHHHHHHHHCCCCCCHHHCCCEEEEEEECCCCCCCEEECCCCCEEEEECCCCE
RVHTELGVLALEPQQIGVIPRGMRFRVELLDAAARGYVCENFGGLLRLPDLGPIGANGLA
EEEEECCEEEECHHHCCCCCCCCEEEHHHHHHHHCCCEECCCCCEEECCCCCCCCCCCCC
NPRDFETPHAAFEQREGTFELVAKFQGHLWRADIGHSPLDVVAWHGNYAPYRYDLRRFNT
CCCCCCCHHHHHHHCCCHHHHHHHHHCCEEEECCCCCCCEEEEECCCCCCEEHHHHHHCC
IGSISFDHPDPSIFTVLTSPSDTHGTANMDFAIFPPRWLVAQHTFRPPWFHRNVASEFMG
CCCEEECCCCCCEEEEEECCCCCCCCCCCCEEEECCHHEECCCCCCCCCHHHHHHHHHHH
LVHGVYDAKAEGFAPGGASLHNCMSGHGPDAATFDKASQADLTRPDVIADTMAFMFETRA
HHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VLRPTQQALSAAHRQADYQQCWSGLRAAFQPPITEDAT
HHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MIQRDPNLLLSWRADQHPDAPMHNDQRYMTGFGNEFATEAVAGSLPIGQNSPQRVAHGLY
CCCCCCCEEEEECCCCCCCCCCCCCCHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHH
AEQLSGTAFTAPRGQNRRSWLYRIRPAAVHGSFSLVEQSHFHNDFGAGPVPPDQLRWSPL
HHHHCCCEEECCCCCCCCCEEEEEEEHHCCCCHHHHHHHHCCCCCCCCCCCHHHCCCCCC
PLPSVPTDFVDGLYTMAGNGGPEAMSGVGVHVYAANASMQDRFFYDADGELLLVPQQGRL
CCCCCCHHHHHHHHHHCCCCCCHHHCCCEEEEEEECCCCCCCEEECCCCCEEEEECCCCE
RVHTELGVLALEPQQIGVIPRGMRFRVELLDAAARGYVCENFGGLLRLPDLGPIGANGLA
EEEEECCEEEECHHHCCCCCCCCEEEHHHHHHHHCCCEECCCCCEEECCCCCCCCCCCCC
NPRDFETPHAAFEQREGTFELVAKFQGHLWRADIGHSPLDVVAWHGNYAPYRYDLRRFNT
CCCCCCCHHHHHHHCCCHHHHHHHHHCCEEEECCCCCCCEEEEECCCCCCEEHHHHHHCC
IGSISFDHPDPSIFTVLTSPSDTHGTANMDFAIFPPRWLVAQHTFRPPWFHRNVASEFMG
CCCEEECCCCCCEEEEEECCCCCCCCCCCCEEEECCHHEECCCCCCCCCHHHHHHHHHHH
LVHGVYDAKAEGFAPGGASLHNCMSGHGPDAATFDKASQADLTRPDVIADTMAFMFETRA
HHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VLRPTQQALSAAHRQADYQQCWSGLRAAFQPPITEDAT
HHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217